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MCL coexpression mm9:1761

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Phase1 CAGE Peaks

 Short description
Mm9::chr2:105522351..105522362,+p19@Pax6
Mm9::chr4:97248379..97248387,+p29@Nfia
Mm9::chr4:97248473..97248496,+p16@Nfia
Mm9::chr4:97248607..97248649,+p15@Nfia
Mm9::chr4:97248652..97248671,+p19@Nfia


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0021902commitment of a neuronal cell to a specific type of neuron in the forebrain0.0076699720593875
GO:0021877forebrain neuron fate commitment0.0076699720593875
GO:0009950dorsal/ventral axis specification0.0131467225601383
GO:0021798forebrain dorsal/ventral pattern formation0.0131467225601383
GO:0022612gland morphogenesis0.0131467225601383
GO:0021871forebrain regionalization0.0131467225601383
GO:0007435salivary gland morphogenesis0.0131467225601383
GO:0021879forebrain neuron differentiation0.0134202449153837
GO:0021872generation of neurons in the forebrain0.013632891141377
GO:0007431salivary gland development0.0145258107822522
GO:0021543pallium development0.0145258107822522
GO:0035272exocrine system development0.0145258107822522
GO:0042462eye photoreceptor cell development0.0145258107822522
GO:0045665negative regulation of neuron differentiation0.0145258107822522
GO:0001754eye photoreceptor cell differentiation0.0145258107822522
GO:0009798axis specification0.0145258107822522
GO:0042461photoreceptor cell development0.0145258107822522
GO:0003700transcription factor activity0.0145258107822522
GO:0021983pituitary gland development0.0145258107822522
GO:0021536diencephalon development0.0146346514277602
GO:0048663neuron fate commitment0.0146346514277602
GO:0046530photoreceptor cell differentiation0.0146346514277602
GO:0021537telencephalon development0.0153302789118187
GO:0001709cell fate determination0.0153302789118187
GO:0045664regulation of neuron differentiation0.0165553396912625
GO:0009953dorsal/ventral pattern formation0.0244021728980764
GO:0048592eye morphogenesis0.0244021728980764
GO:0050767regulation of neurogenesis0.0246237656104948
GO:0035270endocrine system development0.0253575616195415
GO:0030334regulation of cell migration0.0265520884597201
GO:0001764neuron migration0.0271757694889063
GO:0051270regulation of cell motility0.0282380840094746
GO:0040012regulation of locomotion0.0292356083395701
GO:0048732gland development0.032466382107537
GO:0043010camera-type eye development0.032466382107537
GO:0007411axon guidance0.032466382107537
GO:0045596negative regulation of cell differentiation0.032466382107537
GO:0006355regulation of transcription, DNA-dependent0.032466382107537
GO:0006351transcription, DNA-dependent0.032466382107537
GO:0032774RNA biosynthetic process0.032466382107537
GO:0003677DNA binding0.032466382107537
GO:0009952anterior/posterior pattern formation0.032466382107537
GO:0045449regulation of transcription0.032466382107537
GO:0030900forebrain development0.032466382107537
GO:0045165cell fate commitment0.032466382107537
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.032466382107537
GO:0006350transcription0.032466382107537
GO:0001654eye development0.032466382107537
GO:0051093negative regulation of developmental process0.032466382107537
GO:0010468regulation of gene expression0.0336349202078334
GO:0008285negative regulation of cell proliferation0.0350469293638884
GO:0031323regulation of cellular metabolic process0.0350469293638884
GO:0019222regulation of metabolic process0.036975482139595
GO:0006260DNA replication0.0375366993120028
GO:0016070RNA metabolic process0.0375366993120028
GO:0003002regionalization0.0401063015480455
GO:0045595regulation of cell differentiation0.0405594831052453
GO:0007409axonogenesis0.0405594831052453
GO:0048667neuron morphogenesis during differentiation0.041488573222029
GO:0048812neurite morphogenesis0.041488573222029
GO:0007420brain development0.0450598351751236
GO:0000904cellular morphogenesis during differentiation0.0450598351751236
GO:0007423sensory organ development0.0450598351751236
GO:0010467gene expression0.0455415637886521
GO:0031175neurite development0.0455415637886521
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.0455415637886521
GO:0003676nucleic acid binding0.0462836843525849
GO:0048666neuron development0.0488857145340564



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
ectoderm-derived structure3.50e-2095
ectoderm3.50e-2095
presumptive ectoderm3.50e-2095
neurectoderm1.59e-1964
neural plate1.59e-1964
presumptive neural plate1.59e-1964
ecto-epithelium1.19e-1773
pre-chordal neural plate1.28e-1649
central nervous system2.39e-1673
nervous system1.74e-1575
neural tube1.78e-1352
neural rod1.78e-1352
future spinal cord1.78e-1352
neural keel1.78e-1352
regional part of nervous system3.28e-1354
sense organ1.42e-1212
sensory system1.42e-1212
entire sense organ system1.42e-1212
brain3.72e-1247
future brain3.72e-1247
regional part of brain1.73e-1146
structure with developmental contribution from neural crest2.48e-1192
head3.01e-1113
eye1.74e-109
camera-type eye1.74e-109
simple eye1.74e-109
immature eye1.74e-109
ocular region1.74e-109
visual system1.74e-109
face1.74e-109
optic cup1.74e-109
optic vesicle1.74e-109
eye primordium1.74e-109
ectodermal placode7.08e-1013
gray matter1.82e-0934
anterior neural tube2.56e-0940
subdivision of head2.62e-0911
regional part of forebrain4.52e-0939
forebrain4.52e-0939
future forebrain4.52e-0939
brain grey matter6.84e-0829
regional part of telencephalon6.84e-0829
telencephalon6.84e-0829


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0833043
MA0004.10.603793
MA0006.10.419915
MA0007.10.587678
MA0009.11.06266
MA0014.10.0502051
MA0017.10.449113
MA0019.10.874061
MA0024.11.01759
MA0025.11.30092
MA0027.12.72141
MA0028.10.43138
MA0029.10.995171
MA0030.11.00195
MA0031.10.965177
MA0038.10.757669
MA0040.11.07552
MA0041.10.522007
MA0042.10.507715
MA0043.11.1618
MA0046.11.09955
MA0048.10.205696
MA0050.10.645342
MA0051.10.767098
MA0052.11.08379
MA0055.10.0851423
MA0056.10
MA0057.10.562607
MA0058.10.50032
MA0059.10.513699
MA0060.10.330907
MA0061.10.364227
MA0063.10
MA0066.10.746072
MA0067.11.41352
MA0068.10.197245
MA0069.11.08414
MA0070.11.07418
MA0071.10.644448
MA0072.11.06547
MA0073.13.29146
MA0074.10.708108
MA0076.10.470037
MA0077.11.04318
MA0078.11.88054
MA0081.10.53877
MA0083.11.16099
MA0084.11.74401
MA0087.11.11687
MA0088.10.148348
MA0089.10
MA0090.11.39153
MA0091.10.617887
MA0092.10.567278
MA0093.10.440484
MA0095.10
MA0098.10
MA0100.10.695835
MA0101.10.523409
MA0103.10.460936
MA0105.10.693075
MA0106.10.809991
MA0107.10.454197
MA0108.20.897859
MA0109.10
MA0111.10.582193
MA0113.10.780358
MA0114.10.361633
MA0115.11.16466
MA0116.10.419688
MA0117.11.13165
MA0119.10.524046
MA0122.11.15196
MA0124.11.35963
MA0125.11.28445
MA0130.10
MA0131.10.869325
MA0132.10
MA0133.10
MA0135.11.19898
MA0136.10.729175
MA0139.10.295945
MA0140.10.695713
MA0141.10.482463
MA0142.10.950155
MA0143.11.87173
MA0144.10.365053
MA0145.10.157686
MA0146.10.21827
MA0147.10.378658
MA0148.10.621195
MA0149.10.529387
MA0062.20.254018
MA0035.21.67146
MA0039.20.0102623
MA0138.20.861035
MA0002.20.299191
MA0137.20.479301
MA0104.20.315156
MA0047.20.75686
MA0112.20.157681
MA0065.20.158101
MA0150.11.43499
MA0151.10
MA0152.10.756973
MA0153.11.21594
MA0154.10.203217
MA0155.10.173445
MA0156.10.469089
MA0157.10.91689
MA0158.10
MA0159.10.389847
MA0160.10.624415
MA0161.10
MA0162.10.0699535
MA0163.10.0644585
MA0164.11.7313
MA0080.20.455167
MA0018.20.739807
MA0099.20.854449
MA0079.22.32359
MA0102.21.79669
MA0258.10.346619
MA0259.10.366802
MA0442.10
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