MCL coexpression mm9:190
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0000278 | mitotic cell cycle | 0.033383528378983 |
| GO:0022403 | cell cycle phase | 0.033383528378983 |
| GO:0006583 | melanin biosynthetic process from tyrosine | 0.033383528378983 |
| GO:0005954 | calcium- and calmodulin-dependent protein kinase complex | 0.033383528378983 |
| GO:0060048 | cardiac muscle contraction | 0.033383528378983 |
| GO:0030315 | T-tubule | 0.0337504227630374 |
| GO:0006582 | melanin metabolic process | 0.0337504227630374 |
| GO:0042438 | melanin biosynthetic process | 0.0337504227630374 |
| GO:0006570 | tyrosine metabolic process | 0.0337504227630374 |
| GO:0007076 | mitotic chromosome condensation | 0.0337504227630374 |
| GO:0004683 | calmodulin-dependent protein kinase activity | 0.0337504227630374 |
| GO:0030261 | chromosome condensation | 0.0337504227630374 |
| GO:0000070 | mitotic sister chromatid segregation | 0.0337504227630374 |
| GO:0000819 | sister chromatid segregation | 0.0337504227630374 |
| GO:0000082 | G1/S transition of mitotic cell cycle | 0.0383449905330503 |
| GO:0022402 | cell cycle process | 0.0383449905330503 |
| GO:0009072 | aromatic amino acid family metabolic process | 0.0383449905330503 |
| GO:0046148 | pigment biosynthetic process | 0.0383449905330503 |
| GO:0042383 | sarcolemma | 0.0383449905330503 |
| GO:0006941 | striated muscle contraction | 0.0383449905330503 |
| GO:0048066 | pigmentation during development | 0.0383449905330503 |
| GO:0042440 | pigment metabolic process | 0.0391198823684918 |
| GO:0046777 | protein amino acid autophosphorylation | 0.0394885477758235 |
| GO:0016540 | protein autoprocessing | 0.0394885477758235 |
| GO:0007049 | cell cycle | 0.0394885477758235 |
| GO:0051325 | interphase | 0.0394885477758235 |
| GO:0051329 | interphase of mitotic cell cycle | 0.0394885477758235 |
| GO:0019748 | secondary metabolic process | 0.0394885477758235 |
| GO:0060047 | heart contraction | 0.0394885477758235 |
| GO:0003015 | heart process | 0.0394885477758235 |
| GO:0030155 | regulation of cell adhesion | 0.0394885477758235 |
| GO:0007059 | chromosome segregation | 0.0394885477758235 |
| GO:0005938 | cell cortex | 0.0394885477758235 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| connective tissue | 1.50e-14 | 46 |
| thymus | 3.37e-12 | 23 |
| neck | 3.37e-12 | 23 |
| respiratory system epithelium | 3.37e-12 | 23 |
| hemolymphoid system gland | 3.37e-12 | 23 |
| pharyngeal epithelium | 3.37e-12 | 23 |
| thymic region | 3.37e-12 | 23 |
| pharyngeal gland | 3.37e-12 | 23 |
| entire pharyngeal arch endoderm | 3.37e-12 | 23 |
| thymus primordium | 3.37e-12 | 23 |
| early pharyngeal endoderm | 3.37e-12 | 23 |
| pharynx | 1.15e-11 | 24 |
| gland of gut | 1.15e-11 | 24 |
| upper respiratory tract | 1.15e-11 | 24 |
| chordate pharynx | 1.15e-11 | 24 |
| pharyngeal arch system | 1.15e-11 | 24 |
| pharyngeal region of foregut | 1.15e-11 | 24 |
| segment of respiratory tract | 2.65e-10 | 27 |
| hemopoietic organ | 1.50e-09 | 29 |
| immune organ | 1.50e-09 | 29 |
| mixed endoderm/mesoderm-derived structure | 8.39e-08 | 35 |
| organ segment | 8.39e-08 | 35 |
| hematopoietic system | 1.18e-07 | 45 |
| blood island | 1.18e-07 | 45 |
| craniocervical region | 1.44e-07 | 36 |
| hemolymphoid system | 4.02e-07 | 48 |
| immune system | 4.02e-07 | 48 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.1912e-06 |
| MA0004.1 | 1.08764 |
| MA0006.1 | 0.0588308 |
| MA0007.1 | 0.691605 |
| MA0009.1 | 0.614771 |
| MA0014.1 | 0.000125913 |
| MA0017.1 | 0.749801 |
| MA0019.1 | 0.110663 |
| MA0024.1 | 0.187051 |
| MA0025.1 | 0.383522 |
| MA0027.1 | 1.70825 |
| MA0028.1 | 0.0210427 |
| MA0029.1 | 0.173922 |
| MA0030.1 | 0.177847 |
| MA0031.1 | 0.157022 |
| MA0038.1 | 0.491425 |
| MA0040.1 | 0.222824 |
| MA0041.1 | 0.144079 |
| MA0042.1 | 0.0465591 |
| MA0043.1 | 0.280639 |
| MA0046.1 | 0.238407 |
| MA0048.1 | 0.165895 |
| MA0050.1 | 0.302298 |
| MA0051.1 | 0.236374 |
| MA0052.1 | 0.228144 |
| MA0055.1 | 0.0137417 |
| MA0056.1 | 0 |
| MA0057.1 | 0.723378 |
| MA0058.1 | 0.976702 |
| MA0059.1 | 1.03921 |
| MA0060.1 | 0.0502058 |
| MA0061.1 | 4.86482 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0594129 |
| MA0067.1 | 0.473816 |
| MA0068.1 | 1.66704 |
| MA0069.1 | 0.228369 |
| MA0070.1 | 0.632033 |
| MA0071.1 | 1.26202 |
| MA0072.1 | 0.216436 |
| MA0073.1 | 0.013129 |
| MA0074.1 | 0.17954 |
| MA0076.1 | 0.0323376 |
| MA0077.1 | 0.585966 |
| MA0078.1 | 0.57557 |
| MA0081.1 | 0.546493 |
| MA0083.1 | 0.280072 |
| MA0084.1 | 0.763469 |
| MA0087.1 | 0.249896 |
| MA0088.1 | 0.0479638 |
| MA0089.1 | 0 |
| MA0090.1 | 1.29947 |
| MA0091.1 | 0.490328 |
| MA0092.1 | 0.195477 |
| MA0093.1 | 1.66182 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.0440101 |
| MA0101.1 | 3.32367 |
| MA0103.1 | 0.548486 |
| MA0105.1 | 2.44426 |
| MA0106.1 | 0.282193 |
| MA0107.1 | 5.275 |
| MA0108.2 | 1.26369 |
| MA0109.1 | 0 |
| MA0111.1 | 0.214158 |
| MA0113.1 | 0.910634 |
| MA0114.1 | 0.264488 |
| MA0115.1 | 1.41067 |
| MA0116.1 | 0.419744 |
| MA0117.1 | 0.720237 |
| MA0119.1 | 0.770704 |
| MA0122.1 | 0.273795 |
| MA0124.1 | 0.429916 |
| MA0125.1 | 0.3708 |
| MA0130.1 | 0 |
| MA0131.1 | 0.108468 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.307058 |
| MA0136.1 | 0.768486 |
| MA0139.1 | 0.0296623 |
| MA0140.1 | 1.05291 |
| MA0141.1 | 0.224811 |
| MA0142.1 | 0.148854 |
| MA0143.1 | 0.268535 |
| MA0144.1 | 1.12235 |
| MA0145.1 | 0.236787 |
| MA0146.1 | 0.00104964 |
| MA0147.1 | 0.178678 |
| MA0148.1 | 0.110009 |
| MA0149.1 | 0.0115146 |
| MA0062.2 | 0.0714837 |
| MA0035.2 | 0.693023 |
| MA0039.2 | 0.11689 |
| MA0138.2 | 0.104681 |
| MA0002.2 | 1.18301 |
| MA0137.2 | 0.881105 |
| MA0104.2 | 0.088372 |
| MA0047.2 | 0.225984 |
| MA0112.2 | 0.161088 |
| MA0065.2 | 0.740901 |
| MA0150.1 | 0.221082 |
| MA0151.1 | 0 |
| MA0152.1 | 0.490141 |
| MA0153.1 | 0.319381 |
| MA0154.1 | 0.814167 |
| MA0155.1 | 0.144827 |
| MA0156.1 | 0.83587 |
| MA0157.1 | 0.131489 |
| MA0158.1 | 0 |
| MA0159.1 | 0.101355 |
| MA0160.1 | 0.505315 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0321203 |
| MA0163.1 | 0.00339676 |
| MA0164.1 | 0.0540521 |
| MA0080.2 | 0.775537 |
| MA0018.2 | 1.21373 |
| MA0099.2 | 0.333371 |
| MA0079.2 | 0.000652988 |
| MA0102.2 | 0.812014 |
| MA0258.1 | 0.542211 |
| MA0259.1 | 0.433914 |
| MA0442.1 | 0 |
