MCL coexpression mm9:68
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0046649 | lymphocyte activation | 0.00156080128635091 |
| GO:0002376 | immune system process | 0.00156080128635091 |
| GO:0005164 | tumor necrosis factor receptor binding | 0.00156080128635091 |
| GO:0032813 | tumor necrosis factor receptor superfamily binding | 0.00156080128635091 |
| GO:0042110 | T cell activation | 0.00156080128635091 |
| GO:0045321 | leukocyte activation | 0.00156080128635091 |
| GO:0042127 | regulation of cell proliferation | 0.00156080128635091 |
| GO:0050863 | regulation of T cell activation | 0.00164035057079106 |
| GO:0001775 | cell activation | 0.00164035057079106 |
| GO:0051249 | regulation of lymphocyte activation | 0.00431870052836382 |
| GO:0050865 | regulation of cell activation | 0.00451145655046847 |
| GO:0008283 | cell proliferation | 0.00927653768045784 |
| GO:0042129 | regulation of T cell proliferation | 0.00927653768045784 |
| GO:0050870 | positive regulation of T cell activation | 0.00927653768045784 |
| GO:0006955 | immune response | 0.00955241115460229 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0134510631825776 |
| GO:0032944 | regulation of mononuclear cell proliferation | 0.0134510631825776 |
| GO:0050670 | regulation of lymphocyte proliferation | 0.0134510631825776 |
| GO:0042098 | T cell proliferation | 0.0142197735636271 |
| GO:0002520 | immune system development | 0.0154180351297486 |
| GO:0051251 | positive regulation of lymphocyte activation | 0.0174595076172746 |
| GO:0051239 | regulation of multicellular organismal process | 0.023099335261022 |
| GO:0032943 | mononuclear cell proliferation | 0.0268799056070663 |
| GO:0046651 | lymphocyte proliferation | 0.0268799056070663 |
| GO:0008284 | positive regulation of cell proliferation | 0.0304950389345426 |
| GO:0030098 | lymphocyte differentiation | 0.0465363067612523 |
| GO:0048468 | cell development | 0.0466786632896314 |
| GO:0030097 | hemopoiesis | 0.0466786632896314 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 0.0466786632896314 |
| GO:0042102 | positive regulation of T cell proliferation | 0.0466786632896314 |
| GO:0005125 | cytokine activity | 0.0466786632896314 |
| GO:0048522 | positive regulation of cellular process | 0.0466786632896314 |
| GO:0001915 | negative regulation of T cell mediated cytotoxicity | 0.0466786632896314 |
| GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity | 0.0466786632896314 |
| GO:0030586 | [methionine synthase] reductase activity | 0.0466786632896314 |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | 0.0466786632896314 |
| GO:0045768 | positive regulation of anti-apoptosis | 0.0466786632896314 |
| GO:0032426 | stereocilium bundle tip | 0.0466786632896314 |
| GO:0047138 | aquacobalamin reductase activity | 0.0466786632896314 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.00466567 |
| MA0004.1 | 3.71672 |
| MA0006.1 | 0.897487 |
| MA0007.1 | 0.0188257 |
| MA0009.1 | 1.09845 |
| MA0014.1 | 4.36963e-06 |
| MA0017.1 | 0.154662 |
| MA0019.1 | 1.1405 |
| MA0024.1 | 0.110117 |
| MA0025.1 | 0.461192 |
| MA0027.1 | 2.54825 |
| MA0028.1 | 0.0763868 |
| MA0029.1 | 1.13604 |
| MA0030.1 | 0.375384 |
| MA0031.1 | 0.074057 |
| MA0038.1 | 1.00974 |
| MA0040.1 | 0.160636 |
| MA0041.1 | 1.19149 |
| MA0042.1 | 0.725956 |
| MA0043.1 | 0.77484 |
| MA0046.1 | 0.0152924 |
| MA0048.1 | 0.365029 |
| MA0050.1 | 1.97192 |
| MA0051.1 | 0.831021 |
| MA0052.1 | 0.84908 |
| MA0055.1 | 0.12873 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0457788 |
| MA0058.1 | 2.60061 |
| MA0059.1 | 4.47591 |
| MA0060.1 | 0.00214087 |
| MA0061.1 | 3.35577 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0907347 |
| MA0067.1 | 0.32389 |
| MA0068.1 | 2.51694 |
| MA0069.1 | 0.850264 |
| MA0070.1 | 0.319169 |
| MA0071.1 | 0.0480408 |
| MA0072.1 | 0.304856 |
| MA0073.1 | 9.37959 |
| MA0074.1 | 1.43446 |
| MA0076.1 | 0.0419827 |
| MA0077.1 | 0.13104 |
| MA0078.1 | 0.0377029 |
| MA0081.1 | 0.634252 |
| MA0083.1 | 0.104562 |
| MA0084.1 | 0.28211 |
| MA0087.1 | 0.0797259 |
| MA0088.1 | 0.226065 |
| MA0089.1 | 0 |
| MA0090.1 | 0.815447 |
| MA0091.1 | 0.984755 |
| MA0092.1 | 0.389713 |
| MA0093.1 | 5.4745 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.508749 |
| MA0101.1 | 1.63704 |
| MA0103.1 | 0.435312 |
| MA0105.1 | 2.46725 |
| MA0106.1 | 0.0414071 |
| MA0107.1 | 3.18498 |
| MA0108.2 | 0.504924 |
| MA0109.1 | 0 |
| MA0111.1 | 1.33522 |
| MA0113.1 | 1.42256 |
| MA0114.1 | 0.15358 |
| MA0115.1 | 0.48734 |
| MA0116.1 | 0.319402 |
| MA0117.1 | 0.0875923 |
| MA0119.1 | 0.0698917 |
| MA0122.1 | 0.0991472 |
| MA0124.1 | 0.266623 |
| MA0125.1 | 0.434055 |
| MA0130.1 | 0 |
| MA0131.1 | 0.61721 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.559934 |
| MA0136.1 | 0.849057 |
| MA0139.1 | 0.146753 |
| MA0140.1 | 2.21069 |
| MA0141.1 | 0.185653 |
| MA0142.1 | 1.96394 |
| MA0143.1 | 0.38871 |
| MA0144.1 | 0.651735 |
| MA0145.1 | 0.0178605 |
| MA0146.1 | 0.00048897 |
| MA0147.1 | 4.02393 |
| MA0148.1 | 0.641842 |
| MA0149.1 | 0.00542222 |
| MA0062.2 | 0.223898 |
| MA0035.2 | 0.262113 |
| MA0039.2 | 0.0371009 |
| MA0138.2 | 0.0704949 |
| MA0002.2 | 1.03642 |
| MA0137.2 | 0.426382 |
| MA0104.2 | 2.60373 |
| MA0047.2 | 0.584395 |
| MA0112.2 | 0.22737 |
| MA0065.2 | 0.659123 |
| MA0150.1 | 0.47684 |
| MA0151.1 | 0 |
| MA0152.1 | 1.25895 |
| MA0153.1 | 0.141255 |
| MA0154.1 | 0.121609 |
| MA0155.1 | 1.19014 |
| MA0156.1 | 0.735689 |
| MA0157.1 | 0.0485711 |
| MA0158.1 | 0 |
| MA0159.1 | 0.518235 |
| MA0160.1 | 0.266893 |
| MA0161.1 | 0 |
| MA0162.1 | 0.901324 |
| MA0163.1 | 0.00461562 |
| MA0164.1 | 0.337555 |
| MA0080.2 | 1.6719 |
| MA0018.2 | 0.90754 |
| MA0099.2 | 3.20727 |
| MA0079.2 | 0.000564496 |
| MA0102.2 | 0.318901 |
| MA0258.1 | 0.972406 |
| MA0259.1 | 1.23092 |
| MA0442.1 | 0 |
