Coexpression cluster:C2508

Full id: C2508_mature_skeletal_left_Endothelial_adipose_heart_gastric

Phase1 CAGE Peaks

Hg19::chr1:100111421..100111448,+	p5@PALMD
Hg19::chr1:100111479..100111490,+	p8@PALMD
Hg19::chr1:100111546..100111567,+	p3@PALMD
Hg19::chr1:100111580..100111773,+	p1@PALMD

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	2.77e-15	24
blood vessel endothelial cell	8.52e-12	18
embryonic blood vessel endothelial progenitor cell	8.52e-12	18
endothelial cell	8.75e-11	35
meso-epithelial cell	1.25e-08	44
endothelial cell of artery	3.93e-07	9

Uber Anatomy

Ontology term	p-value	n
anatomical cluster	3.11e-34	286
anatomical conduit	4.88e-31	241
adult organism	1.51e-28	115
tube	3.53e-26	194
anatomical system	1.78e-23	625
anatomical group	1.87e-23	626
multi-cellular organism	6.52e-22	659
epithelium	9.57e-22	309
multi-tissue structure	1.15e-21	347
cell layer	1.44e-21	312
organism subdivision	2.85e-18	365
embryonic structure	1.90e-15	605
developing anatomical structure	1.90e-15	605
embryo	1.99e-15	612
germ layer	3.98e-15	604
embryonic tissue	3.98e-15	604
presumptive structure	3.98e-15	604
epiblast (generic)	3.98e-15	604
central nervous system	1.40e-13	82
vessel	1.73e-13	69
anterior region of body	2.08e-13	129
craniocervical region	2.08e-13	129
splanchnic layer of lateral plate mesoderm	2.52e-13	84
head	3.31e-13	123
epithelial tube	4.33e-13	118
neural plate	4.54e-13	86
presumptive neural plate	4.54e-13	86
neural tube	7.22e-13	57
neural rod	7.22e-13	57
future spinal cord	7.22e-13	57
neural keel	7.22e-13	57
vasculature	1.45e-12	79
vascular system	1.45e-12	79
ectoderm-derived structure	1.52e-12	169
regional part of nervous system	1.60e-12	94
nervous system	1.60e-12	94
brain	3.35e-12	69
future brain	3.35e-12	69
blood vessel	4.71e-12	60
epithelial tube open at both ends	4.71e-12	60
blood vasculature	4.71e-12	60
vascular cord	4.71e-12	60
endothelium	8.52e-12	18
blood vessel endothelium	8.52e-12	18
cardiovascular system endothelium	8.52e-12	18
regional part of brain	1.28e-11	59
ectoderm	3.04e-11	173
presumptive ectoderm	3.04e-11	173
neurectoderm	3.74e-11	90
circulatory system	1.52e-10	113
anterior neural tube	1.73e-10	42
organ	2.39e-10	511
organ part	3.40e-10	219
regional part of forebrain	6.16e-10	41
forebrain	6.16e-10	41
future forebrain	6.16e-10	41
simple squamous epithelium	2.05e-09	22
cardiovascular system	2.18e-09	110
pre-chordal neural plate	6.26e-09	61
unilaminar epithelium	1.07e-08	138
squamous epithelium	1.17e-08	25
mesenchyme	3.64e-08	238
entire embryonic mesenchyme	3.64e-08	238
primary circulatory organ	4.91e-08	27
gray matter	6.37e-08	34
brain grey matter	6.37e-08	34
telencephalon	8.50e-08	34
regional part of telencephalon	1.23e-07	33
primordium	1.95e-07	168
cerebral hemisphere	2.28e-07	32
compound organ	3.50e-07	69
endothelial tube	3.93e-07	9
arterial system endothelium	3.93e-07	9
endothelium of artery	3.93e-07	9
artery	4.36e-07	42
arterial blood vessel	4.36e-07	42
arterial system	4.36e-07	42
regional part of cerebral cortex	5.91e-07	22
subdivision of digestive tract	6.58e-07	129
endodermal part of digestive tract	6.58e-07	129

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.