Coexpression cluster:C1295

Full id: C1295_Eosinophils_CD4_CD14_Neutrophils_CD8_Basophils_Mast

Phase1 CAGE Peaks

Hg19::chr10:112632685..112632730,+	p6@PDCD4
Hg19::chr10:112632799..112632821,+	p15@PDCD4
Hg19::chr20:18488007..18488029,-	p@chr20:18488007..18488029 -
Hg19::chr22:39096925..39096954,-	p1@JOSD1
Hg19::chr22:39097117..39097135,+	p@chr22:39097117..39097135 +
Hg19::chr8:146127003..146127014,+	p@chr8:146127003..146127014 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043508	negative regulation of JNK activity	0.00359119274696809
GO:0007569	cell aging	0.00933710114211703
GO:0043407	negative regulation of MAP kinase activity	0.00933710114211703
GO:0043506	regulation of JNK activity	0.00933710114211703
GO:0007568	aging	0.00933710114211703
GO:0006469	negative regulation of protein kinase activity	0.0132425232544448
GO:0033673	negative regulation of kinase activity	0.0132425232544448
GO:0051348	negative regulation of transferase activity	0.0132425232544448
GO:0043086	negative regulation of catalytic activity	0.0166990462734016
GO:0043405	regulation of MAP kinase activity	0.0166990462734016
GO:0045786	negative regulation of progression through cell cycle	0.0316794503036114
GO:0045859	regulation of protein kinase activity	0.0316794503036114
GO:0043549	regulation of kinase activity	0.0316794503036114
GO:0051338	regulation of transferase activity	0.0316794503036114
GO:0016481	negative regulation of transcription	0.0348345696455905
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0357997026963381
GO:0000074	regulation of progression through cell cycle	0.0358121721155984
GO:0051726	regulation of cell cycle	0.0358121721155984
GO:0031324	negative regulation of cellular metabolic process	0.0360064325419696
GO:0009892	negative regulation of metabolic process	0.0391440009419522
GO:0005829	cytosol	0.0485666066732828
GO:0050790	regulation of catalytic activity	0.0487933797142403
GO:0022402	cell cycle process	0.0487933797142403

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	8.78e-41	140
hematopoietic cell	1.38e-33	182
hematopoietic stem cell	7.69e-33	172
angioblastic mesenchymal cell	7.69e-33	172
hematopoietic lineage restricted progenitor cell	1.03e-31	124
nongranular leukocyte	1.26e-29	119
hematopoietic oligopotent progenitor cell	2.41e-29	165
hematopoietic multipotent progenitor cell	2.41e-29	165
CD14-positive, CD16-negative classical monocyte	2.05e-23	42
classical monocyte	8.98e-23	45
myeloid leukocyte	1.49e-17	76
lymphocyte	2.98e-17	53
common lymphoid progenitor	2.98e-17	53
lymphoid lineage restricted progenitor cell	5.99e-17	52
granulocyte monocyte progenitor cell	1.21e-14	71
myeloid lineage restricted progenitor cell	5.33e-14	70
myeloid cell	4.71e-13	112
common myeloid progenitor	4.71e-13	112
macrophage dendritic cell progenitor	3.56e-12	65
monopoietic cell	2.22e-11	63
monocyte	2.22e-11	63
monoblast	2.22e-11	63
promonocyte	2.22e-11	63
T cell	7.65e-11	25
pro-T cell	7.65e-11	25
mature alpha-beta T cell	1.61e-10	18
alpha-beta T cell	1.61e-10	18
immature T cell	1.61e-10	18
mature T cell	1.61e-10	18
immature alpha-beta T cell	1.61e-10	18

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.70e-18	102
blood island	3.70e-18	102
hemolymphoid system	1.57e-16	112
bone marrow	4.59e-14	80
bone element	2.19e-12	86
immune system	5.40e-11	115
skeletal element	3.44e-07	101
skeletal system	3.44e-07	101

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.