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Coexpression cluster:C4063: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000073!2.51e-32!94;UBERON:0001016!2.51e-32!94;UBERON:0005743!4.52e-32!86;UBERON:0001017!2.08e-31!82;UBERON:0002346!1.04e-29!90;UBERON:0003075!3.60e-28!86;UBERON:0007284!3.60e-28!86;UBERON:0001049!8.64e-28!57;UBERON:0005068!8.64e-28!57;UBERON:0006241!8.64e-28!57;UBERON:0007135!8.64e-28!57;UBERON:0000955!1.03e-25!69;UBERON:0006238!1.03e-25!69;UBERON:0002616!2.92e-25!59;UBERON:0003056!1.46e-21!61;UBERON:0002780!7.48e-21!41;UBERON:0001890!7.48e-21!41;UBERON:0006240!7.48e-21!41;UBERON:0003080!3.61e-20!42;UBERON:0000924!6.93e-20!173;UBERON:0006601!6.93e-20!173;UBERON:0002020!6.93e-19!34;UBERON:0003528!6.93e-19!34;UBERON:0004121!1.35e-18!169;UBERON:0001869!1.61e-18!32;UBERON:0001893!1.69e-18!34;UBERON:0002791!7.01e-18!33;UBERON:0000153!3.88e-17!129;UBERON:0007811!3.88e-17!129;UBERON:0000033!9.42e-17!123;UBERON:0002619!4.32e-15!22;UBERON:0000956!6.49e-15!25;UBERON:0000203!6.49e-15!25;UBERON:0000119!5.14e-14!312;UBERON:0001950!7.56e-14!20;UBERON:0007023!2.42e-13!115;UBERON:0000475!3.27e-13!365;UBERON:0000483!3.43e-13!309;UBERON:0000025!3.44e-12!194;UBERON:0000481!3.45e-10!347;UBERON:0000064!6.17e-09!219;UBERON:0003076!9.05e-09!15;UBERON:0003057!9.05e-09!15;UBERON:0004111!3.66e-08!241;UBERON:0000477!7.17e-08!286;UBERON:0004732!9.03e-08!13;UBERON:0004733!1.68e-07!12;UBERON:0002028!1.68e-07!12;UBERON:0007277!1.68e-07!12
|ontology_enrichment_uberon=UBERON:0000073!2.51e-32!94;UBERON:0001016!2.51e-32!94;UBERON:0005743!4.52e-32!86;UBERON:0001017!2.08e-31!82;UBERON:0002346!1.04e-29!90;UBERON:0003075!3.60e-28!86;UBERON:0007284!3.60e-28!86;UBERON:0001049!8.64e-28!57;UBERON:0005068!8.64e-28!57;UBERON:0006241!8.64e-28!57;UBERON:0007135!8.64e-28!57;UBERON:0000955!1.03e-25!69;UBERON:0006238!1.03e-25!69;UBERON:0002616!2.92e-25!59;UBERON:0003056!1.46e-21!61;UBERON:0002780!7.48e-21!41;UBERON:0001890!7.48e-21!41;UBERON:0006240!7.48e-21!41;UBERON:0003080!3.61e-20!42;UBERON:0000924!6.93e-20!173;UBERON:0006601!6.93e-20!173;UBERON:0002020!6.93e-19!34;UBERON:0003528!6.93e-19!34;UBERON:0004121!1.35e-18!169;UBERON:0001869!1.61e-18!32;UBERON:0001893!1.69e-18!34;UBERON:0002791!7.01e-18!33;UBERON:0000153!3.88e-17!129;UBERON:0007811!3.88e-17!129;UBERON:0000033!9.42e-17!123;UBERON:0002619!4.32e-15!22;UBERON:0000956!6.49e-15!25;UBERON:0000203!6.49e-15!25;UBERON:0000119!5.14e-14!312;UBERON:0001950!7.56e-14!20;UBERON:0007023!2.42e-13!115;UBERON:0000475!3.27e-13!365;UBERON:0000483!3.43e-13!309;UBERON:0000025!3.44e-12!194;UBERON:0000481!3.45e-10!347;UBERON:0000064!6.17e-09!219;UBERON:0003076!9.05e-09!15;UBERON:0003057!9.05e-09!15;UBERON:0004111!3.66e-08!241;UBERON:0000477!7.17e-08!286;UBERON:0004732!9.03e-08!13;UBERON:0004733!1.68e-07!12;UBERON:0002028!1.68e-07!12;UBERON:0007277!1.68e-07!12
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74211,0.160149,0.123526,0.0906475,0.0558058,0.00477066,0.517717,0.009894,0.0145999,0.0656973,0.211746,0.220538,0.0801488,0.0757897,0.161801,0.193215,0.0549034,0.0779715,0.0561838,0.0417636,0.0345419,0.0388736,0.254674,0.170307,0.201033,0.0488949,0.174921,0.370421,0.0330727,0.348757,0.219556,0.0394698,0.0596469,0.0178982,0.122476,0.108872,0.11002,0.26144,0.0286025,0.549354,0.144567,0.038848,0.0874516,0.0550279,0.144067,0.253693,0.217069,0.190048,0.131088,0.394069,0.237101,0.286988,0.0761239,0.172491,0.0818785,0.182701,0.335058,0.147698,0.141463,0.167267,0.140622,0.0889592,0.309588,0.28711,0.0473033,0.094881,0.445524,0.132886,0.0774373,0.109194,0.128564,0.131452,0.00681584,0.448776,0.051838,0.0993999,0.0500365,0.061829,0.0755121,0.0936516,0.144075,0.0340203,0.0741807,0.277091,0.0122266,1.97357e-07,0.21727,0.289306,9.77694e-06,0.192475,0.177967,0.547859,0.057571,0.047591,0.0899568,0.0608699,0.175319,0.300597,0.0713214,0.223874,0.291114,0.0355833,0.125606,0.175094,0.00352878,0.00739585,0.206454,0.218192,0.108277,0.0673484,0.108748,0.0494066,0.0958493,0.205732,0.0755808,0.045654,0.110216,0.070276,0.226171,0.0124298,0.0376916,0.13262,0.0450031,0.0539144,0.114242,0.0929549,0.172425,0.104948,0.221645,0.057168,0.234298,0.0759837,0.286863,0.152372,0.194941,0.218271,0.101607,0.060512,0.172982,0.340936,0.151597,0.0626744,0.191335,0.148574,0.504592,0.155821,0.0718905,0.0919008,0.0602373,0.000561466,0.15063,0.0973823,0.15503,0.170295,0.193653,0.137219,0.228144,0.251466,0.288096,0.11903,0.0838874,0.331451,0.113145,0.112651,0.186638,0.174776,0.0948451,0.264079,0.249049,0.140533,0.0997756,0.257598,0.103667,0.113069,0.025556,0.16791,0.09066,0.0125264,0.166967,0.188651,0.0813902,0.184948,0.156261,0.311847,0.511859,0.0590944,0.0334734,0.178389,0.218229,0.231073,0.407281,0.252227,0.0360851,0.412187,0.131093,0.0434602,0.133616,0.0177337,0.36927,0.00328135,0.407369,0.231447,0.544776,0.43956,0.37006,0.42622,0.448797,0.197484,0.396996,0.36145,0.406019,0.381071,0.580441,0.643768,0.432035,1.11226e-10,0.390366,0.48809,0.50058,0.117158,0.522904,0.00567172,0.000283689,0.227104,0.518585,0.617852,0.38649,0.284625,0.504757,0.55194,0.0437169,0.28907,0.164197,0.462688,0.287881,0.574635,0.478174,0.336276,0.0263888,0.258219,0.446557,0.243383,0.000171205,0.390974,0.000456298,0.109758,0.161598,0.013901,0.644754,0.496032,0.00136122,0.37357,0.000199981,0.477353,0.199161,0.0508568,0.000852086,0.20342,0.200493,0.20558,0.300504,0.25656,2.53013e-05,0.349197,0.383291,0.156104,0.141318,2.61429e-14,0.0961477,0.00677445,0.354789,0.163828,0.230581,0.120226,0.28424,0.00162521,0.00677385,0.181415,0.282286,0.00465874,0.616388,0.408413,0.516511,0.322213,0.000830547,0.33942,0.0156581,0.387276,0.522605,0.802166,0.537348,0.222037,0.102227,0.416292,0.462712,0.0115406,0.579431,0.204817,0.452428,0.138871,0.00583733,0.166905,0.19783,0.0833851,0.316453,0.48065,0.175199,0.00818864,0.373557,0.523625,0.408861,0.365487,0.534741,0.39088,0.363192,0.236011,0.203486,0.273398,0.375787,0.4466,0.351067,0.275347,0.019895,0.305885,0.241132,0.371414,0.30666,0.303709,0.495883,0.386538,8.48983e-07,0.250964,0.383276,0.0243456,0.000798597,0.220231,0.159791,0.020816,0.191517,0.000467747,0.0663581,0.0529819,0.0246928,0.283463,0.563586,0.472935,0.399569,0.273281,0.368095,0.275089,0.384593,0.0283414,0.359231,0.339729,0.197805,0.0153645,0.387069,0.332774,0.52832,0.299887,0.634365,0.205413,0.17639,0.0779009,0.276869,0.205298,0.0337138,0.18966,0.258854,0.188263,0.0719199,0.264884,0.162568,0.19104,0.163057,0.219428,0.208013,0.0900729,0.0953646,0.166124,0.252184,0.378361,0.255516,0.20753,0.447185,0.179412,0.193601,0.00215229,0.222977,0.341681,0.310674,0.21801,0.198614,0.186804,0.123324,0.199468,0.0325925,0.0933115,0.12405,0.179889,0.226869,0.27872,0.0855609,0.131118,0.0233967,0.247588,0.222339,0.0673329,0.20847,0.266544,0.113092,0.0111711,0.229428,0.162145,0.228955,0.0151141,0.0384949,0.0660995,0.0521984,0.0455518,0.268741,0.201602,0.350452,0.154941,0.120196,0.0986735,0.108462,0.0595618,0.21593,0.158479,0.220319,0.195218,0.124213,0.259632,0.0532009,0.180606,0.159884,0.257294,0.150733,0.217112,0.123917,0.184317,0.185335,0.0723291,0.258496,0.0377094,0.203781,0.21382,0.207559,0.141867,0.193031,0.249101,0.000284685,0.224568,0.246105,0.000991755,0.200432,0.139785,0.197112,0.00282612,0.156465,0.13108,0.256963,0.222798,0.172134,0.176789,0.0969345,0.202137,0.310405,0.00467879,0.218161,0.0822373,0.202065,0.106739,0.0536053,0.0537737,0.15113,0.078016,0.0407233,0.0537355,0.319922,0.261724,0.211332,0.187731,0.233626,0.189559,0.0812887,0.0981146,0.064145,0.121913,0.0638699,0.104603,0.0663259,0.0762523,0.128736,0.109171,0.04411,0.066952,0.089609,0.0367455,0.13497,0.204393,0.295769,0.286691,0.347036,0.141729,0.263159,0.255956,0.200105,0.227491,0.29837,0.253509,0.177664,0.28365,0.264413,0.131761,0.160658,0.206239,0.19924,0.28689,0.236464,0.0597546,0.115817,0.218052,0.223831,0.11528,0.194982,0.190993,0.281727,0.283218,0.249955,0.164638,0.224257,0.0935776,0.327622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0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}}
}}

Revision as of 11:48, 5 September 2012


Full id: C4063_alveolar_medial_occipital_brain_olfactory_amygdala_hippocampus



Phase1 CAGE Peaks

Hg19::chr20:62284737..62284748,-p3@STMN3
Hg19::chr20:62284766..62284785,-p1@STMN3
Hg19::chr20:62284790..62284807,-p2@STMN3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
neurectodermal cell8.56e-0759
Uber Anatomy
Ontology termp-valuen
regional part of nervous system2.51e-3294
nervous system2.51e-3294
central nervous system2.08e-3182
neurectoderm1.04e-2990
neural plate3.60e-2886
presumptive neural plate3.60e-2886
neural tube8.64e-2857
neural rod8.64e-2857
future spinal cord8.64e-2857
neural keel8.64e-2857
brain1.03e-2569
future brain1.03e-2569
regional part of brain2.92e-2559
pre-chordal neural plate1.46e-2161
regional part of forebrain7.48e-2141
forebrain7.48e-2141
future forebrain7.48e-2141
anterior neural tube3.61e-2042
ectoderm6.93e-20173
presumptive ectoderm6.93e-20173
gray matter6.93e-1934
brain grey matter6.93e-1934
ectoderm-derived structure1.35e-18169
cerebral hemisphere1.61e-1832
telencephalon1.69e-1834
regional part of telencephalon7.01e-1833
anterior region of body3.88e-17129
craniocervical region3.88e-17129
head9.42e-17123
regional part of cerebral cortex4.32e-1522
cerebral cortex6.49e-1525
pallium6.49e-1525
cell layer5.14e-14312
neocortex7.56e-1420
adult organism2.42e-13115
organism subdivision3.27e-13365
epithelium3.43e-13309
tube3.44e-12194
multi-tissue structure3.45e-10347
organ part6.17e-09219
posterior neural tube9.05e-0915
chordal neural plate9.05e-0915
anatomical conduit3.66e-08241
anatomical cluster7.17e-08286
segmental subdivision of nervous system9.03e-0813
segmental subdivision of hindbrain1.68e-0712
hindbrain1.68e-0712
presumptive hindbrain1.68e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190330382950183
E2F4#1874312.66806031528440.0004917987006298980.00437764974815358
E2F6#187635.017155731697390.00791769806886330.0322875509981654
EGR1#195834.988179094810140.008056488137383440.0321173969226731
ELF1#199734.258097958807540.01295179875054610.0463085556216461
ELK4#2005316.2356816584680.0002336043955745990.00255925831001946
ETS1#211339.728760922202340.001085840092584840.00763355233100887
FOSL2#2355316.93020060456170.0002060162053171620.00243367565514298
GABPB1#255337.067683836182170.002832212825417420.0154356559658597
HDAC2#3066313.41562023662630.0004140761399857210.00391789255154636
HMGN3#932438.178547723350590.001827766942164210.0108856154010429
IRF1#365937.63716375356390.002244692747297240.0128295006750384
MAX#414936.452555509007120.003721913834265510.0186854280121547
MXI1#460139.96157162875930.001011470541259020.00721022263726374
MYC#460935.22228187160940.007020843755740150.0294975420792399
RAD21#5885310.35503389545630.0009004912073565420.00665061885334204
REST#597839.650028716128020.001112636247114590.0076879005631757
SIN3A#2594235.408884726815140.006318961977991520.027724166947549
SMARCB1#6598318.25271578115740.000164397760679890.00203382346927826
TAF7#6879311.43306940492390.0006690181981945830.00544001803186266
TCF7L2#6934310.77017656313730.0008003181298398380.00614681755863678
USF1#739136.361499277207960.00388404057290560.0190613840230106
YY1#752834.911170749853860.008441455341808260.0329860124384747
ZBTB7A#5134137.35190930787590.002516255860282270.0140464613711059
ZNF143#7702313.50087655222790.0004062804962997170.00389673328616458



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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