Coexpression cluster:C140

Full id: C140_Renal_Endothelial_Hepatic_Lymphatic_heart_lung_spleen

Phase1 CAGE Peaks

Hg19::chr10:129785574..129785580,+	p14@PTPRE
Hg19::chr10:3466752..3466759,-	p@chr10:3466752..3466759 -
Hg19::chr10:88715509..88715533,+	p@chr10:88715509..88715533 +
Hg19::chr10:88717312..88717335,-	p2@MMRN2
Hg19::chr10:88717337..88717379,-	p1@MMRN2
Hg19::chr10:88717384..88717401,-	p3@MMRN2
Hg19::chr10:99655692..99655725,-	p@chr10:99655692..99655725 -
Hg19::chr11:124632179..124632199,-	p1@ESAM
Hg19::chr11:124761247..124761258,-	p@chr11:124761247..124761258 -
Hg19::chr11:124767043..124767111,-	p2@ROBO4
Hg19::chr11:124767693..124767774,-	p1@ROBO4
Hg19::chr11:124767798..124767809,-	p3@ROBO4
Hg19::chr12:52300721..52300741,+	p1@ACVRL1
Hg19::chr12:52300746..52300751,+	p10@ACVRL1
Hg19::chr12:52301175..52301188,+	p4@ACVRL1
Hg19::chr12:52301280..52301299,+	p2@ACVRL1
Hg19::chr12:53443945..53443959,+	p4@TENC1
Hg19::chr12:54813229..54813273,-	p3@ITGA5
Hg19::chr13:114462172..114462186,+	p2@FAM70B
Hg19::chr13:114462193..114462251,+	p1@FAM70B
Hg19::chr14:105943573..105943602,+	p5@CRIP2
Hg19::chr14:38725228..38725236,-	p5@CLEC14A
Hg19::chr14:38725249..38725254,-	p6@CLEC14A
Hg19::chr14:38725257..38725276,-	p2@CLEC14A
Hg19::chr14:38725279..38725304,-	p1@CLEC14A
Hg19::chr14:38725573..38725605,-	p3@CLEC14A
Hg19::chr14:38725646..38725681,-	p4@CLEC14A
Hg19::chr15:41221536..41221539,+	p1@DLL4
Hg19::chr16:2220346..2220365,+	p@chr16:2220346..2220365 +
Hg19::chr16:2220383..2220402,+	p@chr16:2220383..2220402 +
Hg19::chr16:66400533..66400545,+	p2@CDH5
Hg19::chr16:66400553..66400565,+	p3@CDH5
Hg19::chr16:66400578..66400600,+	p1@CDH5
Hg19::chr16:66413317..66413328,+	p1@AB385138
Hg19::chr16:66422312..66422316,+	p@chr16:66422312..66422316 +
Hg19::chr16:66423348..66423366,+	p@chr16:66423348..66423366 +
Hg19::chr17:47287749..47287777,+	p2@ABI3
Hg19::chr17:47287786..47287797,+	p4@ABI3
Hg19::chr17:62084108..62084111,-	p5@ICAM2
Hg19::chr17:62084115..62084146,-	p2@ICAM2
Hg19::chr17:62084241..62084253,-	p3@ICAM2
Hg19::chr17:6926362..6926377,+	p1@BCL6B
Hg19::chr17:6926381..6926392,+	p2@BCL6B
Hg19::chr17:7758374..7758390,+	p1@TMEM88
Hg19::chr17:80803529..80803573,+	p1@AK296594
Hg19::chr17:8213539..8213566,+	p1@ARHGEF15
Hg19::chr17:8214130..8214149,+	p2@ARHGEF15
Hg19::chr17:8230085..8230130,+	p@chr17:8230085..8230130 +
Hg19::chr19:13213399..13213414,-	p6@LYL1
Hg19::chr19:17375541..17375588,-	p1@USHBP1
Hg19::chr19:41985048..41985050,-	p@chr19:41985048..41985050 -
Hg19::chr19:4639514..4639575,+	p1@TNFAIP8L1
Hg19::chr19:47220191..47220198,-	p14@PRKD2
Hg19::chr19:47220200..47220229,-	p3@PRKD2
Hg19::chr19:47231612..47231624,-	p@chr19:47231612..47231624 -
Hg19::chr19:49243813..49243823,-	p5@RASIP1
Hg19::chr19:49243830..49243844,-	p3@RASIP1
Hg19::chr19:49243845..49243873,-	p2@RASIP1
Hg19::chr19:55598636..55598675,+	p@chr19:55598636..55598675 +
Hg19::chr1:153581416..153581458,-	p4@S100A16
Hg19::chr1:153581468..153581499,-	p3@S100A16
Hg19::chr1:154474878..154474925,-	p1@SHE
Hg19::chr1:155279483..155279532,+	p4@FDPS
Hg19::chr1:208417309..208417348,-	p5@PLXNA2
Hg19::chr1:21606013..21606059,-	p5@ECE1
Hg19::chr1:21606082..21606114,-	p7@ECE1
Hg19::chr1:21606132..21606156,-	p9@ECE1
Hg19::chr1:21606171..21606188,-	p10@ECE1
Hg19::chr1:32041957..32041990,+	p3@TINAGL1
Hg19::chr1:43766619..43766635,+	p3@TIE1
Hg19::chr1:43766642..43766667,+	p2@TIE1
Hg19::chr1:43766668..43766696,+	p1@TIE1
Hg19::chr1:6545502..6545548,-	p2@PLEKHG5
Hg19::chr1:85930471..85930494,+	p@chr1:85930471..85930494 +
Hg19::chr20:19867150..19867175,+	p7@RIN2
Hg19::chr20:19867269..19867283,+	p3@RIN2
Hg19::chr20:62680984..62680999,-	p1@SOX18
Hg19::chr22:23648925..23648941,+	p5@BCR
Hg19::chr22:39640974..39640994,-	p1@PDGFB
Hg19::chr2:56412902..56412919,-	p1@ENST00000432793 p1@uc010fca.1
Hg19::chr3:14852174..14852233,+	p@chr3:14852174..14852233 +
Hg19::chr3:168959838..168959856,+	p@chr3:168959838..168959856 +
Hg19::chr3:194406603..194406619,+	p1@FAM43A
Hg19::chr3:43538305..43538325,-	p@chr3:43538305..43538325 -
Hg19::chr3:50360165..50360183,-	p2@HYAL2
Hg19::chr3:50360192..50360204,-	p3@HYAL2
Hg19::chr3:58034268..58034295,+	p@chr3:58034268..58034295 +
Hg19::chr4:55991752..55991770,-	p1@KDR
Hg19::chr5:138842286..138842336,-	p1@ECSCR
Hg19::chr5:141060389..141060439,-	p3@ARAP3
Hg19::chr5:150019857..150019868,+	p18@SYNPO
Hg19::chr5:150019871..150019935,+	p4@SYNPO
Hg19::chr5:150019938..150019967,+	p14@SYNPO
Hg19::chr5:34656569..34656588,+	p7@RAI14
Hg19::chr6:12290586..12290600,+	p1@EDN1
Hg19::chr6:148664333..148664338,-	p@chr6:148664333..148664338 -
Hg19::chr6:32191791..32191818,-	p3@NOTCH4
Hg19::chr6:7726323..7726348,+	p1@BMP6
Hg19::chr7:150690812..150690817,+	p10@NOS3
Hg19::chr7:150690837..150690856,+	p2@NOS3
Hg19::chr7:150690857..150690878,+	p1@NOS3
Hg19::chr7:39663061..39663072,+	p6@RALA
Hg19::chr7:93551032..93551066,+	p3@GNG11
Hg19::chr8:10588010..10588030,-	p1@SOX7
Hg19::chr8:21924000..21924036,+	p4@EPB49
Hg19::chr9:116263778..116263793,+	p2@RGS3
Hg19::chr9:116263811..116263822,+	p14@RGS3
Hg19::chr9:130524695..130524736,-	p10@SH2D3C
Hg19::chr9:130533558..130533610,-	p1@SH2D3C
Hg19::chr9:130609397..130609424,-	p9@ENG
Hg19::chr9:130616888..130616899,-	p5@ENG
Hg19::chr9:130616926..130616944,-	p1@ENG
Hg19::chr9:139538947..139538969,-	p@chr9:139538947..139538969 -
Hg19::chr9:139543390..139543404,+	p@chr9:139543390..139543404 +
Hg19::chr9:139543445..139543462,+	p@chr9:139543445..139543462 +
Hg19::chr9:139557360..139557376,+	p1@EGFL7
Hg19::chr9:139563710..139563714,+	p@chr9:139563710..139563714 +
Hg19::chr9:139606943..139606979,+	p2@FAM69B
Hg19::chr9:139606983..139607035,+	p1@FAM69B
Hg19::chr9:35909452..35909465,+	p5@LOC158376
Hg19::chr9:35909478..35909495,+	p1@LOC158376
Hg19::chrX:128781635..128781648,-	p@chrX:128781635..128781648 -
Hg19::chrX:128781853..128781866,-	p@chrX:128781853..128781866 -
Hg19::chrX:128782722..128782738,-	p5@APLN
Hg19::chrX:128788923..128788942,-	p1@APLN
Hg19::chrX:71299684..71299699,+	p@chrX:71299684..71299699 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

p.value	FDR	nGenes	nPathway	Name
1.23161703778041e-05	0.00779613584915002	3	23	Angiogenesis (Wikipathways):WP1539

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0001525	angiogenesis	2.11374324114935e-10
GO:0048514	blood vessel morphogenesis	3.33452412540309e-10
GO:0048646	anatomical structure formation	3.33452412540309e-10
GO:0001568	blood vessel development	4.18728600634572e-10
GO:0001944	vasculature development	4.18728600634572e-10
GO:0009887	organ morphogenesis	1.54920920309376e-08
GO:0007165	signal transduction	6.78298039940112e-07
GO:0048513	organ development	6.78298039940112e-07
GO:0007154	cell communication	6.78298039940112e-07
GO:0048731	system development	3.1700273590176e-05
GO:0009653	anatomical structure morphogenesis	0.000175551122952142
GO:0007275	multicellular organismal development	0.000259341093388208
GO:0048856	anatomical structure development	0.000288362204070747
GO:0044459	plasma membrane part	0.00108525939425613
GO:0005515	protein binding	0.00161340307696319
GO:0016020	membrane	0.00254974465118234
GO:0032502	developmental process	0.00254974465118234
GO:0005886	plasma membrane	0.00287052046562877
GO:0008015	blood circulation	0.00287052046562877
GO:0003013	circulatory system process	0.00287052046562877
GO:0005085	guanyl-nucleotide exchange factor activity	0.00287052046562877
GO:0032501	multicellular organismal process	0.00287052046562877
GO:0030334	regulation of cell migration	0.00287052046562877
GO:0005088	Ras guanyl-nucleotide exchange factor activity	0.00300668146559652
GO:0001569	patterning of blood vessels	0.00309874167099624
GO:0051270	regulation of cell motility	0.00385109523932316
GO:0040012	regulation of locomotion	0.00420797208421217
GO:0040011	locomotion	0.00422711851243521
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.00459854589949203
GO:0001570	vasculogenesis	0.00713528780788853
GO:0004871	signal transducer activity	0.00739650586127434
GO:0060089	molecular transducer activity	0.00739650586127434
GO:0007242	intracellular signaling cascade	0.0115242194591448
GO:0030695	GTPase regulator activity	0.0115997662814792
GO:0035295	tube development	0.013033832245552
GO:0005887	integral to plasma membrane	0.013033832245552
GO:0050794	regulation of cellular process	0.013033832245552
GO:0009880	embryonic pattern specification	0.013033832245552
GO:0048754	branching morphogenesis of a tube	0.013033832245552
GO:0007166	cell surface receptor linked signal transduction	0.013033832245552
GO:0031226	intrinsic to plasma membrane	0.013033832245552
GO:0005102	receptor binding	0.0132932641457088
GO:0019199	transmembrane receptor protein kinase activity	0.0139364903259838
GO:0001763	morphogenesis of a branching structure	0.0148506915197131
GO:0007167	enzyme linked receptor protein signaling pathway	0.0148506915197131
GO:0051216	cartilage development	0.0148506915197131
GO:0048523	negative regulation of cellular process	0.0148506915197131
GO:0043179	rhythmic excitation	0.0148506915197131
GO:0032352	positive regulation of hormone metabolic process	0.0148506915197131
GO:0032346	positive regulation of aldosterone metabolic process	0.0148506915197131
GO:0030214	hyaluronan catabolic process	0.0148506915197131
GO:0032344	regulation of aldosterone metabolic process	0.0148506915197131
GO:0008212	mineralocorticoid metabolic process	0.0148506915197131
GO:0031583	G-protein signaling, phospholipase D activating pathway	0.0148506915197131
GO:0032341	aldosterone metabolic process	0.0148506915197131
GO:0031705	bombesin receptor binding	0.0148506915197131
GO:0032349	positive regulation of aldosterone biosynthetic process	0.0148506915197131
GO:0045602	negative regulation of endothelial cell differentiation	0.0148506915197131
GO:0031708	endothelin B receptor binding	0.0148506915197131
GO:0046886	positive regulation of hormone biosynthetic process	0.0148506915197131
GO:0032347	regulation of aldosterone biosynthetic process	0.0148506915197131
GO:0006705	mineralocorticoid biosynthetic process	0.0148506915197131
GO:0060024	rhythmic synaptic transmission	0.0148506915197131
GO:0031707	endothelin A receptor binding	0.0148506915197131
GO:0032342	aldosterone biosynthetic process	0.0148506915197131
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0152219150871958
GO:0005178	integrin binding	0.0167492685695314
GO:0016337	cell-cell adhesion	0.0167617032908913
GO:0035023	regulation of Rho protein signal transduction	0.0167617032908913
GO:0048519	negative regulation of biological process	0.0167617032908913
GO:0005096	GTPase activator activity	0.0167617032908913
GO:0007264	small GTPase mediated signal transduction	0.0171055130606644
GO:0007611	learning and/or memory	0.0176838383971589
GO:0000267	cell fraction	0.019491218977117
GO:0007243	protein kinase cascade	0.020681995047378
GO:0050789	regulation of biological process	0.020681995047378
GO:0007219	Notch signaling pathway	0.020681995047378
GO:0007179	transforming growth factor beta receptor signaling pathway	0.020681995047378
GO:0006928	cell motility	0.020681995047378
GO:0051674	localization of cell	0.020681995047378
GO:0007266	Rho protein signal transduction	0.020681995047378
GO:0044425	membrane part	0.020681995047378
GO:0048522	positive regulation of cellular process	0.020681995047378
GO:0004161	dimethylallyltranstransferase activity	0.020681995047378
GO:0046885	regulation of hormone biosynthetic process	0.020681995047378
GO:0045601	regulation of endothelial cell differentiation	0.020681995047378
GO:0032350	regulation of hormone metabolic process	0.020681995047378
GO:0043266	regulation of potassium ion transport	0.020681995047378
GO:0016512	endothelin-converting enzyme 1 activity	0.020681995047378
GO:0043267	negative regulation of potassium ion transport	0.020681995047378
GO:0030818	negative regulation of cAMP biosynthetic process	0.020681995047378
GO:0004337	geranyltranstransferase activity	0.020681995047378
GO:0030815	negative regulation of cAMP metabolic process	0.020681995047378
GO:0022610	biological adhesion	0.020681995047378
GO:0007155	cell adhesion	0.020681995047378
GO:0008217	regulation of blood pressure	0.0208876090183414
GO:0019992	diacylglycerol binding	0.0237273639474397
GO:0006357	regulation of transcription from RNA polymerase II promoter	0.0244904002179798
GO:0048609	reproductive process in a multicellular organism	0.0245692223867628
GO:0032504	multicellular organism reproduction	0.0245692223867628
GO:0030054	cell junction	0.0249804018170239
GO:0035313	wound healing, spreading of epidermal cells	0.0260506721266188
GO:0051895	negative regulation of focal adhesion formation	0.0260506721266188
GO:0030800	negative regulation of cyclic nucleotide metabolic process	0.0260506721266188
GO:0051926	negative regulation of calcium ion transport	0.0260506721266188
GO:0030809	negative regulation of nucleotide biosynthetic process	0.0260506721266188
GO:0042474	middle ear morphogenesis	0.0260506721266188
GO:0050431	transforming growth factor beta binding	0.0260506721266188
GO:0017112	Rab guanyl-nucleotide exchange factor activity	0.0260506721266188
GO:0045940	positive regulation of steroid metabolic process	0.0260506721266188
GO:0030803	negative regulation of cyclic nucleotide biosynthetic process	0.0260506721266188
GO:0008047	enzyme activator activity	0.0277268203388958
GO:0048518	positive regulation of biological process	0.0284296971339626
GO:0008283	cell proliferation	0.0285356183144314
GO:0016477	cell migration	0.0285356183144314
GO:0048869	cellular developmental process	0.0285356183144314
GO:0030154	cell differentiation	0.0285356183144314
GO:0005625	soluble fraction	0.0285356183144314
GO:0031252	leading edge	0.0285356183144314
GO:0042127	regulation of cell proliferation	0.0287805204218956
GO:0005083	small GTPase regulator activity	0.0294031444630966
GO:0005509	calcium ion binding	0.0294096443542626
GO:0002028	regulation of sodium ion transport	0.0294096443542626
GO:0016361	activin receptor activity, type I	0.0294096443542626
GO:0043271	negative regulation of ion transport	0.0294096443542626
GO:0048662	negative regulation of smooth muscle cell proliferation	0.0294096443542626
GO:0007044	cell-substrate junction assembly	0.0294096443542626
GO:0051893	regulation of focal adhesion formation	0.0294096443542626
GO:0016511	endothelin-converting enzyme activity	0.0294096443542626
GO:0001542	ovulation from ovarian follicle	0.0294096443542626
GO:0030147	natriuresis	0.0294096443542626
GO:0009966	regulation of signal transduction	0.0334764827654863
GO:0035239	tube morphogenesis	0.0341296992268949
GO:0030728	ovulation	0.0341296992268949
GO:0031663	lipopolysaccharide-mediated signaling pathway	0.0341296992268949
GO:0005161	platelet-derived growth factor receptor binding	0.0341296992268949
GO:0030817	regulation of cAMP biosynthetic process	0.0341296992268949
GO:0003091	renal water homeostasis	0.0341296992268949
GO:0043204	perikaryon	0.0341296992268949
GO:0030146	diuresis	0.0341296992268949
GO:0050785	advanced glycation end-product receptor activity	0.0341296992268949
GO:0043086	negative regulation of catalytic activity	0.0345027212697935
GO:0006468	protein amino acid phosphorylation	0.0351613870136064
GO:0005923	tight junction	0.0353020665695773
GO:0006694	steroid biosynthetic process	0.0353020665695773
GO:0045941	positive regulation of transcription	0.0362924477264727
GO:0016021	integral to membrane	0.0362924477264727
GO:0006026	aminoglycan catabolic process	0.0362924477264727
GO:0043197	dendritic spine	0.0362924477264727
GO:0017002	activin receptor activity	0.0362924477264727
GO:0030802	regulation of cyclic nucleotide biosynthetic process	0.0362924477264727
GO:0051346	negative regulation of hydrolase activity	0.0362924477264727
GO:0030808	regulation of nucleotide biosynthetic process	0.0362924477264727
GO:0005025	transforming growth factor beta receptor activity, type I	0.0362924477264727
GO:0051482	elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	0.0362924477264727
GO:0006027	glycosaminoglycan catabolic process	0.0362924477264727
GO:0045980	negative regulation of nucleotide metabolic process	0.0362924477264727
GO:0030814	regulation of cAMP metabolic process	0.0362924477264727
GO:0048185	activin binding	0.0362924477264727
GO:0065007	biological regulation	0.037269427936824
GO:0031224	intrinsic to membrane	0.037269427936824
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.037269427936824
GO:0044464	cell part	0.0384039828222961
GO:0007610	behavior	0.038563865296694
GO:0032403	protein complex binding	0.0395517057274204
GO:0004517	nitric-oxide synthase activity	0.039806510300465
GO:0001953	negative regulation of cell-matrix adhesion	0.039806510300465
GO:0030799	regulation of cyclic nucleotide metabolic process	0.039806510300465
GO:0030104	water homeostasis	0.039806510300465
GO:0043296	apical junction complex	0.0398555597965433
GO:0009888	tissue development	0.0408373114722924
GO:0016327	apicolateral plasma membrane	0.040866500537183
GO:0042995	cell projection	0.0432736643684624
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0433830832959671
GO:0018987	osmoregulation	0.0439011016156574
GO:0006793	phosphorus metabolic process	0.0470645470973383
GO:0006796	phosphate metabolic process	0.0470645470973383
GO:0019229	regulation of vasoconstriction	0.0477164577152317
GO:0003014	renal system process	0.0477164577152317
GO:0051899	membrane depolarization	0.0477164577152317
GO:0005112	Notch binding	0.0477164577152317

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
endothelial cell	3.67e-17	35
endothelial cell of vascular tree	5.44e-17	24
mesodermal cell	8.19e-17	119
meso-epithelial cell	6.31e-15	44
blood vessel endothelial cell	3.02e-13	18
embryonic blood vessel endothelial progenitor cell	3.02e-13	18
lining cell	6.95e-11	57
barrier cell	6.95e-11	57
contractile cell	1.74e-07	59
endothelial cell of artery	1.85e-07	9
vascular associated smooth muscle cell	8.45e-07	32

Uber Anatomy

Ontology term	p-value	n
anatomical conduit	7.78e-42	241
tube	5.16e-40	194
anatomical cluster	9.83e-40	286
cell layer	3.71e-36	312
adult organism	6.19e-36	115
epithelium	3.05e-35	309
vasculature	1.12e-26	79
vascular system	1.12e-26	79
splanchnic layer of lateral plate mesoderm	3.00e-26	84
multi-cellular organism	7.28e-26	659
epithelial tube	1.59e-25	118
anatomical system	9.48e-25	625
vessel	1.23e-24	69
anatomical group	2.62e-24	626
circulatory system	3.59e-24	113
cardiovascular system	1.19e-22	110
multi-tissue structure	3.81e-22	347
blood vessel	1.15e-21	60
epithelial tube open at both ends	1.15e-21	60
blood vasculature	1.15e-21	60
vascular cord	1.15e-21	60
organism subdivision	8.01e-21	365
neural plate	1.62e-18	86
presumptive neural plate	1.62e-18	86
neural tube	2.07e-18	57
neural rod	2.07e-18	57
future spinal cord	2.07e-18	57
neural keel	2.07e-18	57
embryo	3.05e-18	612
regional part of brain	8.84e-18	59
embryonic structure	9.93e-17	605
developing anatomical structure	9.93e-17	605
germ layer	2.58e-16	604
embryonic tissue	2.58e-16	604
presumptive structure	2.58e-16	604
epiblast (generic)	2.58e-16	604
central nervous system	2.67e-16	82
neurectoderm	4.82e-16	90
brain	5.82e-16	69
future brain	5.82e-16	69
unilaminar epithelium	3.89e-14	138
anterior neural tube	7.72e-14	42
regional part of nervous system	1.53e-13	94
nervous system	1.53e-13	94
compound organ	1.58e-13	69
artery	2.55e-13	42
arterial blood vessel	2.55e-13	42
arterial system	2.55e-13	42
regional part of forebrain	2.71e-13	41
forebrain	2.71e-13	41
future forebrain	2.71e-13	41
endothelium	3.02e-13	18
blood vessel endothelium	3.02e-13	18
cardiovascular system endothelium	3.02e-13	18
pre-chordal neural plate	2.35e-12	61
head	3.96e-12	123
anterior region of body	4.18e-12	129
craniocervical region	4.18e-12	129
gray matter	1.76e-11	34
brain grey matter	1.76e-11	34
telencephalon	2.51e-11	34
simple squamous epithelium	2.86e-11	22
regional part of telencephalon	5.23e-11	33
organ part	8.99e-11	219
cerebral hemisphere	1.18e-10	32
primary circulatory organ	1.60e-10	27
squamous epithelium	3.94e-10	25
systemic artery	4.19e-10	33
systemic arterial system	4.19e-10	33
organ	4.45e-10	511
trunk mesenchyme	4.60e-10	143
trunk	4.43e-09	216
ectoderm-derived structure	5.34e-09	169
heart	5.67e-09	24
primitive heart tube	5.67e-09	24
primary heart field	5.67e-09	24
anterior lateral plate mesoderm	5.67e-09	24
heart tube	5.67e-09	24
heart primordium	5.67e-09	24
cardiac mesoderm	5.67e-09	24
cardiogenic plate	5.67e-09	24
heart rudiment	5.67e-09	24
muscle tissue	9.93e-09	63
musculature	9.93e-09	63
musculature of body	9.93e-09	63
regional part of cerebral cortex	1.19e-08	22
cerebral cortex	2.09e-08	25
pallium	2.09e-08	25

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
FOS#2353	31	2.21378265536291	1.58301408387071e-05	0.000370276389485719
GATA2#2624	39	3.94485982229052	4.17751574144885e-14	6.83848850346672e-12
POLR2A#5430	90	1.53389512611291	1.36592983118522e-08	1.0039151698744e-06

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.