MCL coexpression mm9:624

Phase1 CAGE Peaks

	Short description
Mm9::chr17:17539647..17539735,+	p1@Lix1
Mm9::chr1:136763197..136763205,-	p@chr1:136763197..136763205 -
Mm9::chr2:26998050..26998076,-	p3@Fam163b
Mm9::chr3:117278186..117278200,+	p6@4833424O15Rik
Mm9::chr6:5736930..5736933,+	p@chr6:5736930..5736933 +
Mm9::chr6:5739540..5739543,+	p@chr6:5739540..5739543 +
Mm9::chr7:133906383..133906396,+	p7@Mapk3
Mm9::chr7:133906398..133906414,+	p8@Mapk3
Mm9::chr7:151424595..151424610,+	p@chr7:151424595..151424610 +
Mm9::chr7:151424623..151424635,+	p@chr7:151424623..151424635 +
Mm9::chr9:104471931..104471961,+	p3@Cpne4
Mm9::chr9:112138015..112138040,-	p11@Arpp21

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008599	protein phosphatase type 1 regulator activity	0.0403056258892532
GO:0001784	phosphotyrosine binding	0.0403056258892532
GO:0045309	protein phosphorylated amino acid binding	0.0403056258892532
GO:0043330	response to exogenous dsRNA	0.0403056258892532
GO:0031663	lipopolysaccharide-mediated signaling pathway	0.0403056258892532
GO:0032496	response to lipopolysaccharide	0.0403056258892532
GO:0051219	phosphoprotein binding	0.0403056258892532
GO:0004707	MAP kinase activity	0.0403056258892532
GO:0043331	response to dsRNA	0.0403056258892532
GO:0002237	response to molecule of bacterial origin	0.0474158328063201

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.77e-16	23
neuroblast (sensu Vertebrata)	1.77e-16	23
neuron	9.96e-10	33
neuronal stem cell	9.96e-10	33
neuroblast	9.96e-10	33
electrically signaling cell	9.96e-10	33
electrically responsive cell	4.52e-07	39
electrically active cell	4.52e-07	39

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.59e-29	54
neural tube	2.00e-27	52
neural rod	2.00e-27	52
future spinal cord	2.00e-27	52
neural keel	2.00e-27	52
neurectoderm	1.80e-26	64
neural plate	1.80e-26	64
presumptive neural plate	1.80e-26	64
gray matter	1.12e-24	34
ecto-epithelium	2.98e-24	73
brain	4.61e-24	47
future brain	4.61e-24	47
central nervous system	5.87e-24	73
nervous system	1.23e-23	75
pre-chordal neural plate	2.42e-23	49
regional part of brain	5.07e-23	46
ectoderm-derived structure	2.07e-22	95
ectoderm	2.07e-22	95
presumptive ectoderm	2.07e-22	95
anterior neural tube	2.62e-22	40
regional part of forebrain	2.03e-21	39
forebrain	2.03e-21	39
future forebrain	2.03e-21	39
brain grey matter	6.33e-21	29
regional part of telencephalon	6.33e-21	29
telencephalon	6.33e-21	29
structure with developmental contribution from neural crest	5.30e-16	92
cerebral cortex	9.50e-16	21
cerebral hemisphere	9.50e-16	21
pallium	9.50e-16	21
regional part of cerebral cortex	5.05e-13	17
occipital lobe	3.45e-11	10
visual cortex	3.45e-11	10
neocortex	3.45e-11	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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