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Coexpression cluster:C3172: Difference between revisions

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|full_id=C3172_Mesenchymal_Small_Renal_mature_Fibroblast_Urothelial_Endothelial
|full_id=C3172_Mesenchymal_Small_Renal_mature_Fibroblast_Urothelial_Endothelial
|id=C3172
|id=C3172
|ontology_enrichment_celltype=CL:0000220!7.26e-22!246;CL:0002321!2.33e-21!248;CL:0000222!2.55e-20!119;CL:0000055!3.55e-20!180;CL:0000144!2.12e-14!625;CL:0000057!2.59e-14!75;CL:0000548!7.45e-13!679;CL:0000004!7.45e-13!679;CL:0000255!7.45e-13!679;CL:0000012!3.33e-12!682;CL:0002371!5.59e-12!591;CL:0000213!2.99e-11!57;CL:0000215!2.99e-11!57;CL:0002078!1.64e-10!44;CL:0002139!1.81e-10!24;CL:0000066!3.96e-10!254;CL:0000115!7.66e-10!35;CL:0000183!9.15e-09!59;CL:0000680!1.28e-08!57;CL:0000056!1.28e-08!57;CL:0000355!1.28e-08!57;CL:0000076!1.34e-07!62;CL:0000071!1.55e-07!18;CL:0002546!1.55e-07!18;CL:0000136!1.56e-07!15;CL:0000187!2.13e-07!54
|ontology_enrichment_celltype=CL:0000222!3.31e-21!121;CL:0002321!2.16e-20!250;CL:0000057!6.36e-15!76;CL:0000548!4.03e-12!679;CL:0000255!4.03e-12!679;CL:0000213!7.24e-12!58;CL:0000215!7.24e-12!58;CL:0002371!1.39e-11!588;CL:0002139!6.22e-11!24;CL:0002078!7.10e-11!45;CL:0000115!1.51e-10!36;CL:0000680!5.67e-09!58;CL:0000056!5.67e-09!58;CL:0000355!5.67e-09!58;CL:0000183!5.67e-09!59;CL:0000066!1.34e-08!253;CL:0000071!3.38e-08!18;CL:0002546!3.38e-08!18;CL:0000187!8.60e-08!55;CL:0000076!9.57e-08!63;CL:0000055!1.99e-07!106;CL:0000192!5.92e-07!43;CL:0000514!5.92e-07!43;CL:0002620!8.86e-07!23
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002049!2.46e-17!79;UBERON:0007798!2.46e-17!79;UBERON:0000055!8.34e-17!69;UBERON:0000475!2.02e-15!365;UBERON:0000483!4.53e-14!309;UBERON:0000119!7.27e-14!312;UBERON:0001981!1.16e-13!60;UBERON:0007500!1.16e-13!60;UBERON:0004537!1.16e-13!60;UBERON:0006965!1.16e-13!60;UBERON:0004872!1.99e-12!84;UBERON:0003914!2.44e-12!118;UBERON:0004111!1.62e-11!241;UBERON:0000486!2.31e-11!82;UBERON:0001009!3.11e-11!113;UBERON:0004535!4.24e-11!110;UBERON:0000477!5.02e-11!286;UBERON:0000468!1.17e-10!659;UBERON:0005256!2.18e-10!143;UBERON:0000914!2.52e-10!83;UBERON:0002329!2.52e-10!83;UBERON:0003077!2.52e-10!83;UBERON:0003059!2.52e-10!83;UBERON:0007282!2.52e-10!83;UBERON:0009618!2.52e-10!83;UBERON:0007285!2.52e-10!83;UBERON:0002100!4.75e-10!216;UBERON:0001637!1.67e-09!42;UBERON:0003509!1.67e-09!42;UBERON:0004572!1.67e-09!42;UBERON:0004290!5.50e-09!70;UBERON:0000490!1.25e-08!138;UBERON:0000467!1.49e-08!625;UBERON:0000480!2.43e-08!626;UBERON:0003102!2.84e-08!95;UBERON:0000025!4.12e-08!194;UBERON:0001134!4.29e-08!61;UBERON:0002036!4.29e-08!61;UBERON:0003082!4.29e-08!61;UBERON:0000481!8.01e-08!347;UBERON:0004573!9.02e-08!33;UBERON:0004571!9.02e-08!33;UBERON:0001986!1.55e-07!18;UBERON:0004638!1.55e-07!18;UBERON:0004852!1.55e-07!18;UBERON:0002385!2.29e-07!63;UBERON:0001015!2.29e-07!63;UBERON:0000383!2.29e-07!63;UBERON:0002199!3.57e-07!45;UBERON:0002416!3.57e-07!45;UBERON:0000947!9.56e-07!21;UBERON:0010191!9.56e-07!21
|ontology_enrichment_uberon=UBERON:0002049!3.67e-17!78;UBERON:0007798!3.67e-17!78;UBERON:0000055!4.36e-17!68;UBERON:0000483!3.31e-14!306;UBERON:0007500!4.90e-14!59;UBERON:0001981!4.90e-14!59;UBERON:0004537!4.90e-14!59;UBERON:0006965!4.90e-14!59;UBERON:0000119!5.88e-14!309;UBERON:0004872!6.27e-13!83;UBERON:0003914!1.21e-12!117;UBERON:0004111!2.83e-12!240;UBERON:0001009!1.91e-11!112;UBERON:0004535!2.50e-11!109;UBERON:0007503!5.31e-11!78;UBERON:0000486!9.29e-11!83;UBERON:0001637!2.53e-10!42;UBERON:0003509!2.53e-10!42;UBERON:0004572!2.53e-10!42;UBERON:0000490!1.59e-09!148;UBERON:0007524!2.23e-09!73;UBERON:0003104!3.86e-09!160;UBERON:0009142!3.86e-09!160;UBERON:0003077!4.01e-09!72;UBERON:0007285!4.01e-09!72;UBERON:0000025!4.68e-09!192;UBERON:0002329!5.26e-09!71;UBERON:0003059!5.26e-09!71;UBERON:0007282!5.26e-09!71;UBERON:0004290!5.26e-09!71;UBERON:0009618!5.26e-09!71;UBERON:0000477!7.33e-09!373;UBERON:0000468!7.61e-09!656;UBERON:0004573!9.07e-09!33;UBERON:0004571!9.07e-09!33;UBERON:0000475!2.07e-08!264;UBERON:0004638!3.38e-08!18;UBERON:0001986!3.38e-08!18;UBERON:0004852!3.38e-08!18;UBERON:0001134!3.67e-08!62;UBERON:0002036!3.67e-08!62;UBERON:0003082!3.67e-08!62;UBERON:0002100!5.54e-08!199;UBERON:0005256!6.90e-08!122;UBERON:0003102!7.87e-08!99;UBERON:0000947!1.02e-07!21;UBERON:0010191!1.02e-07!21;UBERON:0002385!1.99e-07!64;UBERON:0001015!1.99e-07!64;UBERON:0000383!1.99e-07!64;UBERON:0000481!2.63e-07!342;UBERON:0000467!2.81e-07!624;UBERON:0002199!3.13e-07!46;UBERON:0002416!3.13e-07!46;UBERON:0000480!4.07e-07!625
|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0323766844495048!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0460202398431015!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0127652309194107!NFYB#4801;3:16.7597932535365:0.000212364992329618:0.00245019746287152!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0275517083463222!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0245523322140391!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0139650996807323
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0558058,0.28262,0.517717,0.137332,0.0145999,0.0656973,0.211746,0.220538,0.0801488,0.0757897,0.161801,0.193215,0.0549034,0.0779715,0.0561838,0.0417636,0.0345419,0.0388736,0.254674,0.170307,0.201033,0.0488949,0.174921,0.0117175,0.0330727,0.00956472,0.219556,0.0394698,0.0596469,0.419264,0.122476,0.108872,0.11002,0.26144,0.0286025,0.190156,0.144567,0.038848,0.0874516,0.0550279,0.144067,0.253693,0.217069,0.190048,0.131088,0.394069,0.0306378,0.0458068,0.0761239,0.172491,0.0818785,0.182701,0.00836526,0.147698,0.141463,0.167267,0.140622,0.0889592,0.309588,0.0458479,0.0473033,0.094881,0.022113,0.132886,0.0774373,0.109194,0.128564,0.131452,0.00128046,0.0226843,0.051838,0.0993999,0.0500365,0.061829,0.0755121,0.0936516,0.144075,0.0340203,0.0741807,0.277091,0.0122266,0.655293,0.21727,0.289306,0.119215,0.192475,0.177967,0.000176812,0.057571,0.047591,0.392974,0.0608699,0.175319,0.300597,0.0713214,0.223874,0.291114,0.0355833,0.125606,0.175094,2.90292e-07,3.95406e-08,0.206454,0.218192,0.108277,0.0673484,0.108748,0.0494066,0.0958493,0.205732,0.0755808,0.045654,0.110216,0.070276,0.226171,0.153469,0.0376916,0.13262,0.0450031,0.0539144,0.114242,0.0929549,0.0158019,0.104948,0.221645,0.057168,0.234298,0.0759837,0.286863,0.152372,0.194941,0.218271,0.101607,0.327067,0.172982,0.340936,0.151597,0.0626744,0.191335,0.148574,0.0058211,0.000713799,0.0718905,0.0919008,0.0602373,0.144304,0.15063,0.0973823,0.15503,0.170295,0.193653,0.137219,0.228144,0.251466,0.288096,0.11903,0.000104984,0.331451,0.113145,0.112651,0.186638,0.174776,0.0948451,0.264079,0.249049,0.140533,0.0997756,0.257598,0.103667,0.113069,0.025556,0.16791,0.09066,0.585505,0.166967,0.188651,0.0813902,0.184948,0.156261,0.311847,0.511859,0.0590944,0.247324,0.178389,0.218229,0.231073,0.407281,0.619906,0.0360851,0.0168763,0.131093,0.0434602,0.133616,0.418146,0.0785808,0.449036,0.407369,0.231447,0.0455669,0.43956,0.37006,0.42622,0.448797,0.197484,0.396996,0.36145,0.406019,0.381071,0.216033,0.643768,0.11074,0.722159,0.0140037,0.48809,0.50058,3.39738e-05,0.522904,1.22574e-05,3.95207e-08,0.227104,0.518585,0.617852,0.38649,0.284625,0.0344717,0.55194,0.729153,0.28907,0.164197,0.0252589,0.287881,0.574635,0.478174,0.336276,0.468444,0.258219,0.446557,0.243383,0.0659137,0.390974,0.0115792,0.319063,0.161598,0.164332,0.644754,0.496032,0.000266268,0.37357,0.0704414,0.477353,0.00492096,0.160298,0.00415823,0.20342,0.200493,0.20558,0.300504,0.25656,0.425963,0.349197,0.383291,0.156104,0.141318,0.411941,0.0961477,0.314438,0.354789,0.163828,0.230581,0.120226,0.28424,0.20075,0.314429,0.181415,0.282286,0.446891,0.616388,0.408413,0.516511,0.322213,0.656109,0.33942,0.243065,0.387276,0.522605,0.000283063,0.180745,0.0267088,0.416621,0.416292,0.462712,1.06909e-05,0.215157,0.204817,0.452428,0.138871,0.000165333,0.166905,0.19783,0.0833851,0.316453,0.140384,0.175199,0.332919,0.373557,0.523625,0.408861,0.0768488,0.534741,0.39088,0.00120786,0.236011,0.203486,0.273398,0.375787,0.4466,0.351067,0.275347,0.0830022,0.305885,0.241132,0.371414,0.30666,0.303709,0.495883,0.386538,0.508064,0.250964,0.383276,0.457886,0.504711,0.220231,0.509064,0.196976,0.191517,0.463751,0.601877,0.307334,0.459728,0.283463,0.563586,0.472935,0.399569,0.273281,0.368095,0.275089,0.384593,0.47795,0.359231,0.339729,0.197805,0.608187,0.387069,0.0627969,0.00734059,0.299887,0.634365,0.205413,0.17639,0.0779009,0.276869,0.022685,0.0337138,0.18966,0.258854,0.188263,0.0719199,0.264884,0.162568,0.19104,0.163057,0.219428,0.208013,0.0900729,0.0953646,0.166124,0.252184,0.378361,0.255516,0.20753,0.447185,0.179412,0.193601,0.220904,0.222977,0.341681,0.310674,0.21801,0.198614,0.186804,0.123324,0.00155473,0.0325925,0.0933115,0.12405,0.179889,0.226869,0.27872,0.0855609,0.131118,0.20837,0.247588,0.222339,0.0673329,0.20847,0.266544,0.113092,0.145701,0.229428,0.162145,0.228955,0.168748,0.0384949,0.0660995,0.0521984,0.0455518,0.268741,0.201602,0.350452,0.154941,0.120196,0.0986735,0.108462,0.0595618,0.21593,0.158479,0.220319,0.195218,0.124213,0.259632,0.30793,0.180606,0.159884,0.257294,0.150733,0.217112,0.123917,0.184317,0.185335,0.0723291,0.258496,0.261744,0.203781,0.21382,0.207559,0.141867,0.193031,0.249101,0.115972,0.224568,0.246105,0.173026,0.200432,0.139785,0.197112,0.240478,0.156465,0.13108,0.256963,0.222798,0.172134,0.176789,0.0969345,0.202137,0.310405,0.280943,0.218161,0.0822373,0.202065,0.106739,0.0536053,0.0537737,0.15113,0.078016,0.0407233,0.0537355,0.319922,0.261724,0.211332,0.187731,0.233626,0.189559,0.0812887,0.0981146,0.064145,0.121913,0.00208455,0.104603,0.0663259,0.0762523,0.128736,0.109171,0.04411,0.066952,0.089609,0.0367455,0.13497,0.204393,0.295769,0.286691,0.347036,0.141729,0.263159,0.255956,0.200105,0.227491,0.29837,0.253509,0.177664,0.28365,0.264413,0.131761,0.000785583,0.206239,0.19924,0.28689,0.236464,0.325148,0.115817,0.218052,0.223831,0.11528,0.194982,0.190993,0.281727,0.283218,0.249955,0.164638,0.224257,0.0935776,0.327622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0.171683,0.158847,0.271275,0.071111,0.270604,0.101021,0.222548,0.17593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}}
}}

Revision as of 14:51, 19 October 2012


Full id: C3172_Mesenchymal_Small_Renal_mature_Fibroblast_Urothelial_Endothelial



Phase1 CAGE Peaks

Hg19::chr11:61658913..61658932,-p2@FADS3
Hg19::chr11:61658952..61658974,-p3@FADS3
Hg19::chr11:61659006..61659046,-p1@FADS3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
vasculature3.67e-1778
vascular system3.67e-1778
vessel4.36e-1768
epithelium3.31e-14306
epithelial tube open at both ends4.90e-1459
blood vessel4.90e-1459
blood vasculature4.90e-1459
vascular cord4.90e-1459
cell layer5.88e-14309
splanchnic layer of lateral plate mesoderm6.27e-1383
epithelial tube1.21e-12117
anatomical conduit2.83e-12240
circulatory system1.91e-11112
cardiovascular system2.50e-11109
epithelial vesicle5.31e-1178
multilaminar epithelium9.29e-1183
artery2.53e-1042
arterial blood vessel2.53e-1042
arterial system2.53e-1042
unilaminar epithelium1.59e-09148
dense mesenchyme tissue2.23e-0973
mesenchyme3.86e-09160
entire embryonic mesenchyme3.86e-09160
paraxial mesoderm4.01e-0972
presumptive paraxial mesoderm4.01e-0972
tube4.68e-09192
somite5.26e-0971
presomitic mesoderm5.26e-0971
presumptive segmental plate5.26e-0971
dermomyotome5.26e-0971
trunk paraxial mesoderm5.26e-0971
anatomical cluster7.33e-09373
multi-cellular organism7.61e-09656
systemic artery9.07e-0933
systemic arterial system9.07e-0933
organism subdivision2.07e-08264
blood vessel endothelium3.38e-0818
endothelium3.38e-0818
cardiovascular system endothelium3.38e-0818
skeletal muscle tissue3.67e-0862
striated muscle tissue3.67e-0862
myotome3.67e-0862
trunk5.54e-08199
trunk mesenchyme6.90e-08122
surface structure7.87e-0899
aorta1.02e-0721
aortic system1.02e-0721
muscle tissue1.99e-0764
musculature1.99e-0764
musculature of body1.99e-0764
multi-tissue structure2.63e-07342
anatomical system2.81e-07624
integument3.13e-0746
integumental system3.13e-0746
anatomical group4.07e-07625


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0323766844495048
ELF1#199734.258097958807540.01295179875054610.0460202398431015
IRF1#365937.63716375356390.002244692747297240.0127652309194107
NFYB#4801316.75979325353650.0002123649923296180.00245019746287152
SIN3A#2594235.408884726815140.006318961977991520.0275517083463222
SP1#666735.69838137814090.005403962701712170.0245523322140391
ZBTB7A#5134137.35190930787590.002516255860282270.0139650996807323



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.