Coexpression cluster:C616

Full id: C616_CD14_Natural_CD8_Basophils_Mast_Eosinophils_CD4

Phase1 CAGE Peaks

Hg19::chr10:70716856..70716871,-	p@chr10:70716856..70716871 -
Hg19::chr11:65189036..65189061,+	p@chr11:65189036..65189061 +
Hg19::chr12:3982744..3982748,+	p@chr12:3982744..3982748 +
Hg19::chr12:9917411..9917425,-	p@chr12:9917411..9917425 -
Hg19::chr13:41557163..41557168,+	p@chr13:41557163..41557168 +
Hg19::chr17:40540898..40540910,+	p@chr17:40540898..40540910 +
Hg19::chr19:14485996..14486000,-	p@chr19:14485996..14486000 -
Hg19::chr20:1305835..1305872,-	p@chr20:1305835..1305872 -
Hg19::chr2:145275236..145275249,+	p@chr2:145275236..145275249 +
Hg19::chr4:103790462..103790537,+	p4@CISD2
Hg19::chr5:43018230..43018260,+	p1@ENST00000509036
Hg19::chr7:644391..644410,+	p@chr7:644391..644410 +
Hg19::chr8:29940840..29940888,+	p@chr8:29940840..29940888 +
Hg19::chr9:132890689..132890715,+	p@chr9:132890689..132890715 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.01e-85	136
hematopoietic stem cell	4.96e-75	168
angioblastic mesenchymal cell	4.96e-75	168
hematopoietic cell	6.98e-74	177
hematopoietic lineage restricted progenitor cell	2.71e-71	120
hematopoietic oligopotent progenitor cell	8.71e-71	161
hematopoietic multipotent progenitor cell	8.71e-71	161
nongranular leukocyte	7.65e-68	115
classical monocyte	3.47e-52	42
CD14-positive, CD16-negative classical monocyte	3.47e-52	42
myeloid leukocyte	2.32e-49	72
defensive cell	1.31e-43	48
phagocyte	1.31e-43	48
granulocyte monocyte progenitor cell	7.52e-43	67
myeloid cell	6.43e-41	108
common myeloid progenitor	6.43e-41	108
myeloid lineage restricted progenitor cell	2.74e-40	66
macrophage dendritic cell progenitor	3.14e-38	61
monopoietic cell	1.38e-36	59
monocyte	1.38e-36	59
monoblast	1.38e-36	59
promonocyte	1.38e-36	59
lymphoid lineage restricted progenitor cell	1.26e-26	52
lymphocyte	7.08e-26	53
common lymphoid progenitor	7.08e-26	53
nucleate cell	1.85e-24	55
mesenchymal cell	3.29e-20	354
connective tissue cell	3.49e-19	361
stuff accumulating cell	3.79e-19	87
mature alpha-beta T cell	1.79e-16	18
alpha-beta T cell	1.79e-16	18
immature T cell	1.79e-16	18
mature T cell	1.79e-16	18
immature alpha-beta T cell	1.79e-16	18
motile cell	1.30e-15	386
T cell	3.89e-13	25
pro-T cell	3.89e-13	25
stem cell	4.75e-12	441
multi fate stem cell	8.21e-12	427
intermediate monocyte	1.65e-11	9
CD14-positive, CD16-positive monocyte	1.65e-11	9
somatic stem cell	3.12e-11	433
lymphocyte of B lineage	3.79e-11	24
pro-B cell	3.79e-11	24
CD8-positive, alpha-beta T cell	7.49e-09	11
CD4-positive, alpha-beta T cell	7.71e-09	6
granulocyte	2.40e-08	8
B cell	3.13e-07	14
blood cell	3.18e-07	11
histamine secreting cell	3.64e-07	5
biogenic amine secreting cell	3.64e-07	5
granulocytopoietic cell	3.64e-07	5
mast cell	3.64e-07	5
mast cell progenitor	3.64e-07	5
basophil mast progenitor cell	3.64e-07	5
circulating cell	5.29e-07	6

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	4.67e-47	98
blood island	4.67e-47	98
hemolymphoid system	3.59e-43	108
immune system	1.73e-40	93
bone marrow	5.76e-39	76
bone element	9.67e-35	82
skeletal element	5.24e-30	90
skeletal system	3.42e-25	100
connective tissue	8.60e-18	371
lateral plate mesoderm	2.27e-13	203
musculoskeletal system	1.18e-08	167
hemopoietic organ	3.60e-07	7
immune organ	3.60e-07	7

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	5	8.69921492582273	0.000170731701412579	0.00208306637427901
BCL11A#53335	3	6.07916895077294	0.0119017116435723	0.0433117133817572
BCLAF1#9774	4	6.1864707457491	0.00313252978868284	0.0164492070290234
CEBPB#1051	8	4.55494150047132	9.08334040436614e-05	0.00132475211351989
E2F1#1869	7	2.45369460743966	0.0128734132000325	0.0463104988012605
E2F6#1876	7	2.50857786584869	0.0113880661318771	0.0417347967838835
EBF1#1879	8	5.08940962661086	4.04144399024511e-05	0.000739849901660314
EGR1#1958	8	2.85038805417722	0.0024346941207663	0.0137106124921121
ELF1#1997	10	3.04149854200538	0.000196088323365343	0.00235827595623595
ELK4#2005	4	4.63876618813372	0.00873391381785387	0.0331827722078955
ESR1#2099	3	6.59327213489025	0.00954425887973214	0.0359437780592942
FAM48A#55578	1	82.5120535714286	0.0120519037803125	0.0437424423601063
FOS#2353	6	3.85626656095475	0.00255626107611445	0.0141442834716989
FOSL2#2355	4	4.83720017273191	0.00754162287399241	0.0310902167575943
GATA1#2623	7	6.78015407190022	2.55304819429845e-05	0.000552617202827639
GATA2#2624	5	4.55176133341214	0.00325484420629305	0.0168592309706413
GTF2F1#2962	5	4.5498788845563	0.00326074959137569	0.0168864693099462
HEY1#23462	9	2.59721424199653	0.0019964548250747	0.0116095626657002
HSF1#3297	2	23.4700952380952	0.00320876259262891	0.0168283597675791
IRF4#3662	4	6.26128933906975	0.00299894388765468	0.0159384611817601
JUN#3725	7	6.25641459616817	4.30563398722854e-05	0.000768151875627197
JUNB#3726	5	10.932368807079	5.80714990876497e-05	0.00096621463967103
JUND#3727	7	3.49733197093551	0.00165492127185766	0.0103477412866876
MAX#4149	10	4.60896822071937	4.35925428810888e-06	0.000136596507229464
MEF2A#4205	4	5.35520883132687	0.00526133968973413	0.0243708278642898
MXI1#4601	6	4.26924498375398	0.00150342548111148	0.00960344060072182
MYC#4609	10	3.73020133686386	3.09172673265338e-05	0.000626497571268114
NFKB1#4790	8	3.13603624239648	0.0012726962649026	0.00853522925641575
NR3C1#2908	4	4.27800666604944	0.0115683845516382	0.0422858222801532
NRF1#4899	5	4.36081408846818	0.00392491886644058	0.0191236109863395
PAX5#5079	9	4.28757784147146	3.71976426636989e-05	0.0007180932721172
POLR2A#5430	14	2.14745317655807	2.25331953374171e-05	0.000492743799799937
POU2F2#5452	9	5.85393689426305	2.76328769641543e-06	9.56562823088933e-05
RFX5#5993	6	5.16339035451218	0.000545630242247493	0.00471223657240436
SMARCC1#6599	3	9.35643413992103	0.00361597578852963	0.0183022630308348
SMARCC2#6601	2	13.4507677752711	0.00942583950176718	0.0355606419725124
SMC3#9126	4	4.29855224140938	0.0113787067695173	0.0417048870433976
SP1#6667	9	3.66324517166201	0.000134181452530633	0.00175964047223088
STAT3#6774	5	3.75695178469794	0.00745070695195861	0.030734828318019
TAL1#6886	3	6.40041785945147	0.0103488625911614	0.0384334279268299
TBP#6908	12	3.17723201751119	7.62532496869237e-06	0.000217412316244953
TCF12#6938	5	3.79802317935229	0.0071143968279023	0.0296236540271625
USF1#7391	7	3.18074963860398	0.00291375305793264	0.0157453021998979
USF2#7392	5	4.64007049466771	0.00299162843888793	0.0159036283482142
YY1#7528	7	2.45558537492693	0.0128187546389251	0.046117048423517

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.