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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.137686197531991

Latest revision as of 14:16, 17 September 2013


Full id: C4596_non_CD4_acute_Natural_Peripheral_CD8_blood



Phase1 CAGE Peaks

Hg19::chr6:36515033..36515051,-p5@STK38
Hg19::chr6:36515067..36515090,-p3@STK38
Hg19::chr6:36515092..36515172,-p2@STK38


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell4.82e-26168
angioblastic mesenchymal cell4.82e-26168
hematopoietic cell6.19e-25177
hematopoietic oligopotent progenitor cell4.24e-23161
hematopoietic multipotent progenitor cell4.24e-23161
leukocyte1.03e-22136
nongranular leukocyte2.64e-21115
hematopoietic lineage restricted progenitor cell6.52e-18120
classical monocyte3.01e-1642
CD14-positive, CD16-negative classical monocyte3.01e-1642
mature alpha-beta T cell6.47e-1318
alpha-beta T cell6.47e-1318
immature T cell6.47e-1318
mature T cell6.47e-1318
immature alpha-beta T cell6.47e-1318
myeloid cell6.31e-12108
common myeloid progenitor6.31e-12108
myeloid leukocyte6.92e-1272
lymphocyte1.55e-1153
common lymphoid progenitor1.55e-1153
lymphoid lineage restricted progenitor cell2.25e-1152
defensive cell3.74e-1148
phagocyte3.74e-1148
T cell2.34e-1025
pro-T cell2.34e-1025
nucleate cell3.64e-1055
granulocyte monocyte progenitor cell4.41e-0967
monopoietic cell6.58e-0959
monocyte6.58e-0959
monoblast6.58e-0959
promonocyte6.58e-0959
myeloid lineage restricted progenitor cell1.22e-0866
CD8-positive, alpha-beta T cell1.34e-0811
macrophage dendritic cell progenitor7.59e-0861
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.24e-13108
hematopoietic system2.34e-1398
blood island2.34e-1398
immune system1.68e-0893
blood2.41e-0815
haemolymphatic fluid2.41e-0815
organism substance2.41e-0815
bone element6.59e-0782
bone marrow9.68e-0776


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.12.19699
MA0101.10.646932
MA0103.10.628063
MA0105.11.5295
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.12.94723
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.22.15877
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.17.31477
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.84145
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.69213
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190994511484716
CEBPB#105137.971147625824820.001974187055288560.0115709142975072
CTCF#1066435.360256373075030.0064925092527670.02811123808506
E2F1#186934.907389214879320.008460985347239390.0327413705094792
E2F4#1874312.66806031528440.0004917987006298980.00438737204194806
E2F6#187635.017155731697390.00791769806886330.0324064924800727
ELF1#199734.258097958807540.01295179875054610.0464660406618901
HMGN3#932438.178547723350590.001827766942164210.0109117498383839
IRF1#365937.63716375356390.002244692747297240.0128661141449414
MXI1#460139.96157162875930.001011470541259020.00722897227527209
NFKB1#479035.488063424193840.006049381815655430.0270736796128402
NRF1#4899312.21027944771090.0005492172401020010.0047326484603146
PAX5#507936.669565531177830.003370290999677260.0173616366634751
POU2F2#545239.106124057742520.001324165192682130.00885424729870856
SIN3A#2594235.408884726815140.006318961977991520.027810622419699
SMARCB1#6598318.25271578115740.000164397760679890.00203913749734525
SPI1#668838.204323508522730.001810593189410520.0109392885635106



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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