Coexpression cluster:C140: Difference between revisions
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Latest revision as of 10:41, 17 September 2013
Full id: C140_Renal_Endothelial_Hepatic_Lymphatic_heart_lung_spleen
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
1.23161703778041e-05 | 0.00779613584915002 | 3 | 23 | Angiogenesis (Wikipathways):WP1539 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0001525 | angiogenesis | 2.11374324114935e-10 |
GO:0048514 | blood vessel morphogenesis | 3.33452412540309e-10 |
GO:0048646 | anatomical structure formation | 3.33452412540309e-10 |
GO:0001568 | blood vessel development | 4.18728600634572e-10 |
GO:0001944 | vasculature development | 4.18728600634572e-10 |
GO:0009887 | organ morphogenesis | 1.54920920309376e-08 |
GO:0007165 | signal transduction | 6.78298039940112e-07 |
GO:0048513 | organ development | 6.78298039940112e-07 |
GO:0007154 | cell communication | 6.78298039940112e-07 |
GO:0048731 | system development | 3.1700273590176e-05 |
GO:0009653 | anatomical structure morphogenesis | 0.000175551122952142 |
GO:0007275 | multicellular organismal development | 0.000259341093388208 |
GO:0048856 | anatomical structure development | 0.000288362204070747 |
GO:0044459 | plasma membrane part | 0.00108525939425613 |
GO:0005515 | protein binding | 0.00161340307696319 |
GO:0016020 | membrane | 0.00254974465118234 |
GO:0032502 | developmental process | 0.00254974465118234 |
GO:0005886 | plasma membrane | 0.00287052046562877 |
GO:0008015 | blood circulation | 0.00287052046562877 |
GO:0003013 | circulatory system process | 0.00287052046562877 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 0.00287052046562877 |
GO:0032501 | multicellular organismal process | 0.00287052046562877 |
GO:0030334 | regulation of cell migration | 0.00287052046562877 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.00300668146559652 |
GO:0001569 | patterning of blood vessels | 0.00309874167099624 |
GO:0051270 | regulation of cell motility | 0.00385109523932316 |
GO:0040012 | regulation of locomotion | 0.00420797208421217 |
GO:0040011 | locomotion | 0.00422711851243521 |
GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 0.00459854589949203 |
GO:0001570 | vasculogenesis | 0.00713528780788853 |
GO:0004871 | signal transducer activity | 0.00739650586127434 |
GO:0060089 | molecular transducer activity | 0.00739650586127434 |
GO:0007242 | intracellular signaling cascade | 0.0115242194591448 |
GO:0030695 | GTPase regulator activity | 0.0115997662814792 |
GO:0035295 | tube development | 0.013033832245552 |
GO:0005887 | integral to plasma membrane | 0.013033832245552 |
GO:0050794 | regulation of cellular process | 0.013033832245552 |
GO:0009880 | embryonic pattern specification | 0.013033832245552 |
GO:0048754 | branching morphogenesis of a tube | 0.013033832245552 |
GO:0007166 | cell surface receptor linked signal transduction | 0.013033832245552 |
GO:0031226 | intrinsic to plasma membrane | 0.013033832245552 |
GO:0005102 | receptor binding | 0.0132932641457088 |
GO:0019199 | transmembrane receptor protein kinase activity | 0.0139364903259838 |
GO:0001763 | morphogenesis of a branching structure | 0.0148506915197131 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0148506915197131 |
GO:0051216 | cartilage development | 0.0148506915197131 |
GO:0048523 | negative regulation of cellular process | 0.0148506915197131 |
GO:0043179 | rhythmic excitation | 0.0148506915197131 |
GO:0032352 | positive regulation of hormone metabolic process | 0.0148506915197131 |
GO:0032346 | positive regulation of aldosterone metabolic process | 0.0148506915197131 |
GO:0030214 | hyaluronan catabolic process | 0.0148506915197131 |
GO:0032344 | regulation of aldosterone metabolic process | 0.0148506915197131 |
GO:0008212 | mineralocorticoid metabolic process | 0.0148506915197131 |
GO:0031583 | G-protein signaling, phospholipase D activating pathway | 0.0148506915197131 |
GO:0032341 | aldosterone metabolic process | 0.0148506915197131 |
GO:0031705 | bombesin receptor binding | 0.0148506915197131 |
GO:0032349 | positive regulation of aldosterone biosynthetic process | 0.0148506915197131 |
GO:0045602 | negative regulation of endothelial cell differentiation | 0.0148506915197131 |
GO:0031708 | endothelin B receptor binding | 0.0148506915197131 |
GO:0046886 | positive regulation of hormone biosynthetic process | 0.0148506915197131 |
GO:0032347 | regulation of aldosterone biosynthetic process | 0.0148506915197131 |
GO:0006705 | mineralocorticoid biosynthetic process | 0.0148506915197131 |
GO:0060024 | rhythmic synaptic transmission | 0.0148506915197131 |
GO:0031707 | endothelin A receptor binding | 0.0148506915197131 |
GO:0032342 | aldosterone biosynthetic process | 0.0148506915197131 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0152219150871958 |
GO:0005178 | integrin binding | 0.0167492685695314 |
GO:0016337 | cell-cell adhesion | 0.0167617032908913 |
GO:0035023 | regulation of Rho protein signal transduction | 0.0167617032908913 |
GO:0048519 | negative regulation of biological process | 0.0167617032908913 |
GO:0005096 | GTPase activator activity | 0.0167617032908913 |
GO:0007264 | small GTPase mediated signal transduction | 0.0171055130606644 |
GO:0007611 | learning and/or memory | 0.0176838383971589 |
GO:0000267 | cell fraction | 0.019491218977117 |
GO:0007243 | protein kinase cascade | 0.020681995047378 |
GO:0050789 | regulation of biological process | 0.020681995047378 |
GO:0007219 | Notch signaling pathway | 0.020681995047378 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 0.020681995047378 |
GO:0006928 | cell motility | 0.020681995047378 |
GO:0051674 | localization of cell | 0.020681995047378 |
GO:0007266 | Rho protein signal transduction | 0.020681995047378 |
GO:0044425 | membrane part | 0.020681995047378 |
GO:0048522 | positive regulation of cellular process | 0.020681995047378 |
GO:0004161 | dimethylallyltranstransferase activity | 0.020681995047378 |
GO:0046885 | regulation of hormone biosynthetic process | 0.020681995047378 |
GO:0045601 | regulation of endothelial cell differentiation | 0.020681995047378 |
GO:0032350 | regulation of hormone metabolic process | 0.020681995047378 |
GO:0043266 | regulation of potassium ion transport | 0.020681995047378 |
GO:0016512 | endothelin-converting enzyme 1 activity | 0.020681995047378 |
GO:0043267 | negative regulation of potassium ion transport | 0.020681995047378 |
GO:0030818 | negative regulation of cAMP biosynthetic process | 0.020681995047378 |
GO:0004337 | geranyltranstransferase activity | 0.020681995047378 |
GO:0030815 | negative regulation of cAMP metabolic process | 0.020681995047378 |
GO:0022610 | biological adhesion | 0.020681995047378 |
GO:0007155 | cell adhesion | 0.020681995047378 |
GO:0008217 | regulation of blood pressure | 0.0208876090183414 |
GO:0019992 | diacylglycerol binding | 0.0237273639474397 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0244904002179798 |
GO:0048609 | reproductive process in a multicellular organism | 0.0245692223867628 |
GO:0032504 | multicellular organism reproduction | 0.0245692223867628 |
GO:0030054 | cell junction | 0.0249804018170239 |
GO:0035313 | wound healing, spreading of epidermal cells | 0.0260506721266188 |
GO:0051895 | negative regulation of focal adhesion formation | 0.0260506721266188 |
GO:0030800 | negative regulation of cyclic nucleotide metabolic process | 0.0260506721266188 |
GO:0051926 | negative regulation of calcium ion transport | 0.0260506721266188 |
GO:0030809 | negative regulation of nucleotide biosynthetic process | 0.0260506721266188 |
GO:0042474 | middle ear morphogenesis | 0.0260506721266188 |
GO:0050431 | transforming growth factor beta binding | 0.0260506721266188 |
GO:0017112 | Rab guanyl-nucleotide exchange factor activity | 0.0260506721266188 |
GO:0045940 | positive regulation of steroid metabolic process | 0.0260506721266188 |
GO:0030803 | negative regulation of cyclic nucleotide biosynthetic process | 0.0260506721266188 |
GO:0008047 | enzyme activator activity | 0.0277268203388958 |
GO:0048518 | positive regulation of biological process | 0.0284296971339626 |
GO:0008283 | cell proliferation | 0.0285356183144314 |
GO:0016477 | cell migration | 0.0285356183144314 |
GO:0048869 | cellular developmental process | 0.0285356183144314 |
GO:0030154 | cell differentiation | 0.0285356183144314 |
GO:0005625 | soluble fraction | 0.0285356183144314 |
GO:0031252 | leading edge | 0.0285356183144314 |
GO:0042127 | regulation of cell proliferation | 0.0287805204218956 |
GO:0005083 | small GTPase regulator activity | 0.0294031444630966 |
GO:0005509 | calcium ion binding | 0.0294096443542626 |
GO:0002028 | regulation of sodium ion transport | 0.0294096443542626 |
GO:0016361 | activin receptor activity, type I | 0.0294096443542626 |
GO:0043271 | negative regulation of ion transport | 0.0294096443542626 |
GO:0048662 | negative regulation of smooth muscle cell proliferation | 0.0294096443542626 |
GO:0007044 | cell-substrate junction assembly | 0.0294096443542626 |
GO:0051893 | regulation of focal adhesion formation | 0.0294096443542626 |
GO:0016511 | endothelin-converting enzyme activity | 0.0294096443542626 |
GO:0001542 | ovulation from ovarian follicle | 0.0294096443542626 |
GO:0030147 | natriuresis | 0.0294096443542626 |
GO:0009966 | regulation of signal transduction | 0.0334764827654863 |
GO:0035239 | tube morphogenesis | 0.0341296992268949 |
GO:0030728 | ovulation | 0.0341296992268949 |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | 0.0341296992268949 |
GO:0005161 | platelet-derived growth factor receptor binding | 0.0341296992268949 |
GO:0030817 | regulation of cAMP biosynthetic process | 0.0341296992268949 |
GO:0003091 | renal water homeostasis | 0.0341296992268949 |
GO:0043204 | perikaryon | 0.0341296992268949 |
GO:0030146 | diuresis | 0.0341296992268949 |
GO:0050785 | advanced glycation end-product receptor activity | 0.0341296992268949 |
GO:0043086 | negative regulation of catalytic activity | 0.0345027212697935 |
GO:0006468 | protein amino acid phosphorylation | 0.0351613870136064 |
GO:0005923 | tight junction | 0.0353020665695773 |
GO:0006694 | steroid biosynthetic process | 0.0353020665695773 |
GO:0045941 | positive regulation of transcription | 0.0362924477264727 |
GO:0016021 | integral to membrane | 0.0362924477264727 |
GO:0006026 | aminoglycan catabolic process | 0.0362924477264727 |
GO:0043197 | dendritic spine | 0.0362924477264727 |
GO:0017002 | activin receptor activity | 0.0362924477264727 |
GO:0030802 | regulation of cyclic nucleotide biosynthetic process | 0.0362924477264727 |
GO:0051346 | negative regulation of hydrolase activity | 0.0362924477264727 |
GO:0030808 | regulation of nucleotide biosynthetic process | 0.0362924477264727 |
GO:0005025 | transforming growth factor beta receptor activity, type I | 0.0362924477264727 |
GO:0051482 | elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | 0.0362924477264727 |
GO:0006027 | glycosaminoglycan catabolic process | 0.0362924477264727 |
GO:0045980 | negative regulation of nucleotide metabolic process | 0.0362924477264727 |
GO:0030814 | regulation of cAMP metabolic process | 0.0362924477264727 |
GO:0048185 | activin binding | 0.0362924477264727 |
GO:0065007 | biological regulation | 0.037269427936824 |
GO:0031224 | intrinsic to membrane | 0.037269427936824 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.037269427936824 |
GO:0044464 | cell part | 0.0384039828222961 |
GO:0007610 | behavior | 0.038563865296694 |
GO:0032403 | protein complex binding | 0.0395517057274204 |
GO:0004517 | nitric-oxide synthase activity | 0.039806510300465 |
GO:0001953 | negative regulation of cell-matrix adhesion | 0.039806510300465 |
GO:0030799 | regulation of cyclic nucleotide metabolic process | 0.039806510300465 |
GO:0030104 | water homeostasis | 0.039806510300465 |
GO:0043296 | apical junction complex | 0.0398555597965433 |
GO:0009888 | tissue development | 0.0408373114722924 |
GO:0016327 | apicolateral plasma membrane | 0.040866500537183 |
GO:0042995 | cell projection | 0.0432736643684624 |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 0.0433830832959671 |
GO:0018987 | osmoregulation | 0.0439011016156574 |
GO:0006793 | phosphorus metabolic process | 0.0470645470973383 |
GO:0006796 | phosphate metabolic process | 0.0470645470973383 |
GO:0019229 | regulation of vasoconstriction | 0.0477164577152317 |
GO:0003014 | renal system process | 0.0477164577152317 |
GO:0051899 | membrane depolarization | 0.0477164577152317 |
GO:0005112 | Notch binding | 0.0477164577152317 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
endothelial cell of vascular tree | 3.22e-33 | 24 |
endothelial cell | 2.02e-32 | 36 |
blood vessel endothelial cell | 1.78e-25 | 18 |
embryonic blood vessel endothelial progenitor cell | 1.78e-25 | 18 |
meso-epithelial cell | 1.51e-23 | 45 |
lining cell | 9.33e-16 | 58 |
barrier cell | 9.33e-16 | 58 |
endothelial cell of artery | 1.47e-13 | 9 |
vein endothelial cell | 1.54e-09 | 6 |
aortic endothelial cell | 1.58e-09 | 6 |
lymphangioblast | 2.87e-09 | 6 |
endothelial cell of lymphatic vessel | 2.87e-09 | 6 |
vascular lymphangioblast | 2.87e-09 | 6 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 6.4003 |
MA0004.1 | 0.172938 |
MA0006.1 | 0.117267 |
MA0007.1 | 0.371436 |
MA0009.1 | 0.832098 |
MA0014.1 | 6.24326 |
MA0017.1 | 0.299258 |
MA0019.1 | 0.0812311 |
MA0024.1 | 0.0325915 |
MA0025.1 | 0.114657 |
MA0027.1 | 1.3442 |
MA0028.1 | 0.330025 |
MA0029.1 | 0.0370918 |
MA0030.1 | 0.0343776 |
MA0031.1 | 0.0214681 |
MA0038.1 | 0.394336 |
MA0040.1 | 0.0385281 |
MA0041.1 | 0.00517715 |
MA0042.1 | 0.00303573 |
MA0043.1 | 0.0616603 |
MA0046.1 | 0.0580212 |
MA0048.1 | 1.71295 |
MA0050.1 | 0.00308354 |
MA0051.1 | 0.0155214 |
MA0052.1 | 0.0394966 |
MA0055.1 | 0.177013 |
MA0056.1 | 0 |
MA0057.1 | 4.94042 |
MA0058.1 | 0.267364 |
MA0059.1 | 0.383882 |
MA0060.1 | 0.0824493 |
MA0061.1 | 1.33643 |
MA0063.1 | 0 |
MA0066.1 | 0.125353 |
MA0067.1 | 0.616091 |
MA0068.1 | 2.03964 |
MA0069.1 | 0.207539 |
MA0070.1 | 0.0533368 |
MA0071.1 | 0.671149 |
MA0072.1 | 0.0519821 |
MA0073.1 | 5.98735 |
MA0074.1 | 0.815971 |
MA0076.1 | 0.0324962 |
MA0077.1 | 0.415916 |
MA0078.1 | 0.437629 |
MA0081.1 | 1.95449 |
MA0083.1 | 0.0640654 |
MA0084.1 | 0.343749 |
MA0087.1 | 0.0512539 |
MA0088.1 | 3.32209 |
MA0089.1 | 0 |
MA0090.1 | 0.690922 |
MA0091.1 | 0.0440436 |
MA0092.1 | 0.648732 |
MA0093.1 | 0.192328 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.901833 |
MA0101.1 | 2.7761 |
MA0103.1 | 0.242067 |
MA0105.1 | 4.88291 |
MA0106.1 | 1.03246 |
MA0107.1 | 3.03075 |
MA0108.2 | 0.437466 |
MA0109.1 | 0 |
MA0111.1 | 0.987043 |
MA0113.1 | 1.11394 |
MA0114.1 | 0.199108 |
MA0115.1 | 0.169944 |
MA0116.1 | 7.90959 |
MA0117.1 | 0.550586 |
MA0119.1 | 2.73072 |
MA0122.1 | 0.0845942 |
MA0124.1 | 0.14739 |
MA0125.1 | 0.106507 |
MA0130.1 | 0 |
MA0131.1 | 0.281138 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.0720573 |
MA0136.1 | 1.16131 |
MA0139.1 | 3.50925 |
MA0140.1 | 1.8382 |
MA0141.1 | 0.377361 |
MA0142.1 | 0.0165166 |
MA0143.1 | 0.0904166 |
MA0144.1 | 0.659037 |
MA0145.1 | 3.64043 |
MA0146.1 | 12.9111 |
MA0147.1 | 0.0676417 |
MA0148.1 | 0.0217316 |
MA0149.1 | 0.156099 |
MA0062.2 | 1.44309 |
MA0035.2 | 1.17556 |
MA0039.2 | 9.61879 |
MA0138.2 | 0.4406 |
MA0002.2 | 0.270873 |
MA0137.2 | 0.246704 |
MA0104.2 | 0.0505874 |
MA0047.2 | 0.00387052 |
MA0112.2 | 2.27706 |
MA0065.2 | 2.23266 |
MA0150.1 | 0.139025 |
MA0151.1 | 0 |
MA0152.1 | 0.179981 |
MA0153.1 | 0.0991135 |
MA0154.1 | 3.41096 |
MA0155.1 | 5.56465 |
MA0156.1 | 4.24371 |
MA0157.1 | 0.0619309 |
MA0158.1 | 0 |
MA0159.1 | 4.23857 |
MA0160.1 | 0.140487 |
MA0161.1 | 0 |
MA0162.1 | 2.48234 |
MA0163.1 | 10.1525 |
MA0164.1 | 0.0998519 |
MA0080.2 | 2.40025 |
MA0018.2 | 0.026092 |
MA0099.2 | 0.180528 |
MA0079.2 | 16.1004 |
MA0102.2 | 0.371785 |
MA0258.1 | 0.58359 |
MA0259.1 | 0.272638 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
FOS#2353 | 31 | 2.21378265536291 | 1.58301408387071e-05 | 0.000370276389485719 |
GATA2#2624 | 39 | 3.94485982229052 | 4.17751574144885e-14 | 6.83848850346672e-12 |
POLR2A#5430 | 90 | 1.53389512611291 | 1.36592983118522e-08 | 1.0039151698744e-06 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data