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MCL coexpression mm9:1983: Difference between revisions

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{{MCL_coexpression_mm9
{{MCL_coexpression_mm9|coexpression_dpi_cluster_scores_mean=0.032256856393288,0,0,0,0,0,0,0,0,0,0.0450066463881583,0.00833303134164643,0.0171578335952877,0.00909936926750465,0,0,0,0.0159019233384882,0,0,0.119416636716322,0.0102781632737099,0,0,0,0,0,0,0.0188888770793492,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0243831848235074,0.0200441900598869,0.0522459094430348,0,0.0214140645135388,0.0215620259804927,0.0356646017577273,0,0,0,0,0.0314592371059923,0.0947811242317275,0.110269466318178,0.045151313530137,0.0515005492759427,0.092202461586495,0,0,0,0,0,0,0.0284524349013718,0.0353011470460758,0.0792736720054089,0.145066022257998,0.0738373158426839,0.205486399149104,0.141189519456519,0.0363364305578062,0.0739206697031248,0,0.999984474211378,0.425982991893577,0.686708280757929,0.12106126480604,0.0997308759877748,0.0910522389263605,0.240680851666063,0.209872492504995,0.403473336818917,0.526093363821255,0.325798600842342,0.115008415307307,0.00792543589561178,0.023192158131301,0,0,0,0,0.0543562728340653,0,0.0142685311672479,0.017086391154771,0,0,0.0286130208973782,0,0.137497506199505,0,0,0.0245189459510953,0,0.0340713199571934,0,0,0.0646790669231725,0.0577162951573975,0.0225305949743695,0.0572129565208915,0.0877202089261056,0.0128524442124787,0,0.0642174655105914,0.0688054046018268,0,0.0216648225944688,0,0,0.232122840835015,0.156330588805831,0,0,0,0,0.323044039472482,0.254031227253031,0.250480931683214,0.347736123359425,0.507093227223639,0.348136610697225,0.379532093599278,0.0677583218175101,0,0.0244637418497234,0.0207359831874909,0.0265623655145556,0.0410736528655135,0.0179762183352813,0.118699666963322,0.0474795145987425,0.0537485988507517,0.00972472422872995,0.0499616976077144,0,0.0348290193730755,0.0351946358075573,0.0215183584573789,0.0924949515162612,0.0573887433036898,0,0.0197078987099768,0,0,0,0.0204381305882245,0,0.0333946358132078,0,0,0,0.0574589589526932,0.0258032210994128,0.0119904819044224,0.0639719302719583,0.0980755153284126,0,0.0394850111440962,0.0215499128982231,0,0.308200572539668,0.214045571693705,0,0,0.0419819959588466,0.0828407355402905,0.0248972799586635,0.0567403455253709,0,0,0,0.0165534214268825,0.0685593503018042,0.0394017081901728,0.0580161400507563,0.0696209155451742,0.0212457191650637,0.0197175878056837,0,0.0861459447435924,0,0.0572220516233438,0.0355899330760718,0.0783508022865926,0.0440707782863788,0.0430345052687029,0.0720618796479733,0.0239487044583413,0,0,0.0194835289802596,0,0,0.0234584437654235,0,0,0.0163141664424169,0.02634019156492,0.147078128804623,0,0,0,0,0.042744539113211,0.0784826639015289,0,0.0306301453687217,0.044689235556021,0.0578719051585717,0.0168148042292738,0.042278009573524,0.0551286950933834,0.0754004304981479,0.102653029101401,0.0585088198442199,0.10511769381813,0.0775323046408493,0.0422564259657661,0,0,0,0,0.261310565729821,0.235068449679797,0,0.0244419134150096,0.059546782971018,0,0.0211818981394944,0,0,0.0757716912521152,0,0.027837127384974,0.0361659475089827,0.260260971902003,0.0144108295356794,0,0.0470017428654311,0.06023248543601,0,0.0235986194663499,0.028679724081707,0,0,0,0.0249571184854793,0,0,0.0298170049079623,0.0781599457882663,0,0.0318118128455325,0.0333944813605095,0.0264159477773836,0,0.017725496390744,0.0643549346965916,0.0639681417254711,0.0804923840606362,0,0.020860610454652,0.0216369721519619,0.0165708800247103,0.0162514781947913,0.0244153594439675,0.0244872863598586,0,0.0277719915921702,0.223179215240994,0.0319172343408938,0.0203716502675842,0.0342109703182358,0.0187377789395437,0.037311144793039,0.0223683720951677,0.0170444637653875,0.0142215890540973,0,0.218305188627409,0,0.0200952356777334,0.0111354634473461,0.0907971416040448,0,0.0259277334239458,0.0252324471816173,0,0,0,0.0485378687462348,0.0435338603633564,0.0166242025215361,0.0549600319829109,0.0131888542903607,0.0169495527659021,0.05564156705651,0.0358015833215058,0.0206710975205364,0.0662916417826311,0.054962990285351,0,0.0569954872513595,0.0309001931459925,0.0876550097488915,0.033229211099218,0,0.024646902068351,0.014956104665486,0.0304135769645169,0.015947867244644,0.0391223332759775,0.0379439883841018,0.0275325249359768,0.0456142524280545,0,0,0.03329331325593,0,0.0383547285828163,0,0,0,0,0.777897180149802,0.758212771317467,0.709534331820561,0.845663177589071,0.384120978153036,0.61381420402857,0.549709727259648,0.52942956894673,0.572285482914911,0.689059602489182,0.0606305060566053,0.085461201825952,0,0.0472542065752338,0.0206616260095204,0.0366471485294105,0.0399288946444235,0.095268113819208,0,0.0688741034276064,0.0859344690205967,0.034753406753808,0.0628987116480484,0.0499739169665888,0.0472245945615809,0.07265261965361,0.077659092439776,0.0708531680714075,0.0374652791913625,0.0677278943290575,0.19019462389022,0.155306805904464,0.0655541507762442,0.0817315175575107,0.0516349055216396,0.0819216599995646,0.0520907998199518,0.0760704906227258,0.134529001100718,0.048360620861752,0.0574015251634604,0.0680357487345943,0.037245550361761,0.0938071833558042,0.019151611352809,0.043995389648393,0.0577267996898485,0.0422650922646472,0.0190042220397476,0,0.0452820579159438|coexpression_dpi_cluster_scores_median=0.032256856393288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0976894573070202,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0365927089968535,0,0,0,0,0,0,0,0,0,0.099424903790252,0.054710539498653,0,0,0.092202461586495,0,0,0,0,0,0,0,0,0.0997345966737732,0.145667600888247,0.0414509950648858,0.152691370679199,0.079443034390946,0.0250913949416665,0.0929615792816322,0,1.01696207770936,0.392270997370278,0.696571511676794,0.123224102318956,0.0729756721489083,0.0910522389263605,0.19266946376396,0.163733131191061,0.45642888952766,0.541125235411684,0.364892530881307,0.133566149096974,0,0.0158196551188907,0,0,0,0,0,0,0,0,0,0,0.0286130208973782,0,0,0,0,0,0,0.0234784353458152,0,0,0.0646790669231725,0.0577162951573975,0,0.0572129565208915,0.0917293418104957,0,0,0.0293267487845199,0,0,0,0,0,0.268433791687647,0.0825867363219064,0,0,0,0,0.272992267196782,0.28216905172576,0.301310892263953,0.362113304938093,0.517396617178766,0.383650186121962,0.43016502236021,0.0613144345794207,0,0,0,0.0265623655145556,0,0,0.0810004240799845,0.0546260382375042,0,0,0.0499616976077144,0,0,0.0351946358075573,0,0.0532734549622995,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0661618130246221,0.0660154575426048,0,0,0,0,0.329072578125644,0.205280213725339,0,0,0.0419819959588466,0.0828407355402905,0,0.0398950534645112,0,0,0,0,0.0486868322374133,0.0394017081901728,0.0773548534010084,0,0,0,0,0.0446870545910623,0,0.040250349638994,0,0.0699699572373772,0.0391753538423105,0.0298971899647678,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0368139433955263,0,0,0,0,0,0,0.0387082368603573,0.0912933562119048,0.043440458408578,0.0321269055488328,0.0615543328658565,0.0644208637727105,0.0293361777120366,0,0,0,0,0.254207060770644,0.230252763175294,0,0,0.059546782971018,0,0,0,0,0.054126280606808,0,0,0,0.287241754888108,0,0,0.0327687501780757,0.0331573937563205,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0264159477773836,0,0,0.0356406207688943,0.0661577744756082,0.057716207064756,0,0,0,0,0,0.0127170276859676,0.0244872863598586,0,0,0.192086593839265,0,0,0,0,0,0,0,0,0,0.291073584836546,0,0,0,0.0758651563856525,0,0,0.017244733229267,0,0,0,0,0.0302576134241717,0,0.0385842034280588,0,0,0.0457832701852885,0,0,0.0469880747817416,0.054962990285351,0,0.0400832080528911,0.0212308449966822,0.05015798025338,0,0,0.024646902068351,0,0.0208870423994129,0.015947867244644,0.020859375746038,0.0201939307380272,0,0.0456142524280545,0,0,0,0,0.0383547285828163,0,0,0,0,0.762942003876902,0.784191218994988,0.805156669508271,0.812714830995007,0.300699880676714,0.628475519222729,0.635757637951378,0.607818916769566,0.567160930619926,0.690361800341623,0.0623997076628837,0,0,0.0472542065752338,0,0.0366471485294105,0,0.115608096853184,0,0.0489230553888678,0.049058583180754,0,0.0567146198773073,0.0396401807728516,0.0472245945615809,0,0.0905291472420136,0.0708531680714075,0,0.0560338898194635,0.226790206858766,0.158651849966934,0.0464368173027965,0.0848798800014619,0.0195303707501796,0.0515875539845187,0.0364791508700876,0.101427320830301,0.104353329269123,0,0.0486884105045233,0.0594496181738161,0,0.0828907256914365,0,0,0,0.0422650922646472,0,0,0.0452820579159438|gostat_on_MCL_coexpression=GO:0048691;positive regulation of axon extension involved in regeneration;0.00260231194872076;18213!GO:0048690;regulation of axon extension involved in regeneration;0.00260231194872076;18213!GO:0048677;axon extension involved in regeneration;0.00260231194872076;18213!GO:0048682;sprouting of injured axon;0.00260231194872076;18213!GO:0031103;axon regeneration;0.00433718658120126;18213!GO:0031102;neurite regeneration;0.00433718658120126;18213!GO:0048678;response to axon injury;0.00446110619780701;18213!GO:0031099;regeneration;0.00636120698576186;18213!GO:0042246;tissue regeneration;0.00636120698576186;18213!GO:0048675;axon extension;0.0119706349641155;18213!GO:0042490;mechanoreceptor differentiation;0.0156138716923245;18213!GO:0048589;developmental growth;0.0208184955897661;18213!GO:0004714;transmembrane receptor protein tyrosine kinase activity;0.0248220524339519;18213!GO:0019199;transmembrane receptor protein kinase activity;0.0271383960366593;18213!GO:0042060;wound healing;0.027411019193192;18213!GO:0007409;axonogenesis;0.0424176847641484;18213!GO:0004713;protein-tyrosine kinase activity;0.0424176847641484;18213!GO:0048667;neuron morphogenesis during differentiation;0.0424176847641484;18213!GO:0048812;neurite morphogenesis;0.0424176847641484;18213!GO:0007169;transmembrane receptor protein tyrosine kinase signaling pathway;0.0424176847641484;18213!GO:0000904;cellular morphogenesis during differentiation;0.0458502581441276;18213!GO:0031175;neurite development;0.0461318936364135;18213!GO:0048666;neuron development;0.0493307830279239;18213!GO:0007167;enzyme linked receptor protein signaling pathway;0.0499643894154386;18213!GO:0032990;cell part morphogenesis;0.0499643894154386;18213!GO:0030030;cell projection organization and biogenesis;0.0499643894154386;18213!GO:0048858;cell projection morphogenesis;0.0499643894154386;18213!GO:0030182;neuron differentiation;0.0499643894154386;18213!GO:0009888;tissue development;0.0499643894154386;18213!GO:0009611;response to 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|gostat_on_MCL_coexpression=GO:0048691;positive regulation of axon extension involved in regeneration;0.00260231194872076;18213!GO:0048690;regulation of axon extension involved in regeneration;0.00260231194872076;18213!GO:0048677;axon extension involved in regeneration;0.00260231194872076;18213!GO:0048682;sprouting of injured axon;0.00260231194872076;18213!GO:0031103;axon regeneration;0.00433718658120126;18213!GO:0031102;neurite regeneration;0.00433718658120126;18213!GO:0048678;response to axon injury;0.00446110619780701;18213!GO:0031099;regeneration;0.00636120698576186;18213!GO:0042246;tissue regeneration;0.00636120698576186;18213!GO:0048675;axon extension;0.0119706349641155;18213!GO:0042490;mechanoreceptor differentiation;0.0156138716923245;18213!GO:0048589;developmental growth;0.0208184955897661;18213!GO:0004714;transmembrane receptor protein tyrosine kinase activity;0.0248220524339519;18213!GO:0019199;transmembrane receptor protein kinase activity;0.0271383960366593;18213!GO:0042060;wound healing;0.027411019193192;18213!GO:0007409;axonogenesis;0.0424176847641484;18213!GO:0004713;protein-tyrosine kinase activity;0.0424176847641484;18213!GO:0048667;neuron morphogenesis during differentiation;0.0424176847641484;18213!GO:0048812;neurite morphogenesis;0.0424176847641484;18213!GO:0007169;transmembrane receptor protein tyrosine kinase signaling pathway;0.0424176847641484;18213!GO:0000904;cellular morphogenesis during differentiation;0.0458502581441276;18213!GO:0031175;neurite development;0.0461318936364135;18213!GO:0048666;neuron development;0.0493307830279239;18213!GO:0007167;enzyme linked receptor protein signaling pathway;0.0499643894154386;18213!GO:0032990;cell part morphogenesis;0.0499643894154386;18213!GO:0030030;cell projection organization and biogenesis;0.0499643894154386;18213!GO:0048858;cell projection morphogenesis;0.0499643894154386;18213!GO:0030182;neuron differentiation;0.0499643894154386;18213!GO:0009888;tissue development;0.0499643894154386;18213!GO:0009611;response to wounding;0.0499643894154386;18213!
}}

Latest revision as of 17:48, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr11:68904332..68904343,+p@chr11:68904332..68904343
+
Mm9::chr7:68675006..68675020,-p@chr7:68675006..68675020
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Mm9::chr7:85337416..85337436,-p@chr7:85337416..85337436
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Mm9::chr9:3904162..3904180,+p@chr9:3904162..3904180
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0048691positive regulation of axon extension involved in regeneration0.00260231194872076
GO:0048690regulation of axon extension involved in regeneration0.00260231194872076
GO:0048677axon extension involved in regeneration0.00260231194872076
GO:0048682sprouting of injured axon0.00260231194872076
GO:0031103axon regeneration0.00433718658120126
GO:0031102neurite regeneration0.00433718658120126
GO:0048678response to axon injury0.00446110619780701
GO:0031099regeneration0.00636120698576186
GO:0042246tissue regeneration0.00636120698576186
GO:0048675axon extension0.0119706349641155
GO:0042490mechanoreceptor differentiation0.0156138716923245
GO:0048589developmental growth0.0208184955897661
GO:0004714transmembrane receptor protein tyrosine kinase activity0.0248220524339519
GO:0019199transmembrane receptor protein kinase activity0.0271383960366593
GO:0042060wound healing0.027411019193192
GO:0007409axonogenesis0.0424176847641484
GO:0004713protein-tyrosine kinase activity0.0424176847641484
GO:0048667neuron morphogenesis during differentiation0.0424176847641484
GO:0048812neurite morphogenesis0.0424176847641484
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.0424176847641484
GO:0000904cellular morphogenesis during differentiation0.0458502581441276
GO:0031175neurite development0.0461318936364135
GO:0048666neuron development0.0493307830279239
GO:0007167enzyme linked receptor protein signaling pathway0.0499643894154386
GO:0032990cell part morphogenesis0.0499643894154386
GO:0030030cell projection organization and biogenesis0.0499643894154386
GO:0048858cell projection morphogenesis0.0499643894154386
GO:0030182neuron differentiation0.0499643894154386
GO:0009888tissue development0.0499643894154386
GO:0009611response to wounding0.0499643894154386



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)7.85e-1123
neuroblast (sensu Vertebrata)7.85e-1123
neuron1.84e-0733
neuronal stem cell1.84e-0733
neuroblast1.84e-0733
electrically signaling cell1.84e-0733
electrically responsive cell3.53e-0739
electrically active cell3.53e-0739

Uber Anatomy
Ontology termp-valuen
regional part of nervous system5.90e-2454
neural tube5.41e-2252
neural rod5.41e-2252
future spinal cord5.41e-2252
neural keel5.41e-2252
gray matter4.74e-2034
neurectoderm3.41e-1964
neural plate3.41e-1964
presumptive neural plate3.41e-1964
central nervous system1.35e-1873
brain1.74e-1847
future brain1.74e-1847
nervous system3.50e-1875
regional part of brain9.68e-1846
ecto-epithelium4.50e-1773
anterior neural tube1.57e-1640
brain grey matter1.79e-1629
regional part of telencephalon1.79e-1629
telencephalon1.79e-1629
regional part of forebrain8.28e-1639
forebrain8.28e-1639
future forebrain8.28e-1639
structure with developmental contribution from neural crest9.08e-1592
pre-chordal neural plate1.39e-1449
ectoderm-derived structure2.02e-1495
ectoderm2.02e-1495
presumptive ectoderm2.02e-1495
cerebral cortex4.30e-1121
cerebral hemisphere4.30e-1121
pallium4.30e-1121
occipital lobe2.85e-1010
visual cortex2.85e-1010
neocortex2.85e-1010
regional part of cerebral cortex6.56e-0917
tube3.31e-08114
anatomical conduit1.21e-07122


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0356887
MA0004.10.6888
MA0006.10.497533
MA0007.10.672186
MA0009.11.15569
MA0014.10.0809287
MA0017.10.528196
MA0019.10.964875
MA0024.11.11019
MA0025.11.39562
MA0027.12.81824
MA0028.10.509589
MA0029.11.08753
MA0030.11.09438
MA0031.11.05719
MA0038.10.846479
MA0040.11.16866
MA0041.10.604221
MA0042.10.589368
MA0043.11.25564
MA0046.11.1929
MA0048.10.266382
MA0050.10.731539
MA0051.10.856094
MA0052.11.17701
MA0055.10.396346
MA0056.10
MA0057.10.251896
MA0058.10.581673
MA0059.10.59559
MA0060.10.403071
MA0061.10.438628
MA0063.10
MA0066.10.834648
MA0067.11.50873
MA0068.10.256913
MA0069.11.17737
MA0070.11.16732
MA0071.10.73062
MA0072.11.15853
MA0073.10.0471131
MA0074.10.795862
MA0076.10.550092
MA0077.11.13603
MA0078.10.891476
MA0081.10.621611
MA0083.11.25482
MA0084.11.84013
MA0087.11.21037
MA0088.10.201215
MA0089.10
MA0090.10.650768
MA0091.10.703314
MA0092.10.651119
MA0093.10.519148
MA0095.10
MA0098.10
MA0100.10.783305
MA0101.10.605676
MA0103.10.540576
MA0105.10.313353
MA0106.10.899777
MA0107.10.533522
MA0108.20.989014
MA0109.10
MA0111.10.666525
MA0113.10.869608
MA0114.10.43587
MA0115.11.25852
MA0116.10.497293
MA0117.11.22527
MA0119.10.606338
MA0122.11.24573
MA0124.11.45461
MA0125.11.37907
MA0130.10
MA0131.10.960068
MA0132.10
MA0133.10
MA0135.11.29308
MA0136.10.817395
MA0139.10.365453
MA0140.10.78318
MA0141.10.563066
MA0142.11.04199
MA0143.10.887119
MA0144.10.439506
MA0145.10.21199
MA0146.10.313734
MA0147.10.453952
MA0148.10.706718
MA0149.10.611881
MA0062.20.319836
MA0035.20.788288
MA0039.20.0959929
MA0138.20.951653
MA0002.20.965577
MA0137.20.559766
MA0104.20.386166
MA0047.20.845655
MA0112.20.608441
MA0065.21.14711
MA0150.10.67206
MA0151.10
MA0152.10.84577
MA0153.11.31015
MA0154.10.263609
MA0155.10.230016
MA0156.10.549102
MA0157.11.0083
MA0158.10
MA0159.11.1762
MA0160.10.71003
MA0161.10
MA0162.10.10667
MA0163.10.0996272
MA0164.10.817786
MA0080.20.534538
MA0018.20.828253
MA0099.20.944966
MA0079.20.190089
MA0102.21.8929
MA0258.10.419871
MA0259.10.441366
MA0442.10