Coexpression cluster:C4734

Full id: C4734_Fibroblast_Smooth_Mesenchymal_Preadipocyte_Keratocytes_Chondrocyte_melanoma

Phase1 CAGE Peaks

Hg19::chr8:145025046..145025061,-	p7@PLEC
Hg19::chr8:145025063..145025073,-	p16@PLEC
Hg19::chr8:145025074..145025102,-	p2@PLEC

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	2.64e-33	180
fibroblast	6.82e-28	75
somatic cell	2.83e-26	591
animal cell	6.69e-23	679
eukaryotic cell	6.69e-23	679
multi fate stem cell	4.63e-16	430
somatic stem cell	5.95e-16	436
mesodermal cell	3.84e-15	119
stem cell	4.62e-14	444
native cell	9.74e-13	722
skin fibroblast	1.29e-11	23
muscle precursor cell	4.39e-11	57
myoblast	4.39e-11	57
multi-potent skeletal muscle stem cell	4.39e-11	57
contractile cell	4.60e-11	59
CD14-positive, CD16-negative classical monocyte	2.43e-10	42
classical monocyte	2.72e-10	45
muscle cell	3.94e-10	54
connective tissue cell	5.66e-10	365
smooth muscle cell	5.07e-09	42
smooth muscle myoblast	5.07e-09	42
mesenchymal cell	6.79e-09	358
macrophage dendritic cell progenitor	8.63e-09	65
monopoietic cell	1.31e-08	63
monocyte	1.31e-08	63
monoblast	1.31e-08	63
promonocyte	1.31e-08	63
granulocyte monocyte progenitor cell	6.78e-08	71
preadipocyte	1.70e-07	12
electrically responsive cell	2.07e-07	60
electrically active cell	2.07e-07	60
embryonic cell	2.40e-07	248
motile cell	4.56e-07	390
myeloid lineage restricted progenitor cell	4.65e-07	70

Uber Anatomy

Ontology term	p-value	n
musculoskeletal system	4.08e-23	167
mesoderm	7.61e-20	448
mesoderm-derived structure	7.61e-20	448
presumptive mesoderm	7.61e-20	448
lateral plate mesoderm	4.22e-16	216
somite	5.94e-15	83
paraxial mesoderm	5.94e-15	83
presomitic mesoderm	5.94e-15	83
presumptive segmental plate	5.94e-15	83
trunk paraxial mesoderm	5.94e-15	83
presumptive paraxial mesoderm	5.94e-15	83
multi-cellular organism	3.61e-14	659
anatomical group	2.41e-13	626
dermomyotome	2.41e-13	70
anatomical system	2.64e-13	625
multilaminar epithelium	7.73e-13	82
skeletal element	3.09e-12	101
skeletal system	3.09e-12	101
connective tissue	1.33e-10	375
surface structure	2.09e-10	95
skeletal muscle tissue	3.01e-10	61
striated muscle tissue	3.01e-10	61
myotome	3.01e-10	61
bone element	3.32e-10	86
splanchnic layer of lateral plate mesoderm	4.06e-10	84
germ layer	5.64e-10	604
embryonic tissue	5.64e-10	604
presumptive structure	5.64e-10	604
epiblast (generic)	5.64e-10	604
embryonic structure	6.77e-10	605
developing anatomical structure	6.77e-10	605
artery	7.27e-10	42
arterial blood vessel	7.27e-10	42
arterial system	7.27e-10	42
blood vessel	9.37e-10	60
epithelial tube open at both ends	9.37e-10	60
blood vasculature	9.37e-10	60
vascular cord	9.37e-10	60
integument	9.56e-10	45
integumental system	9.56e-10	45
muscle tissue	9.98e-10	63
musculature	9.98e-10	63
musculature of body	9.98e-10	63
vasculature	3.27e-09	79
vascular system	3.27e-09	79
bone marrow	4.42e-09	80
vessel	5.75e-09	69
trunk mesenchyme	6.20e-09	143
skin of body	9.97e-09	40
embryo	1.09e-08	612
systemic artery	2.48e-08	33
systemic arterial system	2.48e-08	33
trunk	2.15e-07	216
epithelial tube	2.86e-07	118
cardiovascular system	3.20e-07	110
circulatory system	7.45e-07	113

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.