Coexpression cluster:C176

Full id: C176_Eosinophils_Neutrophils_Mast_CD14_CD4_Basophils_CD19

Phase1 CAGE Peaks

Hg19::chr10:124768300..124768334,-	p1@IKZF5
Hg19::chr10:28821674..28821715,+	p2@WAC
Hg19::chr10:32636106..32636150,-	p3@EPC1
Hg19::chr10:69644404..69644425,+	p1@SIRT1
Hg19::chr10:76586348..76586366,+	p1@KAT6B
Hg19::chr10:98592009..98592061,+	p1@C10orf12 p1@LCOR
Hg19::chr11:118661828..118661886,-	p1@DDX6
Hg19::chr11:13299319..13299424,+	p1@ARNTL
Hg19::chr11:65265141..65265306,+	p4@MALAT1
Hg19::chr11:9482551..9482580,+	p1@ZNF143
Hg19::chr12:132195617..132195648,+	p1@SFSWAP
Hg19::chr12:46384334..46384366,-	p1@SCAF11
Hg19::chr12:498415..498492,-	p1@KDM5A
Hg19::chr12:72057607..72057636,-	p1@ZFC3H1
Hg19::chr12:72057639..72057678,-	p2@ZFC3H1
Hg19::chr12:76953542..76953561,-	p1@OSBPL8
Hg19::chr13:108870714..108870780,+	p2@ABHD13
Hg19::chr13:28712299..28712376,+	p1@PAN3
Hg19::chr13:41557016..41557041,-	p@chr13:41557016..41557041 -
Hg19::chr14:50319482..50319564,-	p1@NEMF
Hg19::chr14:58765217..58765301,+	p1@ARID4A
Hg19::chr14:70233822..70233868,+	p1@SRSF5
Hg19::chr14:73525229..73525260,+	p1@RBM25
Hg19::chr15:50716576..50716624,+	p1@USP8
Hg19::chr15:68346646..68346665,+	p1@PIAS1
Hg19::chr15:72766651..72766680,+	p1@ARIH1
Hg19::chr16:3930681..3930721,-	p1@CREBBP
Hg19::chr16:9185450..9185516,+	p1@C16orf72
Hg19::chr17:29641057..29641079,-	p1@EVI2B
Hg19::chr17:34900745..34900821,+	p1@GGNBP2
Hg19::chr17:42264322..42264376,+	p2@TMUB2
Hg19::chr17:62502399..62502411,-	p1@DDX5
Hg19::chr17:7737518..7737579,+	p@chr17:7737518..7737579 +
Hg19::chr18:19180606..19180673,-	p1@ESCO1
Hg19::chr18:60190226..60190314,+	p1@ZCCHC2
Hg19::chr18:72265084..72265143,+	p1@ZNF407
Hg19::chr18:9136763..9136852,+	p1@ANKRD12
Hg19::chr19:52490043..52490113,-	p1@ZNF350
Hg19::chr1:109289279..109289331,+	p1@STXBP3
Hg19::chr1:14075903..14075940,+	p1@PRDM2
Hg19::chr1:1655723..1655803,-	p1@CDK11A p1@CDK11B
Hg19::chr1:173991434..173991556,-	p1@RC3H1
Hg19::chr1:226187013..226187071,-	p1@C1orf55
Hg19::chr1:231473578..231473619,-	p1@EXOC8
Hg19::chr1:235491462..235491510,-	p1@ARID4B
Hg19::chr1:40627038..40627071,+	p1@RLF
Hg19::chr1:67395922..67395976,+	p2@MIER1
Hg19::chr1:89458415..89458463,-	p1@RBMXL1 p2@CCBL2
Hg19::chr20:34330129..34330195,-	p1@RBM39
Hg19::chr21:34915337..34915397,+	p1@SON
Hg19::chr21:38739111..38739164,+	p3@DYRK1A
Hg19::chr21:43430440..43430485,-	p1@ZNF295
Hg19::chr22:39101927..39101990,+	p1@GTPBP1
Hg19::chr22:41487711..41487798,+	p1@EP300
Hg19::chr2:109065634..109065692,+	p1@GCC2
Hg19::chr2:109335929..109336002,+	p1@RANBP2
Hg19::chr2:136499179..136499228,+	p3@UBXN4
Hg19::chr2:149402275..149402341,+	p1@EPC2
Hg19::chr2:160568978..160569064,+	p1@MARCH7
Hg19::chr2:198299726..198299776,-	p1@SF3B1
Hg19::chr2:48133576..48133693,-	p@chr2:48133576..48133693 -
Hg19::chr2:86668464..86668529,+	p1@KDM3A
Hg19::chr3:135915086..135915144,-	p2@MSL2
Hg19::chr3:14693235..14693246,+	p3@C3orf19
Hg19::chr3:156877955..156877974,-	p2@CCNL1
Hg19::chr3:156877978..156877987,-	p3@CCNL1
Hg19::chr3:38206975..38207101,+	p1@OXSR1
Hg19::chr3:53381539..53381577,-	p1@DCP1A
Hg19::chr3:69101413..69101457,-	p1@TMF1
Hg19::chr4:69215699..69215815,-	p1@YTHDC1
Hg19::chr5:130970848..130970965,-	p1@RAPGEF6
Hg19::chr5:137368726..137368784,-	p1@FAM13B
Hg19::chr5:139781393..139781435,+	p1@ANKHD1-EIF4EBP3 p1@ANKHD1
Hg19::chr5:142784003..142784065,-	p2@NR3C1
Hg19::chr5:172483347..172483407,+	p1@C5orf41
Hg19::chr5:176433693..176433812,-	p1@UIMC1
Hg19::chr5:36876833..36876894,+	p2@NIPBL
Hg19::chr5:36876926..36876994,+	p1@NIPBL
Hg19::chr5:39074479..39074515,-	p1@RICTOR
Hg19::chr5:56469958..56469966,+	p8@GPBP1
Hg19::chr5:86708636..86708665,-	p2@CCNH
Hg19::chr5:86708670..86708766,-	p1@CCNH
Hg19::chr5:98264581..98264689,-	p@chr5:98264581..98264689 -
Hg19::chr6:139456200..139456225,+	p2@HECA
Hg19::chr6:155054530..155054561,+	p1@SCAF8
Hg19::chr6:160148525..160148576,+	p1@WTAP
Hg19::chr6:33378517..33378564,+	p3@PHF1
Hg19::chr6:42749679..42749713,+	p3@KIAA0240
Hg19::chr6:87865262..87865311,+	p1@ZNF292
Hg19::chr7:104653471..104653515,-	p1@ENST00000445184 p1@ENST00000450686
Hg19::chr7:104654623..104654669,+	p1@MLL5
Hg19::chr7:130792893..130792908,-	p2@ENST00000429901
Hg19::chr7:152133620..152133652,-	p@chr7:152133620..152133652 -
Hg19::chr7:155437341..155437405,+	p1@RBM33
Hg19::chr8:41909496..41909512,-	p1@KAT6A
Hg19::chr8:68256003..68256034,-	p1@ARFGEF1
Hg19::chr9:135230336..135230398,-	p1@SETX
Hg19::chrX:123094564..123094581,+	p5@STAG2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
0.000446803618670653	0.0404038129455033	4	128	Cell cycle (KEGG):04110
8.6270664663411e-07	0.000546093307319392	6	116	Androgen Receptor Signaling Pathway (Wikipathways):WP138
8.88697950567494e-05	0.0140636450677306	5	162	TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9
4.490266583751e-05	0.00947446249171461	3	25	{BCLAF1,25} (Static Module):NA
1.51977732997624e-05	0.00481009524937481	5	112	{EP300,115} (Static Module):NA
0.000234032280849933	0.0296284867556015	4	108	{HDAC1,108} (Static Module):NA
0.000335435775220664	0.03538847428578	2	10	{TIA1,10} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016070	RNA metabolic process	2.04805303337828e-16
GO:0005634	nucleus	5.91057991685637e-16
GO:0005654	nucleoplasm	7.36093040758252e-12
GO:0044428	nuclear part	1.65553376857781e-11
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.9791392473282e-11
GO:0043283	biopolymer metabolic process	7.54138067960235e-11
GO:0006355	regulation of transcription, DNA-dependent	7.93606534422575e-11
GO:0031981	nuclear lumen	1.4487896449597e-10
GO:0044451	nucleoplasm part	1.4487896449597e-10
GO:0006351	transcription, DNA-dependent	1.4487896449597e-10
GO:0032774	RNA biosynthetic process	1.4487896449597e-10
GO:0043233	organelle lumen	1.07378294608341e-09
GO:0031974	membrane-enclosed lumen	1.07378294608341e-09
GO:0045449	regulation of transcription	1.20411774222063e-09
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	2.07478549350105e-09
GO:0010467	gene expression	3.23347342085246e-09
GO:0043231	intracellular membrane-bound organelle	3.89486616805506e-09
GO:0043227	membrane-bound organelle	3.89486616805506e-09
GO:0006350	transcription	4.01781254181114e-09
GO:0010468	regulation of gene expression	5.09781748222147e-09
GO:0016607	nuclear speck	5.39835757687086e-09
GO:0044424	intracellular part	5.58612787508296e-09
GO:0031323	regulation of cellular metabolic process	1.12509981391023e-08
GO:0003677	DNA binding	2.93357379289555e-08
GO:0016604	nuclear body	2.93357379289555e-08
GO:0019222	regulation of metabolic process	6.3952309874976e-08
GO:0003676	nucleic acid binding	1.00348876840398e-07
GO:0050794	regulation of cellular process	5.85585363872622e-07
GO:0005622	intracellular	5.98883247284247e-07
GO:0043229	intracellular organelle	1.61683472984701e-06
GO:0043226	organelle	1.61683472984701e-06
GO:0044446	intracellular organelle part	3.17560673516358e-06
GO:0044422	organelle part	3.29559932897327e-06
GO:0016071	mRNA metabolic process	3.98629041141266e-06
GO:0050789	regulation of biological process	4.84705507682382e-06
GO:0065007	biological regulation	1.44141419662829e-05
GO:0043170	macromolecule metabolic process	1.88498361909312e-05
GO:0006325	establishment and/or maintenance of chromatin architecture	2.78098088741691e-05
GO:0006323	DNA packaging	2.98809127512521e-05
GO:0006259	DNA metabolic process	4.37513673725924e-05
GO:0016568	chromatin modification	4.47292275502309e-05
GO:0008380	RNA splicing	5.09901043828198e-05
GO:0051276	chromosome organization and biogenesis	8.84265175142438e-05
GO:0018076	N-terminal peptidyl-lysine acetylation	0.000109206058845818
GO:0018394	peptidyl-lysine acetylation	0.000109206058845818
GO:0008270	zinc ion binding	0.000122435686528734
GO:0006397	mRNA processing	0.000136985932640894
GO:0045941	positive regulation of transcription	0.000151644506336996
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.000181131400730647
GO:0003724	RNA helicase activity	0.0002380279519532
GO:0044237	cellular metabolic process	0.000260749868446827
GO:0006366	transcription from RNA polymerase II promoter	0.000260749868446827
GO:0044238	primary metabolic process	0.000322919765554256
GO:0006396	RNA processing	0.000546972447298479
GO:0045893	positive regulation of transcription, DNA-dependent	0.000577921422521647
GO:0031325	positive regulation of cellular metabolic process	0.000580837189861837
GO:0006474	N-terminal protein amino acid acetylation	0.0006005290158013
GO:0009893	positive regulation of metabolic process	0.000817596507976426
GO:0018205	peptidyl-lysine modification	0.000992124687775453
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.00113536569907426
GO:0017053	transcriptional repressor complex	0.0011980133531595
GO:0016481	negative regulation of transcription	0.00177456209167396
GO:0000123	histone acetyltransferase complex	0.00197189449901821
GO:0016573	histone acetylation	0.00197189449901821
GO:0018409	peptide or protein amino-terminal blocking	0.00226235410115885
GO:0046914	transition metal ion binding	0.00239710015130057
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00250271221666721
GO:0003723	RNA binding	0.00356557517576573
GO:0031365	N-terminal protein amino acid modification	0.00356557517576573
GO:0005515	protein binding	0.00362308024683212
GO:0006473	protein amino acid acetylation	0.00467267787776979
GO:0000184	mRNA catabolic process, nonsense-mediated decay	0.00467267787776979
GO:0016564	transcription repressor activity	0.00478296814858988
GO:0031324	negative regulation of cellular metabolic process	0.00505553640616498
GO:0004468	lysine N-acetyltransferase activity	0.00629279275980798
GO:0004402	histone acetyltransferase activity	0.00629279275980798
GO:0045814	negative regulation of gene expression, epigenetic	0.00672036348106831
GO:0006887	exocytosis	0.00746455895371333
GO:0006357	regulation of transcription from RNA polymerase II promoter	0.00753245338880945
GO:0006402	mRNA catabolic process	0.00805062666196582
GO:0009892	negative regulation of metabolic process	0.00839215155288564
GO:0003682	chromatin binding	0.00846323818811058
GO:0043543	protein amino acid acylation	0.00886539050646993
GO:0018193	peptidyl-amino acid modification	0.00887745789516632
GO:0043425	bHLH transcription factor binding	0.00978168405706219
GO:0051577	MyoD binding	0.00978168405706219
GO:0043426	MRF binding	0.00978168405706219
GO:0004883	glucocorticoid receptor activity	0.00978168405706219
GO:0031932	TORC 2 complex	0.00978168405706219
GO:0004386	helicase activity	0.0100200006009732
GO:0044464	cell part	0.0104811135956777
GO:0006950	response to stress	0.0111099691207288
GO:0048522	positive regulation of cellular process	0.0111447540751904
GO:0016043	cellular component organization and biogenesis	0.0114322406403173
GO:0006996	organelle organization and biogenesis	0.011529206903564
GO:0003712	transcription cofactor activity	0.0128320861573194
GO:0016563	transcription activator activity	0.0137873544696713
GO:0031965	nuclear membrane	0.0142219074408801
GO:0030323	respiratory tube development	0.0142219074408801
GO:0043687	post-translational protein modification	0.014700746057638
GO:0006401	RNA catabolic process	0.0159192083747378
GO:0006464	protein modification process	0.0164906416690819
GO:0042975	peroxisome proliferator activated receptor binding	0.0164906416690819
GO:0051896	regulation of protein kinase B signaling cascade	0.0164906416690819
GO:0016570	histone modification	0.0164906416690819
GO:0001666	response to hypoxia	0.0164906416690819
GO:0006512	ubiquitin cycle	0.0171365002087408
GO:0048518	positive regulation of biological process	0.0173445567288284
GO:0016569	covalent chromatin modification	0.0173730484453595
GO:0009952	anterior/posterior pattern formation	0.0207410997161865
GO:0008026	ATP-dependent helicase activity	0.0217252221298926
GO:0007049	cell cycle	0.0217252221298926
GO:0003713	transcription coactivator activity	0.022472748674848
GO:0007243	protein kinase cascade	0.0233284123103522
GO:0043412	biopolymer modification	0.0233284123103522
GO:0005635	nuclear envelope	0.0240200551782881
GO:0006281	DNA repair	0.0262042156577
GO:0040029	regulation of gene expression, epigenetic	0.0265266456191394
GO:0045892	negative regulation of transcription, DNA-dependent	0.0265266456191394
GO:0007519	skeletal muscle development	0.0276633383013126
GO:0003700	transcription factor activity	0.0283948889122752
GO:0005667	transcription factor complex	0.0283948889122752
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	0.0289101437357237
GO:0000398	nuclear mRNA splicing, via spliceosome	0.0289101437357237
GO:0000375	RNA splicing, via transesterification reactions	0.0289101437357237
GO:0008080	N-acetyltransferase activity	0.0310977097245966
GO:0008134	transcription factor binding	0.0331028901367043
GO:0043491	protein kinase B signaling cascade	0.0331028901367043
GO:0017016	Ras GTPase binding	0.0331496531642673
GO:0006974	response to DNA damage stimulus	0.0367141147123424
GO:0045045	secretory pathway	0.0374313327026615
GO:0043285	biopolymer catabolic process	0.0378322604307343
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	0.0382270460094718
GO:0031267	small GTPase binding	0.038589881052216
GO:0003002	regionalization	0.0392664956444353
GO:0016407	acetyltransferase activity	0.0392664956444353
GO:0008415	acyltransferase activity	0.0392664956444353
GO:0014706	striated muscle development	0.0395550349984727
GO:0016747	transferase activity, transferring groups other than amino-acyl groups	0.0395550349984727
GO:0016410	N-acyltransferase activity	0.0400757210967511
GO:0006359	regulation of transcription from RNA polymerase III promoter	0.0417907099392139
GO:0051020	GTPase binding	0.0465388385645271
GO:0031532	actin cytoskeleton reorganization	0.0467486869842573
GO:0017022	myosin binding	0.0467486869842573
GO:0006333	chromatin assembly or disassembly	0.0474676277540671

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	2.62e-46	140
hematopoietic stem cell	6.82e-45	172
angioblastic mesenchymal cell	6.82e-45	172
hematopoietic oligopotent progenitor cell	3.27e-41	165
hematopoietic multipotent progenitor cell	3.27e-41	165
hematopoietic cell	4.36e-39	182
hematopoietic lineage restricted progenitor cell	1.73e-37	124
nongranular leukocyte	1.27e-34	119
myeloid leukocyte	1.08e-26	76
myeloid cell	3.90e-26	112
common myeloid progenitor	3.90e-26	112
CD14-positive, CD16-negative classical monocyte	2.10e-23	42
granulocyte monocyte progenitor cell	3.20e-23	71
myeloid lineage restricted progenitor cell	2.66e-22	70
classical monocyte	2.22e-21	45
macrophage dendritic cell progenitor	3.80e-20	65
monopoietic cell	3.76e-19	63
monocyte	3.76e-19	63
monoblast	3.76e-19	63
promonocyte	3.76e-19	63
lymphoid lineage restricted progenitor cell	1.29e-13	52
lymphocyte	1.95e-13	53
common lymphoid progenitor	1.95e-13	53
mature alpha-beta T cell	4.57e-10	18
alpha-beta T cell	4.57e-10	18
immature T cell	4.57e-10	18
mature T cell	4.57e-10	18
immature alpha-beta T cell	4.57e-10	18
T cell	8.48e-08	25
pro-T cell	8.48e-08	25
CD8-positive, alpha-beta T cell	7.98e-07	11

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	9.65e-27	102
blood island	9.65e-27	102
adult organism	4.51e-26	115
hemolymphoid system	3.44e-23	112
bone marrow	1.31e-18	80
bone element	8.10e-18	86
immune system	2.01e-13	115
skeletal element	4.94e-13	101
skeletal system	4.94e-13	101
neural tube	8.73e-10	57
neural rod	8.73e-10	57
future spinal cord	8.73e-10	57
neural keel	8.73e-10	57
anterior neural tube	5.58e-09	42
regional part of forebrain	7.12e-09	41
forebrain	7.12e-09	41
future forebrain	7.12e-09	41
regional part of brain	1.68e-07	59
central nervous system	2.63e-07	82
blood	4.11e-07	15
haemolymphatic fluid	4.11e-07	15
organism substance	4.11e-07	15
gray matter	5.01e-07	34
brain grey matter	5.01e-07	34
telencephalon	6.08e-07	34
brain	6.53e-07	69
future brain	6.53e-07	69
regional part of telencephalon	8.56e-07	33

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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