MCL coexpression mm9:3631

Phase1 CAGE Peaks

	Short description
Mm9::chr7:53356097..53356140,-	p1@Kcnj11
Mm9::chr7:53356146..53356191,-	p3@Kcnj11
Mm9::chr7:53435299..53435402,-	p1@Abcc8

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015272	ATP-activated inward rectifier potassium channel activity	0.00536898044157125
GO:0005242	inward rectifier potassium channel activity	0.0375694788804962

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.37e-11	23
neuroblast (sensu Vertebrata)	1.37e-11	23

Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	8.87e-25	92
regional part of nervous system	8.70e-22	54
neural tube	2.12e-20	52
neural rod	2.12e-20	52
future spinal cord	2.12e-20	52
neural keel	2.12e-20	52
neurectoderm	4.36e-20	64
neural plate	4.36e-20	64
presumptive neural plate	4.36e-20	64
brain	4.71e-18	47
future brain	4.71e-18	47
pre-chordal neural plate	7.02e-18	49
regional part of brain	1.43e-17	46
ecto-epithelium	4.22e-17	73
anterior neural tube	5.57e-17	40
regional part of forebrain	1.98e-16	39
forebrain	1.98e-16	39
future forebrain	1.98e-16	39
central nervous system	5.19e-16	73
gray matter	6.10e-15	34
nervous system	1.19e-14	75
ectoderm-derived structure	4.97e-13	95
ectoderm	4.97e-13	95
presumptive ectoderm	4.97e-13	95
brain grey matter	8.15e-13	29
regional part of telencephalon	8.15e-13	29
telencephalon	8.15e-13	29
cerebral cortex	1.47e-09	21
cerebral hemisphere	1.47e-09	21
pallium	1.47e-09	21
tube	1.54e-09	114
anatomical conduit	2.88e-08	122
occipital lobe	4.21e-07	10
visual cortex	4.21e-07	10
neocortex	4.21e-07	10
multi-cellular organism	4.54e-07	333
regional part of cerebral cortex	6.08e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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