Coexpression cluster:C151

Full id: C151_CD14_Natural_Basophils_CD8_Eosinophils_CD4_Mast

Phase1 CAGE Peaks

Hg19::chr10:17553392..17553414,-	p@chr10:17553392..17553414 -
Hg19::chr10:17553468..17553477,-	p@chr10:17553468..17553477 -
Hg19::chr10:3799978..3799981,+	p@chr10:3799978..3799981 +
Hg19::chr10:3825575..3825583,-	p@chr10:3825575..3825583 -
Hg19::chr10:3825586..3825604,+	p@chr10:3825586..3825604 +
Hg19::chr10:3825673..3825701,+	p@chr10:3825673..3825701 +
Hg19::chr10:3827371..3827386,-	p2@KLF6
Hg19::chr10:3847590..3847615,+	p@chr10:3847590..3847615 +
Hg19::chr10:3847617..3847639,+	p@chr10:3847617..3847639 +
Hg19::chr10:3894565..3894585,-	p@chr10:3894565..3894585 -
Hg19::chr10:3894940..3894969,+	p@chr10:3894940..3894969 +
Hg19::chr10:3930116..3930153,-	p@chr10:3930116..3930153 -
Hg19::chr10:3930230..3930262,+	p@chr10:3930230..3930262 +
Hg19::chr10:99408822..99408843,-	p@chr10:99408822..99408843 -
Hg19::chr11:108338193..108338213,-	p2@C11orf65
Hg19::chr11:58341454..58341467,+	p@chr11:58341454..58341467 +
Hg19::chr11:9482158..9482185,-	p1@LOC644656
Hg19::chr12:47785018..47785030,+	p@chr12:47785018..47785030 +
Hg19::chr12:62997510..62997571,-	p1@C12orf61
Hg19::chr12:64616313..64616329,-	p2@C12orf66
Hg19::chr12:64845781..64845792,+	p5@TBK1
Hg19::chr12:92270910..92270924,-	p@chr12:92270910..92270924 -
Hg19::chr12:96793507..96793519,+	p@chr12:96793507..96793519 +
Hg19::chr13:114894670..114894687,+	p@chr13:114894670..114894687 +
Hg19::chr13:52378012..52378023,+	p5@ENST00000456688
Hg19::chr13:52378405..52378429,+	p3@ENST00000456688
Hg19::chr13:71865578..71865595,+	p@chr13:71865578..71865595 +
Hg19::chr13:99935844..99935865,-	p@chr13:99935844..99935865 -
Hg19::chr14:102414353..102414415,-	p@chr14:102414353..102414415 -
Hg19::chr14:23790136..23790163,-	p@chr14:23790136..23790163 -
Hg19::chr14:81636804..81636835,+	p@chr14:81636804..81636835 +
Hg19::chr14:81685834..81685853,+	p@chr14:81685834..81685853 +
Hg19::chr15:85525866..85525879,-	p@chr15:85525866..85525879 -
Hg19::chr16:20912122..20912137,-	p3@DCUN1D3
Hg19::chr17:26926162..26926194,+	p1@SPAG5-AS1
Hg19::chr17:33569446..33569460,+	p@chr17:33569446..33569460 +
Hg19::chr17:33570565..33570588,-	p@chr17:33570565..33570588 -
Hg19::chr17:38255699..38255715,+	p@chr17:38255699..38255715 +
Hg19::chr17:38476516..38476528,-	p@chr17:38476516..38476528 -
Hg19::chr17:38477491..38477543,-	p@chr17:38477491..38477543 -
Hg19::chr18:11851262..11851282,-	p@chr18:11851262..11851282 -
Hg19::chr18:3448924..3448950,-	p@chr18:3448924..3448950 -
Hg19::chr18:60829037..60829058,-	p@chr18:60829037..60829058 -
Hg19::chr18:711915..711927,+	p@chr18:711915..711927 +
Hg19::chr19:11201287..11201316,+	p9@LDLR
Hg19::chr19:14480830..14480845,+	p@chr19:14480830..14480845 +
Hg19::chr19:2504035..2504041,+	p@chr19:2504035..2504041 +
Hg19::chr19:45959099..45959131,-	p@chr19:45959099..45959131 -
Hg19::chr1:171455486..171455504,+	p@chr1:171455486..171455504 +
Hg19::chr1:184942941..184942967,-	p@chr1:184942941..184942967 -
Hg19::chr1:206753511..206753542,+	p@chr1:206753511..206753542 +
Hg19::chr1:221885672..221885702,-	p@chr1:221885672..221885702 -
Hg19::chr1:221915746..221915770,+	p@chr1:221915746..221915770 +
Hg19::chr1:221916350..221916370,+	p@chr1:221916350..221916370 +
Hg19::chr1:221916408..221916416,+	p@chr1:221916408..221916416 +
Hg19::chr1:224033536..224033567,-	p4@TP53BP2
Hg19::chr1:226867811..226867833,-	p@chr1:226867811..226867833 -
Hg19::chr1:226891331..226891354,+	p@chr1:226891331..226891354 +
Hg19::chr1:226891361..226891380,+	p@chr1:226891361..226891380 +
Hg19::chr1:234746616..234746632,-	p@chr1:234746616..234746632 -
Hg19::chr1:24286129..24286138,-	p@chr1:24286129..24286138 -
Hg19::chr1:37944377..37944382,-	p@chr1:37944377..37944382 -
Hg19::chr1:59249927..59249963,+	p@chr1:59249927..59249963 +
Hg19::chr22:36782241..36782263,+	p@chr22:36782241..36782263 +
Hg19::chr22:42929620..42929624,+	p@chr22:42929620..42929624 +
Hg19::chr2:135810133..135810145,-	p@chr2:135810133..135810145 -
Hg19::chr2:178077129..178077179,-	p@chr2:178077129..178077179 -
Hg19::chr2:178129611..178129638,+	p@chr2:178129611..178129638 +
Hg19::chr2:178129685..178129703,+	p@chr2:178129685..178129703 +
Hg19::chr2:191979419..191979439,+	p@chr2:191979419..191979439 +
Hg19::chr2:192015854..192015875,+	p@chr2:192015854..192015875 +
Hg19::chr2:232258341..232258363,-	p@chr2:232258341..232258363 -
Hg19::chr2:241564662..241564674,-	p@chr2:241564662..241564674 -
Hg19::chr2:48133949..48133962,+	p2@ENST00000417692
Hg19::chr2:61991361..61991380,-	p@chr2:61991361..61991380 -
Hg19::chr2:61991387..61991406,-	p@chr2:61991387..61991406 -
Hg19::chr2:70370094..70370116,+	p@chr2:70370094..70370116 +
Hg19::chr2:88927395..88927420,+	p2@uc002std.1
Hg19::chr2:88927653..88927687,-	p@chr2:88927653..88927687 -
Hg19::chr3:11331017..11331048,+	p@chr3:11331017..11331048 +
Hg19::chr3:113933266..113933281,+	p2@ENST00000493033 p2@uc003ebe.1
Hg19::chr3:5026037..5026052,+	p@chr3:5026037..5026052 +
Hg19::chr3:5048654..5048681,+	p@chr3:5048654..5048681 +
Hg19::chr4:103436594..103436605,+	p@chr4:103436594..103436605 +
Hg19::chr4:139936151..139936155,-	p@chr4:139936151..139936155 -
Hg19::chr4:139938135..139938140,+	p@chr4:139938135..139938140 +
Hg19::chr4:170541477..170541493,-	p@chr4:170541477..170541493 -
Hg19::chr4:2748210..2748233,+	p@chr4:2748210..2748233 +
Hg19::chr5:142784911..142784925,-	p15@NR3C1
Hg19::chr5:1521157..1521164,+	p@chr5:1521157..1521164 +
Hg19::chr5:75843262..75843275,-	p@chr5:75843262..75843275 -
Hg19::chr6:138028841..138028852,-	p@chr6:138028841..138028852 -
Hg19::chr6:28105422..28105451,-	p1@uc003nkl.1 p1@uc010jqw.1 p2@uc003nkk.1
Hg19::chr6:29617855..29617871,-	p@chr6:29617855..29617871 -
Hg19::chr6:33281942..33281963,+	p@chr6:33281942..33281963 +
Hg19::chr6:33386279..33386304,+	p@chr6:33386279..33386304 +
Hg19::chr7:12727041..12727066,-	p@chr7:12727041..12727066 -
Hg19::chr7:130626444..130626463,+	p@chr7:130626444..130626463 +
Hg19::chr7:151722642..151722676,-	p@chr7:151722642..151722676 -
Hg19::chr7:30634289..30634301,-	p@chr7:30634289..30634301 -
Hg19::chr7:44673697..44673718,+	p@chr7:44673697..44673718 +
Hg19::chr7:44925415..44925438,+	p@chr7:44925415..44925438 +
Hg19::chr7:66093620..66093638,-	p@chr7:66093620..66093638 -
Hg19::chr8:101964395..101964441,+	p@chr8:101964395..101964441 +
Hg19::chr8:141475127..141475140,+	p@chr8:141475127..141475140 +
Hg19::chr8:141601516..141601544,-	p@chr8:141601516..141601544 -
Hg19::chr9:132891288..132891326,-	p@chr9:132891288..132891326 -
Hg19::chr9:135991340..135991361,+	p@chr9:135991340..135991361 +
Hg19::chr9:26892877..26892898,+	p@chr9:26892877..26892898 +
Hg19::chr9:34989341..34989353,-	p@chr9:34989341..34989353 -
Hg19::chr9:91933623..91933645,-	p@chr9:91933623..91933645 -
Hg19::chr9:99417081..99417092,+	p@chr9:99417081..99417092 +
Hg19::chrX:70752106..70752119,+	p@chrX:70752106..70752119 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030229	very-low-density lipoprotein receptor activity	0.0155274932297186
GO:0004883	glucocorticoid receptor activity	0.0155274932297186
GO:0065007	biological regulation	0.0214504329188226
GO:0045192	low-density lipoprotein catabolic process	0.0228181386588504
GO:0004871	signal transducer activity	0.0228181386588504
GO:0060089	molecular transducer activity	0.0228181386588504
GO:0042159	lipoprotein catabolic process	0.0266107250734418
GO:0030299	cholesterol absorption	0.0275930581833342
GO:0044241	lipid digestion	0.0275930581833342
GO:0050892	intestinal absorption	0.0284503157301035
GO:0005041	low-density lipoprotein receptor activity	0.0284503157301035
GO:0030228	lipoprotein receptor activity	0.0284503157301035
GO:0042632	cholesterol homeostasis	0.0286397731579021
GO:0055092	sterol homeostasis	0.0286397731579021
GO:0030169	low-density lipoprotein binding	0.0286397731579021
GO:0055088	lipid homeostasis	0.0286397731579021
GO:0015918	sterol transport	0.0286397731579021
GO:0051059	NF-kappaB binding	0.0286397731579021
GO:0030301	cholesterol transport	0.0286397731579021
GO:0022600	digestive system process	0.0286397731579021
GO:0006952	defense response	0.0286397731579021
GO:0007530	sex determination	0.0296085113281691
GO:0050794	regulation of cellular process	0.0315335977428127
GO:0030183	B cell differentiation	0.0356404869340457
GO:0008034	lipoprotein binding	0.0356404869340457
GO:0006493	protein amino acid O-linked glycosylation	0.0356404869340457
GO:0050789	regulation of biological process	0.0356404869340457
GO:0005905	coated pit	0.0475738017393153

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	6.69e-85	136
classical monocyte	5.77e-73	42
CD14-positive, CD16-negative classical monocyte	5.77e-73	42
hematopoietic lineage restricted progenitor cell	2.11e-67	120
nongranular leukocyte	1.38e-66	115
hematopoietic stem cell	4.36e-66	168
angioblastic mesenchymal cell	4.36e-66	168
hematopoietic cell	6.54e-65	177
defensive cell	4.40e-62	48
phagocyte	4.40e-62	48
myeloid leukocyte	9.83e-60	72
hematopoietic oligopotent progenitor cell	9.81e-59	161
hematopoietic multipotent progenitor cell	9.81e-59	161
granulocyte monocyte progenitor cell	4.74e-54	67
macrophage dendritic cell progenitor	1.99e-52	61
myeloid lineage restricted progenitor cell	5.49e-50	66
monopoietic cell	2.52e-49	59
monocyte	2.52e-49	59
monoblast	2.52e-49	59
promonocyte	2.52e-49	59
myeloid cell	3.81e-41	108
common myeloid progenitor	3.81e-41	108
stuff accumulating cell	3.63e-28	87
mesenchymal cell	1.06e-20	354
connective tissue cell	7.44e-20	361
motile cell	7.01e-17	386
intermediate monocyte	5.07e-16	9
CD14-positive, CD16-positive monocyte	5.07e-16	9
lymphoid lineage restricted progenitor cell	1.91e-15	52
lymphocyte	5.10e-15	53
common lymphoid progenitor	5.10e-15	53
nucleate cell	3.24e-14	55
stem cell	1.89e-13	441
multi fate stem cell	2.79e-13	427
somatic stem cell	8.68e-13	433
CD4-positive, alpha-beta T cell	8.96e-12	6
T cell	2.37e-11	25
pro-T cell	2.37e-11	25
mature alpha-beta T cell	5.84e-11	18
alpha-beta T cell	5.84e-11	18
immature T cell	5.84e-11	18
mature T cell	5.84e-11	18
immature alpha-beta T cell	5.84e-11	18
granulocyte	1.29e-08	8
blood cell	6.15e-08	11
natural killer cell	1.50e-07	3
pro-NK cell	1.50e-07	3
circulating cell	1.97e-07	6
basophil	4.47e-07	3
dendritic cell	7.89e-07	10

Uber Anatomy

Ontology term	p-value	n
bone marrow	5.36e-48	76
hematopoietic system	1.95e-46	98
blood island	1.95e-46	98
bone element	2.13e-43	82
hemolymphoid system	1.36e-40	108
immune system	4.66e-40	93
skeletal element	3.18e-38	90
skeletal system	6.29e-33	100
connective tissue	1.06e-18	371
lateral plate mesoderm	1.26e-15	203
musculoskeletal system	4.34e-14	167

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ATF3#467	25	4.96972887743557	2.66467314316163e-11	3.13396169367857e-09
BATF#10538	30	6.4666730422045	1.78853175422964e-16	3.55118760228117e-14
BCL11A#53335	22	5.523256745835	6.95516102941178e-11	7.6704336087723e-09
BCL3#602	10	3.0572657348441	0.00169883084558186	0.0106133992152733
BCLAF1#9774	12	2.29939620638462	0.00612337720706482	0.0270868018690658
BRCA1#672	23	4.10829473269156	7.05821815684309e-09	5.48885514581188e-07
CCNT2#905	40	2.24290321308412	2.72979303212699e-07	1.40303570119247e-05
CEBPB#1051	40	2.82164517728312	3.93737605036592e-10	3.88672606166509e-08
CHD2#1106	27	2.47158067717836	7.91815342052214e-06	0.000223443400455529
CTCF#10664	34	1.61282050163319	0.00223436588138661	0.0128343932618048
E2F1#1869	48	2.0845547107452	8.25544338046805e-08	4.92117723294921e-06
E2F4#1874	28	3.13898839670765	4.17937700915703e-08	2.75214347704509e-06
E2F6#1876	49	2.17558080401037	1.31376188976336e-08	9.67616205959067e-07
EBF1#1879	41	3.23154991778167	2.95693619281385e-12	3.93400584765969e-10
EGR1#1958	52	2.29544524716927	4.5236953710125e-10	4.40718489601842e-08
ELF1#1997	56	2.11020783799312	1.50435047935138e-09	1.33485862118079e-07
EP300#2033	54	3.23710489571728	9.13461812603964e-17	1.84171888506844e-14
ETS1#2113	29	2.4967616526006	2.70068542736109e-06	9.41444877664103e-05
FOS#2353	52	4.14065200055318	1.11873731240395e-20	2.92831594411419e-18
FOSL1#8061	8	2.81158086487597	0.0079768558500489	0.0322517458914969
FOSL2#2355	24	3.59579481866797	3.97259582102482e-08	2.62757400222933e-06
FOXA1#3169	20	1.96131322997973	0.00266079800673348	0.0146822572528788
GABPB1#2553	35	2.18910561297678	3.72692965840947e-06	0.000121979569600322
GATA1#2623	35	4.20009544277005	1.33491818158606e-13	2.06238934861933e-11
GATA2#2624	31	3.49639720124048	4.77408719987822e-10	4.63814784249378e-08
GATA3#2625	13	3.13340453666972	0.000271776241334566	0.00290077045158311
GTF2B#2959	18	5.08839768865342	1.60268193608411e-08	1.16887219778414e-06
GTF2F1#2962	30	3.38221085223654	2.14376572639155e-09	1.83669194994756e-07
HEY1#23462	56	2.00217892401699	1.13798507624104e-08	8.54421447717744e-07
HMGN3#9324	29	2.09891932723157	7.27131734507085e-05	0.00114231214230123
HSF1#3297	4	5.815598820059	0.00520433428297113	0.024116401995706
IRF1#3659	32	2.16273663817739	1.46675799887184e-05	0.000348547755731913
IRF3#3661	9	3.74192539737528	0.000728987744417308	0.00581181305642743
IRF4#3662	24	4.65440977417574	2.66844518639816e-10	2.71892435924134e-08
JUN#3725	42	4.65078607148784	4.61058878097027e-18	1.02234667026699e-15
JUNB#3726	18	4.87602998121045	3.04894406944946e-08	2.06236185018933e-06
JUND#3727	50	3.09498404507568	1.57466873110116e-14	2.67844996103378e-12
MAFK#7975	10	2.39829496794955	0.00918468877586073	0.0347386995640502
MAX#4149	37	2.11278366224127	4.0391830074391e-06	0.00013028049231437
MEF2A#4205	28	4.64434040238968	6.57314347228091e-12	8.42322124050977e-10
MEF2C#4208	14	5.11822091059059	6.76449638682922e-07	3.0623200613093e-05
MXI1#4601	30	2.64466503418388	5.15462307509125e-07	2.40869655185438e-05
MYC#4609	46	2.1258846556994	1.02375377015787e-07	5.99326345299986e-06
NANOG#79923	12	3.10564019267391	0.00051076881113866	0.00443131615438699
NFKB1#4790	78	3.78822077068247	3.69176964866529e-32	1.62685540226563e-29
NFYA#4800	23	3.75033943447878	3.76520743942639e-08	2.49672698264287e-06
NFYB#4801	21	3.11465184357757	3.19693126773653e-06	0.000107635172363358
NR3C1#2908	18	2.38508336248774	0.000505872521691929	0.00443377142438598
PAX5#5079	55	3.24624870986531	3.39068642342045e-17	7.01227523516055e-15
PBX3#5090	14	2.71507236826918	0.000655584472774918	0.00536798014520891
POLR2A#5430	97	1.84338900996578	3.54610992376171e-18	7.89663484707353e-16
POU2F2#5452	49	3.94867326397685	1.89972792138008e-18	4.2852199650327e-16
PRDM1#639	4	4.66658250539684	0.0110568330771537	0.0406693171002625
RAD21#5885	20	1.83274936202767	0.00570128947395228	0.0257041645314095
REST#5978	25	2.13496210533806	0.000200104827063713	0.00240160285379305
RFX5#5993	33	3.51841643626052	9.30893924055347e-11	1.01272531806684e-08
RXRA#6256	14	2.48712070750324	0.00151146046011237	0.009651814062591
SETDB1#9869	8	2.85451512764676	0.00731590640336676	0.0302588392087926
SIN3A#25942	49	2.34544558950391	9.93910696295933e-10	9.23514583722873e-08
SIX5#147912	16	2.41935792643667	0.000917786344495913	0.00667730324157496
SMARCB1#6598	17	2.74598379008563	0.000145425300201715	0.00187947938717571
SMARCC2#6601	5	4.16616701003972	0.00734312923157739	0.0303654210412065
SP1#6667	55	2.77354845838716	3.49835029250443e-14	5.78107921200745e-12
SP2#6668	13	3.00881324265469	0.000399431059947058	0.00390053113322214
SPI1#6688	34	2.4685575158387	3.50947156535219e-07	1.73380180138986e-05
SREBF1#6720	13	5.40775259049865	9.5226189052277e-07	4.06928312538084e-05
SREBF2#6721	5	19.3337726730685	7.02435613897748e-06	0.000202768582310301
SRF#6722	32	3.90716552556965	1.339630289454e-11	1.65377834279298e-09
STAT3#6774	31	2.88587092842284	4.42424132863666e-08	2.89876624919375e-06
TAF1#6872	73	2.15966706955227	2.84227679809916e-14	4.71930916560696e-12
TAF7#6879	23	2.32708492312611	0.000108050283908867	0.0015040202054056
TAL1#6886	11	2.90756445532604	0.00148824058556373	0.00951750404235447
TBP#6908	78	2.55865587250901	1.52483061793185e-20	3.97136620713678e-18
TCF12#6938	32	3.011529883805	9.03457520958592e-09	6.90748170068773e-07
TCF7L2#6934	29	2.76402761354852	3.39933605809316e-07	1.68737290195433e-05
TFAP2C#7022	24	2.29576536846589	9.16183333387457e-05	0.00133508122164996
THAP1#55145	11	3.05363354541031	0.0010081221974441	0.00721837886870045
TRIM28#10155	18	2.96132257358164	3.45147705808527e-05	0.000677318324820307
USF1#7391	45	2.53334042012706	6.26621038400348e-10	5.98752741349441e-08
USF2#7392	31	3.56423114103679	2.98657280119873e-10	3.02242903860847e-08
YY1#7528	55	2.39039284284922	1.77009623719073e-11	2.14214462243294e-09
ZBTB7A#51341	27	1.75665089657212	0.00221351968296139	0.012727951449034
ZNF263#10127	27	1.96451083362202	0.000406205744510708	0.00390677979104464

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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