Coexpression cluster:C168

Full id: C168_Mast_CD14_immature_Basophils_Eosinophils_CD34_Peripheral

Phase1 CAGE Peaks

Hg19::chr10:126847337..126847340,+	p@chr10:126847337..126847340 +
Hg19::chr10:127751126..127751139,-	p@chr10:127751126..127751139 -
Hg19::chr10:17270214..17270247,+	p5@VIM
Hg19::chr10:17270313..17270321,+	p17@VIM
Hg19::chr10:17278167..17278185,+	p12@VIM
Hg19::chr10:3846319..3846333,+	p@chr10:3846319..3846333 +
Hg19::chr10:63805867..63805883,-	p@chr10:63805867..63805883 -
Hg19::chr11:72470335..72470363,+	p@chr11:72470335..72470363 +
Hg19::chr11:72470426..72470435,+	p@chr11:72470426..72470435 +
Hg19::chr11:75051987..75052000,+	p@chr11:75051987..75052000 +
Hg19::chr12:51787972..51787981,-	p@chr12:51787972..51787981 -
Hg19::chr12:52432402..52432424,-	p@chr12:52432402..52432424 -
Hg19::chr12:52444929..52444945,-	p@chr12:52444929..52444945 -
Hg19::chr14:102553761..102553785,+	p@chr14:102553761..102553785 +
Hg19::chr14:105143676..105143707,+	p@chr14:105143676..105143707 +
Hg19::chr16:2560210..2560219,+	p@chr16:2560210..2560219 +
Hg19::chr16:29302386..29302409,-	p@chr16:29302386..29302409 -
Hg19::chr16:87887433..87887438,+	p@chr16:87887433..87887438 +
Hg19::chr16:87887504..87887535,-	p@chr16:87887504..87887535 -
Hg19::chr17:38476709..38476744,+	p@chr17:38476709..38476744 +
Hg19::chr17:40168540..40168552,+	p16@NKIRAS2
Hg19::chr17:41437738..41437747,-	p3@AK023939
Hg19::chr17:41437922..41437939,+	p@chr17:41437922..41437939 +
Hg19::chr17:72270457..72270470,+	p3@DNAI2
Hg19::chr17:80250634..80250653,-	p1@ENST00000499745 p1@uc002kek.1
Hg19::chr18:2848716..2848718,+	p@chr18:2848716..2848718 +
Hg19::chr18:74206012..74206020,+	p@chr18:74206012..74206020 +
Hg19::chr19:10527253..10527264,-	p@chr19:10527253..10527264 -
Hg19::chr19:10542701..10542730,-	p@chr19:10542701..10542730 -
Hg19::chr19:12902103..12902116,-	p@chr19:12902103..12902116 -
Hg19::chr19:13951943..13951963,-	p@chr19:13951943..13951963 -
Hg19::chr19:2168550..2168572,+	p@chr19:2168550..2168572 +
Hg19::chr19:2476825..2476847,+	p12@GADD45B
Hg19::chr19:2477163..2477216,+	p2@GADD45B
Hg19::chr19:2477661..2477696,+	p5@GADD45B
Hg19::chr19:2495478..2495481,-	p@chr19:2495478..2495481 -
Hg19::chr19:2546698..2546709,-	p@chr19:2546698..2546709 -
Hg19::chr19:2546728..2546743,-	p@chr19:2546728..2546743 -
Hg19::chr19:2547016..2547029,+	p@chr19:2547016..2547029 +
Hg19::chr19:45947743..45947780,+	p@chr19:45947743..45947780 +
Hg19::chr19:45959758..45959769,+	p@chr19:45959758..45959769 +
Hg19::chr19:49377218..49377242,+	p@chr19:49377218..49377242 +
Hg19::chr19:49377471..49377488,+	p@chr19:49377471..49377488 +
Hg19::chr19:49378119..49378134,+	p@chr19:49378119..49378134 +
Hg19::chr19:49379626..49379630,-	p@chr19:49379626..49379630 -
Hg19::chr19:54692317..54692331,+	p@chr19:54692317..54692331 +
Hg19::chr1:1136756..1136767,-	p@chr1:1136756..1136767 -
Hg19::chr1:1136782..1136795,-	p@chr1:1136782..1136795 -
Hg19::chr1:161469716..161469730,+	p@chr1:161469716..161469730 +
Hg19::chr1:168148677..168148693,+	p@chr1:168148677..168148693 +
Hg19::chr1:224522323..224522330,+	p@chr1:224522323..224522330 +
Hg19::chr1:226850887..226850894,+	p@chr1:226850887..226850894 +
Hg19::chr1:235111193..235111206,+	p@chr1:235111193..235111206 +
Hg19::chr22:22171149..22171186,+	p@chr22:22171149..22171186 +
Hg19::chr22:44423030..44423043,+	p@chr22:44423030..44423043 +
Hg19::chr22:50364701..50364715,+	p@chr22:50364701..50364715 +
Hg19::chr2:145271497..145271510,+	p@chr2:145271497..145271510 +
Hg19::chr2:157190984..157191018,-	p@chr2:157190984..157191018 -
Hg19::chr2:157191084..157191095,-	p@chr2:157191084..157191095 -
Hg19::chr2:157191294..157191331,+	p@chr2:157191294..157191331 +
Hg19::chr2:157199008..157199023,-	p3@NR4A2
Hg19::chr2:208394431..208394446,+	p9@CREB1
Hg19::chr2:218767650..218767673,+	p@chr2:218767650..218767673 +
Hg19::chr2:232476619..232476634,-	p@chr2:232476619..232476634 -
Hg19::chr2:28114069..28114081,-	p3@LOC100302650
Hg19::chr3:15837528..15837578,-	p@chr3:15837528..15837578 -
Hg19::chr3:15839395..15839435,-	p2@ANKRD28
Hg19::chr3:20227970..20227982,+	p@chr3:20227970..20227982 +
Hg19::chr3:5020551..5020568,-	p@chr3:5020551..5020568 -
Hg19::chr3:5048638..5048647,+	p@chr3:5048638..5048647 +
Hg19::chr3:71150221..71150222,-	p@chr3:71150221..71150222 -
Hg19::chr3:72532128..72532133,-	p@chr3:72532128..72532133 -
Hg19::chr4:170581182..170581201,-	p@chr4:170581182..170581201 -
Hg19::chr4:48533348..48533351,+	p@chr4:48533348..48533351 +
Hg19::chr5:172185174..172185217,-	p@chr5:172185174..172185217 -
Hg19::chr5:179245946..179245962,-	p@chr5:179245946..179245962 -
Hg19::chr5:179245976..179245995,-	p@chr5:179245976..179245995 -
Hg19::chr5:95297924..95297956,+	p@chr5:95297924..95297956 +
Hg19::chr5:96038250..96038274,-	p@chr5:96038250..96038274 -
Hg19::chr6:130005395..130005398,+	p@chr6:130005395..130005398 +
Hg19::chr6:134610234..134610241,+	p@chr6:134610234..134610241 +
Hg19::chr6:134617297..134617322,+	p@chr6:134617297..134617322 +
Hg19::chr6:138187511..138187525,+	p@chr6:138187511..138187525 +
Hg19::chr6:138200216..138200227,+	p@chr6:138200216..138200227 +
Hg19::chr6:14711644..14711656,+	p@chr6:14711644..14711656 +
Hg19::chr6:14712257..14712276,-	p@chr6:14712257..14712276 -
Hg19::chr6:14712846..14712851,+	p@chr6:14712846..14712851 +
Hg19::chr7:37726701..37726704,-	p@chr7:37726701..37726704 -
Hg19::chr7:38409431..38409457,-	p@chr7:38409431..38409457 -
Hg19::chr7:643862..643881,-	p@chr7:643862..643881 -
Hg19::chr7:963120..963124,-	p14@ADAP1
Hg19::chr8:103819280..103819302,+	p2@ENST00000405813 p2@ENST00000517910 p2@uc003ykw.1
Hg19::chr8:12624204..12624207,-	p@chr8:12624204..12624207 -
Hg19::chr8:2075387..2075430,-	p@chr8:2075387..2075430 -
Hg19::chr8:29260411..29260429,+	p@chr8:29260411..29260429 +
Hg19::chr8:38627853..38627874,-	p@chr8:38627853..38627874 -
Hg19::chr8:81397624..81397636,-	p@chr8:81397624..81397636 -
Hg19::chr9:102581773..102581785,-	p@chr9:102581773..102581785 -
Hg19::chr9:107814448..107814480,+	p@chr9:107814448..107814480 +
Hg19::chr9:108061944..108061969,+	p@chr9:108061944..108061969 +
Hg19::chr9:127048403..127048433,+	p9@NEK6
Hg19::chr9:132245474..132245496,-	p@chr9:132245474..132245496 -
Hg19::chr9:33165989..33166005,+	p@chr9:33165989..33166005 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007243	protein kinase cascade	0.0148895998999346
GO:0007249	I-kappaB kinase/NF-kappaB cascade	0.0346361068868663
GO:0042069	regulation of catecholamine metabolic process	0.0346361068868663
GO:0035085	cilium axoneme	0.0346361068868663
GO:0042053	regulation of dopamine metabolic process	0.0346361068868663
GO:0042384	cilium biogenesis	0.0346361068868663
GO:0000185	activation of MAPKKK activity	0.0346361068868663
GO:0044441	cilium part	0.0424204890790849
GO:0048468	cell development	0.0427417232591816
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.0427417232591816
GO:0042417	dopamine metabolic process	0.0427417232591816
GO:0000186	activation of MAPKK activity	0.0427417232591816
GO:0007091	mitotic metaphase/anaphase transition	0.0427417232591816
GO:0007165	signal transduction	0.0427417232591816
GO:0005858	axonemal dynein complex	0.0427417232591816
GO:0045103	intermediate filament-based process	0.0427417232591816
GO:0044447	axoneme part	0.0427417232591816
GO:0007154	cell communication	0.048522230700641
GO:0005930	axoneme	0.0489452501682876
GO:0032502	developmental process	0.0489452501682876

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
classical monocyte	4.74e-119	42
CD14-positive, CD16-negative classical monocyte	4.74e-119	42
defensive cell	5.99e-103	48
phagocyte	5.99e-103	48
granulocyte monocyte progenitor cell	1.89e-95	67
myeloid leukocyte	1.48e-92	72
myeloid lineage restricted progenitor cell	3.55e-88	66
macrophage dendritic cell progenitor	4.12e-86	61
monopoietic cell	2.10e-80	59
monocyte	2.10e-80	59
monoblast	2.10e-80	59
promonocyte	2.10e-80	59
leukocyte	8.36e-72	136
hematopoietic lineage restricted progenitor cell	1.42e-64	120
myeloid cell	3.39e-64	108
common myeloid progenitor	3.39e-64	108
nongranular leukocyte	1.14e-58	115
hematopoietic stem cell	5.13e-56	168
angioblastic mesenchymal cell	5.13e-56	168
hematopoietic cell	1.35e-52	177
stuff accumulating cell	2.04e-52	87
hematopoietic oligopotent progenitor cell	5.51e-52	161
hematopoietic multipotent progenitor cell	5.51e-52	161
mesenchymal cell	1.68e-20	354
connective tissue cell	7.13e-20	361
motile cell	1.15e-17	386
stem cell	5.33e-15	441
multi fate stem cell	5.83e-15	427
somatic stem cell	1.38e-14	433
intermediate monocyte	2.88e-13	9
CD14-positive, CD16-positive monocyte	2.88e-13	9
histamine secreting cell	5.08e-12	5
biogenic amine secreting cell	5.08e-12	5
granulocytopoietic cell	5.08e-12	5
mast cell	5.08e-12	5
mast cell progenitor	5.08e-12	5
basophil mast progenitor cell	5.08e-12	5
basophil	5.82e-11	3
natural killer cell	1.01e-10	3
pro-NK cell	1.01e-10	3
single nucleate cell	1.28e-10	3
mononuclear cell	1.28e-10	3
CD1a-positive Langerhans cell	1.08e-07	2
immature CD1a-positive Langerhans cell	1.08e-07	2
somatic cell	1.82e-07	588

Uber Anatomy

Ontology term	p-value	n
bone marrow	4.75e-83	76
bone element	2.82e-76	82
hematopoietic system	1.28e-71	98
blood island	1.28e-71	98
skeletal element	1.24e-68	90
immune system	4.21e-66	93
hemolymphoid system	4.85e-64	108
skeletal system	8.83e-61	100
musculoskeletal system	2.81e-32	167
lateral plate mesoderm	4.52e-29	203
connective tissue	5.11e-19	371
mesoderm	7.50e-15	315
mesoderm-derived structure	7.50e-15	315
presumptive mesoderm	7.50e-15	315

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ATF3#467	13	2.8351579498846	0.000672792718113972	0.0054297039399664
BATF#10538	21	4.96615376347938	1.16077477380197e-09	1.06435607200267e-07
BCL11A#53335	26	7.16122167663868	1.92719180107166e-15	3.53732837455401e-13
BCL3#602	8	2.6832701206787	0.0102758692198993	0.0381867885517032
BHLHE40#8553	9	3.92083807692036	0.000514540613802721	0.00445885389685881
BRCA1#672	11	2.15559744733458	0.0132409834343884	0.0468437745640084
CCNT2#905	33	2.03004516543463	3.15721512839807e-05	0.000634230411222863
CEBPB#1051	26	2.01213435214995	0.000334185831231801	0.00340208929018599
CHD2#1106	19	1.90812071697301	0.00442971862585193	0.0209716855650657
E2F6#1876	31	1.51001774449145	0.00913792944638309	0.0345668518762289
EBF1#1879	30	2.59411655725311	6.32812689574944e-07	2.88730120080898e-05
EGR1#1958	40	1.93715693002335	8.91683125747582e-06	0.000240326436051488
ELF1#1997	38	1.57094876150181	0.00154364679776067	0.00981175387446455
EP300#2033	43	2.82795625463687	3.26974537581366e-11	3.76503789751492e-09
FOS#2353	40	3.49435157626967	3.01982620722442e-13	4.486310515737e-11
FOSL1#8061	25	9.63921837776044	8.42341747685346e-18	1.82517281714751e-15
FOSL2#2355	19	3.12304671346284	8.93730378292971e-06	0.000240753951453546
FOXA1#3169	17	1.82897219164614	0.0107269052935433	0.0395938244195925
GATA1#2623	26	3.42299040523118	2.14782927650375e-08	1.52285907541599e-06
GATA2#2624	23	2.84595562982274	4.0275252107329e-06	0.000130024947599299
GATA3#2625	9	2.37988977878499	0.0137097810730359	0.0482814885853386
HDAC2#3066	26	3.38646724419692	2.66652060204438e-08	1.83578605904359e-06
HDAC8#55869	2	15.079301623562	0.00796235826369986	0.0321943761015311
HEY1#23462	41	1.60819954143043	0.000535077046476424	0.0046241548743857
HMGN3#9324	24	1.90568102291664	0.00129355603464657	0.00866900017341201
HNF4A#3172	11	2.47043877662612	0.00504022749117583	0.0234799196641649
HNF4G#3174	9	2.51243497803904	0.00989933058963853	0.0371390253413053
IRF4#3662	11	2.34038485004064	0.00745731147156218	0.0307608575685644
JUN#3725	37	4.49489980695577	1.54574387035481e-15	2.86233943397139e-13
JUNB#3726	23	6.8353839919989	2.73705844172212e-13	4.09535310308047e-11
JUND#3727	44	2.98801178099345	2.53603723070725e-12	3.42197922917099e-10
MAFK#7975	13	3.42048088147368	0.00011173971222313	0.00154467025875201
MAX#4149	25	1.56615424975901	0.0133491952610508	0.0471866446851987
MEF2A#4205	25	4.5493278906903	1.39234497305929e-10	1.48231515434596e-08
MEF2C#4208	13	5.21405445052537	1.35547938097667e-06	5.33000418184571e-05
MXI1#4601	18	1.74085717784143	0.0139254959768677	0.0488944318146946
NFE2#4778	6	4.49733557193956	0.00230753689562699	0.013090540241303
NFKB1#4790	39	2.07800459751029	2.17673777088325e-06	7.83108219267226e-05
NR3C1#2908	24	3.48885980532187	5.98045133211694e-08	3.71781164687477e-06
PAX5#5079	29	1.87783883887531	0.000443208783197467	0.00412809079714263
POLR2A#5430	82	1.70962291725982	5.99081800988995e-12	7.73393129956609e-10
PRDM1#639	5	6.39956096007091	0.00118174851205072	0.00801745049045505
RFX5#5993	17	1.98849013652735	0.00479093015202612	0.0225123708335938
RXRA#6256	17	3.31328632393462	1.3365721109624e-05	0.000326145454899071
SIRT6#51548	4	5.96653996077767	0.00474356257104014	0.0223430718151293
SMARCB1#6598	15	2.65816249240157	0.000497420126714867	0.00439658603706618
SMARCC1#6599	11	4.66307720889268	2.59187428613474e-05	0.000560092610324076
SMC3#9126	17	2.48314425595979	0.000444803649196032	0.00414072986169751
SP1#6667	35	1.93634318674691	4.47669723279248e-05	0.00079325039412218
SPI1#6688	23	1.83203340481575	0.00278233689533085	0.0152409778145106
SRF#6722	15	2.00929780517007	0.00737577376119642	0.0304835154667824
STAT1#6772	11	2.21138313076885	0.0111101639484303	0.0408611618343525
STAT3#6774	26	2.65539893132049	2.90859979083336e-06	9.9826241720291e-05
TAL1#6886	12	3.47983883620663	0.000178209564665508	0.00216192690487873
TBP#6908	48	1.72742711631676	1.5821530720177e-05	0.000370157895807474
TCF12#6938	26	2.68442803356162	2.3806799689872e-06	8.42833339935777e-05
TCF7L2#6934	22	2.30042606202934	0.000170002916592163	0.00207684344437583
TFAP2A#7020	18	2.88675163800786	4.48589510610971e-05	0.00079420647395659
TFAP2C#7022	23	2.4137112429785	5.63626269724667e-05	0.000944856564747585
USF1#7391	36	2.22343664057754	1.34941661350107e-06	5.31216440623589e-05
USF2#7392	19	2.39661893510992	0.000307067077191257	0.00316457257497312
YY1#7528	32	1.52580062131382	0.00678829041349021	0.0287880075727658
ZBTB7A#51341	32	2.28408832866047	3.84483790774418e-06	0.000125563172685083

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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