MCL coexpression mm9:669

Phase1 CAGE Peaks

	Short description
Mm9::chr13:49748436..49748466,+	p2@Nol8
Mm9::chr13:49748467..49748505,+	p3@Nol8
Mm9::chr15:34012419..34012489,+	p1@Mtdh
Mm9::chr15:81958346..81958431,+	p1@Ccdc134
Mm9::chr1:43990825..43990921,+	p1@Tpp2
Mm9::chr4:48486254..48486273,-	p2@Tex10
Mm9::chr5:21290933..21291050,-	p1@Dnajc2
Mm9::chr6:71582645..71582688,-	p2@Kdm3a
Mm9::chr8:127421777..127421801,+	p1@Gm505
Mm9::chr8:32279219..32279241,-	p2@Mak16
Mm9::chr9:14588950..14589021,-	p1@Ankrd49

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004294	tripeptidyl-peptidase II activity	0.0101342096230186
GO:0000085	G2 phase of mitotic cell cycle	0.0101342096230186
GO:0008240	tripeptidyl-peptidase activity	0.0101342096230186
GO:0051319	G2 phase	0.0101342096230186
GO:0003676	nucleic acid binding	0.0319481498724259
GO:0004289	subtilase activity	0.047230829021569

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
lymphocyte	3.69e-09	13
common lymphoid progenitor	3.69e-09	13
lymphoid lineage restricted progenitor cell	7.21e-09	12
hematopoietic cell	1.71e-08	32
hematopoietic oligopotent progenitor cell	1.71e-08	32
hematopoietic stem cell	1.71e-08	32
angioblastic mesenchymal cell	1.71e-08	32
hematopoietic multipotent progenitor cell	1.71e-08	32
T cell	3.21e-08	11
pro-T cell	3.21e-08	11
mature alpha-beta T cell	3.37e-07	9
alpha-beta T cell	3.37e-07	9
immature T cell	3.37e-07	9
mature T cell	3.37e-07	9
immature alpha-beta T cell	3.37e-07	9

Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	3.74e-10	29
immune organ	3.74e-10	29
mixed endoderm/mesoderm-derived structure	1.57e-09	35
mesoderm	4.33e-09	120
mesoderm-derived structure	4.33e-09	120
presumptive mesoderm	4.33e-09	120
hemolymphoid system	4.47e-09	48
immune system	4.47e-09	48
hematopoietic system	8.71e-09	45
blood island	8.71e-09	45
pharynx	1.86e-08	24
upper respiratory tract	1.86e-08	24
chordate pharynx	1.86e-08	24
pharyngeal arch system	1.86e-08	24
pharyngeal region of foregut	1.86e-08	24
thymus	2.03e-08	23
neck	2.03e-08	23
respiratory system epithelium	2.03e-08	23
hemolymphoid system gland	2.03e-08	23
pharyngeal epithelium	2.03e-08	23
thymic region	2.03e-08	23
pharyngeal gland	2.03e-08	23
entire pharyngeal arch endoderm	2.03e-08	23
thymus primordium	2.03e-08	23
early pharyngeal endoderm	2.03e-08	23
anterior region of body	2.09e-08	43
segment of respiratory tract	9.17e-08	27
gland of gut	1.04e-07	24
craniocervical region	1.18e-07	36
lateral plate mesoderm	5.82e-07	87
respiratory tract	8.73e-07	41

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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