MCL coexpression mm9:1280

Phase1 CAGE Peaks

	Short description
Mm9::chr11:120459934..120459954,+	p4@Anapc11
Mm9::chr16:17530781..17530882,-	p2@Thap7
Mm9::chr17:34742844..34742884,+	p1@Agpat1
Mm9::chr17:36394802..36394816,-	p2@Rpp21
Mm9::chr4:147514791..147514807,+	p4@Mad2l2
Mm9::chr5:45911521..45911566,+	p1@Med28

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007067	mitosis	0.0324891498879796
GO:0000087	M phase of mitotic cell cycle	0.0324891498879796
GO:0007094	mitotic cell cycle spindle assembly checkpoint	0.0324891498879796
GO:0031577	spindle checkpoint	0.0324891498879796
GO:0000278	mitotic cell cycle	0.0324891498879796
GO:0000279	M phase	0.0324891498879796
GO:0051301	cell division	0.0324891498879796
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	0.0324891498879796
GO:0022403	cell cycle phase	0.0324891498879796
GO:0004526	ribonuclease P activity	0.0324891498879796
GO:0004549	tRNA-specific ribonuclease activity	0.0324891498879796
GO:0007093	mitotic cell cycle checkpoint	0.0324891498879796
GO:0016411	acylglycerol O-acyltransferase activity	0.0324891498879796
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	0.0463685948603288
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.0475920528897136

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	2.09e-19	49
ectodermal cell	3.16e-19	44
neurectodermal cell	3.16e-19	44
neural cell	5.01e-19	43
animal cell	2.19e-15	115
eukaryotic cell	2.19e-15	115
somatic cell	4.23e-15	118
electrically responsive cell	1.62e-13	39
electrically active cell	1.62e-13	39
neuron	4.12e-13	33
neuronal stem cell	4.12e-13	33
neuroblast	4.12e-13	33
electrically signaling cell	4.12e-13	33
embryonic cell	4.62e-12	70
somatic stem cell	5.58e-12	91
multi fate stem cell	5.58e-12	91
CNS neuron (sensu Vertebrata)	1.07e-11	23
neuroblast (sensu Vertebrata)	1.07e-11	23
stem cell	1.51e-10	97
migratory neural crest cell	4.74e-07	10
neuron associated cell	4.74e-07	10
glial cell (sensu Vertebrata)	4.74e-07	10
neuron associated cell (sensu Vertebrata)	4.74e-07	10
glial cell	4.74e-07	10
glioblast	4.74e-07	10
glioblast (sensu Vertebrata)	4.74e-07	10

Uber Anatomy

Ontology term	p-value	n
nervous system	3.86e-30	75
central nervous system	2.72e-29	73
regional part of nervous system	3.87e-22	54
neural tube	8.56e-21	52
neural rod	8.56e-21	52
future spinal cord	8.56e-21	52
neural keel	8.56e-21	52
ectoderm-derived structure	3.88e-18	95
ectoderm	3.88e-18	95
presumptive ectoderm	3.88e-18	95
brain	5.28e-18	47
future brain	5.28e-18	47
regional part of brain	6.79e-18	46
neurectoderm	7.65e-17	64
neural plate	7.65e-17	64
presumptive neural plate	7.65e-17	64
anterior neural tube	1.63e-16	40
gray matter	2.74e-16	34
regional part of forebrain	3.37e-16	39
forebrain	3.37e-16	39
future forebrain	3.37e-16	39
brain grey matter	1.51e-13	29
regional part of telencephalon	1.51e-13	29
telencephalon	1.51e-13	29
structure with developmental contribution from neural crest	6.01e-13	92
pre-chordal neural plate	7.42e-12	49
ecto-epithelium	9.24e-12	73
cerebral cortex	7.38e-10	21
cerebral hemisphere	7.38e-10	21
pallium	7.38e-10	21
regional part of cerebral cortex	2.23e-08	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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