MCL coexpression mm9:1791

Phase1 CAGE Peaks

	Short description
Mm9::chr3:26230826..26230839,-	p6@Nlgn1
Mm9::chr5:84846323..84846334,-	p3@Epha5
Mm9::chr5:84846349..84846362,-	p2@Epha5
Mm9::chr5:84846393..84846414,-	p1@Epha5
Mm9::chr5:84846420..84846425,-	p4@Epha5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0016080	synaptic vesicle targeting	0.0240970418475486
GO:0006903	vesicle targeting	0.0240970418475486
GO:0042043	neurexin binding	0.0240970418475486
GO:0016079	synaptic vesicle exocytosis	0.0240970418475486
GO:0051650	establishment of vesicle localization	0.0240970418475486
GO:0051648	vesicle localization	0.0240970418475486
GO:0005003	ephrin receptor activity	0.0240970418475486
GO:0007416	synaptogenesis	0.0270995143755786
GO:0051656	establishment of organelle localization	0.0270995143755786
GO:0048489	synaptic vesicle transport	0.0270995143755786
GO:0051640	organelle localization	0.0270995143755786
GO:0045664	regulation of neuron differentiation	0.0270995143755786
GO:0050808	synapse organization and biogenesis	0.0407460835267628
GO:0007269	neurotransmitter secretion	0.0438465372469897
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0481280481196195
GO:0045055	regulated secretory pathway	0.0481280481196195

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.03e-16	23
neuroblast (sensu Vertebrata)	1.03e-16	23
neuron	4.04e-16	33
neuronal stem cell	4.04e-16	33
neuroblast	4.04e-16	33
electrically signaling cell	4.04e-16	33
ectodermal cell	3.21e-14	44
neurectodermal cell	3.21e-14	44
neural cell	4.83e-14	43
electrically responsive cell	1.27e-11	39
electrically active cell	1.27e-11	39
non-terminally differentiated cell	1.38e-10	49

Uber Anatomy

Ontology term	p-value	n
neurectoderm	1.20e-34	64
neural plate	1.20e-34	64
presumptive neural plate	1.20e-34	64
ectoderm-derived structure	5.12e-34	95
ectoderm	5.12e-34	95
presumptive ectoderm	5.12e-34	95
nervous system	6.23e-33	75
central nervous system	4.35e-32	73
pre-chordal neural plate	1.09e-30	49
regional part of nervous system	1.51e-30	54
ecto-epithelium	8.58e-30	73
neural tube	1.93e-28	52
neural rod	1.93e-28	52
future spinal cord	1.93e-28	52
neural keel	1.93e-28	52
brain	1.78e-25	47
future brain	1.78e-25	47
regional part of brain	1.51e-24	46
anterior neural tube	3.30e-24	40
regional part of forebrain	1.33e-23	39
forebrain	1.33e-23	39
future forebrain	1.33e-23	39
gray matter	1.64e-23	34
structure with developmental contribution from neural crest	1.51e-21	92
brain grey matter	2.40e-20	29
regional part of telencephalon	2.40e-20	29
telencephalon	2.40e-20	29
cerebral cortex	1.82e-15	21
cerebral hemisphere	1.82e-15	21
pallium	1.82e-15	21
regional part of cerebral cortex	2.34e-12	17
occipital lobe	1.79e-08	10
visual cortex	1.79e-08	10
neocortex	1.79e-08	10
sense organ	3.30e-07	12
sensory system	3.30e-07	12
entire sense organ system	3.30e-07	12
eye	4.48e-07	9
camera-type eye	4.48e-07	9
simple eye	4.48e-07	9
immature eye	4.48e-07	9
ocular region	4.48e-07	9
visual system	4.48e-07	9
face	4.48e-07	9
optic cup	4.48e-07	9
optic vesicle	4.48e-07	9
eye primordium	4.48e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}