MCL coexpression mm9:2942

Phase1 CAGE Peaks

	Short description
Mm9::chr14:76362197..76362208,+	p@chr14:76362197..76362208 +
Mm9::chr18:62483890..62483902,+	p3@Htr4
Mm9::chr4:128798891..128798906,-	p6@Hpca

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004993	serotonin receptor activity	0.0476529527425605

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	3.90e-17	23
neuroblast (sensu Vertebrata)	3.90e-17	23
neuron	8.24e-11	33
neuronal stem cell	8.24e-11	33
neuroblast	8.24e-11	33
electrically signaling cell	8.24e-11	33
electrically responsive cell	1.35e-08	39
electrically active cell	1.35e-08	39
neuron of the ventral spinal cord	1.56e-07	3
neural cell	1.80e-07	43
raphe nuclei neuron	1.81e-07	3
ectodermal cell	3.18e-07	44
neurectodermal cell	3.18e-07	44
neuron of the substantia nigra	6.50e-07	3

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.26e-22	54
neural tube	1.13e-19	52
neural rod	1.13e-19	52
future spinal cord	1.13e-19	52
neural keel	1.13e-19	52
central nervous system	2.03e-19	73
nervous system	1.07e-18	75
gray matter	1.02e-17	34
neurectoderm	4.69e-16	64
neural plate	4.69e-16	64
presumptive neural plate	4.69e-16	64
ectoderm-derived structure	3.31e-14	95
ectoderm	3.31e-14	95
presumptive ectoderm	3.31e-14	95
ecto-epithelium	2.94e-13	73
spinal cord	5.06e-13	6
dorsal region element	5.06e-13	6
dorsum	5.06e-13	6
brain	5.33e-13	47
future brain	5.33e-13	47
regional part of brain	6.79e-12	46
anterior neural tube	3.85e-11	40
regional part of spinal cord	4.42e-11	5
gray matter of spinal cord	4.42e-11	5
brain grey matter	1.09e-10	29
regional part of telencephalon	1.09e-10	29
telencephalon	1.09e-10	29
posterior neural tube	1.69e-10	12
chordal neural plate	1.69e-10	12
regional part of forebrain	6.36e-10	39
forebrain	6.36e-10	39
future forebrain	6.36e-10	39
pre-chordal neural plate	2.17e-09	49
structure with developmental contribution from neural crest	3.49e-09	92
basal ganglion	5.34e-09	8
nuclear complex of neuraxis	5.34e-09	8
aggregate regional part of brain	5.34e-09	8
collection of basal ganglia	5.34e-09	8
cerebral subcortex	5.34e-09	8
regional part of midbrain	5.61e-09	4
midbrain	5.61e-09	4
presumptive midbrain	5.61e-09	4
midbrain neural tube	5.61e-09	4
ventral horn of spinal cord	1.56e-07	3
raphe nuclei	1.81e-07	3
reticular formation	1.81e-07	3
substantia nigra	6.50e-07	3
telencephalic nucleus	6.50e-07	3
midbrain nucleus	6.50e-07	3
neural nucleus	6.50e-07	3
nucleus of brain	6.50e-07	3

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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