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Coexpression cluster:C1631

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Full id: C1631_Monocytederived_Melanocyte_CD14_Macrophage_Mast_Mesenchymal_Fibroblast



Phase1 CAGE Peaks

Hg19::chr11:2920913..2920942,+p4@SLC22A18
Hg19::chr11:844067..844158,+p2@TSPAN4
Hg19::chr15:72668805..72668860,-p4@HEXA
Hg19::chr18:74845649..74845670,-p10@MBP
Hg19::chr18:74845672..74845681,-p42@MBP


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007272ensheathment of neurons0.000345141160614551
GO:0008366axon ensheathment0.000345141160614551
GO:0001508regulation of action potential0.000361727870421891
GO:0043209myelin sheath0.00716883192883501
GO:0003008system process0.00716883192883501
GO:0050884neuromuscular process controlling posture0.00716883192883501
GO:0004563beta-N-acetylhexosaminidase activity0.00716883192883501
GO:0006689ganglioside catabolic process0.00716883192883501
GO:0019226transmission of nerve impulse0.00716883192883501
GO:0046479glycosphingolipid catabolic process0.00716883192883501
GO:0019377glycolipid catabolic process0.00716883192883501
GO:0019915sequestering of lipid0.00716883192883501
GO:0001573ganglioside metabolic process0.00716883192883501
GO:0007628adult walking behavior0.00716883192883501
GO:0015904tetracycline transport0.00716883192883501
GO:0015520tetracycline:hydrogen antiporter activity0.00716883192883501
GO:0015307drug:hydrogen antiporter activity0.00716883192883501
GO:0044459plasma membrane part0.00716883192883501
GO:0015101organic cation transmembrane transporter activity0.00716883192883501
GO:0042895antibiotic transporter activity0.00716883192883501
GO:0046677response to antibiotic0.00716883192883501
GO:0008493tetracycline transporter activity0.00716883192883501
GO:0019911structural constituent of myelin sheath0.00754252487059236
GO:0008344adult locomotory behavior0.00919837608377269
GO:0030149sphingolipid catabolic process0.00946076904077037
GO:0015929hexosaminidase activity0.00978570597354006
GO:0015893drug transport0.00978570597354006
GO:0007267cell-cell signaling0.00978570597354006
GO:0050885neuromuscular process controlling balance0.00978570597354006
GO:0006687glycosphingolipid metabolic process0.00998460349909566
GO:0007040lysosome organization and biogenesis0.0101706240274497
GO:0007399nervous system development0.0101996367455477
GO:0007033vacuole organization and biogenesis0.0101996367455477
GO:0015238drug transporter activity0.0101996367455477
GO:0050905neuromuscular process0.0103581346894914
GO:0046466membrane lipid catabolic process0.0105077885383775
GO:0042552myelination0.0109104886857533
GO:0015299solute:hydrogen antiporter activity0.0109104886857533
GO:0030534adult behavior0.0109104886857533
GO:0006664glycolipid metabolic process0.0114246970871211
GO:0006672ceramide metabolic process0.0122974558044596
GO:0046519sphingoid metabolic process0.0131283565550644
GO:0065008regulation of biological quality0.0141560905259556
GO:0007588excretion0.0150332874311201
GO:0005886plasma membrane0.0151829793304564
GO:0032501multicellular organismal process0.0151829793304564
GO:0015298solute:cation antiporter activity0.0154113469493529
GO:0044242cellular lipid catabolic process0.0157428993076182
GO:0030203glycosaminoglycan metabolic process0.0157428993076182
GO:0006022aminoglycan metabolic process0.0157428993076182
GO:0015300solute:solute antiporter activity0.0157428993076182
GO:0016020membrane0.0174546116642479
GO:0042493response to drug0.0187033419075893
GO:0050877neurological system process0.0191020292066077
GO:0016324apical plasma membrane0.0191020292066077
GO:0006665sphingolipid metabolic process0.0191020292066077
GO:0045177apical part of cell0.0237157522220542
GO:0015297antiporter activity0.0246564633342525
GO:0046982protein heterodimerization activity0.0279502739579866
GO:0048731system development0.028044494614052
GO:0050954sensory perception of mechanical stimulus0.0333974226952198
GO:0007605sensory perception of sound0.0333974226952198
GO:0016042lipid catabolic process0.0363307499073583
GO:0048856anatomical structure development0.0403753673555447
GO:0007626locomotory behavior0.0435868571927119
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds0.045042994673342
GO:0005764lysosome0.0464547052074452
GO:0000323lytic vacuole0.0464547052074452
GO:0001501skeletal development0.0473532810576143
GO:0007275multicellular organismal development0.0479593152336682
GO:0016798hydrolase activity, acting on glycosyl bonds0.0484179111847522



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm2.34e-32216
bone marrow1.43e-2980
musculoskeletal system1.90e-29167
bone element1.07e-2686
hemolymphoid system5.73e-25112
skeletal element1.76e-23101
skeletal system1.76e-23101
hematopoietic system4.40e-23102
blood island4.40e-23102
immune system8.98e-23115
mesoderm8.82e-22448
mesoderm-derived structure8.82e-22448
presumptive mesoderm8.82e-22448
connective tissue2.38e-12375
splanchnic layer of lateral plate mesoderm3.76e-1084
anatomical system1.85e-09625
artery3.16e-0942
arterial blood vessel3.16e-0942
arterial system3.16e-0942
anatomical group3.49e-09626
vessel3.76e-0969
blood vessel2.06e-0860
epithelial tube open at both ends2.06e-0860
blood vasculature2.06e-0860
vascular cord2.06e-0860
systemic artery5.24e-0833
systemic arterial system5.24e-0833
cardiovascular system5.34e-08110
circulatory system8.45e-08113
multi-cellular organism8.60e-08659
vasculature9.03e-0879
vascular system9.03e-0879


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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