MCL coexpression mm9:353
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005275 | amine transmembrane transporter activity | 1.94117445984349e-05 |
| GO:0008504 | monoamine transmembrane transporter activity | 4.45609887683677e-05 |
| GO:0015370 | solute:sodium symporter activity | 0.00290317603935904 |
| GO:0022804 | active transmembrane transporter activity | 0.00290317603935904 |
| GO:0006836 | neurotransmitter transport | 0.00290317603935904 |
| GO:0015294 | solute:cation symporter activity | 0.00290317603935904 |
| GO:0015837 | amine transport | 0.00290317603935904 |
| GO:0008292 | acetylcholine biosynthetic process | 0.00602640661809018 |
| GO:0005307 | choline:sodium symporter activity | 0.00602640661809018 |
| GO:0008291 | acetylcholine metabolic process | 0.00903837176009507 |
| GO:0015871 | choline transport | 0.00903837176009507 |
| GO:0015220 | choline transmembrane transporter activity | 0.00903837176009507 |
| GO:0015293 | symporter activity | 0.00984208619353216 |
| GO:0031133 | regulation of axon diameter | 0.0101667754957099 |
| GO:0045110 | intermediate filament bundle assembly | 0.0101667754957099 |
| GO:0015844 | monoamine transport | 0.0101667754957099 |
| GO:0042439 | ethanolamine and derivative metabolic process | 0.0123921007879047 |
| GO:0015291 | secondary active transmembrane transporter activity | 0.0123921007879047 |
| GO:0022857 | transmembrane transporter activity | 0.014520768102974 |
| GO:0043195 | terminal button | 0.0154858644013815 |
| GO:0005883 | neurofilament | 0.0154858644013815 |
| GO:0006810 | transport | 0.0187540123604468 |
| GO:0060053 | neurofilament cytoskeleton | 0.0187540123604468 |
| GO:0060052 | neurofilament cytoskeleton organization and biogenesis | 0.0187540123604468 |
| GO:0045109 | intermediate filament organization | 0.0187540123604468 |
| GO:0033267 | axon part | 0.0187540123604468 |
| GO:0051234 | establishment of localization | 0.0192789108118965 |
| GO:0008088 | axon cargo transport | 0.019346727717088 |
| GO:0042176 | regulation of protein catabolic process | 0.020112330883035 |
| GO:0048265 | response to pain | 0.020112330883035 |
| GO:0031594 | neuromuscular junction | 0.020112330883035 |
| GO:0007274 | neuromuscular synaptic transmission | 0.020112330883035 |
| GO:0009894 | regulation of catabolic process | 0.020112330883035 |
| GO:0042136 | neurotransmitter biosynthetic process | 0.020112330883035 |
| GO:0007271 | synaptic transmission, cholinergic | 0.020112330883035 |
| GO:0051179 | localization | 0.0228123038652274 |
| GO:0045104 | intermediate filament cytoskeleton organization and biogenesis | 0.0248654523517968 |
| GO:0005328 | neurotransmitter:sodium symporter activity | 0.0256317698159375 |
| GO:0045103 | intermediate filament-based process | 0.0270483470018585 |
| GO:0005326 | neurotransmitter transporter activity | 0.0270483470018585 |
| GO:0042401 | biogenic amine biosynthetic process | 0.0316490147677722 |
| GO:0033555 | multicellular organismal response to stress | 0.0321783707287936 |
| GO:0008324 | cation transmembrane transporter activity | 0.0335335216595175 |
| GO:0042398 | amino acid derivative biosynthetic process | 0.0343874727040846 |
| GO:0050770 | regulation of axonogenesis | 0.0360151058030516 |
| GO:0004601 | peroxidase activity | 0.0379152230653866 |
| GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | 0.0379152230653866 |
| GO:0042133 | neurotransmitter metabolic process | 0.0416025674897824 |
| GO:0050767 | regulation of neurogenesis | 0.0495108445735055 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| neuron of the ventral spinal cord | 1.51e-08 | 3 |
| CNS neuron (sensu Vertebrata) | 3.15e-07 | 23 |
| neuroblast (sensu Vertebrata) | 3.15e-07 | 23 |
| Ontology term | p-value | n |
|---|---|---|
| posterior neural tube | 7.37e-20 | 12 |
| chordal neural plate | 7.37e-20 | 12 |
| spinal cord | 1.15e-15 | 6 |
| dorsal region element | 1.15e-15 | 6 |
| dorsum | 1.15e-15 | 6 |
| regional part of spinal cord | 3.10e-13 | 5 |
| gray matter of spinal cord | 3.10e-13 | 5 |
| regional part of nervous system | 2.49e-09 | 54 |
| neural tube | 1.06e-08 | 52 |
| neural rod | 1.06e-08 | 52 |
| future spinal cord | 1.06e-08 | 52 |
| neural keel | 1.06e-08 | 52 |
| ventral horn of spinal cord | 1.51e-08 | 3 |
| neurectoderm | 2.88e-07 | 64 |
| neural plate | 2.88e-07 | 64 |
| presumptive neural plate | 2.88e-07 | 64 |
| central nervous system | 7.37e-07 | 73 |
| segmental subdivision of hindbrain | 9.41e-07 | 6 |
| segmental subdivision of nervous system | 9.41e-07 | 6 |
| hindbrain | 9.41e-07 | 6 |
| presumptive hindbrain | 9.41e-07 | 6 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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