MCL coexpression mm9:2050

Phase1 CAGE Peaks

	Short description
Mm9::chr12:8928823..8928834,+	p@chr12:8928823..8928834 +
Mm9::chr2:118305373..118305423,-	p1@LOC100504988 p1@Srp14
Mm9::chr6:29417733..29417764,+	p2@Atp6v1f
Mm9::chr7:85928189..85928227,+	p2@Mrps11

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015985	energy coupled proton transport, down electrochemical gradient	0.0417526751697796
GO:0015986	ATP synthesis coupled proton transport	0.0417526751697796
GO:0006754	ATP biosynthetic process	0.0417526751697796
GO:0006753	nucleoside phosphate metabolic process	0.0417526751697796
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	0.0417526751697796
GO:0016469	proton-transporting two-sector ATPase complex	0.0417526751697796
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	0.0417526751697796
GO:0044249	cellular biosynthetic process	0.0417526751697796
GO:0046034	ATP metabolic process	0.0417526751697796
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	0.0417526751697796
GO:0009201	ribonucleoside triphosphate biosynthetic process	0.0417526751697796
GO:0009145	purine nucleoside triphosphate biosynthetic process	0.0417526751697796
GO:0019829	cation-transporting ATPase activity	0.0417526751697796
GO:0009142	nucleoside triphosphate biosynthetic process	0.0417526751697796
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.0417526751697796
GO:0009199	ribonucleoside triphosphate metabolic process	0.0417526751697796
GO:0009144	purine nucleoside triphosphate metabolic process	0.0417526751697796
GO:0006119	oxidative phosphorylation	0.0417526751697796
GO:0015992	proton transport	0.0417526751697796
GO:0006752	group transfer coenzyme metabolic process	0.0417526751697796
GO:0009141	nucleoside triphosphate metabolic process	0.0417526751697796
GO:0009152	purine ribonucleotide biosynthetic process	0.0417526751697796
GO:0006818	hydrogen transport	0.0417526751697796
GO:0009260	ribonucleotide biosynthetic process	0.0417526751697796
GO:0009150	purine ribonucleotide metabolic process	0.0417526751697796
GO:0006164	purine nucleotide biosynthetic process	0.0417526751697796
GO:0009058	biosynthetic process	0.0417526751697796
GO:0009259	ribonucleotide metabolic process	0.0417526751697796
GO:0006163	purine nucleotide metabolic process	0.0426071727823965
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.0446838862837438
GO:0009108	coenzyme biosynthetic process	0.0446838862837438
GO:0015078	hydrogen ion transmembrane transporter activity	0.0470887349534143
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.0470887349534143
GO:0051188	cofactor biosynthetic process	0.0470887349534143

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	3.40e-23	49
ectodermal cell	1.70e-21	44
neurectodermal cell	1.70e-21	44
neural cell	2.51e-21	43
electrically responsive cell	1.33e-16	39
electrically active cell	1.33e-16	39
somatic cell	2.91e-15	118
neuron	7.76e-15	33
neuronal stem cell	7.76e-15	33
neuroblast	7.76e-15	33
electrically signaling cell	7.76e-15	33
somatic stem cell	1.69e-14	91
multi fate stem cell	1.69e-14	91
animal cell	2.75e-14	115
eukaryotic cell	2.75e-14	115
embryonic cell	3.51e-14	70
stem cell	5.61e-14	97
CNS neuron (sensu Vertebrata)	5.15e-13	23
neuroblast (sensu Vertebrata)	5.15e-13	23
migratory neural crest cell	1.58e-07	10
neuron associated cell	1.58e-07	10
glial cell (sensu Vertebrata)	1.58e-07	10
neuron associated cell (sensu Vertebrata)	1.58e-07	10
glial cell	1.58e-07	10
glioblast	1.58e-07	10
glioblast (sensu Vertebrata)	1.58e-07	10

Uber Anatomy

Ontology term	p-value	n
nervous system	1.45e-31	75
central nervous system	2.49e-30	73
ectoderm-derived structure	4.94e-22	95
ectoderm	4.94e-22	95
presumptive ectoderm	4.94e-22	95
regional part of nervous system	5.17e-22	54
neural tube	8.56e-21	52
neural rod	8.56e-21	52
future spinal cord	8.56e-21	52
neural keel	8.56e-21	52
neurectoderm	3.22e-19	64
neural plate	3.22e-19	64
presumptive neural plate	3.22e-19	64
structure with developmental contribution from neural crest	3.66e-19	92
brain	4.25e-18	47
future brain	4.25e-18	47
regional part of brain	9.28e-18	46
gray matter	1.70e-16	34
anterior neural tube	7.11e-16	40
regional part of forebrain	8.74e-16	39
forebrain	8.74e-16	39
future forebrain	8.74e-16	39
ecto-epithelium	1.97e-14	73
brain grey matter	5.90e-14	29
regional part of telencephalon	5.90e-14	29
telencephalon	5.90e-14	29
pre-chordal neural plate	2.20e-13	49
cerebral cortex	7.47e-10	21
cerebral hemisphere	7.47e-10	21
pallium	7.47e-10	21
regional part of cerebral cortex	2.15e-08	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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