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MCL coexpression mm9:118

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:12533338..12533388,-p1@Utrn
Mm9::chr10:12533399..12533410,-p7@Utrn
Mm9::chr11:100721761..100721851,+p1@Stat5a
Mm9::chr11:103032277..103032292,+p5@Fmnl1
Mm9::chr11:11585627..11585658,-p1@ENSMUST00000145789
Mm9::chr11:11590081..11590082,+p16@Ikzf1
Mm9::chr11:11590085..11590106,+p7@Ikzf1
Mm9::chr11:11590117..11590138,+p4@Ikzf1
Mm9::chr11:11590140..11590187,+p3@Ikzf1
Mm9::chr11:11590188..11590200,+p8@Ikzf1
Mm9::chr11:11590205..11590216,+p9@Ikzf1
Mm9::chr11:46202956..46202969,-p2@Itk
Mm9::chr11:46202973..46203007,-p1@Itk
Mm9::chr11:5344782..5344826,-p1@Znrf3
Mm9::chr11:97857177..97857249,-p1@Arl5c
Mm9::chr11:99016332..99016351,-p2@Ccr7
Mm9::chr12:74685775..74685797,+p1@Prkch
Mm9::chr12:77470718..77470752,-p4@Zbtb25
Mm9::chr13:24508844..24508851,+p12@Cmah
Mm9::chr14:53965564..53965568,+p1@uc007trv.1
p1@uc007trw.1
Mm9::chr14:54048383..54048396,+p1@ENSMUST00000103638
Mm9::chr14:54062918..54062937,+p1@ENSMUST00000103639
Mm9::chr14:54157921..54157933,+p1@ENSMUST00000103650
Mm9::chr14:54164650..54164665,+p1@ENSMUST00000103651
p1@uc007tsn.1
p1@uc011zkx.1
Mm9::chr14:54426172..54426195,+p1@ENSMUST00000103672
p1@uc007tto.1
Mm9::chr14:54464938..54464951,+p2@ENSMUST00000103674
p2@uc007ttp.1
Mm9::chr14:54464982..54464996,+p1@ENSMUST00000103674
p1@uc007ttp.1
Mm9::chr14:54811976..54811990,+p1@ENSMUST00000103714
Mm9::chr14:54840241..54840260,+p@chr14:54840241..54840260
+
Mm9::chr14:54840371..54840385,+p@chr14:54840371..54840385
+
Mm9::chr15:100430393..100430410,-p3@Pou6f1
Mm9::chr15:100430414..100430470,-p1@Pou6f1
Mm9::chr15:80403104..80403111,+p10@Grap2
Mm9::chr15:97661968..97662011,-p3@Hdac7
Mm9::chr16:23175423..23175450,+p2@ENSMUST00000149488
Mm9::chr16:52031698..52031759,+p1@Cblb
Mm9::chr17:47645236..47645255,+p@chr17:47645236..47645255
+
Mm9::chr17:51953616..51953628,-p@chr17:51953616..51953628
-
Mm9::chr17:51966047..51966066,+p@chr17:51966047..51966066
+
Mm9::chr17:51971209..51971220,-p43@Satb1
Mm9::chr17:51971932..51971958,-p2@Satb1
Mm9::chr19:10813429..10813446,-p2@Cd5
Mm9::chr19:10869146..10869168,-p@chr19:10869146..10869168
-
Mm9::chr19:10904411..10904532,-p1@Cd6
Mm9::chr19:10904535..10904553,-p2@Cd6
Mm9::chr19:8831629..8831645,+p1@Nxf1
Mm9::chr1:135027985..135028014,+p3@Ppp1r15b
Mm9::chr1:140041614..140041617,-p@chr1:140041614..140041617
-
Mm9::chr1:167718815..167718859,+p2@Cd247
Mm9::chr1:55420578..55420600,-p2@Boll
Mm9::chr1:60803211..60803271,+p1@Cd28
p1@LOC100048845
Mm9::chr1:60803273..60803321,+p2@Cd28
p2@LOC100048845
Mm9::chr1:60803329..60803340,+p3@Cd28
p3@LOC100048845
Mm9::chr1:64574357..64574362,-p@chr1:64574357..64574362
-
Mm9::chr2:132517620..132517639,+p@chr2:132517620..132517639
+
Mm9::chr2:160557512..160557532,+p3@Plcg1
Mm9::chr2:22630785..22630799,-p@chr2:22630785..22630799
-
Mm9::chr2:73288647..73288669,+p@chr2:73288647..73288669
+
Mm9::chr2:73290723..73290769,-p10@Wipf1
Mm9::chr3:101091820..101091880,-p1@Cd2
Mm9::chr3:106839074..106839099,+p1@Kcna3
Mm9::chr3:130814473..130814487,+p@chr3:130814473..130814487
+
Mm9::chr3:60305179..60305197,+p1@Mbnl1
Mm9::chr4:129250843..129250873,-p2@Lck
Mm9::chr4:129251001..129251012,+p@chr4:129251001..129251012
+
Mm9::chr4:129252589..129252596,-p@chr4:129252589..129252596
-
Mm9::chr4:129419424..129419433,-p4@Khdrbs1
Mm9::chr4:151498695..151498722,+p@chr4:151498695..151498722
+
Mm9::chr4:62295400..62295422,+p9@Rgs3
Mm9::chr4:6917606..6917681,-p1@Tox
Mm9::chr5:123439299..123439324,+p3@ENSMUST00000148466
p3@uc008zmw.1
Mm9::chr5:130363286..130363299,-p3@Chchd2
p3@Gm12350
p3@Gm13202
p3@LOC100045688
Mm9::chr6:125181157..125181191,-p@chr6:125181157..125181191
-
Mm9::chr6:125186941..125186952,-p4@Cd27
Mm9::chr6:40841402..40841426,+p4@1810009J06Rik
Mm9::chr6:40841430..40841450,+p3@1810009J06Rik
Mm9::chr6:41007727..41007736,+p@chr6:41007727..41007736
+
Mm9::chr6:41128837..41128859,+p2@Gm5409
Mm9::chr6:41221420..41221423,+p1@uc012ekt.1
Mm9::chr6:41491801..41491815,-p@chr6:41491801..41491815
-
Mm9::chr6:41494355..41494368,-p@chr6:41494355..41494368
-
Mm9::chr6:41494376..41494389,-p@chr6:41494376..41494389
-
Mm9::chr6:41494819..41494832,+p@chr6:41494819..41494832
+
Mm9::chr6:41504409..41504422,-p@chr6:41504409..41504422
-
Mm9::chr6:41504514..41504522,+p@chr6:41504514..41504522
+
Mm9::chr6:48626407..48626421,+p@chr6:48626407..48626421
+
Mm9::chr6:48688916..48688931,-p@chr6:48688916..48688931
-
Mm9::chr6:48691327..48691343,-p@chr6:48691327..48691343
-
Mm9::chr6:48691433..48691448,-p@chr6:48691433..48691448
-
Mm9::chr6:48691461..48691472,-p@chr6:48691461..48691472
-
Mm9::chr7:132746934..132746951,+p2@Il21r
Mm9::chr7:133513014..133513040,-p2@Lat
Mm9::chr7:133513065..133513092,-p1@Lat
Mm9::chr7:133848402..133848420,-p9@Coro1a
Mm9::chr7:29160541..29160603,-p@chr7:29160541..29160603
-
Mm9::chr8:126545419..126545430,+p4@Urb2
Mm9::chrX:156146587..156146592,+p26@Sh3kbp1
Mm9::chrX:34519665..34519666,-p@chrX:34519665..34519666
-
Mm9::chrX:74756216..74756236,+p5@Tbl1x
Mm9::chrX:74756248..74756265,+p3@Tbl1x


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005515protein binding0.000732003941750997
GO:0050870positive regulation of T cell activation0.000732003941750997
GO:0045321leukocyte activation0.000856604389875852
GO:0042110T cell activation0.000856604389875852
GO:0001775cell activation0.000856604389875852
GO:0006417regulation of translation0.000856604389875852
GO:0051251positive regulation of lymphocyte activation0.000856604389875852
GO:0050863regulation of T cell activation0.000856604389875852
GO:0031326regulation of cellular biosynthetic process0.000876283834534143
GO:0002376immune system process0.0011136549310473
GO:0009889regulation of biosynthetic process0.00121499007636724
GO:0051239regulation of multicellular organismal process0.00149222120358652
GO:0051249regulation of lymphocyte activation0.0015771067843541
GO:0050865regulation of cell activation0.00168456114761738
GO:0042108positive regulation of cytokine biosynthetic process0.0020225994520369
GO:0046649lymphocyte activation0.00216112170926091
GO:0005522profilin binding0.00276394954686717
GO:0045727positive regulation of translation0.00331794579367454
GO:0031328positive regulation of cellular biosynthetic process0.00380315419863275
GO:0051246regulation of protein metabolic process0.00380315419863275
GO:0031294lymphocyte costimulation0.00380315419863275
GO:0031295T cell costimulation0.00380315419863275
GO:0045086positive regulation of interleukin-2 biosynthetic process0.00380315419863275
GO:0050856regulation of T cell receptor signaling pathway0.00466966713143797
GO:0042035regulation of cytokine biosynthetic process0.00466966713143797
GO:0007242intracellular signaling cascade0.00497680671866625
GO:0009891positive regulation of biosynthetic process0.00514494169406404
GO:0050854regulation of antigen receptor-mediated signaling pathway0.00611164206805233
GO:0042089cytokine biosynthetic process0.00692533152575002
GO:0042107cytokine metabolic process0.00703037073106021
GO:0048518positive regulation of biological process0.0070739884332495
GO:0045076regulation of interleukin-2 biosynthetic process0.00756353113539419
GO:0045621positive regulation of lymphocyte differentiation0.00908952033762646
GO:0042094interleukin-2 biosynthetic process0.00908952033762646
GO:0006405RNA export from nucleus0.00908952033762646
GO:0051247positive regulation of protein metabolic process0.00908952033762646
GO:0006955immune response0.00908952033762646
GO:0032623interleukin-2 production0.00908952033762646
GO:0032943mononuclear cell proliferation0.00908952033762646
GO:0048732gland development0.00908952033762646
GO:0046651lymphocyte proliferation0.00908952033762646
GO:0031349positive regulation of defense response0.00976123523726513
GO:0050729positive regulation of inflammatory response0.00976123523726513
GO:0050852T cell receptor signaling pathway0.0107173362862481
GO:0008624induction of apoptosis by extracellular signals0.0116962206835666
GO:0042113B cell activation0.0121454574214118
GO:0001772immunological synapse0.0123616527377006
GO:0031325positive regulation of cellular metabolic process0.0123616527377006
GO:0030097hemopoiesis0.0136179774384505
GO:0030098lymphocyte differentiation0.0136179774384505
GO:0040018positive regulation of multicellular organism growth0.0136179774384505
GO:0030879mammary gland development0.0136179774384505
GO:0009893positive regulation of metabolic process0.0138309058830415
GO:0050789regulation of biological process0.0138309058830415
GO:0045619regulation of lymphocyte differentiation0.0138309058830415
GO:0051168nuclear export0.0138309058830415
GO:0050778positive regulation of immune response0.0139510050672506
GO:0007165signal transduction0.0142475669200382
GO:0002684positive regulation of immune system process0.0143052548597772
GO:0001816cytokine production0.014485077860282
GO:0050871positive regulation of B cell activation0.0157291000176367
GO:0045927positive regulation of growth0.0157291000176367
GO:0005044scavenger receptor activity0.0157291000176367
GO:0048534hemopoietic or lymphoid organ development0.016193424702035
GO:0050851antigen receptor-mediated signaling pathway0.016193424702035
GO:0042102positive regulation of T cell proliferation0.016193424702035
GO:0050776regulation of immune response0.0176129731681724
GO:0003779actin binding0.0176129731681724
GO:0031347regulation of defense response0.0176129731681724
GO:0050727regulation of inflammatory response0.0176129731681724
GO:0002682regulation of immune system process0.0178999325386018
GO:0002520immune system development0.0186757732366673
GO:0051240positive regulation of multicellular organismal process0.0186757732366673
GO:0004871signal transducer activity0.0186757732366673
GO:0060089molecular transducer activity0.0186757732366673
GO:0006412translation0.0186757732366673
GO:0002429immune response-activating cell surface receptor signaling pathway0.0186757732366673
GO:0021542dentate gyrus development0.0186757732366673
GO:0000164protein phosphatase type 1 complex0.0186757732366673
GO:0030338CMP-N-acetylneuraminate monooxygenase activity0.0186757732366673
GO:0046831regulation of RNA export from nucleus0.0186757732366673
GO:0002768immune response-regulating cell surface receptor signaling pathway0.0206361137915273
GO:0010468regulation of gene expression0.0207823045086254
GO:0002521leukocyte differentiation0.0210575175617036
GO:0006917induction of apoptosis0.0210575175617036
GO:0012502induction of programmed cell death0.0210575175617036
GO:0002757immune response-activating signal transduction0.0210575175617036
GO:0050671positive regulation of lymphocyte proliferation0.0210575175617036
GO:0032946positive regulation of mononuclear cell proliferation0.0210575175617036
GO:0000792heterochromatin0.0210575175617036
GO:0050864regulation of B cell activation0.0218613711677571
GO:0007154cell communication0.0218613711677571
GO:0002252immune effector process0.022200941104786
GO:0004715non-membrane spanning protein tyrosine kinase activity0.022200941104786
GO:0002764immune response-regulating signal transduction0.022200941104786
GO:0002377immunoglobulin production0.0231260799055712
GO:0002440production of molecular mediator of immune response0.0240598754174787
GO:0031323regulation of cellular metabolic process0.0241916454060806
GO:0042129regulation of T cell proliferation0.0259519270168955
GO:0050794regulation of cellular process0.0275712176750654
GO:0048522positive regulation of cellular process0.0275712176750654
GO:0048583regulation of response to stimulus0.0276009528750531
GO:0046544development of secondary male sexual characteristics0.0279731342327435
GO:0046543development of secondary female sexual characteristics0.0279731342327435
GO:0046381CMP-N-acetylneuraminate metabolic process0.0279731342327435
GO:0042405nuclear inclusion body0.0279731342327435
GO:0007527adult somatic muscle development0.0279731342327435
GO:0016716oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen0.0279731342327435
GO:0065007biological regulation0.0279731342327435
GO:0019222regulation of metabolic process0.0285936106661784
GO:0043065positive regulation of apoptosis0.0317220006838718
GO:0050657nucleic acid transport0.0317220006838718
GO:0050658RNA transport0.0317220006838718
GO:0051236establishment of RNA localization0.0317220006838718
GO:0043068positive regulation of programmed cell death0.0321316261835247
GO:0006403RNA localization0.0321316261835247
GO:0007517muscle development0.0321316261835247
GO:0008092cytoskeletal protein binding0.0328064009132407
GO:0040014regulation of multicellular organism growth0.0328064009132407
GO:0032944regulation of mononuclear cell proliferation0.0334843856276656
GO:0050670regulation of lymphocyte proliferation0.0334843856276656
GO:0015931nucleobase, nucleoside, nucleotide and nucleic acid transport0.0345707701314824
GO:0042098T cell proliferation0.0345707701314824
GO:0045136development of secondary sexual characteristics0.0345707701314824
GO:0051283negative regulation of sequestering of calcium ion0.0345707701314824
GO:0051238sequestering of metal ion0.0345707701314824
GO:0051209release of sequestered calcium ion into cytosol0.0345707701314824
GO:0051208sequestering of calcium ion0.0345707701314824
GO:0001553luteinization0.0345707701314824
GO:0007525somatic muscle development0.0345707701314824
GO:0051282regulation of sequestering of calcium ion0.0345707701314824
GO:0048523negative regulation of cellular process0.0392872805480568
GO:0030217T cell differentiation0.0397245761498175
GO:0035264multicellular organism growth0.0397245761498175
GO:0044260cellular macromolecule metabolic process0.0401401268775371
GO:0010467gene expression0.0401401268775371
GO:0030326embryonic limb morphogenesis0.0401401268775371
GO:0035113embryonic appendage morphogenesis0.0401401268775371
GO:0042981regulation of apoptosis0.0401401268775371
GO:0048468cell development0.0401401268775371
GO:0043067regulation of programmed cell death0.0401401268775371
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.0401401268775371
GO:0001779natural killer cell differentiation0.0401401268775371
GO:0016973poly(A)+ mRNA export from nucleus0.0401401268775371
GO:0045078positive regulation of interferon-gamma biosynthetic process0.0401401268775371
GO:0045647negative regulation of erythrocyte differentiation0.0401401268775371
GO:0008301DNA bending activity0.0401401268775371
GO:0005721centric heterochromatin0.0401401268775371
GO:0016234inclusion body0.0401401268775371
GO:0045931positive regulation of progression through mitotic cell cycle0.0401401268775371
GO:0006357regulation of transcription from RNA polymerase II promoter0.0401401268775371
GO:0006915apoptosis0.0407460559508609
GO:0019955cytokine binding0.0416979237786254
GO:0012501programmed cell death0.0430101101597071
GO:0022618protein-RNA complex assembly0.0447770707926913
GO:0019538protein metabolic process0.0462101674809143
GO:0048519negative regulation of biological process0.0462101674809143
GO:0006929substrate-bound cell migration0.0462101674809143
GO:0050858negative regulation of antigen receptor-mediated signaling pathway0.0462101674809143
GO:0006054N-acetylneuraminate metabolic process0.0462101674809143
GO:0045579positive regulation of B cell differentiation0.0462101674809143
GO:0050860negative regulation of T cell receptor signaling pathway0.0462101674809143
GO:0021766hippocampus development0.0462101674809143
GO:0008219cell death0.0471947735251408
GO:0016265death0.0475058868548293
GO:0009059macromolecule biosynthetic process0.0478184469273156
GO:0035107appendage morphogenesis0.048363105703525
GO:0035108limb morphogenesis0.048363105703525
GO:0043009chordate embryonic development0.0486511061122982
GO:0002253activation of immune response0.0490029627721072
GO:0009792embryonic development ending in birth or egg hatching0.0496411960596491
GO:0006916anti-apoptosis0.0496411960596491
GO:0006366transcription from RNA polymerase II promoter0.0496713185699524
GO:0048736appendage development0.0498856979602618
GO:0060173limb development0.0498856979602618
GO:0048341paraxial mesoderm formation0.0498856979602618
GO:0045885positive regulation of survival gene product activity0.0498856979602618
GO:0048304positive regulation of isotype switching to IgG isotypes0.0498856979602618
GO:0042105alpha-beta T cell receptor complex0.0498856979602618
GO:0045072regulation of interferon-gamma biosynthetic process0.0498856979602618
GO:0006983ER overload response0.0498856979602618



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
lymphoid lineage restricted progenitor cell1.86e-2012
mature alpha-beta T cell8.87e-209
alpha-beta T cell8.87e-209
immature T cell8.87e-209
mature T cell8.87e-209
immature alpha-beta T cell8.87e-209
T cell4.69e-1911
pro-T cell4.69e-1911
lymphocyte1.14e-1813
common lymphoid progenitor1.14e-1813
CD4-positive, alpha-beta T cell9.90e-188
hematopoietic lineage restricted progenitor cell7.15e-1625
nucleate cell1.18e-1416
thymocyte9.24e-146
double negative thymocyte9.24e-146
naive T cell9.24e-146
double-positive, alpha-beta thymocyte9.24e-146
CD4-positive, alpha-beta thymocyte9.24e-146
naive thymus-derived CD4-positive, alpha-beta T cell9.24e-146
DN4 thymocyte9.24e-146
DN1 thymic pro-T cell9.24e-146
DN2 thymocyte9.24e-146
DN3 thymocyte9.24e-146
immature single positive thymocyte9.24e-146
early T lineage precursor9.24e-146
mature CD4 single-positive thymocyte9.24e-146
resting double-positive thymocyte9.24e-146
double-positive blast9.24e-146
CD69-positive double-positive thymocyte9.24e-146
CD69-positive, CD4-positive single-positive thymocyte9.24e-146
CD4-positive, CD8-intermediate double-positive thymocyte9.24e-146
CD24-positive, CD4 single-positive thymocyte9.24e-146
leukocyte1.24e-1317
nongranular leukocyte1.24e-1317
hematopoietic cell4.22e-1332
hematopoietic oligopotent progenitor cell4.22e-1332
hematopoietic stem cell4.22e-1332
angioblastic mesenchymal cell4.22e-1332
hematopoietic multipotent progenitor cell4.22e-1332
connective tissue cell6.62e-0846
mesenchymal cell6.62e-0846

Uber Anatomy
Ontology termp-valuen
hemopoietic organ7.09e-3729
immune organ7.09e-3729
thymus2.01e-3323
neck2.01e-3323
respiratory system epithelium2.01e-3323
hemolymphoid system gland2.01e-3323
pharyngeal epithelium2.01e-3323
thymic region2.01e-3323
pharyngeal gland2.01e-3323
entire pharyngeal arch endoderm2.01e-3323
thymus primordium2.01e-3323
early pharyngeal endoderm2.01e-3323
pharynx8.50e-3224
gland of gut8.50e-3224
upper respiratory tract8.50e-3224
chordate pharynx8.50e-3224
pharyngeal arch system8.50e-3224
pharyngeal region of foregut8.50e-3224
hemolymphoid system3.71e-3048
immune system3.71e-3048
hematopoietic system3.83e-3045
blood island3.83e-3045
mixed endoderm/mesoderm-derived structure1.99e-2935
respiratory tract7.59e-2841
segment of respiratory tract1.21e-2727
respiratory system5.10e-2742
organ segment4.61e-2035
craniocervical region2.36e-1936
foregut9.66e-1680
anterior region of body2.55e-1543
endo-epithelium8.55e-1469
lateral plate mesoderm4.46e-1287
gut epithelium7.92e-1155
endocrine gland1.69e-0960
subdivision of digestive tract7.69e-09114
digestive system1.45e-08116
digestive tract1.45e-08116
primitive gut1.45e-08116
gland2.22e-0865
endoderm-derived structure2.69e-08118
endoderm2.69e-08118
presumptive endoderm2.69e-08118
unilaminar epithelium3.53e-0866
connective tissue6.62e-0846
organ part3.26e-0799
endocrine system4.34e-0772
mesoderm7.25e-07120
mesoderm-derived structure7.25e-07120
presumptive mesoderm7.25e-07120


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}

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