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Coexpression cluster:C443

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Full id: C443_CD4_CD8_Natural_Eosinophils_Neutrophils_Peripheral_blood



Phase1 CAGE Peaks

Hg19::chr11:117103208..117103288,-p2@PCSK7
Hg19::chr12:46123273..46123329,+p3@ARID2
Hg19::chr14:91884150..91884234,-p1@CCDC88C
Hg19::chr15:34394292..34394326,+p1@PGBD4
Hg19::chr17:38297024..38297041,-p@chr17:38297024..38297041
-
Hg19::chr1:100818009..100818072,+p1@CDC14A
Hg19::chr1:155533011..155533044,+p1@LOC645676
Hg19::chr1:226926972..226927038,-p1@ITPKB
Hg19::chr1:231473640..231473651,-p3@EXOC8
Hg19::chr2:234160287..234160335,+p1@ATG16L1
Hg19::chr4:54930662..54930701,-p3@CHIC2
Hg19::chr4:78741344..78741385,-p@chr4:78741344..78741385
-
Hg19::chr4:83351124..83351222,-p4@HNRPDL
Hg19::chr6:12009042..12009092,+p6@HIVEP1
Hg19::chr6:38607628..38607651,-p3@BTBD9
Hg19::chr7:130791091..130791104,+p@chr7:130791091..130791104
+
Hg19::chr7:35734730..35734777,-p1@HERPUD2
Hg19::chr7:39989788..39989876,+p1@CDK13
Hg19::chr8:29940544..29940555,-p3@TMEM66
Hg19::chr8:29940569..29940596,-p1@TMEM66
Hg19::chr8:41909898..41909910,-p4@KAT6A
Hg19::chr8:41909982..41910009,-p2@KAT6A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell9.42e-49168
angioblastic mesenchymal cell9.42e-49168
leukocyte2.07e-48136
hematopoietic cell4.80e-45177
hematopoietic oligopotent progenitor cell1.38e-44161
hematopoietic multipotent progenitor cell1.38e-44161
hematopoietic lineage restricted progenitor cell2.56e-39120
nongranular leukocyte4.64e-38115
myeloid cell7.34e-24108
common myeloid progenitor7.34e-24108
myeloid leukocyte4.31e-2372
granulocyte monocyte progenitor cell6.81e-2067
lymphoid lineage restricted progenitor cell1.93e-1952
lymphocyte2.77e-1953
common lymphoid progenitor2.77e-1953
nucleate cell4.40e-1955
classical monocyte7.80e-1942
CD14-positive, CD16-negative classical monocyte7.80e-1942
myeloid lineage restricted progenitor cell1.77e-1866
macrophage dendritic cell progenitor2.01e-1761
defensive cell2.97e-1748
phagocyte2.97e-1748
monopoietic cell1.28e-1659
monocyte1.28e-1659
monoblast1.28e-1659
promonocyte1.28e-1659
mature alpha-beta T cell3.25e-1218
alpha-beta T cell3.25e-1218
immature T cell3.25e-1218
mature T cell3.25e-1218
immature alpha-beta T cell3.25e-1218
T cell4.37e-1225
pro-T cell4.37e-1225
CD8-positive, alpha-beta T cell3.81e-0811
B cell2.37e-0714
lymphocyte of B lineage4.13e-0724
pro-B cell4.13e-0724
Uber Anatomy
Ontology termp-valuen
adult organism2.50e-24114
hematopoietic system4.07e-2398
blood island4.07e-2398
hemolymphoid system3.56e-22108
immune system4.97e-1693
bone marrow2.12e-1476
bone element1.37e-1382
skeletal element1.83e-0990
neural tube2.60e-0956
neural rod2.60e-0956
future spinal cord2.60e-0956
neural keel2.60e-0956
regional part of nervous system1.16e-0853
regional part of brain1.16e-0853
regional part of forebrain1.68e-0841
forebrain1.68e-0841
anterior neural tube1.68e-0841
future forebrain1.68e-0841
blood5.45e-0815
haemolymphatic fluid5.45e-0815
organism substance5.45e-0815
skeletal system3.47e-07100
telencephalon3.49e-0734
brain grey matter4.81e-0734
gray matter4.81e-0734
regional part of telencephalon9.85e-0732


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#905144.032128276248955.3255677989785e-072.48080720498446e-05
CHD2#110683.761462848769770.0007002358370560630.00563073071961027
CTCF#10664102.436480169579560.003638785887981990.0183936479045037
CTCFL#14069065.38540209790210.0006213706856700010.00511631449390486
E2F1#1869173.792073484224931.62782457128445e-081.18307843006526e-06
E2F6#1876143.192735465625619.67498624322738e-060.000254008518918156
EGR1#1958163.627766614407371.4495292347058e-078.17426478096324e-06
ELF1#1997173.290348422714921.51205004624337e-078.49472806775748e-06
EP300#203382.463251536808440.01035214973756950.0384415348068273
ESR1#209945.594291508391720.005100083402562160.0237196121517719
ETS1#2113125.306596866655823.3208296738816e-071.65944559957187e-05
FOXA1#316963.022205386196030.01131979263328250.0415239304143651
GABPB1#2553134.176358630471281.27824244751352e-065.11096336048486e-05
GTF2B#295968.711953618452064.54391450162014e-050.000799060257004051
GTF2F1#296274.053528460786530.001086335381078520.00759663748673984
HEY1#23462203.672828221005191.00244780445966e-101.08604404823613e-08
HMGN3#9324114.08927386167531.75075923090601e-050.000400016502552161
HNF4A#317244.205870975082490.01366811432388140.0482193011711881
HSF1#3297214.93551515151520.007887097992253930.0323789554722095
IRF1#3659113.818581876781953.37303442817872e-050.000669472334938345
MAX#414982.346383821457140.01378982480437180.0485093978491625
MYC#4609102.373764487095180.004433727172616130.0209887604106996
NFKB1#4790153.741861425586713.73038743635991e-071.83253966823138e-05
NRF1#489984.440101617349420.0002260202218294570.00249448652093909
PAX5#5079123.637944835187911.89263444381865e-050.000428774075223374
POLR2A#5430222.147453176558074.97800844931664e-083.19151764541547e-06
POU2F2#545293.725232569076490.0003013583254279080.00311065053858127
REST#5978104.38637668914912.82986167844788e-050.00059682537123469
SIN3A#25942184.425451140121482.15116950284204e-102.21345804637754e-08
SMC3#912653.419302919302920.01314679266670590.0466147641934509
SP1#6667102.590173353700410.002272441397234830.0129026588608138
TAF1#6872213.191089636393231.5427848500858e-101.63083913925214e-08
TAF7#687984.15747978360870.0003553555440743310.00355795011672698
TBP#6908162.695833226979191.01813841677941e-050.000266700170830261
TCF12#693883.867078146249610.0005812033956957090.00487591786031522
TCF7L2#693462.937320880855640.01293511757195360.0464988381267775
TFAP2A#702086.006776135652712.66432781136025e-050.00057114066562121
YY1#7528153.348525511263991.66506439304847e-066.30520885226935e-05
ZBTB33#1000957.19652841590480.0005265454341736820.00455910119380411
ZBTB7A#51341103.341776958125410.000290672692040720.00308700074069969
ZNF263#1012793.363480669686190.0006495303045566220.00532132848114128



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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