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Coexpression cluster:C681

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Full id: C681_immature_CD14_migratory_CD34_Eosinophils_Basophils_Dendritic



Phase1 CAGE Peaks

Hg19::chr10:98460169..98460181,-p@chr10:98460169..98460181
-
Hg19::chr1:157108130..157108173,-p1@ETV3
Hg19::chr22:24899372..24899395,+p@chr22:24899372..24899395
+
Hg19::chr22:24899422..24899435,+p@chr22:24899422..24899435
+
Hg19::chr3:182887417..182887421,-p@chr3:182887417..182887421
-
Hg19::chr3:197518355..197518387,+p2@LRCH3
Hg19::chr4:142558078..142558101,+p3@IL15
Hg19::chr4:142558116..142558127,+p7@IL15
Hg19::chr4:142558137..142558151,+p4@IL15
Hg19::chr8:145086769..145086785,+p5@SPATC1
Hg19::chr8:145086786..145086804,+p6@SPATC1
Hg19::chr8:145087600..145087607,-p@chr8:145087600..145087607
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte1.26e-8542
CD14-positive, CD16-negative classical monocyte1.26e-8542
defensive cell1.28e-7748
phagocyte1.28e-7748
macrophage dendritic cell progenitor1.88e-7561
myeloid leukocyte3.14e-7572
monopoietic cell2.98e-7459
monocyte2.98e-7459
monoblast2.98e-7459
promonocyte2.98e-7459
granulocyte monocyte progenitor cell5.24e-7167
myeloid lineage restricted progenitor cell1.69e-6866
leukocyte2.29e-61136
myeloid cell6.32e-59108
common myeloid progenitor6.32e-59108
nongranular leukocyte4.01e-51115
hematopoietic stem cell8.83e-49168
angioblastic mesenchymal cell8.83e-49168
hematopoietic lineage restricted progenitor cell1.90e-48120
hematopoietic oligopotent progenitor cell1.76e-47161
hematopoietic multipotent progenitor cell1.76e-47161
hematopoietic cell1.43e-45177
stuff accumulating cell5.36e-3887
conventional dendritic cell7.22e-208
dendritic cell5.65e-1610
mesenchymal cell1.50e-15354
connective tissue cell5.70e-15361
motile cell6.27e-13386
immature conventional dendritic cell1.27e-115
common dendritic progenitor1.27e-115
intermediate monocyte7.41e-119
CD14-positive, CD16-positive monocyte7.41e-119
multi fate stem cell1.91e-10427
Langerhans cell2.00e-105
stem cell2.44e-10441
somatic stem cell4.19e-10433
basophil7.66e-093


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187953.711027852737090.007149884520589760.0297252016020809
ELF1#199782.838731972538360.001804270346094040.010915610883144
ESR1#209937.692150824038620.006055325582880180.0268597217477351
MEF2C#4208310.3278386231560.002646808953776950.0146197419252967
NANOG#7992337.311194620253160.006971199585208680.0294799009385597
NFKB1#479094.116047568145382.84752237283376e-050.000599823293861205
PAX5#507973.890579893187070.0006699722807011360.00540986817876496
SPI1#668853.418468128551140.01014461279531980.0378972427560328



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.