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Coexpression cluster:C175

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Full id: C175_Eosinophils_Neutrophils_CD4_Basophils_CD19_CD8_Natural



Phase1 CAGE Peaks

Hg19::chr10:64893130..64893144,+p2@NRBF2
Hg19::chr10:65028938..65028989,-p1@JMJD1C
Hg19::chr10:65028994..65029018,-p2@JMJD1C
Hg19::chr10:74033760..74033769,+p2@DDIT4
Hg19::chr10:99079008..99079060,+p1@FRAT1
Hg19::chr11:118740871..118740882,-p@chr11:118740871..118740882
-
Hg19::chr11:18655879..18655901,-p1@SPTY2D1
Hg19::chr11:65192718..65192744,-p@chr11:65192718..65192744
-
Hg19::chr11:67055986..67056054,+p2@ANKRD13D
Hg19::chr12:104850711..104850737,+p3@CHST11
Hg19::chr12:106696652..106696665,+p4@TCP11L2
Hg19::chr12:32112161..32112179,+p6@C12orf35
Hg19::chr12:8113506..8113536,+p@chr12:8113506..8113536
+
Hg19::chr12:8179195..8179208,-p@chr12:8179195..8179208
-
Hg19::chr13:48807931..48807969,-p2@AK308603
Hg19::chr14:102227782..102227817,-p@chr14:102227782..102227817
-
Hg19::chr14:39900808..39900830,+p@chr14:39900808..39900830
+
Hg19::chr14:39901341..39901359,-p3@FBXO33
Hg19::chr14:39901360..39901381,-p1@FBXO33
Hg19::chr14:65569101..65569119,-p3@MAX
Hg19::chr14:71374433..71374453,+p4@PCNX
Hg19::chr15:59226114..59226145,-p23@SLTM
Hg19::chr16:19079327..19079354,+p6@COQ7
Hg19::chr16:28153289..28153320,-p@chr16:28153289..28153320
-
Hg19::chr17:1419878..1419912,-p1@INPP5K
Hg19::chr17:44270777..44270806,-p@chr17:44270777..44270806
-
Hg19::chr17:5487779..5487837,-p1@NLRP1
Hg19::chr17:60142609..60142657,-p1@MED13
Hg19::chr17:61776859..61776879,+p@chr17:61776859..61776879
+
Hg19::chr18:2655551..2655594,-p1@CBX3P2
Hg19::chr18:29672617..29672669,+p2@RNF138
Hg19::chr18:29672676..29672696,+p4@RNF138
Hg19::chr18:3593927..3593946,-p@chr18:3593927..3593946
-
Hg19::chr18:9136427..9136477,-p@chr18:9136427..9136477
-
Hg19::chr19:10381663..10381700,-p@chr19:10381663..10381700
-
Hg19::chr19:14629224..14629262,-p2@DNAJB1
Hg19::chr19:42772659..42772716,+p@chr19:42772659..42772716
+
Hg19::chr19:909481..909504,+p@chr19:909481..909504
+
Hg19::chr1:153895251..153895342,-p2@GATAD2B
Hg19::chr1:212459184..212459282,+p3@PPP2R5A
Hg19::chr1:235491168..235491187,-p3@ARID4B
Hg19::chr1:25573937..25573953,-p1@C1orf63
Hg19::chr1:38019843..38019859,-p2@SNIP1
Hg19::chr1:65432171..65432252,-p1@JAK1
Hg19::chr20:34359708..34359736,-p@chr20:34359708..34359736
-
Hg19::chr20:42839378..42839477,-p1@C20orf111
Hg19::chr20:43595119..43595220,+p1@STK4
Hg19::chr20:47835996..47836021,+p3@DDX27
Hg19::chr20:5591546..5591563,-p3@GPCPD1
Hg19::chr20:57227361..57227387,-p@chr20:57227361..57227387
-
Hg19::chr21:42734309..42734343,-p@chr21:42734309..42734343
-
Hg19::chr21:45432174..45432254,+p1@TRAPPC10
Hg19::chr22:39097167..39097175,+p@chr22:39097167..39097175
+
Hg19::chr22:41488590..41488631,+p2@EP300
Hg19::chr22:42177091..42177105,-p@chr22:42177091..42177105
-
Hg19::chr22:42177363..42177403,+p1@MEI1
Hg19::chr2:136875712..136875725,-p1@CXCR4
Hg19::chr2:158296532..158296549,-p@chr2:158296532..158296549
-
Hg19::chr2:158300556..158300612,-p1@CYTIP
Hg19::chr2:174828545..174828644,-p1@SP3
Hg19::chr2:197036269..197036287,-p2@STK17B
Hg19::chr2:197036289..197036314,-p1@STK17B
Hg19::chr2:197076072..197076125,-p@chr2:197076072..197076125
-
Hg19::chr2:198318223..198318283,+p1@COQ10B
Hg19::chr2:201980867..201980923,+p1@CFLAR
Hg19::chr2:28974354..28974386,-p@chr2:28974354..28974386
-
Hg19::chr2:30369807..30369847,+p2@YPEL5
Hg19::chr2:70313796..70313812,-p8@PCBP1-AS1
Hg19::chr3:12705793..12705819,+p@chr3:12705793..12705819
+
Hg19::chr3:16926464..16926475,+p5@PLCL2
Hg19::chr3:169491091..169491164,-p@chr3:169491091..169491164
-
Hg19::chr3:195270131..195270160,-p1@PPP1R2
Hg19::chr3:43328024..43328095,+p1@SNRK
Hg19::chr3:63898321..63898396,+p3@ATXN7
Hg19::chr4:153457197..153457268,-p@chr4:153457197..153457268
-
Hg19::chr4:38665659..38665670,+p6@KLF3
Hg19::chr4:38665703..38665713,+p5@KLF3
Hg19::chr4:38665769..38665801,+p2@KLF3
Hg19::chr4:38665810..38665827,+p1@KLF3
Hg19::chr4:77997242..77997264,+p@chr4:77997242..77997264
+
Hg19::chr5:108745515..108745519,-p7@PJA2
Hg19::chr5:130599735..130599802,+p1@CDC42SE2
Hg19::chr5:171601789..171601804,-p@chr5:171601789..171601804
-
Hg19::chr5:172197625..172197630,+p@chr5:172197625..172197630
+
Hg19::chr5:75698832..75698887,+p4@IQGAP2
Hg19::chr6:15249128..15249177,+p4@JARID2
Hg19::chr6:159466136..159466147,-p5@TAGAP
Hg19::chr6:17706978..17707056,-p2@NUP153
Hg19::chr6:42750780..42750792,+p1@FLJ38717
Hg19::chr7:130791019..130791085,+p@chr7:130791019..130791085
+
Hg19::chr7:32931196..32931212,-p2@KBTBD2
Hg19::chr7:44613636..44613679,+p@chr7:44613636..44613679
+
Hg19::chr7:99097863..99097936,-p1@ZNF394
Hg19::chr8:125487084..125487163,+p1@RNF139
Hg19::chr8:23315131..23315183,-p1@ENTPD4
Hg19::chr8:42010083..42010104,-p2@LOC728445
Hg19::chr8:67579374..67579416,-p3@VCPIP1
Hg19::chr9:117147885..117147913,+p@chr9:117147885..117147913
+
Hg19::chrX:40945032..40945116,+p2@USP9X
Hg19::chrX:44732481..44732492,+p4@KDM6A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0043231intracellular membrane-bound organelle2.00929791310734e-05
GO:0043227membrane-bound organelle2.00929791310734e-05
GO:0044424intracellular part2.00929791310734e-05
GO:0005634nucleus2.23850107378566e-05
GO:0050789regulation of biological process2.36490426387637e-05
GO:0050794regulation of cellular process2.36490426387637e-05
GO:0005622intracellular4.0132310206678e-05
GO:0005515protein binding6.14241783218931e-05
GO:0043229intracellular organelle6.14241783218931e-05
GO:0043226organelle6.14241783218931e-05
GO:0065007biological regulation0.000114041797104917
GO:0008219cell death0.000114041797104917
GO:0016265death0.000114041797104917
GO:0043283biopolymer metabolic process0.000200635873300654
GO:0007243protein kinase cascade0.00039507661929914
GO:0006915apoptosis0.000544550867032678
GO:0012501programmed cell death0.000544550867032678
GO:0048468cell development0.00100894717394533
GO:0043170macromolecule metabolic process0.0016171534722155
GO:0007165signal transduction0.00163563275083118
GO:0006512ubiquitin cycle0.00233480609996001
GO:0048869cellular developmental process0.0025960305645621
GO:0030154cell differentiation0.0025960305645621
GO:0044238primary metabolic process0.0025960305645621
GO:0043687post-translational protein modification0.0029134465650679
GO:0007242intracellular signaling cascade0.00462050747171611
GO:0007154cell communication0.00505811137582919
GO:0008134transcription factor binding0.00553116473850967
GO:0006355regulation of transcription, DNA-dependent0.00593178786824636
GO:0044237cellular metabolic process0.00593178786824636
GO:0043065positive regulation of apoptosis0.00661195532487194
GO:0006351transcription, DNA-dependent0.00661195532487194
GO:0032774RNA biosynthetic process0.00661195532487194
GO:0043068positive regulation of programmed cell death0.00661195532487194
GO:0006350transcription0.00702630858840345
GO:0010468regulation of gene expression0.00767206357890407
GO:0046966thyroid hormone receptor binding0.00809067641426571
GO:0018193peptidyl-amino acid modification0.00874997488750814
GO:0006464protein modification process0.00970417535690027
GO:0045449regulation of transcription0.00978470602682331
GO:0031323regulation of cellular metabolic process0.00978470602682331
GO:0016563transcription activator activity0.0105269427212639
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.01070744314417
GO:0043412biopolymer modification0.0120346947535803
GO:0032502developmental process0.0140057100823751
GO:0001667ameboidal cell migration0.0145462930256289
GO:0046048UDP metabolic process0.0145462930256289
GO:0009195pyrimidine ribonucleoside diphosphate catabolic process0.0145462930256289
GO:0009140pyrimidine nucleoside diphosphate catabolic process0.0145462930256289
GO:0009222pyrimidine ribonucleotide catabolic process0.0145462930256289
GO:0009193pyrimidine ribonucleoside diphosphate metabolic process0.0145462930256289
GO:0006256UDP catabolic process0.0145462930256289
GO:0045134uridine-diphosphatase activity0.0145462930256289
GO:0032027myosin light chain binding0.0145462930256289
GO:0019222regulation of metabolic process0.0153136016538708
GO:0016070RNA metabolic process0.0153136016538708
GO:0048522positive regulation of cellular process0.0160668303072055
GO:0001666response to hypoxia0.0190343299892699
GO:0003713transcription coactivator activity0.0197477665414595
GO:0035257nuclear hormone receptor binding0.0241535730739225
GO:0044464cell part0.0241535730739225
GO:0051427hormone receptor binding0.0241535730739225
GO:0048518positive regulation of biological process0.0241535730739225
GO:0042975peroxisome proliferator activated receptor binding0.0241535730739225
GO:0009191ribonucleoside diphosphate catabolic process0.0241535730739225
GO:0006917induction of apoptosis0.0251404959497479
GO:0012502induction of programmed cell death0.0251404959497479
GO:0018076N-terminal peptidyl-lysine acetylation0.0326867856542673
GO:0006244pyrimidine nucleotide catabolic process0.0326867856542673
GO:0047756chondroitin 4-sulfotransferase activity0.0326867856542673
GO:0018394peptidyl-lysine acetylation0.0326867856542673
GO:0009134nucleoside diphosphate catabolic process0.0326867856542673
GO:0044260cellular macromolecule metabolic process0.0406855338775701
GO:0019888protein phosphatase regulator activity0.0406855338775701
GO:0009185ribonucleoside diphosphate metabolic process0.041023657906431
GO:0005131growth hormone receptor binding0.041023657906431
GO:0019208phosphatase regulator activity0.041023657906431
GO:0005737cytoplasm0.0477724148508908
GO:0017110nucleoside-diphosphatase activity0.0477724148508908
GO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity0.0477724148508908
GO:0008045motor axon guidance0.0477724148508908
GO:0004718Janus kinase activity0.0477724148508908
GO:0042981regulation of apoptosis0.048462135687202
GO:0043067regulation of programmed cell death0.0496535213762199



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.84e-56140
hematopoietic stem cell5.28e-53172
angioblastic mesenchymal cell5.28e-53172
hematopoietic oligopotent progenitor cell6.94e-49165
hematopoietic multipotent progenitor cell6.94e-49165
hematopoietic cell5.64e-47182
hematopoietic lineage restricted progenitor cell1.45e-46124
nongranular leukocyte2.39e-44119
myeloid leukocyte7.50e-2976
myeloid cell5.17e-27112
common myeloid progenitor5.17e-27112
granulocyte monocyte progenitor cell5.74e-2571
myeloid lineage restricted progenitor cell2.20e-2470
CD14-positive, CD16-negative classical monocyte5.39e-2342
macrophage dendritic cell progenitor1.71e-2265
monopoietic cell1.30e-2163
monocyte1.30e-2163
monoblast1.30e-2163
promonocyte1.30e-2163
classical monocyte8.64e-2145
lymphoid lineage restricted progenitor cell5.61e-2052
lymphocyte6.70e-2053
common lymphoid progenitor6.70e-2053
T cell1.62e-1125
pro-T cell1.62e-1125
mature alpha-beta T cell3.70e-1118
alpha-beta T cell3.70e-1118
immature T cell3.70e-1118
mature T cell3.70e-1118
immature alpha-beta T cell3.70e-1118
mesenchymal cell3.92e-08358
lymphocyte of B lineage5.25e-0824
pro-B cell5.25e-0824
CD8-positive, alpha-beta T cell4.90e-0711
connective tissue cell6.24e-07365
granulocyte8.21e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system9.71e-31102
blood island9.71e-31102
hemolymphoid system1.70e-27112
bone marrow4.91e-2180
adult organism5.52e-21115
bone element2.73e-1986
immune system6.86e-15115
skeletal element3.98e-14101
skeletal system3.98e-14101
blood3.19e-0815
haemolymphatic fluid3.19e-0815
organism substance3.19e-0815


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.

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