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Coexpression cluster:C1876

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Full id: C1876_neuroectodermal_breast_Hepatic_acute_left_Endothelial_spleen



Phase1 CAGE Peaks

Hg19::chr21:27945275..27945302,-p5@CYYR1
Hg19::chr21:27945464..27945495,-p4@CYYR1
Hg19::chr21:27945502..27945527,-p3@CYYR1
Hg19::chr21:27945531..27945559,-p2@CYYR1
Hg19::chr21:27945562..27945618,-p1@CYYR1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.55e-37115
ectoderm3.97e-23173
presumptive ectoderm3.97e-23173
neurectoderm1.27e-2190
ectoderm-derived structure2.21e-21169
neural plate1.04e-1986
presumptive neural plate1.04e-1986
multi-cellular organism7.90e-18659
anterior region of body1.33e-17129
craniocervical region1.33e-17129
neural tube4.64e-1757
neural rod4.64e-1757
future spinal cord4.64e-1757
neural keel4.64e-1757
head5.75e-17123
embryo2.83e-16612
regional part of nervous system3.33e-1694
nervous system3.33e-1694
pre-chordal neural plate1.67e-1561
central nervous system2.58e-1582
regional part of brain1.46e-1459
cell layer2.85e-14312
epithelium6.67e-14309
embryonic structure1.15e-13605
developing anatomical structure1.15e-13605
anatomical system1.75e-13625
anatomical group2.77e-13626
germ layer3.02e-13604
embryonic tissue3.02e-13604
presumptive structure3.02e-13604
epiblast (generic)3.02e-13604
anatomical conduit3.07e-13241
anterior neural tube5.20e-1342
anatomical cluster1.08e-12286
regional part of forebrain2.32e-1241
forebrain2.32e-1241
future forebrain2.32e-1241
organ part2.80e-11219
brain4.88e-1169
future brain4.88e-1169
gray matter1.62e-1034
brain grey matter1.62e-1034
telencephalon1.93e-1034
regional part of telencephalon3.31e-1033
multi-tissue structure4.40e-10347
tube6.84e-10194
cerebral hemisphere8.65e-1032
endothelium9.80e-0918
blood vessel endothelium9.80e-0918
cardiovascular system endothelium9.80e-0918
cerebral cortex2.81e-0825
pallium2.81e-0825
organism subdivision4.84e-08365
regional part of cerebral cortex2.91e-0722
neocortex9.53e-0720


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.