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Coexpression cluster:C2094

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Full id: C2094_Fibroblast_Mesenchymal_neuroectodermal_Hep2_smooth_Smooth_left



Phase1 CAGE Peaks

Hg19::chr11:111685355..111685370,-p5@ALG9
Hg19::chr11:111685389..111685410,-p7@ALG9
Hg19::chr11:111685420..111685437,-p6@ALG9
Hg19::chr11:111685458..111685469,-p9@ALG9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.45e-42115
regional part of brain6.61e-3059
neural tube1.10e-2757
neural rod1.10e-2757
future spinal cord1.10e-2757
neural keel1.10e-2757
brain1.94e-2569
future brain1.94e-2569
central nervous system3.01e-2482
regional part of forebrain4.24e-2441
forebrain4.24e-2441
future forebrain4.24e-2441
neurectoderm1.04e-2390
anterior neural tube3.48e-2342
neural plate4.20e-2386
presumptive neural plate4.20e-2386
regional part of nervous system1.31e-2194
nervous system1.31e-2194
gray matter6.81e-2034
brain grey matter6.81e-2034
multi-tissue structure3.23e-19347
telencephalon4.47e-1934
regional part of telencephalon1.64e-1833
anatomical cluster1.96e-18286
head2.77e-18123
anterior region of body3.45e-18129
craniocervical region3.45e-18129
cerebral hemisphere4.89e-1832
pre-chordal neural plate1.29e-1761
ectoderm7.86e-17173
presumptive ectoderm7.86e-17173
ectoderm-derived structure3.60e-16169
regional part of cerebral cortex9.82e-1522
neocortex3.38e-1320
cerebral cortex4.21e-1325
pallium4.21e-1325
organism subdivision4.14e-12365
larynx9.98e-119
organ1.90e-10511
anatomical conduit2.89e-10241
organ part3.31e-10219
multi-cellular organism2.09e-09659
tube2.11e-09194
nucleus of brain1.44e-089
neural nucleus1.44e-089
basal ganglion1.78e-089
nuclear complex of neuraxis1.78e-089
aggregate regional part of brain1.78e-089
collection of basal ganglia1.78e-089
cerebral subcortex1.78e-089
cell layer1.84e-08312
embryonic structure3.47e-08605
developing anatomical structure3.47e-08605
embryo3.61e-08612
germ layer6.34e-08604
embryonic tissue6.34e-08604
presumptive structure6.34e-08604
epiblast (generic)6.34e-08604
epithelium1.17e-07309
temporal lobe4.44e-077
anatomical system6.11e-07625
telencephalic nucleus6.59e-077
anatomical group7.49e-07626


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA1#2623413.56030814380042.95627390049268e-050.000613086358009441



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.