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Coexpression cluster:C265

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Full id: C265_CD4_Eosinophils_CD14_Natural_CD19_Basophils_CD8



Phase1 CAGE Peaks

Hg19::chr10:1094998..1095041,+p1@uc001igd.2
Hg19::chr10:27443390..27443429,+p2@MASTL
Hg19::chr10:35416125..35416138,+p10@CREM
Hg19::chr10:52384324..52384340,-p@chr10:52384324..52384340
-
Hg19::chr11:102217835..102217893,-p@chr11:102217835..102217893
-
Hg19::chr11:506455..506475,+p1@AK095144
Hg19::chr11:58345569..58345646,-p2@LPXN
Hg19::chr11:6633553..6633568,+p@chr11:6633553..6633568
+
Hg19::chr12:12714174..12714202,+p@chr12:12714174..12714202
+
Hg19::chr12:22697211..22697230,+p@chr12:22697211..22697230
+
Hg19::chr12:25539120..25539152,-p@chr12:25539120..25539152
-
Hg19::chr12:92270935..92270983,-p@chr12:92270935..92270983
-
Hg19::chr13:22178048..22178078,+p@chr13:22178048..22178078
+
Hg19::chr13:50699797..50699825,+p1@FLJ31945
Hg19::chr13:52377944..52378010,+p1@ENST00000456688
Hg19::chr13:52378231..52378277,-p2@DHRS12
Hg19::chr13:52378340..52378382,+p2@ENST00000456688
Hg19::chr14:64970670..64970712,-p3@ZBTB25
Hg19::chr14:78227105..78227137,+p2@C14orf178
Hg19::chr14:81685812..81685827,+p@chr14:81685812..81685827
+
Hg19::chr15:31620147..31620158,-p@chr15:31620147..31620158
-
Hg19::chr15:31620170..31620188,-p@chr15:31620170..31620188
-
Hg19::chr15:45492834..45492856,+p@chr15:45492834..45492856
+
Hg19::chr15:72766533..72766572,-p@chr15:72766533..72766572
-
Hg19::chr18:11908408..11908445,+p@chr18:11908408..11908445
+
Hg19::chr1:174968752..174968799,-p1@BC038430
Hg19::chr1:179851611..179851688,-p1@BC069736
Hg19::chr1:62901922..62901944,-p@chr1:62901922..62901944
-
Hg19::chr22:42228870..42228891,-p@chr22:42228870..42228891
-
Hg19::chr22:42228898..42228928,-p@chr22:42228898..42228928
-
Hg19::chr2:157198383..157198413,+p@chr2:157198383..157198413
+
Hg19::chr2:235355325..235355351,+p@chr2:235355325..235355351
+
Hg19::chr2:235355717..235355722,+p@chr2:235355717..235355722
+
Hg19::chr2:61698499..61698527,+p@chr2:61698499..61698527
+
Hg19::chr2:85555169..85555184,+p@chr2:85555169..85555184
+
Hg19::chr3:142297846..142297858,+p@chr3:142297846..142297858
+
Hg19::chr4:4250016..4250052,+p@chr4:4250016..4250052
+
Hg19::chr5:98265404..98265448,-p@chr5:98265404..98265448
-
Hg19::chr6:158245076..158245129,-p@chr6:158245076..158245129
-
Hg19::chr7:139875446..139875459,+p@chr7:139875446..139875459
+
Hg19::chr7:158622384..158622412,+p@chr7:158622384..158622412
+
Hg19::chr7:158622429..158622444,+p@chr7:158622429..158622444
+
Hg19::chr7:17980172..17980237,+p1@AK096065
Hg19::chr7:44646370..44646405,-p@chr7:44646370..44646405
-
Hg19::chr8:123794727..123794742,-p@chr8:123794727..123794742
-
Hg19::chr9:132175926..132175968,-p@chr9:132175926..132175968
-
Hg19::chr9:6757547..6757566,-p@chr9:6757547..6757566
-
Hg19::chr9:6757859..6757874,-p@chr9:6757859..6757874
-
Hg19::chrX:123094129..123094146,-p@chrX:123094129..123094146
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0032311angiogenin-PRI complex0.0259579720862203
GO:0008428ribonuclease inhibitor activity0.0259579720862203
GO:0008140cAMP response element binding protein binding0.0259579720862203



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.26e-48140
hematopoietic stem cell4.32e-42172
angioblastic mesenchymal cell4.32e-42172
hematopoietic cell2.79e-40182
hematopoietic lineage restricted progenitor cell3.88e-40124
hematopoietic oligopotent progenitor cell2.21e-38165
hematopoietic multipotent progenitor cell2.21e-38165
nongranular leukocyte3.04e-38119
CD14-positive, CD16-negative classical monocyte9.57e-2442
myeloid leukocyte1.02e-2276
classical monocyte1.91e-2245
granulocyte monocyte progenitor cell7.26e-2071
lymphocyte1.71e-1953
common lymphoid progenitor1.71e-1953
lymphoid lineage restricted progenitor cell2.25e-1952
myeloid lineage restricted progenitor cell4.30e-1970
myeloid cell1.29e-18112
common myeloid progenitor1.29e-18112
macrophage dendritic cell progenitor9.86e-1865
monopoietic cell8.74e-1763
monocyte8.74e-1763
monoblast8.74e-1763
promonocyte8.74e-1763
mature alpha-beta T cell1.01e-1018
alpha-beta T cell1.01e-1018
immature T cell1.01e-1018
mature T cell1.01e-1018
immature alpha-beta T cell1.01e-1018
T cell7.21e-1025
pro-T cell7.21e-1025
lymphocyte of B lineage5.97e-0924
pro-B cell5.97e-0924
B cell1.25e-0714
CD8-positive, alpha-beta T cell7.13e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.45e-24102
blood island1.45e-24102
hemolymphoid system1.55e-23112
bone marrow8.25e-1880
bone element8.70e-1686
immune system1.73e-14115
adult organism3.45e-12115
skeletal element1.98e-10101
skeletal system1.98e-10101
neural tube1.49e-0857
neural rod1.49e-0857
future spinal cord1.49e-0857
neural keel1.49e-0857


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467125.501185598206221.18585786823215e-064.82845262769193e-05
BCLAF1#977493.977016907981560.0003643466253222930.0036368151774859
BHLHE40#855376.410259078139630.0001027616377835390.00143710801934589
BRCA1#672114.531153817866562.21715017652059e-050.000485444333932146
CCNT2#905314.008617324200858.06396210264447e-141.2760486939971e-11
CEBPB#1051172.765500196714735.58404995787418e-050.000943066936530435
CHD2#1106173.588742615918091.73006809458607e-066.52298128990884e-05
CTBP2#148845.119755129741070.007730253402104120.0318163521206838
CTCF#10664222.406645718523482.31179848306162e-050.000504686291330418
CTCFL#14069072.820924908424910.01128838175918480.0414188906178857
E2F1#1869404.006032012146396.40540940858776e-201.61198687523734e-17
E2F4#1874194.912105020212332.03255772399953e-091.75147109023751e-07
E2F6#1876383.890855465397976.46745685155434e-181.41902253386446e-15
EBF1#1879132.362940183783610.002362508301357790.013389299136396
EGR1#1958303.053987200904173.6253968623884e-103.62675117730826e-08
ELF1#1997342.954598583662371.31063476127527e-111.62181734399085e-09
ELK4#2005144.638766188133729.66692069300339e-074.1074187561293e-05
EP300#2033162.211899339174920.001292432116283410.00866202385885408
ETS1#2113173.37528440158044.01365311537851e-060.00012965725880514
FOSL2#2355144.837200172731915.86191261122966e-072.69697044583355e-05
FOXA1#3169184.070725622223231.14729927301646e-076.65312541779932e-06
FOXA2#3170115.529287781210573.41569904988976e-060.000113935545535432
GABPB1#2553223.173245804000162.05522055036064e-071.1035741853939e-05
GATA1#2623133.597632772845023.96023418025606e-050.000738444737639283
GTF2B#295974.563404276332030.0007956398411549630.00614614122562006
GTF2F1#2962174.419882344997559.05083970660663e-085.34649687849711e-06
HDAC2#3066102.737881680944130.002921782723990410.0157854257881555
HEY1#23462423.462952322662044.1603653191097e-199.89759438638948e-17
HMGN3#9324254.172728430280914.78373384157692e-115.40701708528628e-09
HSF1#3297310.0586122448980.003363998340704770.0173489024099978
IRF1#3659243.740651634398651.42394454138473e-091.274338851394e-07
IRF4#366273.130644669534880.006552629287133130.0280092518364055
JUN#3725143.575094054953241.97220037995901e-050.000441437281359921
JUNB#372695.622361100783472.64819100181548e-050.00057037413907735
JUND#3727263.711454336502992.10546935672642e-102.17071188694127e-08
MAX#4149263.423804963962961.26089494517609e-091.14510093199344e-07
MEF2A#4205103.825149165233480.0002242269747414780.00248493644047381
MEF2C#420875.901622070374860.0001708064118275540.00208349110544942
MXI1#4601153.049460702681425.93528028297096e-050.00098034910244062
MYC#4609343.623624155810612.79903604832913e-144.65491283202939e-12
NANOG#7992363.58099328338930.006328612505674530.0275581204753228
NFKB1#4790333.696042714252995.87975187250173e-149.49111910065236e-12
NFYA#480093.384290332621930.001156364207900260.00790686928826079
NFYB#480182.736292776087580.008033446840236980.032209964471265
NR3C1#2908103.055719047178170.00129579623688420.0086834560913666
NRF1#4899153.737840647258445.27766341971107e-060.0001614037744923
PAX5#5079233.130612392185511.1632558148794e-076.7419130993446e-06
PBX3#509083.577879622325570.001580934995527690.00996386880682615
POLR2A#5430482.103627601526273.09308838190185e-155.56005262508515e-13
POU2F2#5452305.575177994536243.65022295288725e-177.5341034580354e-15
REST#5978203.938787231072662.84928677417381e-081.94113934382217e-06
RFX5#5993204.917514623344946.2442975793816e-105.97205306678604e-08
SETDB1#986975.760003739715780.0001980787664131720.00237947415291296
SIN3A#25942343.753103687994189.5353800974906e-151.65426173090004e-12
SMARCB1#6598145.215061651759262.36554145992893e-071.24273030449456e-05
SMC3#9126103.070394458149560.001249739927546650.00840177587982265
SP1#6667242.791043940313914.64982889759276e-072.2003782520874e-05
SPI1#6688172.846397951936463.85539760633801e-050.000724718989575837
SREBF1#672054.796515249029420.003811381661291130.0188242168411796
SREBF2#6721326.75162831089880.0002027855095931740.00240831428660467
SRF#6722123.378900798898240.0001525884296881570.00194580989111128
STAT1#677272.958083928171310.008831209132892060.0335329085849887
TAF1#6872443.001919113730472.90003442941987e-186.51347732847703e-16
TAF7#6879225.13321483486382.45701050058341e-112.90938457676226e-09
TBP#6908413.101583636141871.81894286409033e-163.60471677007077e-14
TCF7L2#6934163.516792347146895.07044190547414e-060.000156440733283845
TFAP2A#7020113.708264859254990.0001353300496605910.00177292210944587
TFAP2C#7022153.308947533630682.28581321579838e-050.00049911780565496
THAP1#5514563.841119747287920.004524196548603040.0213879487298367
TRIM28#10155124.552781643737768.28679503509411e-060.000229080091760242
USF1#7391222.856183348950511.30558131929861e-065.18454781012274e-05
USF2#7392174.507497051962926.80931366643833e-084.13945232834199e-06
WRNIP1#5689748.964895048928660.001047707838144140.00740585847092626
YY1#7528333.307523158064841.53068063760009e-122.11179333038726e-10
ZBTB33#1000963.877313268977280.004323673954582750.0205254629155758
ZBTB7A#51341233.450896205737671.84164723609789e-081.32283215743348e-06
ZEB1#6935103.446618779090580.0005132235236031470.00444780944167198
ZNF143#770292.479752836123490.009132338096998520.0345469522787753
ZNF263#10127152.516890297044080.0005043696059751260.00444372003361196



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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