MCL coexpression mm9:81
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0003735 | structural constituent of ribosome | 1.68709826044685e-16 |
| GO:0005840 | ribosome | 1.68709826044685e-16 |
| GO:0006412 | translation | 7.53213649444514e-14 |
| GO:0030529 | ribonucleoprotein complex | 5.60202646732735e-12 |
| GO:0009059 | macromolecule biosynthetic process | 5.82599771196891e-12 |
| GO:0044249 | cellular biosynthetic process | 1.22556080151665e-10 |
| GO:0009058 | biosynthetic process | 3.61849484968386e-09 |
| GO:0032991 | macromolecular complex | 5.29861511206671e-09 |
| GO:0044267 | cellular protein metabolic process | 2.06866238834972e-07 |
| GO:0044260 | cellular macromolecule metabolic process | 2.29040418915371e-07 |
| GO:0019538 | protein metabolic process | 2.92839328884756e-07 |
| GO:0043232 | intracellular non-membrane-bound organelle | 6.23995002846423e-07 |
| GO:0043228 | non-membrane-bound organelle | 6.23995002846423e-07 |
| GO:0044444 | cytoplasmic part | 1.1078293146103e-06 |
| GO:0033279 | ribosomal subunit | 6.96199056526569e-06 |
| GO:0010467 | gene expression | 2.28080486478423e-05 |
| GO:0019843 | rRNA binding | 2.28080486478423e-05 |
| GO:0044445 | cytosolic part | 3.10537298367029e-05 |
| GO:0015935 | small ribosomal subunit | 4.65684013540712e-05 |
| GO:0005737 | cytoplasm | 6.79317585104317e-05 |
| GO:0005830 | cytosolic ribosome (sensu Eukaryota) | 0.000177379526168898 |
| GO:0043170 | macromolecule metabolic process | 0.000622853057704488 |
| GO:0005843 | cytosolic small ribosomal subunit (sensu Eukaryota) | 0.000935290174700948 |
| GO:0005829 | cytosol | 0.00339831371243851 |
| GO:0044424 | intracellular part | 0.00339831371243851 |
| GO:0044238 | primary metabolic process | 0.00502003776117627 |
| GO:0044237 | cellular metabolic process | 0.00510549783614348 |
| GO:0005622 | intracellular | 0.00524475172124167 |
| GO:0006414 | translational elongation | 0.00827087314633101 |
| GO:0043284 | biopolymer biosynthetic process | 0.0158794550471434 |
| GO:0043229 | intracellular organelle | 0.0241137530171598 |
| GO:0043226 | organelle | 0.0241137530171598 |
| GO:0043234 | protein complex | 0.0241137530171598 |
| GO:0048875 | chemical homeostasis within a tissue | 0.0241137530171598 |
| GO:0042719 | mitochondrial intermembrane space protein transporter complex | 0.0241137530171598 |
| GO:0007007 | inner mitochondrial membrane organization and biogenesis | 0.0241137530171598 |
| GO:0045039 | protein import into mitochondrial inner membrane | 0.0241137530171598 |
| GO:0001938 | positive regulation of endothelial cell proliferation | 0.0241137530171598 |
| GO:0043129 | surfactant homeostasis | 0.0241137530171598 |
| GO:0043681 | protein import into mitochondrion | 0.0241137530171598 |
| GO:0005853 | eukaryotic translation elongation factor 1 complex | 0.0293925209401559 |
| GO:0001936 | regulation of endothelial cell proliferation | 0.0344142695780648 |
| GO:0042254 | ribosome biogenesis and assembly | 0.0383060962032322 |
| GO:0006626 | protein targeting to mitochondrion | 0.0383060962032322 |
| GO:0001935 | endothelial cell proliferation | 0.0427844513644846 |
| GO:0010464 | regulation of mesenchymal cell proliferation | 0.0432979155665769 |
| GO:0005842 | cytosolic large ribosomal subunit (sensu Eukaryota) | 0.0432979155665769 |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | 0.0432979155665769 |
| GO:0010463 | mesenchymal cell proliferation | 0.0432979155665769 |
| GO:0016272 | prefoldin complex | 0.0432979155665769 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| connective tissue | 3.60e-16 | 46 |
| hemolymphoid system | 2.54e-11 | 48 |
| immune system | 2.54e-11 | 48 |
| hematopoietic system | 2.14e-10 | 45 |
| blood island | 2.14e-10 | 45 |
| unilaminar epithelium | 5.50e-07 | 66 |
| mucosa | 8.81e-07 | 15 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
