MCL coexpression mm9:123
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0003676 | nucleic acid binding | 6.04249900836944e-05 |
| GO:0016070 | RNA metabolic process | 0.000144609430801015 |
| GO:0043283 | biopolymer metabolic process | 0.000144609430801015 |
| GO:0050789 | regulation of biological process | 0.000144609430801015 |
| GO:0043170 | macromolecule metabolic process | 0.000147915531054353 |
| GO:0019222 | regulation of metabolic process | 0.000214075200626794 |
| GO:0050794 | regulation of cellular process | 0.000319364604303831 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000418549991844582 |
| GO:0031323 | regulation of cellular metabolic process | 0.00044431535329671 |
| GO:0003677 | DNA binding | 0.00044431535329671 |
| GO:0065007 | biological regulation | 0.000549174522709008 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000564970487741933 |
| GO:0005634 | nucleus | 0.000740222579883123 |
| GO:0010468 | regulation of gene expression | 0.000844361037870367 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.00107438648694831 |
| GO:0006351 | transcription, DNA-dependent | 0.00111405541609713 |
| GO:0032774 | RNA biosynthetic process | 0.00111405541609713 |
| GO:0010467 | gene expression | 0.00120754781530943 |
| GO:0045449 | regulation of transcription | 0.00135665362047548 |
| GO:0044238 | primary metabolic process | 0.00152869350552634 |
| GO:0006350 | transcription | 0.00176016174777587 |
| GO:0003700 | transcription factor activity | 0.00185708016705504 |
| GO:0044237 | cellular metabolic process | 0.00552146585177274 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 0.0414713688806204 |
| GO:0050776 | regulation of immune response | 0.0449529524925541 |
| GO:0002682 | regulation of immune system process | 0.0449529524925541 |
| GO:0021542 | dentate gyrus development | 0.0449529524925541 |
| GO:0030338 | CMP-N-acetylneuraminate monooxygenase activity | 0.0449529524925541 |
| GO:0005521 | lamin binding | 0.0449529524925541 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.0449529524925541 |
| GO:0001756 | somitogenesis | 0.0449529524925541 |
| GO:0048518 | positive regulation of biological process | 0.0449529524925541 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0449529524925541 |
| GO:0043227 | membrane-bound organelle | 0.0449529524925541 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 0.0449904172636834 |
| GO:0002757 | immune response-activating signal transduction | 0.0489777847153195 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| lymphoid lineage restricted progenitor cell | 2.70e-11 | 12 |
| hematopoietic cell | 1.34e-10 | 32 |
| hematopoietic oligopotent progenitor cell | 1.34e-10 | 32 |
| hematopoietic stem cell | 1.34e-10 | 32 |
| angioblastic mesenchymal cell | 1.34e-10 | 32 |
| hematopoietic multipotent progenitor cell | 1.34e-10 | 32 |
| T cell | 2.03e-10 | 11 |
| pro-T cell | 2.03e-10 | 11 |
| lymphocyte | 4.40e-10 | 13 |
| common lymphoid progenitor | 4.40e-10 | 13 |
| hematopoietic lineage restricted progenitor cell | 2.49e-09 | 25 |
| mature alpha-beta T cell | 5.39e-09 | 9 |
| alpha-beta T cell | 5.39e-09 | 9 |
| immature T cell | 5.39e-09 | 9 |
| mature T cell | 5.39e-09 | 9 |
| immature alpha-beta T cell | 5.39e-09 | 9 |
| CD4-positive, alpha-beta T cell | 5.52e-08 | 8 |
| nucleate cell | 2.14e-07 | 16 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
