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MCL coexpression mm9:464

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:83222718..83222791,+p2@Rasl10b
Mm9::chr13:96727565..96727567,-p@chr13:96727565..96727567
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Mm9::chr13:96902476..96902485,-p5@Sv2c
Mm9::chr13:96902498..96902522,-p2@Sv2c
Mm9::chr13:96902523..96902583,-p1@Sv2c
Mm9::chr13:96902624..96902642,-p3@Sv2c
Mm9::chr13:96902655..96902666,-p4@Sv2c
Mm9::chr14:33274087..33274102,-p1@Chat
Mm9::chr14:68701910..68701927,+p1@Nefl
Mm9::chr1:136543278..136543288,+p5@Syt2
Mm9::chr1:33964526..33964536,-p5@Bend6
Mm9::chr4:119165152..119165166,-p2@Rimkla
Mm9::chr5:125342609..125342620,-p9@Ccdc92
Mm9::chr5:23929310..23929319,-p3@Cdk5
Mm9::chr8:107995347..107995358,-p3@Tppp3
Mm9::chr8:107995381..107995387,-p5@Tppp3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008021synaptic vesicle0.00973174846942184
GO:0030136clathrin-coated vesicle0.00973174846942184
GO:0005057receptor signaling protein activity0.00973174846942184
GO:0030546receptor activator activity0.00973174846942184
GO:0030549acetylcholine receptor activator activity0.00973174846942184
GO:0014012axon regeneration in the peripheral nervous system0.00973174846942184
GO:0043125ErbB-3 class receptor binding0.00973174846942184
GO:0030135coated vesicle0.00973174846942184
GO:0005176ErbB-2 class receptor binding0.0153816653953618
GO:0005068transmembrane receptor protein tyrosine kinase adaptor protein activity0.0153816653953618
GO:0031133regulation of axon diameter0.0161440679945559
GO:0045110intermediate filament bundle assembly0.0161440679945559
GO:0014044Schwann cell development0.0161440679945559
GO:0007409axonogenesis0.0161440679945559
GO:0048667neuron morphogenesis during differentiation0.0161440679945559
GO:0048812neurite morphogenesis0.0161440679945559
GO:0030548acetylcholine receptor regulator activity0.0161440679945559
GO:0000904cellular morphogenesis during differentiation0.0161440679945559
GO:0016023cytoplasmic membrane-bound vesicle0.0161440679945559
GO:0007268synaptic transmission0.0161440679945559
GO:0031988membrane-bound vesicle0.0161440679945559
GO:0031103axon regeneration0.0161440679945559
GO:0031102neurite regeneration0.0161440679945559
GO:0031175neurite development0.0161440679945559
GO:0005883neurofilament0.0177383537688552
GO:0048678response to axon injury0.0177383537688552
GO:0048666neuron development0.0178843840841467
GO:0019226transmission of nerve impulse0.0183547129593702
GO:0014037Schwann cell differentiation0.0185513690271993
GO:0030545receptor regulator activity0.0189410615211977
GO:0005066transmembrane receptor protein tyrosine kinase signaling protein activity0.0189410615211977
GO:0060053neurofilament cytoskeleton0.0189410615211977
GO:0060052neurofilament cytoskeleton organization and biogenesis0.0189410615211977
GO:0008045motor axon guidance0.0189410615211977
GO:0045109intermediate filament organization0.0189410615211977
GO:0032990cell part morphogenesis0.0189410615211977
GO:0048858cell projection morphogenesis0.0189410615211977
GO:0030030cell projection organization and biogenesis0.0189410615211977
GO:0021782glial cell development0.0192384216766405
GO:0030182neuron differentiation0.0192384216766405
GO:0031099regeneration0.0192384216766405
GO:0042246tissue regeneration0.0192384216766405
GO:0043113receptor clustering0.0192384216766405
GO:0031410cytoplasmic vesicle0.0192384216766405
GO:0031982vesicle0.0196092906005297
GO:0050772positive regulation of axonogenesis0.0196092906005297
GO:0060078regulation of postsynaptic membrane potential0.0196092906005297
GO:0048699generation of neurons0.0199660593857038
GO:0030175filopodium0.0199660593857038
GO:0007172signal complex assembly0.0199660593857038
GO:0007267cell-cell signaling0.0207466497552354
GO:0007264small GTPase mediated signal transduction0.0213254175566963
GO:0022008neurogenesis0.0213254175566963
GO:0050769positive regulation of neurogenesis0.0213254175566963
GO:0045104intermediate filament cytoskeleton organization and biogenesis0.0235730400710741
GO:0042995cell projection0.0235730400710741
GO:0022607cellular component assembly0.0240352414148993
GO:0030054cell junction0.0247094857841336
GO:0005544calcium-dependent phospholipid binding0.0247094857841336
GO:0045103intermediate filament-based process0.0255729826199389
GO:0007422peripheral nervous system development0.0284485638868522
GO:0043524negative regulation of neuron apoptosis0.0284485638868522
GO:0043112receptor metabolic process0.0304231868708594
GO:0000902cell morphogenesis0.0319966118086197
GO:0032989cellular structure morphogenesis0.0319966118086197
GO:0050770regulation of axonogenesis0.034304754781197
GO:0004693cyclin-dependent protein kinase activity0.034304754781197
GO:0050885neuromuscular process controlling balance0.0360437513677712
GO:0043523regulation of neuron apoptosis0.037731129007329
GO:0005622intracellular0.0393759908222754
GO:0051402neuron apoptosis0.0403908683748798
GO:0010001glial cell differentiation0.0403908683748798
GO:0050877neurological system process0.0411317890707139
GO:0043623cellular protein complex assembly0.0413562758033976
GO:0042063gliogenesis0.0418192535023569
GO:0042391regulation of membrane potential0.0422697727458422
GO:0060090molecular adaptor activity0.0436955521739576
GO:0050767regulation of neurogenesis0.0441096615291231
GO:0050905neuromuscular process0.044575348617974
GO:0006836neurotransmitter transport0.044575348617974
GO:0048589developmental growth0.044575348617974
GO:0007399nervous system development0.044575348617974
GO:0003008system process0.044575348617974
GO:0030027lamellipodium0.044575348617974
GO:0030334regulation of cell migration0.046728730596565



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)5.02e-1123
neuroblast (sensu Vertebrata)5.02e-1123
neuron4.33e-1033
neuronal stem cell4.33e-1033
neuroblast4.33e-1033
electrically signaling cell4.33e-1033
ectodermal cell9.53e-0844
neurectodermal cell9.53e-0844
neural cell1.30e-0743
electrically responsive cell3.23e-0739
electrically active cell3.23e-0739

Uber Anatomy
Ontology termp-valuen
nervous system1.07e-2275
central nervous system7.97e-2273
ectoderm-derived structure3.87e-2195
ectoderm3.87e-2195
presumptive ectoderm3.87e-2195
neurectoderm1.22e-2064
neural plate1.22e-2064
presumptive neural plate1.22e-2064
regional part of nervous system4.47e-2054
neural tube1.86e-1852
neural rod1.86e-1852
future spinal cord1.86e-1852
neural keel1.86e-1852
ecto-epithelium3.62e-1773
pre-chordal neural plate9.97e-1549
gray matter2.31e-1434
brain3.03e-1447
future brain3.03e-1447
structure with developmental contribution from neural crest6.54e-1492
regional part of brain1.55e-1346
anterior neural tube1.05e-1140
regional part of forebrain5.50e-1139
forebrain5.50e-1139
future forebrain5.50e-1139
brain grey matter2.66e-1029
regional part of telencephalon2.66e-1029
telencephalon2.66e-1029
posterior neural tube4.97e-0812
chordal neural plate4.97e-0812
occipital lobe8.66e-0810
visual cortex8.66e-0810
neocortex8.66e-0810
basal ganglion2.37e-078
nuclear complex of neuraxis2.37e-078
aggregate regional part of brain2.37e-078
collection of basal ganglia2.37e-078
cerebral subcortex2.37e-078
spinal cord5.17e-076
dorsal region element5.17e-076
dorsum5.17e-076


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.15.52105
MA0004.10.221835
MA0006.10.344361
MA0007.11.13959
MA0009.10.599391
MA0014.12.56684
MA0017.10.122138
MA0019.10.434009
MA0024.12.35463
MA0025.10.819843
MA0027.12.21717
MA0028.10.112137
MA0029.10.53905
MA0030.10.545058
MA0031.10.512616
MA0038.10.33811
MA0040.10.611015
MA0041.10.166538
MA0042.10.15744
MA0043.10.689898
MA0046.10.632833
MA0048.10.420794
MA0050.10.251816
MA0051.10.345658
MA0052.10.618515
MA0055.10.0964477
MA0056.10
MA0057.12.67464
MA0058.10.152805
MA0059.10.161227
MA0060.10.485984
MA0061.10.267107
MA0063.10
MA0066.10.328887
MA0067.10.92691
MA0068.10.965504
MA0069.10.618831
MA0070.10.609808
MA0071.11.29438
MA0072.10.601934
MA0073.114.8109
MA0074.10.299171
MA0076.10.134359
MA0077.11.42301
MA0078.10.37382
MA0081.10.177433
MA0083.10.68915
MA0084.11.24749
MA0087.10.648637
MA0088.11.68962
MA0089.10
MA0090.10.570974
MA0091.10.231874
MA0092.10.196497
MA0093.10.11723
MA0095.10
MA0098.10
MA0100.10.289731
MA0101.10.167439
MA0103.10.404646
MA0105.12.75889
MA0106.10.380511
MA0107.10.125067
MA0108.21.15138
MA0109.10
MA0111.13.29239
MA0113.10.356344
MA0114.10.0762439
MA0115.10.692537
MA0116.11.15654
MA0117.10.662171
MA0119.10.502046
MA0122.10.680832
MA0124.10.875485
MA0125.10.804312
MA0130.10
MA0131.10.43
MA0132.10
MA0133.10
MA0135.10.724328
MA0136.10.315568
MA0139.10.717229
MA0140.10.788302
MA0141.12.00151
MA0142.10.499475
MA0143.10.37032
MA0144.10.268209
MA0145.10.4773
MA0146.10.673403
MA0147.11.00795
MA0148.10.23425
MA0149.10.510517
MA0062.20.0332891
MA0035.20.293466
MA0039.23.1527
MA0138.21.08375
MA0002.20.049318
MA0137.20.139909
MA0104.20.783486
MA0047.20.337465
MA0112.21.39379
MA0065.20.136177
MA0150.10.210447
MA0151.10
MA0152.10.337555
MA0153.10.740107
MA0154.10.676749
MA0155.10.54521
MA0156.10.133796
MA0157.10.47062
MA0158.10
MA0159.10.0900717
MA0160.11.23947
MA0161.10
MA0162.12.38061
MA0163.10.120454
MA0164.10.315868
MA0080.20.125629
MA0018.20.865591
MA0099.20.417463
MA0079.212.1748
MA0102.21.29919
MA0258.10.893749
MA0259.10.570812
MA0442.10
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