MCL coexpression mm9:1496
From FANTOM5_SSTAR
Phase1 CAGE Peaks
| Short description | |
|---|---|
| Mm9::chr10:126602421..126602454,+ | p3@B4galnt1 |
| Mm9::chr11:3004786..3004802,- | p@chr11:3004786..3004802 - |
| Mm9::chr16:45224438..45224459,+ | p3@Btla |
| Mm9::chr16:45224470..45224477,+ | p@chr16:45224470..45224477 + |
| Mm9::chr1:140072269..140072281,- | p7@Ptprc |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0042100 | B cell proliferation | 0.000987627375769529 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 0.000987627375769529 |
| GO:0002764 | immune response-regulating signal transduction | 0.000987627375769529 |
| GO:0042129 | regulation of T cell proliferation | 0.000987627375769529 |
| GO:0032944 | regulation of mononuclear cell proliferation | 0.000987627375769529 |
| GO:0050670 | regulation of lymphocyte proliferation | 0.000987627375769529 |
| GO:0042098 | T cell proliferation | 0.000987627375769529 |
| GO:0050863 | regulation of T cell activation | 0.00113618692507234 |
| GO:0032943 | mononuclear cell proliferation | 0.00125657145191464 |
| GO:0046651 | lymphocyte proliferation | 0.00125657145191464 |
| GO:0051249 | regulation of lymphocyte activation | 0.00130742180675326 |
| GO:0042113 | B cell activation | 0.00130742180675326 |
| GO:0050865 | regulation of cell activation | 0.00130742180675326 |
| GO:0042110 | T cell activation | 0.00229019272800312 |
| GO:0001915 | negative regulation of T cell mediated cytotoxicity | 0.00250650800414308 |
| GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity | 0.00250650800414308 |
| GO:0009897 | external side of plasma membrane | 0.00250650800414308 |
| GO:0009986 | cell surface | 0.00364831547158889 |
| GO:0046649 | lymphocyte activation | 0.00364831547158889 |
| GO:0001960 | negative regulation of cytokine and chemokine mediated signaling pathway | 0.00364831547158889 |
| GO:0046642 | negative regulation of alpha-beta T cell proliferation | 0.00364831547158889 |
| GO:0045321 | leukocyte activation | 0.00364831547158889 |
| GO:0001775 | cell activation | 0.00364831547158889 |
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | 0.00364831547158889 |
| GO:0051283 | negative regulation of sequestering of calcium ion | 0.00364831547158889 |
| GO:0001574 | ganglioside biosynthetic process | 0.00364831547158889 |
| GO:0051208 | sequestering of calcium ion | 0.00364831547158889 |
| GO:0002711 | positive regulation of T cell mediated immunity | 0.00364831547158889 |
| GO:0001959 | regulation of cytokine and chemokine mediated signaling pathway | 0.00364831547158889 |
| GO:0001914 | regulation of T cell mediated cytotoxicity | 0.00364831547158889 |
| GO:0051238 | sequestering of metal ion | 0.00364831547158889 |
| GO:0046636 | negative regulation of alpha-beta T cell activation | 0.00364831547158889 |
| GO:0051282 | regulation of sequestering of calcium ion | 0.00364831547158889 |
| GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 0.00364831547158889 |
| GO:0051209 | release of sequestered calcium ion into cytosol | 0.00364831547158889 |
| GO:0002709 | regulation of T cell mediated immunity | 0.00436526650418391 |
| GO:0001911 | negative regulation of leukocyte mediated cytotoxicity | 0.00436526650418391 |
| GO:0030259 | lipid glycosylation | 0.00436526650418391 |
| GO:0001913 | T cell mediated cytotoxicity | 0.00436526650418391 |
| GO:0051239 | regulation of multicellular organismal process | 0.00444467753486734 |
| GO:0006688 | glycosphingolipid biosynthetic process | 0.0051901239530375 |
| GO:0042127 | regulation of cell proliferation | 0.00549853888593896 |
| GO:0050853 | B cell receptor signaling pathway | 0.00692745276002293 |
| GO:0001573 | ganglioside metabolic process | 0.00724289717845153 |
| GO:0002456 | T cell mediated immunity | 0.00724289717845153 |
| GO:0030889 | negative regulation of B cell proliferation | 0.00724289717845153 |
| GO:0009247 | glycolipid biosynthetic process | 0.00724289717845153 |
| GO:0046640 | regulation of alpha-beta T cell proliferation | 0.00781524904835845 |
| GO:0051607 | defense response to virus | 0.00781524904835845 |
| GO:0019915 | sequestering of lipid | 0.00834261915458024 |
| GO:0006687 | glycosphingolipid metabolic process | 0.00834261915458024 |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 0.00866657941083101 |
| GO:0050869 | negative regulation of B cell activation | 0.00866657941083101 |
| GO:0046634 | regulation of alpha-beta T cell activation | 0.00866657941083101 |
| GO:0008283 | cell proliferation | 0.0088796772213343 |
| GO:0046633 | alpha-beta T cell proliferation | 0.0089563567987543 |
| GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 0.0089563567987543 |
| GO:0006955 | immune response | 0.00897164778533966 |
| GO:0042130 | negative regulation of T cell proliferation | 0.00981593102114039 |
| GO:0002705 | positive regulation of leukocyte mediated immunity | 0.00981593102114039 |
| GO:0051235 | maintenance of localization | 0.00981593102114039 |
| GO:0031341 | regulation of cell killing | 0.00981593102114039 |
| GO:0002708 | positive regulation of lymphocyte mediated immunity | 0.00981593102114039 |
| GO:0030148 | sphingolipid biosynthetic process | 0.00981593102114039 |
| GO:0001910 | regulation of leukocyte mediated cytotoxicity | 0.00981593102114039 |
| GO:0002699 | positive regulation of immune effector process | 0.0101572226932141 |
| GO:0006664 | glycolipid metabolic process | 0.0101572226932141 |
| GO:0007204 | elevation of cytosolic calcium ion concentration | 0.0103289666262468 |
| GO:0002703 | regulation of leukocyte mediated immunity | 0.0103289666262468 |
| GO:0002706 | regulation of lymphocyte mediated immunity | 0.0103289666262468 |
| GO:0002824 | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.010344820902777 |
| GO:0050868 | negative regulation of T cell activation | 0.010344820902777 |
| GO:0008376 | acetylgalactosaminyltransferase activity | 0.010344820902777 |
| GO:0002821 | positive regulation of adaptive immune response | 0.010344820902777 |
| GO:0002697 | regulation of immune effector process | 0.0103589893539178 |
| GO:0050672 | negative regulation of lymphocyte proliferation | 0.0103589893539178 |
| GO:0051480 | cytosolic calcium ion homeostasis | 0.0103589893539178 |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 0.0103589893539178 |
| GO:0030888 | regulation of B cell proliferation | 0.0112701985488289 |
| GO:0001909 | leukocyte mediated cytotoxicity | 0.0112701985488289 |
| GO:0001906 | cell killing | 0.0112701985488289 |
| GO:0002819 | regulation of adaptive immune response | 0.0112701985488289 |
| GO:0002822 | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | 0.0112701985488289 |
| GO:0006672 | ceramide metabolic process | 0.0115046148733659 |
| GO:0030258 | lipid modification | 0.0115046148733659 |
| GO:0030173 | integral to Golgi membrane | 0.0119416837886238 |
| GO:0046519 | sphingoid metabolic process | 0.0119416837886238 |
| GO:0031228 | intrinsic to Golgi membrane | 0.0119416837886238 |
| GO:0051250 | negative regulation of lymphocyte activation | 0.0119416837886238 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 0.0124750958328535 |
| GO:0005925 | focal adhesion | 0.0124750958328535 |
| GO:0042102 | positive regulation of T cell proliferation | 0.0124750958328535 |
| GO:0002376 | immune system process | 0.0125726643711438 |
| GO:0005924 | cell-substrate adherens junction | 0.0138679036118073 |
| GO:0046631 | alpha-beta T cell activation | 0.0138679036118073 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.0141653615311815 |
| GO:0030055 | cell-matrix junction | 0.0147069576839938 |
| GO:0030183 | B cell differentiation | 0.0147069576839938 |
| GO:0048523 | negative regulation of cellular process | 0.0147069576839938 |
| GO:0032946 | positive regulation of mononuclear cell proliferation | 0.0147069576839938 |
| GO:0002757 | immune response-activating signal transduction | 0.0147069576839938 |
| GO:0006469 | negative regulation of protein kinase activity | 0.0147069576839938 |
| GO:0033673 | negative regulation of kinase activity | 0.0147069576839938 |
| GO:0050671 | positive regulation of lymphocyte proliferation | 0.0147069576839938 |
| GO:0050864 | regulation of B cell activation | 0.0149707065010711 |
| GO:0051348 | negative regulation of transferase activity | 0.0152294350073338 |
| GO:0048519 | negative regulation of biological process | 0.0162830468959154 |
| GO:0006665 | sphingolipid metabolic process | 0.0165171969946909 |
| GO:0050870 | positive regulation of T cell activation | 0.0167544030354514 |
| GO:0019221 | cytokine and chemokine mediated signaling pathway | 0.0173723752787155 |
| GO:0043086 | negative regulation of catalytic activity | 0.0179790452016474 |
| GO:0019901 | protein kinase binding | 0.0181966375578793 |
| GO:0009615 | response to virus | 0.0184103375493916 |
| GO:0019900 | kinase binding | 0.0184583324124759 |
| GO:0031301 | integral to organelle membrane | 0.0184583324124759 |
| GO:0031300 | intrinsic to organelle membrane | 0.020123610986793 |
| GO:0006874 | cellular calcium ion homeostasis | 0.0213896047952791 |
| GO:0005912 | adherens junction | 0.0213896047952791 |
| GO:0055074 | calcium ion homeostasis | 0.0213896047952791 |
| GO:0051251 | positive regulation of lymphocyte activation | 0.0213896047952791 |
| GO:0030217 | T cell differentiation | 0.0213896047952791 |
| GO:0006875 | cellular metal ion homeostasis | 0.0229468613137807 |
| GO:0055065 | metal ion homeostasis | 0.0234474349854449 |
| GO:0000139 | Golgi membrane | 0.0235990826085657 |
| GO:0016323 | basolateral plasma membrane | 0.0237482666926464 |
| GO:0046467 | membrane lipid biosynthetic process | 0.0242302665272944 |
| GO:0002253 | activation of immune response | 0.0257018337805838 |
| GO:0043413 | biopolymer glycosylation | 0.0261605319984295 |
| GO:0008194 | UDP-glycosyltransferase activity | 0.028029654037201 |
| GO:0004725 | protein tyrosine phosphatase activity | 0.028029654037201 |
| GO:0002250 | adaptive immune response | 0.0285632234116239 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.0285632234116239 |
| GO:0009968 | negative regulation of signal transduction | 0.0286654112364548 |
| GO:0030098 | lymphocyte differentiation | 0.0288651420565354 |
| GO:0002449 | lymphocyte mediated immunity | 0.0288651420565354 |
| GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.0295823609825766 |
| GO:0050778 | positive regulation of immune response | 0.0296739229998401 |
| GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0298529945699952 |
| GO:0002684 | positive regulation of immune system process | 0.0298529945699952 |
| GO:0002443 | leukocyte mediated immunity | 0.0299405620188862 |
| GO:0030003 | cellular cation homeostasis | 0.0312210729278844 |
| GO:0006470 | protein amino acid dephosphorylation | 0.031593914463362 |
| GO:0055080 | cation homeostasis | 0.0316672110673864 |
| GO:0050776 | regulation of immune response | 0.0324807880405482 |
| GO:0044459 | plasma membrane part | 0.0324807880405482 |
| GO:0002682 | regulation of immune system process | 0.0327449710873612 |
| GO:0043412 | biopolymer modification | 0.0332728919083019 |
| GO:0051240 | positive regulation of multicellular organismal process | 0.0332728919083019 |
| GO:0016311 | dephosphorylation | 0.0332728919083019 |
| GO:0008285 | negative regulation of cell proliferation | 0.0332728919083019 |
| GO:0002521 | leukocyte differentiation | 0.0353220015837589 |
| GO:0045859 | regulation of protein kinase activity | 0.0353220015837589 |
| GO:0006917 | induction of apoptosis | 0.0354084129998478 |
| GO:0012502 | induction of programmed cell death | 0.0354084129998478 |
| GO:0043549 | regulation of kinase activity | 0.0356539908169318 |
| GO:0044431 | Golgi apparatus part | 0.0356539908169318 |
| GO:0019899 | enzyme binding | 0.0356539908169318 |
| GO:0016758 | transferase activity, transferring hexosyl groups | 0.0356539908169318 |
| GO:0002252 | immune effector process | 0.0356539908169318 |
| GO:0051338 | regulation of transferase activity | 0.0356539908169318 |
| GO:0004721 | phosphoprotein phosphatase activity | 0.0377760273175131 |
| GO:0006873 | cellular ion homeostasis | 0.0378265910635761 |
| GO:0055082 | cellular chemical homeostasis | 0.0378265910635761 |
| GO:0006643 | membrane lipid metabolic process | 0.0388727940883598 |
| GO:0043065 | positive regulation of apoptosis | 0.0416802166691896 |
| GO:0051707 | response to other organism | 0.0416810069524464 |
| GO:0043068 | positive regulation of programmed cell death | 0.041681760089472 |
| GO:0050801 | ion homeostasis | 0.0416824767451136 |
| GO:0008284 | positive regulation of cell proliferation | 0.0439078312950332 |
| GO:0016021 | integral to membrane | 0.045164041073696 |
| GO:0031224 | intrinsic to membrane | 0.045164041073696 |
| GO:0005886 | plasma membrane | 0.045164041073696 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0833043 |
| MA0004.1 | 1.46913 |
| MA0006.1 | 0.419915 |
| MA0007.1 | 0.587678 |
| MA0009.1 | 1.06266 |
| MA0014.1 | 0.0502051 |
| MA0017.1 | 0.449113 |
| MA0019.1 | 0.874061 |
| MA0024.1 | 1.01759 |
| MA0025.1 | 1.30092 |
| MA0027.1 | 2.72141 |
| MA0028.1 | 0.43138 |
| MA0029.1 | 0.995171 |
| MA0030.1 | 1.00195 |
| MA0031.1 | 0.965177 |
| MA0038.1 | 0.757669 |
| MA0040.1 | 1.07552 |
| MA0041.1 | 0.522007 |
| MA0042.1 | 0.507715 |
| MA0043.1 | 1.1618 |
| MA0046.1 | 1.09955 |
| MA0048.1 | 0.205696 |
| MA0050.1 | 0.645342 |
| MA0051.1 | 0.767098 |
| MA0052.1 | 1.08379 |
| MA0055.1 | 0.0851423 |
| MA0056.1 | 0 |
| MA0057.1 | 0.192781 |
| MA0058.1 | 0.50032 |
| MA0059.1 | 0.513699 |
| MA0060.1 | 0.330907 |
| MA0061.1 | 0.364227 |
| MA0063.1 | 0 |
| MA0066.1 | 0.746072 |
| MA0067.1 | 1.41352 |
| MA0068.1 | 0.197245 |
| MA0069.1 | 1.08414 |
| MA0070.1 | 1.07418 |
| MA0071.1 | 0.644448 |
| MA0072.1 | 1.06547 |
| MA0073.1 | 0.000589538 |
| MA0074.1 | 0.708108 |
| MA0076.1 | 0.470037 |
| MA0077.1 | 1.04318 |
| MA0078.1 | 0.801834 |
| MA0081.1 | 1.33193 |
| MA0083.1 | 1.16099 |
| MA0084.1 | 1.74401 |
| MA0087.1 | 1.11687 |
| MA0088.1 | 0.148348 |
| MA0089.1 | 0 |
| MA0090.1 | 0.566938 |
| MA0091.1 | 0.617887 |
| MA0092.1 | 0.567278 |
| MA0093.1 | 1.12162 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.695835 |
| MA0101.1 | 0.523409 |
| MA0103.1 | 0.460936 |
| MA0105.1 | 0.693075 |
| MA0106.1 | 0.809991 |
| MA0107.1 | 0.454197 |
| MA0108.2 | 0.897859 |
| MA0109.1 | 0 |
| MA0111.1 | 0.582193 |
| MA0113.1 | 0.780358 |
| MA0114.1 | 0.361633 |
| MA0115.1 | 1.16466 |
| MA0116.1 | 0.419688 |
| MA0117.1 | 1.13165 |
| MA0119.1 | 0.524046 |
| MA0122.1 | 1.15196 |
| MA0124.1 | 1.35963 |
| MA0125.1 | 1.28445 |
| MA0130.1 | 0 |
| MA0131.1 | 0.869325 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 9.99086 |
| MA0136.1 | 0.729175 |
| MA0139.1 | 0.295945 |
| MA0140.1 | 0.695713 |
| MA0141.1 | 0.482463 |
| MA0142.1 | 0.950155 |
| MA0143.1 | 0.797553 |
| MA0144.1 | 0.365053 |
| MA0145.1 | 0.476962 |
| MA0146.1 | 0.822925 |
| MA0147.1 | 0.986917 |
| MA0148.1 | 0.621195 |
| MA0149.1 | 0.529387 |
| MA0062.2 | 0.254018 |
| MA0035.2 | 0.700704 |
| MA0039.2 | 0.0511423 |
| MA0138.2 | 0.861035 |
| MA0002.2 | 1.47075 |
| MA0137.2 | 0.479301 |
| MA0104.2 | 0.845917 |
| MA0047.2 | 0.75686 |
| MA0112.2 | 0.157681 |
| MA0065.2 | 0.158101 |
| MA0150.1 | 1.43499 |
| MA0151.1 | 0 |
| MA0152.1 | 0.756973 |
| MA0153.1 | 1.21594 |
| MA0154.1 | 0.203217 |
| MA0155.1 | 0.173445 |
| MA0156.1 | 0.469089 |
| MA0157.1 | 0.91689 |
| MA0158.1 | 0 |
| MA0159.1 | 0.389847 |
| MA0160.1 | 0.624415 |
| MA0161.1 | 0 |
| MA0162.1 | 0.245828 |
| MA0163.1 | 0.0644585 |
| MA0164.1 | 0.729558 |
| MA0080.2 | 1.15331 |
| MA0018.2 | 0.739807 |
| MA0099.2 | 0.854449 |
| MA0079.2 | 0.00167664 |
| MA0102.2 | 1.79669 |
| MA0258.1 | 0.91616 |
| MA0259.1 | 0.960816 |
| MA0442.1 | 0 |
