Coexpression cluster:C4450

Full id: C4450_brain_hippocampus_amygdala_spinal_corpus_thalamus_globus

Phase1 CAGE Peaks

Hg19::chr5:11589158..11589169,-	p25@CTNND2
Hg19::chr7:31092040..31092051,+	p7@ADCYAP1R1
Hg19::chrX:13917521..13917525,-	p@chrX:13917521..13917525 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007158	neuron adhesion	0.0248690319985808
GO:0004999	vasoactive intestinal polypeptide receptor activity	0.0248690319985808

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
neural tube	1.23e-72	57
neural rod	1.23e-72	57
future spinal cord	1.23e-72	57
neural keel	1.23e-72	57
central nervous system	4.45e-69	82
regional part of nervous system	1.34e-67	94
nervous system	1.34e-67	94
neural plate	4.99e-62	86
presumptive neural plate	4.99e-62	86
brain	1.53e-60	69
future brain	1.53e-60	69
neurectoderm	2.32e-60	90
regional part of brain	2.38e-60	59
adult organism	1.50e-55	115
anterior neural tube	1.17e-54	42
regional part of forebrain	3.13e-53	41
forebrain	3.13e-53	41
future forebrain	3.13e-53	41
telencephalon	4.96e-49	34
gray matter	5.04e-49	34
brain grey matter	5.04e-49	34
regional part of telencephalon	1.96e-47	33
cerebral hemisphere	1.33e-45	32
pre-chordal neural plate	3.42e-41	61
ectoderm-derived structure	1.97e-40	169
ectoderm	3.45e-40	173
presumptive ectoderm	3.45e-40	173
anterior region of body	1.45e-35	129
craniocervical region	1.45e-35	129
cerebral cortex	2.74e-34	25
pallium	2.74e-34	25
head	3.60e-34	123
regional part of cerebral cortex	1.19e-30	22
neocortex	1.90e-27	20
posterior neural tube	3.16e-18	15
chordal neural plate	3.16e-18	15
tube	6.76e-18	194
basal ganglion	2.75e-16	9
nuclear complex of neuraxis	2.75e-16	9
aggregate regional part of brain	2.75e-16	9
collection of basal ganglia	2.75e-16	9
cerebral subcortex	2.75e-16	9
nucleus of brain	4.47e-16	9
neural nucleus	4.47e-16	9
organ part	1.81e-15	219
brainstem	4.24e-14	8
segmental subdivision of hindbrain	1.81e-13	12
hindbrain	1.81e-13	12
presumptive hindbrain	1.81e-13	12
anatomical conduit	2.01e-13	241
epithelium	3.84e-13	309
cell layer	8.11e-13	312
telencephalic nucleus	8.32e-13	7
anatomical cluster	9.40e-13	286
segmental subdivision of nervous system	3.16e-12	13
organism subdivision	4.52e-11	365
temporal lobe	5.13e-11	7
embryo	5.71e-11	612
gyrus	8.59e-11	6
limbic system	5.68e-10	5
organ	6.33e-10	511
occipital lobe	2.52e-09	5
multi-cellular organism	4.30e-09	659
regional part of metencephalon	5.70e-09	9
metencephalon	5.70e-09	9
future metencephalon	5.70e-09	9
multi-tissue structure	9.16e-09	347
germ layer	2.50e-08	604
embryonic tissue	2.50e-08	604
presumptive structure	2.50e-08	604
epiblast (generic)	2.50e-08	604
embryonic structure	2.87e-08	605
developing anatomical structure	2.87e-08	605
anatomical system	4.23e-08	625
anatomical group	4.85e-08	626
corpus striatum	7.88e-08	4
striatum	7.88e-08	4
ventral part of telencephalon	7.88e-08	4
future corpus striatum	7.88e-08	4

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.