Coexpression cluster:C4134

Full id: C4134_nonsmall_cerebellum_medulloblastoma_small_gastrointestinal_eye_pons

Phase1 CAGE Peaks

Hg19::chr2:155554797..155554837,+	p3@KCNJ3
Hg19::chr4:163084826..163084834,-	p4@FSTL5
Hg19::chr4:163085107..163085118,-	p2@FSTL5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015467	G-protein activated inward rectifier potassium channel activity	0.00721139691311709
GO:0030315	T-tubule	0.00721139691311709
GO:0042383	sarcolemma	0.0153818225045911
GO:0005242	inward rectifier potassium channel activity	0.0187438363623487
GO:0009897	external side of plasma membrane	0.028826481240087

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
neural tube	1.40e-50	57
neural rod	1.40e-50	57
future spinal cord	1.40e-50	57
neural keel	1.40e-50	57
central nervous system	3.62e-50	82
neurectoderm	8.59e-45	90
regional part of nervous system	5.05e-44	94
nervous system	5.05e-44	94
neural plate	8.42e-44	86
presumptive neural plate	8.42e-44	86
regional part of brain	1.42e-43	59
brain	2.65e-42	69
future brain	2.65e-42	69
adult organism	5.96e-41	115
regional part of forebrain	9.95e-39	41
forebrain	9.95e-39	41
future forebrain	9.95e-39	41
anterior neural tube	1.59e-37	42
gray matter	9.94e-33	34
brain grey matter	9.94e-33	34
telencephalon	2.31e-32	34
regional part of cerebral cortex	4.91e-31	22
regional part of telencephalon	5.05e-31	33
cerebral hemisphere	2.97e-30	32
pre-chordal neural plate	1.40e-28	61
neocortex	3.32e-28	20
ectoderm	8.98e-27	173
presumptive ectoderm	8.98e-27	173
cerebral cortex	1.65e-26	25
pallium	1.65e-26	25
ectoderm-derived structure	1.18e-25	169
head	9.79e-22	123
anterior region of body	6.50e-21	129
craniocervical region	6.50e-21	129
tube	3.14e-15	194
posterior neural tube	9.68e-14	15
chordal neural plate	9.68e-14	15
anatomical conduit	1.99e-12	241
epithelium	4.28e-12	309
cell layer	9.15e-12	312
temporal lobe	1.46e-11	7
segmental subdivision of hindbrain	2.50e-10	12
hindbrain	2.50e-10	12
presumptive hindbrain	2.50e-10	12
anatomical cluster	2.71e-10	286
gyrus	1.18e-09	6
brainstem	2.10e-09	8
segmental subdivision of nervous system	2.42e-09	13
organ part	9.64e-09	219
multi-tissue structure	2.35e-08	347
occipital lobe	2.74e-08	5
limbic system	3.70e-08	5
nucleus of brain	9.60e-08	9
neural nucleus	9.60e-08	9
diencephalon	1.10e-07	7
future diencephalon	1.10e-07	7
basal ganglion	1.80e-07	9
nuclear complex of neuraxis	1.80e-07	9
aggregate regional part of brain	1.80e-07	9
collection of basal ganglia	1.80e-07	9
cerebral subcortex	1.80e-07	9
organism subdivision	2.33e-07	365
parietal lobe	2.43e-07	5
organ	6.97e-07	511

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
PBX3#5090	2	14.6096751244961	0.00605612247321789	0.0268461534371988

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.