MCL coexpression mm9:607

Phase1 CAGE Peaks

	Short description
Mm9::chr11:78136622..78136647,+	p2@Aldoc
Mm9::chr11:78136653..78136668,+	p3@Aldoc
Mm9::chr11:78137906..78137917,+	p13@Aldoc
Mm9::chr11:78138138..78138150,+	p11@Aldoc
Mm9::chr11:78138215..78138264,+	p5@Aldoc
Mm9::chr11:78138393..78138432,+	p8@Aldoc
Mm9::chr11:78139435..78139445,+	p@chr11:78139435..78139445 +
Mm9::chr11:78139806..78139834,+	p@chr11:78139806..78139834 +
Mm9::chr16:36784785..36784814,-	p@chr16:36784785..36784814 -
Mm9::chr16:36784832..36784844,-	p@chr16:36784832..36784844 -
Mm9::chr17:25922269..25922288,-	p2@Haghl
Mm9::chr5:35399708..35399745,+	p2@Dok7

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015334	high affinity oligopeptide transporter activity	0.0293650358845121
GO:0004332	fructose-bisphosphate aldolase activity	0.0381369142928167
GO:0016832	aldehyde-lyase activity	0.0381369142928167
GO:0015198	oligopeptide transporter activity	0.0381369142928167
GO:0015197	peptide transporter activity	0.0381369142928167
GO:0006857	oligopeptide transport	0.0381369142928167
GO:0043113	receptor clustering	0.0381369142928167
GO:0031594	neuromuscular junction	0.0381369142928167
GO:0005158	insulin receptor binding	0.0381369142928167
GO:0007172	signal complex assembly	0.0381369142928167

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.22e-16	23
neuroblast (sensu Vertebrata)	1.22e-16	23
ectodermal cell	4.09e-16	44
neurectodermal cell	4.09e-16	44
neural cell	1.78e-15	43
non-terminally differentiated cell	2.43e-12	49
neuron	2.32e-11	33
neuronal stem cell	2.32e-11	33
neuroblast	2.32e-11	33
electrically signaling cell	2.32e-11	33
electrically responsive cell	1.66e-08	39
electrically active cell	1.66e-08	39
oligodendrocyte precursor cell	5.47e-07	8

Uber Anatomy

Ontology term	p-value	n
central nervous system	1.24e-34	73
regional part of nervous system	1.91e-33	54
nervous system	3.44e-33	75
ectoderm-derived structure	2.04e-32	95
ectoderm	2.04e-32	95
presumptive ectoderm	2.04e-32	95
neural tube	4.31e-31	52
neural rod	4.31e-31	52
future spinal cord	4.31e-31	52
neural keel	4.31e-31	52
neurectoderm	9.79e-30	64
neural plate	9.79e-30	64
presumptive neural plate	9.79e-30	64
gray matter	6.79e-29	34
ecto-epithelium	6.34e-28	73
brain	1.57e-25	47
future brain	1.57e-25	47
regional part of brain	1.11e-24	46
brain grey matter	1.75e-23	29
regional part of telencephalon	1.75e-23	29
telencephalon	1.75e-23	29
pre-chordal neural plate	2.94e-21	49
anterior neural tube	2.91e-20	40
regional part of forebrain	2.11e-19	39
forebrain	2.11e-19	39
future forebrain	2.11e-19	39
structure with developmental contribution from neural crest	2.57e-17	92
cerebral cortex	4.12e-17	21
cerebral hemisphere	4.12e-17	21
pallium	4.12e-17	21
regional part of cerebral cortex	4.54e-14	17
posterior neural tube	1.62e-11	12
chordal neural plate	1.62e-11	12
occipital lobe	1.41e-10	10
visual cortex	1.41e-10	10
neocortex	1.41e-10	10
spinal cord	1.26e-07	6
dorsal region element	1.26e-07	6
dorsum	1.26e-07	6
basal ganglion	1.77e-07	8
nuclear complex of neuraxis	1.77e-07	8
aggregate regional part of brain	1.77e-07	8
collection of basal ganglia	1.77e-07	8
cerebral subcortex	1.77e-07	8
tube	2.32e-07	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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