Coexpression cluster:C2733

Full id: C2733_small_medial_medulloblastoma_paracentral_frontal_parietal_smallcell

Phase1 CAGE Peaks

Hg19::chr3:179754706..179754732,-	p4@PEX5L
Hg19::chr3:179754733..179754773,-	p3@PEX5L
Hg19::chr3:179754789..179754804,-	p6@PEX5L
Hg19::chr3:179754806..179754872,-	p2@PEX5L

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
nervous system	5.74e-59	89
neural tube	2.92e-57	56
neural rod	2.92e-57	56
future spinal cord	2.92e-57	56
neural keel	2.92e-57	56
central nervous system	2.93e-56	81
regional part of nervous system	2.33e-53	53
regional part of brain	2.33e-53	53
brain	1.01e-49	68
future brain	1.01e-49	68
regional part of forebrain	4.56e-46	41
forebrain	4.56e-46	41
anterior neural tube	4.56e-46	41
future forebrain	4.56e-46	41
neural plate	1.72e-40	82
presumptive neural plate	1.72e-40	82
telencephalon	2.32e-40	34
brain grey matter	3.08e-40	34
gray matter	3.08e-40	34
neurectoderm	2.89e-39	86
cerebral hemisphere	5.69e-38	32
regional part of telencephalon	1.46e-37	32
adult organism	1.89e-35	114
regional part of cerebral cortex	4.72e-34	22
pre-chordal neural plate	9.82e-34	61
ecto-epithelium	2.33e-33	104
neocortex	3.34e-31	20
cerebral cortex	4.12e-29	25
pallium	4.12e-29	25
ectoderm-derived structure	4.00e-28	171
ectoderm	4.00e-28	171
presumptive ectoderm	4.00e-28	171
structure with developmental contribution from neural crest	3.03e-25	132
organ system subdivision	1.55e-24	223
basal ganglion	9.29e-13	9
nuclear complex of neuraxis	9.29e-13	9
aggregate regional part of brain	9.29e-13	9
collection of basal ganglia	9.29e-13	9
cerebral subcortex	9.29e-13	9
neural nucleus	1.85e-12	9
nucleus of brain	1.85e-12	9
posterior neural tube	3.49e-12	15
chordal neural plate	3.49e-12	15
temporal lobe	3.46e-11	6
tube	4.75e-11	192
gyrus	1.39e-10	6
segmental subdivision of nervous system	5.66e-10	13
epithelium	5.91e-10	306
telencephalic nucleus	7.26e-10	7
cell layer	1.17e-09	309
brainstem	2.21e-09	6
anatomical cluster	3.13e-09	373
parietal lobe	8.24e-09	5
limbic system	8.76e-09	5
segmental subdivision of hindbrain	9.15e-09	12
hindbrain	9.15e-09	12
presumptive hindbrain	9.15e-09	12
occipital lobe	2.28e-08	5
anatomical conduit	2.45e-07	240
diencephalon	3.99e-07	7
future diencephalon	3.99e-07	7
organ part	5.61e-07	218

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
GATA3#2625	3	20.4273872679045	0.000192441557625832	0.00232083185183421
REST#5978	4	9.65002871612802	0.000115282561421917	0.00157303311109794
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0322882269301217
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244755930353214

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.