Coexpression cluster:C3589

Full id: C3589_pineal_Reticulocytes_putamen_amygdala_medial_cerebellum_occipital

Phase1 CAGE Peaks

Hg19::chr16:75681623..75681648,+	p3@TERF2IP
Hg19::chr16:75681650..75681696,+	p2@TERF2IP
Hg19::chr16:75681700..75681764,+	p1@TERF2IP

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	6.06e-43	114
neural tube	3.83e-31	56
neural rod	3.83e-31	56
future spinal cord	3.83e-31	56
neural keel	3.83e-31	56
regional part of nervous system	1.80e-29	53
regional part of brain	1.80e-29	53
neural plate	1.88e-27	82
presumptive neural plate	1.88e-27	82
central nervous system	5.62e-27	81
nervous system	4.78e-26	89
neurectoderm	9.13e-26	86
brain	1.38e-25	68
future brain	1.38e-25	68
regional part of forebrain	3.17e-23	41
forebrain	3.17e-23	41
anterior neural tube	3.17e-23	41
future forebrain	3.17e-23	41
pre-chordal neural plate	4.40e-20	61
brain grey matter	7.80e-19	34
gray matter	7.80e-19	34
telencephalon	8.08e-19	34
ecto-epithelium	1.64e-18	104
cerebral hemisphere	1.04e-17	32
regional part of telencephalon	1.25e-17	32
structure with developmental contribution from neural crest	8.25e-16	132
ectoderm-derived structure	1.34e-14	171
ectoderm	1.34e-14	171
presumptive ectoderm	1.34e-14	171
regional part of cerebral cortex	5.30e-14	22
cerebral cortex	1.72e-13	25
pallium	1.72e-13	25
neocortex	6.97e-13	20
posterior neural tube	5.26e-09	15
chordal neural plate	5.26e-09	15
organ system subdivision	2.38e-08	223
segmental subdivision of nervous system	6.53e-08	13
segmental subdivision of hindbrain	1.88e-07	12
hindbrain	1.88e-07	12
presumptive hindbrain	1.88e-07	12
basal ganglion	6.71e-07	9
nuclear complex of neuraxis	6.71e-07	9
aggregate regional part of brain	6.71e-07	9
collection of basal ganglia	6.71e-07	9
cerebral subcortex	6.71e-07	9
neural nucleus	7.21e-07	9
nucleus of brain	7.21e-07	9

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0189758529622469
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0324766381961974
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0320074393099585
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0461505598672222
ETS1#2113	3	9.72876092220234	0.00108584009258484	0.00761254302406308
FOSL2#2355	3	16.9302006045617	0.000206016205317162	0.0024270870239277
GABPB1#2553	3	7.06768383618217	0.00283221282541742	0.0153906798102799
GTF2F1#2962	3	12.7396608767577	0.000483552504743859	0.00433454124478104
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.0108589880921946
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.0127889076337885
MAX#4149	3	6.45255550900712	0.00372191383426551	0.018629011738563
MYC#4609	3	5.2222818716094	0.00702084375574015	0.0294076321892093
NFKB1#4790	3	5.48806342419384	0.00604938181565543	0.0269282834986462
NR2C2#7182	3	32.6146109052409	2.88098172333076e-05	0.000604554651804183
NRF1#4899	3	12.2102794477109	0.000549217240102001	0.0047070161939121
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0172713357073255
POU2F2#5452	3	9.10612405774252	0.00132416519268213	0.00881193376822537
REST#5978	3	9.65002871612802	0.00111263624711459	0.0076671032602534
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0276220521521621
SIX5#147912	3	17.086715355459	0.000200406054632501	0.00239476063384025
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0246122916839264
STAT1#6772	3	20.7065874971992	0.000112599244104667	0.00154733584934833
TAF7#6879	3	11.4330694049239	0.000669018198194583	0.00541976354337915
THAP1#55145	3	31.3691446028513	3.23800758564397e-05	0.000646234042111734
TRIM28#10155	3	18.5905250452625	0.000155596929725528	0.00196831246894433
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0328814394466326
ZEB1#6935	3	16.8884320175439	0.000207548691732758	0.00242517093487106

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.