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{{Coexpression_clusters
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|full_id=C2799_hippocampus_cerebellum_pituitary_amygdala_olfactory_middle_medial
|id=C2799
}}

Latest revision as of 12:13, 17 September 2013


Full id: C2799_hippocampus_cerebellum_pituitary_amygdala_olfactory_middle_medial



Phase1 CAGE Peaks

Hg19::chr5:113697717..113697728,+p6@KCNN2
Hg19::chr5:113697740..113697793,+p1@KCNN2
Hg19::chr5:113697798..113697814,+p3@KCNN2
Hg19::chr5:113697983..113698024,+p4@KCNN2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism9.11e-47114
neural tube3.10e-4056
neural rod3.10e-4056
future spinal cord3.10e-4056
neural keel3.10e-4056
central nervous system4.29e-3981
nervous system5.03e-3889
regional part of nervous system2.11e-3753
regional part of brain2.11e-3753
regional part of forebrain2.27e-3141
forebrain2.27e-3141
anterior neural tube2.27e-3141
future forebrain2.27e-3141
brain1.20e-3068
future brain1.20e-3068
neural plate2.62e-2982
presumptive neural plate2.62e-2982
neurectoderm6.86e-2886
telencephalon1.04e-2434
brain grey matter1.17e-2434
gray matter1.17e-2434
organ system subdivision1.38e-24223
cerebral hemisphere7.00e-2332
regional part of telencephalon8.21e-2332
ecto-epithelium1.67e-22104
ectoderm-derived structure6.18e-21171
ectoderm6.18e-21171
presumptive ectoderm6.18e-21171
pre-chordal neural plate8.46e-2161
regional part of cerebral cortex1.06e-2022
neocortex1.21e-1820
structure with developmental contribution from neural crest2.57e-18132
cerebral cortex2.85e-1725
pallium2.85e-1725
anatomical cluster2.20e-16373
anatomical conduit4.18e-14240
tube6.40e-13192
posterior neural tube6.81e-1015
chordal neural plate6.81e-1015
basal ganglion4.87e-099
nuclear complex of neuraxis4.87e-099
aggregate regional part of brain4.87e-099
collection of basal ganglia4.87e-099
cerebral subcortex4.87e-099
neural nucleus6.24e-099
nucleus of brain6.24e-099
diencephalon3.49e-087
future diencephalon3.49e-087
multi-tissue structure1.14e-07342
brainstem1.51e-076
segmental subdivision of hindbrain2.46e-0712
hindbrain2.46e-0712
presumptive hindbrain2.46e-0712
gyrus2.71e-076
telencephalic nucleus4.31e-077
epithelium8.18e-07306


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.11.31813
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.12.02743
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.12.02223
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.16.61141
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.11.80156
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.214613
MA0074.10.819248
MA0076.10.623864
MA0077.12.62367
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.11.29536
MA0105.10.656404
MA0106.10.869173
MA0107.12.00595
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.9994
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.12.2938
MA0143.14.85709
MA0144.10.430413
MA0145.11.70272
MA0146.10.061409
MA0147.11.16748
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.10559
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.21.01696
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.11.06783
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.21.38179
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
JUND#372735.245997956403270.01043432751748420.0387095315287913
MYC#460945.22228187160940.001344309395272740.00889216093057758
TAF1#687243.343046285745290.008005664898701650.0323056928385882
TAF7#6879411.43306940492395.85061525419808e-050.00097128025199999
TBP#690843.706770687096390.005296377814784350.0244842600300222
ZNF143#7702413.50087655222793.00867915035614e-050.00062160918255993



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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