Coexpression cluster:C4: Difference between revisions
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|id=C4 | |id=C4 | ||
|kegg_enrichment=hsa01100;Metabolic_pathways;4.41E-11!hsa04530;Tight_junction;4.53E-09!hsa04144;Endocytosis;1.59E-06!hsa00340;Histidine_metabolism;7.05E-05!hsa00565;Ether_lipid_metabolism;7.05E-05!hsa04360;Axon_guidance;7.48E-05!hsa00600;Sphingolipid_metabolism;9.83E-05!hsa00250;Alanine,_aspartate_and_glutamate_metabolism;0.000130768!hsa00410;beta-Alanine_metabolism;0.000130768 | |kegg_enrichment=hsa01100;Metabolic_pathways;4.41E-11!hsa04530;Tight_junction;4.53E-09!hsa04144;Endocytosis;1.59E-06!hsa00340;Histidine_metabolism;7.05E-05!hsa00565;Ether_lipid_metabolism;7.05E-05!hsa04360;Axon_guidance;7.48E-05!hsa00600;Sphingolipid_metabolism;9.83E-05!hsa00250;Alanine,_aspartate_and_glutamate_metabolism;0.000130768!hsa00410;beta-Alanine_metabolism;0.000130768 | ||
|ontology_enrichment_celltype= | |ontology_enrichment_celltype= | ||
|ontology_enrichment_disease= | |ontology_enrichment_disease= | ||
|ontology_enrichment_uberon=UBERON: | |ontology_enrichment_uberon=UBERON:0001049!2.24e-118!56;UBERON:0005068!2.24e-118!56;UBERON:0006241!2.24e-118!56;UBERON:0007135!2.24e-118!56;UBERON:0000073!5.73e-107!53;UBERON:0002616!5.73e-107!53;UBERON:0001017!2.72e-95!81;UBERON:0000955!8.27e-90!68;UBERON:0006238!8.27e-90!68;UBERON:0001016!2.10e-89!89;UBERON:0003075!7.22e-87!82;UBERON:0007284!7.22e-87!82;UBERON:0002780!4.21e-86!41;UBERON:0001890!4.21e-86!41;UBERON:0003080!4.21e-86!41;UBERON:0006240!4.21e-86!41;UBERON:0003528!4.91e-84!34;UBERON:0002020!4.91e-84!34;UBERON:0001893!7.26e-84!34;UBERON:0002346!1.87e-82!86;UBERON:0002791!3.07e-76!32;UBERON:0001869!7.75e-76!32;UBERON:0007023!2.91e-70!114;UBERON:0010371!9.42e-67!104;UBERON:0003056!5.03e-64!61;UBERON:0002619!4.02e-58!22;UBERON:0010314!4.41e-56!132;UBERON:0000956!7.08e-51!25;UBERON:0000203!7.08e-51!25;UBERON:0001950!9.41e-51!20;UBERON:0004121!5.77e-45!171;UBERON:0000924!5.77e-45!171;UBERON:0006601!5.77e-45!171;UBERON:0000125!4.33e-36!9;UBERON:0002308!4.33e-36!9;UBERON:0002420!2.95e-35!9;UBERON:0007245!2.95e-35!9;UBERON:0010009!2.95e-35!9;UBERON:0010011!2.95e-35!9;UBERON:0000454!2.95e-35!9;UBERON:0011216!2.38e-32!223;UBERON:0003076!2.09e-31!15;UBERON:0003057!2.09e-31!15;UBERON:0000025!1.39e-28!192;UBERON:0009663!4.07e-28!7;UBERON:0002298!2.46e-25!6;UBERON:0004732!1.44e-24!13;UBERON:0000200!1.72e-23!6;UBERON:0004111!4.59e-21!240;UBERON:0004733!6.15e-21!12;UBERON:0002028!6.15e-21!12;UBERON:0007277!6.15e-21!12;UBERON:0000349!5.05e-20!5;UBERON:0000064!5.54e-17!218;UBERON:0000483!1.07e-16!306;UBERON:0000477!1.27e-16!373;UBERON:0000119!1.92e-16!309;UBERON:0000369!6.02e-16!4;UBERON:0002435!6.02e-16!4;UBERON:0000204!6.02e-16!4;UBERON:0010082!6.02e-16!4;UBERON:0001871!4.10e-14!6;UBERON:0000988!1.30e-13!3;UBERON:0001896!1.75e-13!3;UBERON:0005290!1.75e-13!3;UBERON:0010096!1.75e-13!3;UBERON:0002240!2.54e-13!3;UBERON:0005174!2.54e-13!3;UBERON:0001137!2.54e-13!3;UBERON:0002021!3.82e-13!5;UBERON:0001872!4.07e-13!5;UBERON:0001870!1.59e-12!3;UBERON:0005383!2.47e-12!3;UBERON:0005382!2.47e-12!3;UBERON:0000481!5.73e-12!342;UBERON:0002680!3.49e-11!9;UBERON:0001895!3.49e-11!9;UBERON:0010092!3.49e-11!9;UBERON:0005162!4.85e-10!2;UBERON:0000122!4.85e-10!2;UBERON:0001897!6.02e-10!2;UBERON:0010225!6.02e-10!2;UBERON:0001875!8.48e-10!2;UBERON:0006514!8.48e-10!2;UBERON:0002148!1.05e-09!2;UBERON:0006331!1.05e-09!2;UBERON:0009662!1.05e-09!2;UBERON:0001954!2.87e-09!2;UBERON:0003022!2.87e-09!2;UBERON:0002421!2.87e-09!2;UBERON:0002600!2.87e-09!2;UBERON:0002771!3.99e-09!2;UBERON:0000062!4.84e-09!503;UBERON:0002702!6.50e-09!2;UBERON:0001873!7.04e-09!2;UBERON:0010122!7.04e-09!2;UBERON:0001876!7.33e-09!2;UBERON:0002360!2.14e-08!2;UBERON:0000094!2.14e-08!2;UBERON:0010743!2.14e-08!2;UBERON:0000923!9.02e-08!560;UBERON:0010316!9.02e-08!560;UBERON:0005291!9.02e-08!560;UBERON:0006598!9.02e-08!560;UBERON:0010317!9.02e-08!560;UBERON:0002532!9.02e-08!560;UBERON:0002050!1.21e-07!564;UBERON:0005423!3.98e-07!581;UBERON:0000922!8.32e-07!592 | ||
|pathway_enrichment=0.000455497735315056;0.0480550110757384;12;204;Endocytosis (KEGG):04144!1.23862032650889e-06;0.000392023333340064;13;133;Tight junction (KEGG):04530!0.000388578425303139;0.0480550110757384;10;145;Regulation of Actin Cytoskeleton (Wikipathways):WP51!5.85825024718095e-09;3.70827240646554e-06;22;265;Axon guidance (Reactome):REACT_18266!0.000255706039208234;0.0480550110757384;28;728;TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9!0.000446219018444749;0.0480550110757384;4;20;{SEPT2,21} (Static Module):NA | |pathway_enrichment=0.000455497735315056;0.0480550110757384;12;204;Endocytosis (KEGG):04144!1.23862032650889e-06;0.000392023333340064;13;133;Tight junction (KEGG):04530!0.000388578425303139;0.0480550110757384;10;145;Regulation of Actin Cytoskeleton (Wikipathways):WP51!5.85825024718095e-09;3.70827240646554e-06;22;265;Axon guidance (Reactome):REACT_18266!0.000255706039208234;0.0480550110757384;28;728;TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9!0.000446219018444749;0.0480550110757384;4;20;{SEPT2,21} (Static Module):NA | ||
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Revision as of 15:35, 19 October 2012
Full id: C4_optic_corpus_substantia_medulla_spinal_thalamus_globus
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
0.000455497735315056 | 0.0480550110757384 | 12 | 204 | Endocytosis (KEGG):04144 |
1.23862032650889e-06 | 0.000392023333340064 | 13 | 133 | Tight junction (KEGG):04530 |
0.000388578425303139 | 0.0480550110757384 | 10 | 145 | Regulation of Actin Cytoskeleton (Wikipathways):WP51 |
5.85825024718095e-09 | 3.70827240646554e-06 | 22 | 265 | Axon guidance (Reactome):REACT_18266 |
0.000255706039208234 | 0.0480550110757384 | 28 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
0.000446219018444749 | 0.0480550110757384 | 4 | 20 | {SEPT2,21} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0007399 | nervous system development | 7.62802929681149e-36 |
GO:0016020 | membrane | 2.93544116341676e-23 |
GO:0044425 | membrane part | 1.12056877507018e-18 |
GO:0044464 | cell part | 2.32723044079086e-18 |
GO:0008092 | cytoskeletal protein binding | 4.32292787472301e-18 |
GO:0005886 | plasma membrane | 5.98026358830576e-18 |
GO:0048856 | anatomical structure development | 5.98026358830576e-18 |
GO:0048731 | system development | 9.30468756701889e-18 |
GO:0005515 | protein binding | 2.2422557870013e-17 |
GO:0032502 | developmental process | 3.62912255220677e-17 |
GO:0005737 | cytoplasm | 4.57850014999345e-16 |
GO:0007275 | multicellular organismal development | 4.57850014999345e-16 |
GO:0022610 | biological adhesion | 4.83766074770396e-16 |
GO:0007155 | cell adhesion | 4.83766074770396e-16 |
GO:0032501 | multicellular organismal process | 2.83403626315056e-15 |
GO:0016021 | integral to membrane | 4.77698980630879e-14 |
GO:0031224 | intrinsic to membrane | 7.64322110847033e-14 |
GO:0003779 | actin binding | 1.34057695508074e-13 |
GO:0007010 | cytoskeleton organization and biogenesis | 1.28412345309015e-12 |
GO:0030054 | cell junction | 1.28412345309015e-12 |
GO:0007154 | cell communication | 1.33496346418656e-12 |
GO:0005856 | cytoskeleton | 7.39297960222583e-12 |
GO:0044459 | plasma membrane part | 3.57464514160195e-11 |
GO:0030695 | GTPase regulator activity | 4.41403003610958e-09 |
GO:0007267 | cell-cell signaling | 1.04750699867004e-08 |
GO:0016043 | cellular component organization and biogenesis | 5.05464150622618e-08 |
GO:0001508 | regulation of action potential | 1.26073996079989e-07 |
GO:0019226 | transmission of nerve impulse | 1.96956210256914e-07 |
GO:0044424 | intracellular part | 3.1144981328493e-07 |
GO:0008366 | axon ensheathment | 3.60090293850089e-07 |
GO:0007272 | ensheathment of neurons | 3.60090293850089e-07 |
GO:0048869 | cellular developmental process | 4.61019722862125e-07 |
GO:0030154 | cell differentiation | 4.61019722862125e-07 |
GO:0005624 | membrane fraction | 7.28547092261564e-07 |
GO:0005622 | intracellular | 1.11336892324559e-06 |
GO:0007165 | signal transduction | 2.58003912870551e-06 |
GO:0003008 | system process | 2.86933489209992e-06 |
GO:0000902 | cell morphogenesis | 2.89602304212069e-06 |
GO:0032989 | cellular structure morphogenesis | 2.89602304212069e-06 |
GO:0008289 | lipid binding | 1.00525834485181e-05 |
GO:0005083 | small GTPase regulator activity | 1.87782579033247e-05 |
GO:0000267 | cell fraction | 2.38036198604208e-05 |
GO:0005887 | integral to plasma membrane | 2.39204687317401e-05 |
GO:0009653 | anatomical structure morphogenesis | 2.78818810624975e-05 |
GO:0031226 | intrinsic to plasma membrane | 3.44756439181395e-05 |
GO:0030036 | actin cytoskeleton organization and biogenesis | 3.86091238949661e-05 |
GO:0050877 | neurological system process | 5.81309620220444e-05 |
GO:0030029 | actin filament-based process | 7.0142877408911e-05 |
GO:0022008 | neurogenesis | 7.55638654120488e-05 |
GO:0015630 | microtubule cytoskeleton | 0.000140666972199391 |
GO:0048699 | generation of neurons | 0.000140666972199391 |
GO:0015629 | actin cytoskeleton | 0.000309737077306256 |
GO:0048468 | cell development | 0.000309737077306256 |
GO:0005874 | microtubule | 0.000326495178106564 |
GO:0031175 | neurite development | 0.00037550194615179 |
GO:0007417 | central nervous system development | 0.000455983061479573 |
GO:0048858 | cell projection morphogenesis | 0.000502268000218197 |
GO:0032990 | cell part morphogenesis | 0.000502268000218197 |
GO:0030030 | cell projection organization and biogenesis | 0.000502268000218197 |
GO:0005516 | calmodulin binding | 0.00050450221588856 |
GO:0051179 | localization | 0.000516033877675488 |
GO:0005911 | intercellular junction | 0.000522118083651145 |
GO:0042552 | myelination | 0.000544804110195395 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 0.000667733433204366 |
GO:0015631 | tubulin binding | 0.000734872847573226 |
GO:0048667 | neuron morphogenesis during differentiation | 0.000766991793937902 |
GO:0048812 | neurite morphogenesis | 0.000766991793937902 |
GO:0007268 | synaptic transmission | 0.000812211874055458 |
GO:0006629 | lipid metabolic process | 0.00090423506924232 |
GO:0048666 | neuron development | 0.00092771639605446 |
GO:0008017 | microtubule binding | 0.00103190304689554 |
GO:0000904 | cellular morphogenesis during differentiation | 0.00105084401298936 |
GO:0031109 | microtubule polymerization or depolymerization | 0.001352921350636 |
GO:0044430 | cytoskeletal part | 0.0014587372483156 |
GO:0042995 | cell projection | 0.00168058975947955 |
GO:0007158 | neuron adhesion | 0.00174997744229423 |
GO:0007242 | intracellular signaling cascade | 0.00224815269444086 |
GO:0016044 | membrane organization and biogenesis | 0.00228588017223452 |
GO:0030182 | neuron differentiation | 0.00236883755235154 |
GO:0007409 | axonogenesis | 0.00281923398533642 |
GO:0009966 | regulation of signal transduction | 0.0028507791390555 |
GO:0005875 | microtubule associated complex | 0.00289534133549436 |
GO:0007265 | Ras protein signal transduction | 0.00308771772176905 |
GO:0005826 | contractile ring | 0.00349296978728758 |
GO:0004572 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | 0.00349296978728758 |
GO:0031114 | regulation of microtubule depolymerization | 0.00349296978728758 |
GO:0007026 | negative regulation of microtubule depolymerization | 0.00349296978728758 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 0.00349296978728758 |
GO:0050953 | sensory perception of light stimulus | 0.00353248176073426 |
GO:0007601 | visual perception | 0.00353248176073426 |
GO:0007019 | microtubule depolymerization | 0.00399693303361887 |
GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 0.00399693303361887 |
GO:0005096 | GTPase activator activity | 0.00406378529841967 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 0.00436596981345683 |
GO:0007017 | microtubule-based process | 0.00510088471314355 |
GO:0010324 | membrane invagination | 0.00510088471314355 |
GO:0006897 | endocytosis | 0.00510088471314355 |
GO:0006996 | organelle organization and biogenesis | 0.00520148931359077 |
GO:0004385 | guanylate kinase activity | 0.00599123697206624 |
GO:0008047 | enzyme activator activity | 0.00606969145534406 |
GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 0.00625060272493628 |
GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.00665185054151881 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.00789700541093445 |
GO:0005783 | endoplasmic reticulum | 0.00824331964102461 |
GO:0005594 | collagen type IX | 0.00852886210856089 |
GO:0031110 | regulation of microtubule polymerization or depolymerization | 0.00869377254360897 |
GO:0006928 | cell motility | 0.00907526081278021 |
GO:0051674 | localization of cell | 0.00907526081278021 |
GO:0006810 | transport | 0.0100964059358843 |
GO:0016337 | cell-cell adhesion | 0.0110983645959851 |
GO:0019899 | enzyme binding | 0.0113880101567791 |
GO:0007043 | intercellular junction assembly | 0.0113880101567791 |
GO:0065007 | biological regulation | 0.0114345341354466 |
GO:0006631 | fatty acid metabolic process | 0.0146814173154532 |
GO:0032155 | cell division site part | 0.0153477263882897 |
GO:0032153 | cell division site | 0.0153477263882897 |
GO:0019717 | synaptosome | 0.0180818691619343 |
GO:0005794 | Golgi apparatus | 0.0200991953459061 |
GO:0051234 | establishment of localization | 0.0206456433123382 |
GO:0032787 | monocarboxylic acid metabolic process | 0.0207817160341849 |
GO:0043228 | non-membrane-bound organelle | 0.0207817160341849 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.0207817160341849 |
GO:0048519 | negative regulation of biological process | 0.0207817160341849 |
GO:0006936 | muscle contraction | 0.0207817160341849 |
GO:0003012 | muscle system process | 0.0207817160341849 |
GO:0005099 | Ras GTPase activator activity | 0.0207817160341849 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.0207817160341849 |
GO:0045216 | intercellular junction assembly and maintenance | 0.0213351275437189 |
GO:0005543 | phospholipid binding | 0.0213351275437189 |
GO:0005319 | lipid transporter activity | 0.0220484157385909 |
GO:0009062 | fatty acid catabolic process | 0.0223540480697841 |
GO:0048523 | negative regulation of cellular process | 0.0237779638994941 |
GO:0006461 | protein complex assembly | 0.0240243512312942 |
GO:0012505 | endomembrane system | 0.0240345216205105 |
GO:0051094 | positive regulation of developmental process | 0.0254473508634744 |
GO:0051128 | regulation of cellular component organization and biogenesis | 0.0258091686328295 |
GO:0006869 | lipid transport | 0.0258091686328295 |
GO:0007264 | small GTPase mediated signal transduction | 0.0272904328254707 |
GO:0044255 | cellular lipid metabolic process | 0.0272904328254707 |
GO:0008081 | phosphoric diester hydrolase activity | 0.0286191410127116 |
GO:0001726 | ruffle | 0.0294360896998962 |
GO:0005593 | FACIT collagen | 0.0307384931403469 |
GO:0031252 | leading edge | 0.0309639114925554 |
GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | 0.0338883379554932 |
GO:0030286 | dynein complex | 0.0338883379554932 |
GO:0051261 | protein depolymerization | 0.0364955915398225 |
GO:0044446 | intracellular organelle part | 0.040161636986754 |
GO:0007266 | Rho protein signal transduction | 0.0401874109204143 |
GO:0001609 | adenosine receptor activity, G-protein coupled | 0.0401874109204143 |
GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | 0.0401874109204143 |
GO:0001578 | microtubule bundle formation | 0.0401874109204143 |
GO:0044422 | organelle part | 0.0414734264661 |
GO:0007422 | peripheral nervous system development | 0.0414789730862933 |
GO:0007028 | cytoplasm organization and biogenesis | 0.0414789730862933 |
GO:0016477 | cell migration | 0.0414789730862933 |
GO:0005070 | SH3/SH2 adaptor activity | 0.0428232216115219 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0435394068095353 |
GO:0043229 | intracellular organelle | 0.0475275948903329 |
GO:0043226 | organelle | 0.0482981557627676 |
GO:0042135 | neurotransmitter catabolic process | 0.0496037695751093 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data