MCL coexpression mm9:1237

Phase1 CAGE Peaks

	Short description
Mm9::chr10:20672299..20672310,+	p5@Ahi1
Mm9::chr16:72027752..72027771,+	p@chr16:72027752..72027771 +
Mm9::chr17:48015995..48016037,-	p12@Foxp4
Mm9::chr2:178062247..178062272,+	p5@Phactr3
Mm9::chr2:32178983..32179012,-	p@chr2:32178983..32179012 -
Mm9::chr5:137972432..137972464,-	p15@Gnb2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048617	embryonic foregut morphogenesis	0.0274254607533146
GO:0007440	foregut morphogenesis	0.0274254607533146
GO:0048613	embryonic ectodermal gut morphogenesis	0.0274254607533146
GO:0048611	embryonic ectodermal gut development	0.0274254607533146
GO:0048558	embryonic gut morphogenesis	0.0274254607533146
GO:0048557	embryonic digestive tract morphogenesis	0.0274254607533146
GO:0007439	ectodermal gut development	0.0274254607533146
GO:0048567	ectodermal gut morphogenesis	0.0274254607533146
GO:0048547	gut morphogenesis	0.0274254607533146
GO:0048566	embryonic gut development	0.0274254607533146
GO:0048546	digestive tract morphogenesis	0.0274254607533146
GO:0004864	protein phosphatase inhibitor activity	0.0309339166018306
GO:0048565	gut development	0.031478544579051
GO:0019212	phosphatase inhibitor activity	0.031478544579051
GO:0048562	embryonic organ morphogenesis	0.0324672658235487
GO:0019888	protein phosphatase regulator activity	0.0449732511525825
GO:0005834	heterotrimeric G-protein complex	0.0449732511525825
GO:0019208	phosphatase regulator activity	0.0450415573124482
GO:0048568	embryonic organ development	0.0451018725408811

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	3.18e-19	23
neuroblast (sensu Vertebrata)	3.18e-19	23
neuron	1.23e-11	33
neuronal stem cell	1.23e-11	33
neuroblast	1.23e-11	33
electrically signaling cell	1.23e-11	33
electrically responsive cell	1.45e-08	39
electrically active cell	1.45e-08	39
ectodermal cell	2.85e-07	44
neurectodermal cell	2.85e-07	44
neural cell	4.78e-07	43

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.83e-23	54
neural tube	2.75e-23	52
neural rod	2.75e-23	52
future spinal cord	2.75e-23	52
neural keel	2.75e-23	52
neurectoderm	1.23e-21	64
neural plate	1.23e-21	64
presumptive neural plate	1.23e-21	64
gray matter	5.65e-21	34
central nervous system	6.63e-20	73
nervous system	6.77e-19	75
brain	9.79e-19	47
future brain	9.79e-19	47
ecto-epithelium	1.84e-18	73
regional part of brain	4.24e-18	46
pre-chordal neural plate	1.86e-17	49
anterior neural tube	3.02e-17	40
regional part of forebrain	2.08e-16	39
forebrain	2.08e-16	39
future forebrain	2.08e-16	39
brain grey matter	2.80e-16	29
regional part of telencephalon	2.80e-16	29
telencephalon	2.80e-16	29
ectoderm-derived structure	4.88e-16	95
ectoderm	4.88e-16	95
presumptive ectoderm	4.88e-16	95
structure with developmental contribution from neural crest	5.49e-15	92
cerebral cortex	1.13e-09	21
cerebral hemisphere	1.13e-09	21
pallium	1.13e-09	21
basal ganglion	2.31e-08	8
nuclear complex of neuraxis	2.31e-08	8
aggregate regional part of brain	2.31e-08	8
collection of basal ganglia	2.31e-08	8
cerebral subcortex	2.31e-08	8
regional part of cerebral cortex	3.31e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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