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Coexpression cluster:C2316

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Full id: C2316_mycosis_occipital_frontal_parietal_paracentral_postcentral_medial



Phase1 CAGE Peaks

Hg19::chr14:78870030..78870098,+p5@NRXN3
Hg19::chr6:128134199..128134253,-p3@THEMIS
Hg19::chrX:21977968..21977978,+p@chrX:21977968..21977978
+
Hg19::chrX:21977990..21978030,+p@chrX:21977990..21978030
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube4.99e-5157
neural rod4.99e-5157
future spinal cord4.99e-5157
neural keel4.99e-5157
regional part of brain2.19e-4859
central nervous system5.15e-4782
brain2.26e-4569
future brain2.26e-4569
regional part of nervous system2.81e-4094
nervous system2.81e-4094
regional part of forebrain1.68e-3841
forebrain1.68e-3841
future forebrain1.68e-3841
neural plate1.72e-3886
presumptive neural plate1.72e-3886
anterior neural tube2.96e-3742
telencephalon2.09e-3634
gray matter3.25e-3634
brain grey matter3.25e-3634
neurectoderm7.73e-3690
regional part of telencephalon4.55e-3533
cerebral hemisphere1.34e-3432
adult organism4.64e-32115
regional part of cerebral cortex2.45e-2922
cerebral cortex5.43e-2725
pallium5.43e-2725
neocortex6.38e-2720
anterior region of body8.46e-26129
craniocervical region8.46e-26129
pre-chordal neural plate3.74e-2561
head1.18e-23123
ectoderm-derived structure9.58e-22169
ectoderm1.05e-20173
presumptive ectoderm1.05e-20173
posterior neural tube1.92e-1415
chordal neural plate1.92e-1415
segmental subdivision of hindbrain9.34e-1212
hindbrain9.34e-1212
presumptive hindbrain9.34e-1212
tube2.23e-11194
temporal lobe4.86e-117
basal ganglion7.58e-119
nuclear complex of neuraxis7.58e-119
aggregate regional part of brain7.58e-119
collection of basal ganglia7.58e-119
cerebral subcortex7.58e-119
segmental subdivision of nervous system1.35e-1013
nucleus of brain1.45e-109
neural nucleus1.45e-109
gyrus1.83e-096
epithelium3.44e-09309
cell layer6.94e-09312
regional part of metencephalon1.26e-089
metencephalon1.26e-089
future metencephalon1.26e-089
telencephalic nucleus1.77e-087
organ part5.52e-08219
parietal lobe1.05e-075
limbic system1.23e-075
brainstem1.67e-078
occipital lobe1.85e-075
organism subdivision2.28e-07365
anatomical cluster4.58e-07286


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.