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Coexpression cluster:C174

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Full id: C174_CD14_Neutrophils_Smooth_mesothelioma_embryonic_Monocytederived_Eosinophils



Phase1 CAGE Peaks

Hg19::chr10:104160765..104160775,+p@chr10:104160765..104160775
+
Hg19::chr10:91064212..91064218,+p@chr10:91064212..91064218
+
Hg19::chr10:91066585..91066596,+p@chr10:91066585..91066596
+
Hg19::chr10:91066632..91066642,+p@chr10:91066632..91066642
+
Hg19::chr10:91066692..91066705,+p@chr10:91066692..91066705
+
Hg19::chr10:91066836..91066845,+p@chr10:91066836..91066845
+
Hg19::chr10:91067074..91067087,+p@chr10:91067074..91067087
+
Hg19::chr10:91067335..91067346,+p2@AF026944
Hg19::chr10:91067543..91067553,+p4@AF026944
Hg19::chr10:91098875..91098881,+p8@IFIT3
Hg19::chr10:91099205..91099221,+p@chr10:91099205..91099221
+
Hg19::chr10:91099381..91099392,+p@chr10:91099381..91099392
+
Hg19::chr10:91099524..91099535,+p@chr10:91099524..91099535
+
Hg19::chr10:91099822..91099840,+p@chr10:91099822..91099840
+
Hg19::chr10:91100385..91100400,+p1@AF026943
Hg19::chr13:43466640..43466643,-p@chr13:43466640..43466643
-
Hg19::chr13:43527382..43527387,-p@chr13:43527382..43527387
-
Hg19::chr13:77523604..77523611,+p@chr13:77523604..77523611
+
Hg19::chr13:77523659..77523668,+p@chr13:77523659..77523668
+
Hg19::chr13:77523716..77523728,+p@chr13:77523716..77523728
+
Hg19::chr13:77523731..77523760,+p@chr13:77523731..77523760
+
Hg19::chr13:77523801..77523815,+p@chr13:77523801..77523815
+
Hg19::chr13:77523867..77523878,+p@chr13:77523867..77523878
+
Hg19::chr13:77523885..77523908,+p@chr13:77523885..77523908
+
Hg19::chr13:77523928..77523953,+p@chr13:77523928..77523953
+
Hg19::chr13:77523974..77523977,+p@chr13:77523974..77523977
+
Hg19::chr13:77524004..77524015,+p@chr13:77524004..77524015
+
Hg19::chr13:77524020..77524025,+p@chr13:77524020..77524025
+
Hg19::chr13:77524100..77524108,+p@chr13:77524100..77524108
+
Hg19::chr13:77524143..77524160,-p@chr13:77524143..77524160
-
Hg19::chr13:77524293..77524304,+p@chr13:77524293..77524304
+
Hg19::chr13:77524315..77524323,+p@chr13:77524315..77524323
+
Hg19::chr13:77524327..77524341,+p@chr13:77524327..77524341
+
Hg19::chr13:77524439..77524449,+p@chr13:77524439..77524449
+
Hg19::chr13:77524465..77524486,+p@chr13:77524465..77524486
+
Hg19::chr13:77524669..77524674,+p@chr13:77524669..77524674
+
Hg19::chr13:77524780..77524802,+p@chr13:77524780..77524802
+
Hg19::chr13:77524836..77524855,+p@chr13:77524836..77524855
+
Hg19::chr13:77525063..77525075,+p@chr13:77525063..77525075
+
Hg19::chr13:77525104..77525111,+p@chr13:77525104..77525111
+
Hg19::chr13:77526078..77526093,+p@chr13:77526078..77526093
+
Hg19::chr13:77526602..77526613,+p2@IRG1
Hg19::chr13:77527823..77527839,+p@chr13:77527823..77527839
+
Hg19::chr13:77529551..77529562,+p@chr13:77529551..77529562
+
Hg19::chr13:77529598..77529625,+p@chr13:77529598..77529625
+
Hg19::chr13:77531401..77531411,+p@chr13:77531401..77531411
+
Hg19::chr13:77531942..77531948,+p@chr13:77531942..77531948
+
Hg19::chr13:77532118..77532127,+p@chr13:77532118..77532127
+
Hg19::chr13:77532353..77532362,+p@chr13:77532353..77532362
+
Hg19::chr13:77532575..77532588,+p@chr13:77532575..77532588
+
Hg19::chr14:23317235..23317240,+p@chr14:23317235..23317240
+
Hg19::chr15:39557638..39557647,-p@chr15:39557638..39557647
-
Hg19::chr15:45948197..45948201,+p@chr15:45948197..45948201
+
Hg19::chr16:28518153..28518187,-p1@IL27
Hg19::chr16:28518346..28518378,+p@chr16:28518346..28518378
+
Hg19::chr17:14295218..14295226,+p@chr17:14295218..14295226
+
Hg19::chr17:41375281..41375285,+p@chr17:41375281..41375285
+
Hg19::chr18:57570198..57570221,+p@chr18:57570198..57570221
+
Hg19::chr18:57570353..57570374,+p@chr18:57570353..57570374
+
Hg19::chr19:35494139..35494155,-p@chr19:35494139..35494155
-
Hg19::chr1:157082506..157082509,-p@chr1:157082506..157082509
-
Hg19::chr1:79127415..79127445,+p@chr1:79127415..79127445
+
Hg19::chr1:8064977..8064981,-p@chr1:8064977..8064981
-
Hg19::chr20:19916038..19916060,+p@chr20:19916038..19916060
+
Hg19::chr20:19920057..19920064,+p@chr20:19920057..19920064
+
Hg19::chr20:19977319..19977334,+p@chr20:19977319..19977334
+
Hg19::chr2:113534770..113534781,-p@chr2:113534770..113534781
-
Hg19::chr2:152170811..152170815,-p@chr2:152170811..152170815
-
Hg19::chr2:152193688..152193700,-p@chr2:152193688..152193700
-
Hg19::chr2:152219301..152219305,+p@chr2:152219301..152219305
+
Hg19::chr2:152231734..152231766,+p@chr2:152231734..152231766
+
Hg19::chr2:163134134..163134143,-p@chr2:163134134..163134143
-
Hg19::chr2:163154392..163154394,-p@chr2:163154392..163154394
-
Hg19::chr2:173939494..173939525,-p@chr2:173939494..173939525
-
Hg19::chr2:223310826..223310832,+p@chr2:223310826..223310832
+
Hg19::chr4:103212519..103212530,-p@chr4:103212519..103212530
-
Hg19::chr4:103213023..103213027,-p@chr4:103213023..103213027
-
Hg19::chr4:185765733..185765737,+p@chr4:185765733..185765737
+
Hg19::chr4:185774396..185774408,-p@chr4:185774396..185774408
-
Hg19::chr5:159905166..159905205,+p@chr5:159905166..159905205
+
Hg19::chr5:90607150..90607158,-p@chr5:90607150..90607158
-
Hg19::chr6:136917108..136917113,+p@chr6:136917108..136917113
+
Hg19::chr6:143237311..143237314,-p@chr6:143237311..143237314
-
Hg19::chr6:18467649..18467652,+p3@RNF144B
Hg19::chr7:22767500..22767518,+p@chr7:22767500..22767518
+
Hg19::chr7:22769276..22769283,+p@chr7:22769276..22769283
+
Hg19::chr7:37731277..37731281,-p@chr7:37731277..37731281
-
Hg19::chr8:123916899..123916917,+p@chr8:123916899..123916917
+
Hg19::chr8:23402147..23402156,+p@chr8:23402147..23402156
+
Hg19::chr8:79741110..79741114,+p@chr8:79741110..79741114
+
Hg19::chr8:79741203..79741212,+p@chr8:79741203..79741212
+
Hg19::chr8:79742160..79742165,+p@chr8:79742160..79742165
+
Hg19::chr9:117754052..117754067,-p@chr9:117754052..117754067
-
Hg19::chr9:123666399..123666408,-p@chr9:123666399..123666408
-
Hg19::chr9:123666433..123666454,+p@chr9:123666433..123666454
+
Hg19::chr9:123666898..123666910,-p@chr9:123666898..123666910
-
Hg19::chr9:32445457..32445459,-p@chr9:32445457..32445459
-
Hg19::chr9:32491708..32491712,-p@chr9:32491708..32491712
-
Hg19::chr9:32523976..32523988,-p@chr9:32523976..32523988
-
Hg19::chr9:32524255..32524274,-p@chr9:32524255..32524274
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0045523interleukin-27 receptor binding0.012211741008308
GO:0045625regulation of T-helper 1 cell differentiation0.012211741008308
GO:0045063T-helper 1 cell differentiation0.012211741008308
GO:0042787protein ubiquitination during ubiquitin-dependent protein catabolic process0.012211741008308
GO:0045622regulation of T-helper cell differentiation0.012211741008308
GO:0045078positive regulation of interferon-gamma biosynthetic process0.012211741008308
GO:0002294CD4-positive, alpha-beta T cell differentiation during immune response0.012211741008308
GO:0002292T cell differentiation during immune response0.012211741008308
GO:0042093T-helper cell differentiation0.012211741008308
GO:0002366leukocyte activation during immune response0.012211741008308
GO:0002285lymphocyte activation during immune response0.012211741008308
GO:0002293alpha-beta T cell differentiation during immune response0.012211741008308
GO:0002286T cell activation during immune response0.012211741008308
GO:0002263cell activation during immune response0.012211741008308
GO:0043367CD4-positive, alpha beta T cell differentiation0.012211741008308
GO:0045072regulation of interferon-gamma biosynthetic process0.012211741008308
GO:0042088T-helper 1 type immune response0.012211741008308
GO:0042095interferon-gamma biosynthetic process0.0124938684735764
GO:0046632alpha-beta T cell differentiation0.0145658197070558
GO:0032609interferon-gamma production0.0155658449870154
GO:0046631alpha-beta T cell activation0.0156475129463439
GO:0042129regulation of T cell proliferation0.0267103489548182
GO:0042098T cell proliferation0.0268754292715547
GO:0042108positive regulation of cytokine biosynthetic process0.0268754292715547
GO:0030217T cell differentiation0.0268754292715547
GO:0050670regulation of lymphocyte proliferation0.0268754292715547
GO:0032944regulation of mononuclear cell proliferation0.0268754292715547
GO:0032943mononuclear cell proliferation0.0305079837093949
GO:0045727positive regulation of translation0.0305079837093949
GO:0046651lymphocyte proliferation0.0305079837093949
GO:0050863regulation of T cell activation0.0313878759468907
GO:0042035regulation of cytokine biosynthetic process0.0313878759468907
GO:0031328positive regulation of cellular biosynthetic process0.0313878759468907
GO:0030098lymphocyte differentiation0.0316256848458442
GO:0042089cytokine biosynthetic process0.0316256848458442
GO:0042107cytokine metabolic process0.0316256848458442
GO:0009891positive regulation of biosynthetic process0.0316256848458442
GO:0016567protein ubiquitination0.0316256848458442
GO:0002250adaptive immune response0.0316256848458442
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0316256848458442
GO:0051249regulation of lymphocyte activation0.0316256848458442
GO:0032446protein modification by small protein conjugation0.0316256848458442
GO:0050865regulation of cell activation0.0320894655001998
GO:0000151ubiquitin ligase complex0.0323258815618499
GO:0051247positive regulation of protein metabolic process0.0323258815618499
GO:0051536iron-sulfur cluster binding0.0323258815618499
GO:0002521leukocyte differentiation0.0323258815618499
GO:0051540metal cluster binding0.0323258815618499
GO:0042110T cell activation0.0344687565798637
GO:0001816cytokine production0.0389238922781131
GO:0048869cellular developmental process0.0447761208584112
GO:0030154cell differentiation0.0447761208584112
GO:0045595regulation of cell differentiation0.0467304104186421
GO:0046649lymphocyte activation0.049344620573025



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte9.43e-8342
CD14-positive, CD16-negative classical monocyte9.43e-8342
defensive cell3.51e-7248
phagocyte3.51e-7248
monopoietic cell2.26e-5759
monocyte2.26e-5759
monoblast2.26e-5759
promonocyte2.26e-5759
macrophage dendritic cell progenitor1.84e-5561
myeloid lineage restricted progenitor cell3.52e-5166
granulocyte monocyte progenitor cell2.12e-5067
myeloid leukocyte8.15e-4772
stuff accumulating cell5.75e-3987
myeloid cell1.07e-30108
common myeloid progenitor1.07e-30108
nongranular leukocyte1.02e-28115
hematopoietic lineage restricted progenitor cell1.90e-27120
leukocyte5.34e-24136
hematopoietic oligopotent progenitor cell5.76e-20161
hematopoietic multipotent progenitor cell5.76e-20161
hematopoietic stem cell4.75e-19168
angioblastic mesenchymal cell4.75e-19168
hematopoietic cell5.62e-18177
mesenchymal cell7.48e-08354
connective tissue cell1.18e-07361
motile cell5.99e-07386
Uber Anatomy
Ontology termp-valuen
bone marrow2.78e-4476
bone element6.12e-4182
skeletal element3.63e-3790
immune system6.45e-3693
hematopoietic system5.31e-3498
blood island5.31e-3498
skeletal system2.74e-33100
hemolymphoid system1.07e-30108
musculoskeletal system3.55e-19167
lateral plate mesoderm2.10e-15203
mesoderm4.02e-09315
mesoderm-derived structure4.02e-09315
presumptive mesoderm4.02e-09315
connective tissue2.22e-07371


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10
MA0004.10.0128701
MA0006.10.0116225
MA0007.10.46483
MA0009.10.0972626
MA0014.10
MA0017.10.0550552
MA0019.11.13865
MA0024.10.0576551
MA0025.10.491251
MA0027.11.44251
MA0028.10.00490258
MA0029.10.495376
MA0030.10.217661
MA0031.10.15933
MA0038.10.238592
MA0040.10.506119
MA0041.12.61266
MA0042.10.311843
MA0043.10.321786
MA0046.10.638964
MA0048.10.0670221
MA0050.11.55736
MA0051.10.915077
MA0052.10.238734
MA0055.14.17443e-07
MA0056.10
MA0057.10.00628459
MA0058.10.146197
MA0059.10.0336009
MA0060.10.000100863
MA0061.10.00505853
MA0063.10
MA0066.10.0399676
MA0067.10.279326
MA0068.10.0258763
MA0069.10.304472
MA0070.11.5168
MA0071.10.769695
MA0072.10.286874
MA0073.10.00736016
MA0074.10.405868
MA0076.10.00383178
MA0077.10.58486
MA0078.10.0190242
MA0081.10.73454
MA0083.10.676452
MA0084.10.419501
MA0087.11.00163
MA0088.10.0215245
MA0089.10
MA0090.11.79394
MA0091.11.03054
MA0092.10.14911
MA0093.10.00372404
MA0095.10
MA0098.10
MA0100.10.26119
MA0101.10.0332258
MA0103.10.391493
MA0105.12.7166e-09
MA0106.10.0116703
MA0107.10.00733969
MA0108.20.644893
MA0109.10
MA0111.10.12674
MA0113.10.339156
MA0114.10.501238
MA0115.10.64658
MA0116.10.00800018
MA0117.10.11421
MA0119.10.322505
MA0122.10.126683
MA0124.10.202128
MA0125.10.153634
MA0130.10
MA0131.10.0961295
MA0132.10
MA0133.10
MA0135.10.11084
MA0136.10.119877
MA0139.10.000363134
MA0140.10.0804147
MA0141.10.529906
MA0142.10.0331787
MA0143.10.33949
MA0144.10.142239
MA0145.12.04265e-06
MA0146.15.01776e-10
MA0147.10.000739515
MA0148.10.131845
MA0149.10.0238374
MA0062.20.000491339
MA0035.20.3212
MA0039.20
MA0138.21.00588
MA0002.20.226926
MA0137.20.156168
MA0104.29.77769e-05
MA0047.20.14092
MA0112.20.00154083
MA0065.20.00977461
MA0150.10.308215
MA0151.10
MA0152.10.537345
MA0153.10.144632
MA0154.11.93244e-07
MA0155.15.86873e-07
MA0156.10.0445753
MA0157.10.114075
MA0158.10
MA0159.10.0215532
MA0160.10.150041
MA0161.10
MA0162.11.41573e-10
MA0163.18.46001e-06
MA0164.10.185088
MA0080.20.0314807
MA0018.20.0575235
MA0099.20.028437
MA0079.20
MA0102.21.1409
MA0258.10.0204273
MA0259.10.000944777
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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