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MCL coexpression mm9:3390

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Phase1 CAGE Peaks

 Short description
Mm9::chr3:125106990..125107049,+p1@Ndst4
Mm9::chr5:118291848..118291866,+p4@Nos1
Mm9::chr5:118292122..118292176,+p3@Nos1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0042737drug catabolic process0.00488035647693281
GO:0042738exogenous drug catabolic process0.00488035647693281
GO:0051926negative regulation of calcium ion transport0.00488035647693281
GO:0004517nitric-oxide synthase activity0.00488035647693281
GO:0043267negative regulation of potassium ion transport0.00488035647693281
GO:0002028regulation of sodium ion transport0.00488035647693281
GO:0043271negative regulation of ion transport0.00488035647693281
GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity0.00488035647693281
GO:0043266regulation of potassium ion transport0.00488035647693281
GO:0051346negative regulation of hydrolase activity0.00488035647693281
GO:0017144drug metabolic process0.00488035647693281
GO:0051924regulation of calcium ion transport0.00626278096051241
GO:0010181FMN binding0.00825793342837634
GO:0050661NADP binding0.00843465802018453
GO:0043269regulation of ion transport0.00858778011195526
GO:0046209nitric oxide metabolic process0.0107329601891086
GO:0006809nitric oxide biosynthetic process0.0107329601891086
GO:0051051negative regulation of transport0.0107329601891086
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0124262756955159
GO:0042383sarcolemma0.0146310413010513
GO:0006941striated muscle contraction0.0146310413010513
GO:0042493response to drug0.0146310413010513
GO:0008146sulfotransferase activity0.0205179883055715
GO:0043086negative regulation of catalytic activity0.0210020079537489
GO:0016782transferase activity, transferring sulfur-containing groups0.0218754360374072
GO:0050660FAD binding0.0243281954543166
GO:0044271nitrogen compound biosynthetic process0.0299979280437709
GO:0003012muscle system process0.0299979280437709
GO:0006936muscle contraction0.0299979280437709
GO:0051049regulation of transport0.0299979280437709
GO:0006816calcium ion transport0.033305406688356
GO:0005516calmodulin binding0.033305406688356
GO:0051336regulation of hydrolase activity0.033305406688356
GO:0020037heme binding0.033305406688356
GO:0046906tetrapyrrole binding0.033305406688356
GO:0006814sodium ion transport0.033305406688356
GO:0050662coenzyme binding0.0335589023897373
GO:0004497monooxygenase activity0.0342996321555843
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0342996321555843
GO:0015674di-, tri-valent inorganic cation transport0.0354868763548967
GO:0009055electron carrier activity0.0354868763548967
GO:0006813potassium ion transport0.0389539777543435
GO:0048037cofactor binding0.0417610353083993



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
central nervous system1.48e-3473
nervous system5.60e-3475
regional part of nervous system6.37e-2654
neural tube5.45e-2452
neural rod5.45e-2452
future spinal cord5.45e-2452
neural keel5.45e-2452
ectoderm-derived structure1.52e-2395
ectoderm1.52e-2395
presumptive ectoderm1.52e-2395
neurectoderm2.06e-2264
neural plate2.06e-2264
presumptive neural plate2.06e-2264
brain5.73e-2147
future brain5.73e-2147
regional part of brain5.38e-2046
gray matter4.10e-1934
anterior neural tube2.26e-1840
regional part of forebrain1.86e-1739
forebrain1.86e-1739
future forebrain1.86e-1739
ecto-epithelium2.21e-1773
brain grey matter4.52e-1629
regional part of telencephalon4.52e-1629
telencephalon4.52e-1629
pre-chordal neural plate2.52e-1449
structure with developmental contribution from neural crest2.69e-1092
cerebral cortex3.09e-1021
cerebral hemisphere3.09e-1021
pallium3.09e-1021
autonomic nervous system2.48e-099
peripheral nervous system4.55e-0811
basal ganglion2.49e-078
nuclear complex of neuraxis2.49e-078
aggregate regional part of brain2.49e-078
collection of basal ganglia2.49e-078
cerebral subcortex2.49e-078
regional part of cerebral cortex2.50e-0717


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.245953
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.10.416365
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.10.61552
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.12.51309
MA0050.10.845669
MA0051.10.973068
MA0052.11.29825
MA0055.11.6728
MA0056.10
MA0057.11.60767
MA0058.10.690848
MA0059.10.705317
MA0060.10.502699
MA0061.10.5406
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.10.343188
MA0069.11.29861
MA0070.12.87039
MA0071.10.844726
MA0072.11.2796
MA0073.10.00834468
MA0074.10.911576
MA0076.10.657929
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.10.766354
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.10.405648
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.10.462282
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.794492
MA0146.10.151124
MA0147.10.556853
MA0148.10.820161
MA0149.10.722227
MA0062.20.412742
MA0035.20.903829
MA0039.20.40695
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.794478
MA0065.20.292912
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.925147
MA0155.10.312898
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.10.823568
MA0161.10
MA0162.10.166722
MA0163.10.157796
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.21.16605
MA0102.22.01714
MA0258.11.29343
MA0259.10.543506
MA0442.10