MCL coexpression mm9:3390

Phase1 CAGE Peaks

	Short description
Mm9::chr3:125106990..125107049,+	p1@Ndst4
Mm9::chr5:118291848..118291866,+	p4@Nos1
Mm9::chr5:118292122..118292176,+	p3@Nos1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0042737	drug catabolic process	0.00488035647693281
GO:0042738	exogenous drug catabolic process	0.00488035647693281
GO:0051926	negative regulation of calcium ion transport	0.00488035647693281
GO:0004517	nitric-oxide synthase activity	0.00488035647693281
GO:0043267	negative regulation of potassium ion transport	0.00488035647693281
GO:0002028	regulation of sodium ion transport	0.00488035647693281
GO:0043271	negative regulation of ion transport	0.00488035647693281
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	0.00488035647693281
GO:0043266	regulation of potassium ion transport	0.00488035647693281
GO:0051346	negative regulation of hydrolase activity	0.00488035647693281
GO:0017144	drug metabolic process	0.00488035647693281
GO:0051924	regulation of calcium ion transport	0.00626278096051241
GO:0010181	FMN binding	0.00825793342837634
GO:0050661	NADP binding	0.00843465802018453
GO:0043269	regulation of ion transport	0.00858778011195526
GO:0046209	nitric oxide metabolic process	0.0107329601891086
GO:0006809	nitric oxide biosynthetic process	0.0107329601891086
GO:0051051	negative regulation of transport	0.0107329601891086
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.0124262756955159
GO:0042383	sarcolemma	0.0146310413010513
GO:0006941	striated muscle contraction	0.0146310413010513
GO:0042493	response to drug	0.0146310413010513
GO:0008146	sulfotransferase activity	0.0205179883055715
GO:0043086	negative regulation of catalytic activity	0.0210020079537489
GO:0016782	transferase activity, transferring sulfur-containing groups	0.0218754360374072
GO:0050660	FAD binding	0.0243281954543166
GO:0044271	nitrogen compound biosynthetic process	0.0299979280437709
GO:0003012	muscle system process	0.0299979280437709
GO:0006936	muscle contraction	0.0299979280437709
GO:0051049	regulation of transport	0.0299979280437709
GO:0006816	calcium ion transport	0.033305406688356
GO:0005516	calmodulin binding	0.033305406688356
GO:0051336	regulation of hydrolase activity	0.033305406688356
GO:0020037	heme binding	0.033305406688356
GO:0046906	tetrapyrrole binding	0.033305406688356
GO:0006814	sodium ion transport	0.033305406688356
GO:0050662	coenzyme binding	0.0335589023897373
GO:0004497	monooxygenase activity	0.0342996321555843
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.0342996321555843
GO:0015674	di-, tri-valent inorganic cation transport	0.0354868763548967
GO:0009055	electron carrier activity	0.0354868763548967
GO:0006813	potassium ion transport	0.0389539777543435
GO:0048037	cofactor binding	0.0417610353083993

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
neuron	2.37e-24	33
neuronal stem cell	2.37e-24	33
neuroblast	2.37e-24	33
electrically signaling cell	2.37e-24	33
electrically responsive cell	1.54e-18	39
electrically active cell	1.54e-18	39
CNS neuron (sensu Vertebrata)	3.05e-17	23
neuroblast (sensu Vertebrata)	3.05e-17	23
neural cell	1.87e-16	43
ectodermal cell	8.73e-16	44
neurectodermal cell	8.73e-16	44
non-terminally differentiated cell	6.85e-13	49
autonomic neuron	2.48e-09	9

Uber Anatomy

Ontology term	p-value	n
central nervous system	1.48e-34	73
nervous system	5.60e-34	75
regional part of nervous system	6.37e-26	54
neural tube	5.45e-24	52
neural rod	5.45e-24	52
future spinal cord	5.45e-24	52
neural keel	5.45e-24	52
ectoderm-derived structure	1.52e-23	95
ectoderm	1.52e-23	95
presumptive ectoderm	1.52e-23	95
neurectoderm	2.06e-22	64
neural plate	2.06e-22	64
presumptive neural plate	2.06e-22	64
brain	5.73e-21	47
future brain	5.73e-21	47
regional part of brain	5.38e-20	46
gray matter	4.10e-19	34
anterior neural tube	2.26e-18	40
regional part of forebrain	1.86e-17	39
forebrain	1.86e-17	39
future forebrain	1.86e-17	39
ecto-epithelium	2.21e-17	73
brain grey matter	4.52e-16	29
regional part of telencephalon	4.52e-16	29
telencephalon	4.52e-16	29
pre-chordal neural plate	2.52e-14	49
structure with developmental contribution from neural crest	2.69e-10	92
cerebral cortex	3.09e-10	21
cerebral hemisphere	3.09e-10	21
pallium	3.09e-10	21
autonomic nervous system	2.48e-09	9
peripheral nervous system	4.55e-08	11
basal ganglion	2.49e-07	8
nuclear complex of neuraxis	2.49e-07	8
aggregate regional part of brain	2.49e-07	8
collection of basal ganglia	2.49e-07	8
cerebral subcortex	2.49e-07	8
regional part of cerebral cortex	2.50e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}