MCL coexpression mm9:22: Difference between revisions
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|ontology_enrichment_uberon=UBERON:0001017!2.92e-31!73;UBERON:0002346!6.86e-30!64;UBERON:0003075!6.86e-30!64;UBERON:0007284!6.86e-30!64;UBERON:0001016!1.04e-29!75;UBERON:0004121!9.06e-28!95;UBERON:0000924!9.06e-28!95;UBERON:0006601!9.06e-28!95;UBERON:0000073!1.80e-26!54;UBERON:0001049!6.56e-25!52;UBERON:0005068!6.56e-25!52;UBERON:0006241!6.56e-25!52;UBERON:0007135!6.56e-25!52;UBERON:0010371!6.62e-25!73;UBERON:0003056!2.44e-24!49;UBERON:0002020!1.83e-21!34;UBERON:0000955!3.37e-21!47;UBERON:0006238!3.37e-21!47;UBERON:0002616!1.64e-20!46;UBERON:0003080!1.97e-20!40;UBERON:0002780!8.45e-20!39;UBERON:0001890!8.45e-20!39;UBERON:0006240!8.45e-20!39;UBERON:0003528!2.08e-17!29;UBERON:0002791!2.08e-17!29;UBERON:0001893!2.08e-17!29;UBERON:0010314!1.11e-16!92;UBERON:0000956!7.85e-12!21;UBERON:0001869!7.85e-12!21;UBERON:0000203!7.85e-12!21;UBERON:0002619!6.69e-09!17;UBERON:0002021!3.96e-07!10;UBERON:0000411!3.96e-07!10;UBERON:0001950!3.96e-07!10;UBERON:0002420!6.99e-07!8;UBERON:0007245!6.99e-07!8;UBERON:0010009!6.99e-07!8;UBERON:0010011!6.99e-07!8;UBERON:0000454!6.99e-07!8 | |ontology_enrichment_uberon=UBERON:0001017!2.92e-31!73;UBERON:0002346!6.86e-30!64;UBERON:0003075!6.86e-30!64;UBERON:0007284!6.86e-30!64;UBERON:0001016!1.04e-29!75;UBERON:0004121!9.06e-28!95;UBERON:0000924!9.06e-28!95;UBERON:0006601!9.06e-28!95;UBERON:0000073!1.80e-26!54;UBERON:0001049!6.56e-25!52;UBERON:0005068!6.56e-25!52;UBERON:0006241!6.56e-25!52;UBERON:0007135!6.56e-25!52;UBERON:0010371!6.62e-25!73;UBERON:0003056!2.44e-24!49;UBERON:0002020!1.83e-21!34;UBERON:0000955!3.37e-21!47;UBERON:0006238!3.37e-21!47;UBERON:0002616!1.64e-20!46;UBERON:0003080!1.97e-20!40;UBERON:0002780!8.45e-20!39;UBERON:0001890!8.45e-20!39;UBERON:0006240!8.45e-20!39;UBERON:0003528!2.08e-17!29;UBERON:0002791!2.08e-17!29;UBERON:0001893!2.08e-17!29;UBERON:0010314!1.11e-16!92;UBERON:0000956!7.85e-12!21;UBERON:0001869!7.85e-12!21;UBERON:0000203!7.85e-12!21;UBERON:0002619!6.69e-09!17;UBERON:0002021!3.96e-07!10;UBERON:0000411!3.96e-07!10;UBERON:0001950!3.96e-07!10;UBERON:0002420!6.99e-07!8;UBERON:0007245!6.99e-07!8;UBERON:0010009!6.99e-07!8;UBERON:0010011!6.99e-07!8;UBERON:0000454!6.99e-07!8 | ||
|tfbs_overrepresentation_for_novel_motifs=0.750709,7.4939,1.6233,0.00375325,0.000427281,0.00685335,2.61958,0.0310216,0.558456,13.9825,1.44487,0.0238213,7.82673,0.86046,0.000962817,0,1.75494,0.00681654,0.603173,0.625459,0.00424423,0.162672,0.428967,0.000975918,0.801794,2.27973,1.4956,1.66025,3.45058,1.02479,0.89465,0.0381984,2.79092,0.794415,0.780494,13.1987,17.5271,0.953626,0.000520553,6.05889,0.000305334,0.958383,0.092783,0.0166344,2.01811,0.547157,1.45759,1.77176,0.0319722,0.417787,0.978618,1.14299,0.334675,1.02452,0.240277,1.55567,0.000864289,0.854463,0.105272,4.03287,0.668844,1.08567,0.105172,0.151554,0.37503,0.184661,0.0755169,0.136481,0.0823951,0.785588,7.13773,6.14194e-06,42.0723,0.200315,17.63,2.26595,0.381724,0.703608,0.0038323,0.0237184,0.0724937,1.08893,0.0355821,0.000430174,3.5191,46.6544,21.1259,18.1181,0.690525,0.981752,0.251744,0.535552,0.00121308,0.00258983,13.2148,0.00091767,0.460445,0.301552,0.340641,1.31043,0.856119,0.176153,0.39431,0.0513845,1.3434,3.6615,1.10073,0.047537,5.62415,3.13443,0.758688,0.933855,0.73424,0.433553,0.140506,0.0201515,19.7848,0.203047,0.405401,0.0398193,0.20962,0.046119,0.0402124,0.0320032,0.361663,0.749738,2.13581,0.379178,0.074487,1.07162,0.0449035,0.0377289,0.213978,0.020428,0.300499,4.71157,0.0215429,0.749477,0.114186,0.276094,0.245081,0.00126286,0.000763579,0.286616,0.395959,0.0379669,0.00376724,0.249926,0.063082,5.89031,2.77852,66.3627,0.455405,1.30885,0.0716764,0.037122,0.0302279,0.00740295,0.0140744,3.85628,0.389438,0.172995,0.0731341,2.51094,0.00103489,0.0162296,1.61501,0.00848091,9.76649 | |tfbs_overrepresentation_for_novel_motifs=0.750709,7.4939,1.6233,0.00375325,0.000427281,0.00685335,2.61958,0.0310216,0.558456,13.9825,1.44487,0.0238213,7.82673,0.86046,0.000962817,0,1.75494,0.00681654,0.603173,0.625459,0.00424423,0.162672,0.428967,0.000975918,0.801794,2.27973,1.4956,1.66025,3.45058,1.02479,0.89465,0.0381984,2.79092,0.794415,0.780494,13.1987,17.5271,0.953626,0.000520553,6.05889,0.000305334,0.958383,0.092783,0.0166344,2.01811,0.547157,1.45759,1.77176,0.0319722,0.417787,0.978618,1.14299,0.334675,1.02452,0.240277,1.55567,0.000864289,0.854463,0.105272,4.03287,0.668844,1.08567,0.105172,0.151554,0.37503,0.184661,0.0755169,0.136481,0.0823951,0.785588,7.13773,6.14194e-06,42.0723,0.200315,17.63,2.26595,0.381724,0.703608,0.0038323,0.0237184,0.0724937,1.08893,0.0355821,0.000430174,3.5191,46.6544,21.1259,18.1181,0.690525,0.981752,0.251744,0.535552,0.00121308,0.00258983,13.2148,0.00091767,0.460445,0.301552,0.340641,1.31043,0.856119,0.176153,0.39431,0.0513845,1.3434,3.6615,1.10073,0.047537,5.62415,3.13443,0.758688,0.933855,0.73424,0.433553,0.140506,0.0201515,19.7848,0.203047,0.405401,0.0398193,0.20962,0.046119,0.0402124,0.0320032,0.361663,0.749738,2.13581,0.379178,0.074487,1.07162,0.0449035,0.0377289,0.213978,0.020428,0.300499,4.71157,0.0215429,0.749477,0.114186,0.276094,0.245081,0.00126286,0.000763579,0.286616,0.395959,0.0379669,0.00376724,0.249926,0.063082,5.89031,2.77852,66.3627,0.455405,1.30885,0.0716764,0.037122,0.0302279,0.00740295,0.0140744,3.85628,0.389438,0.172995,0.0731341,2.51094,0.00103489,0.0162296,1.61501,0.00848091,9.76649 | ||
|tfbs_overrepresentation_jaspar=MA0003.1;43.1586,MA0004.1;0.149476,MA0006.1;7.02993,MA0007.1;0.208938,MA0009.1;0.235341,MA0014.1;42.9039,MA0017.1;0.000230231,MA0019.1;0.571172,MA0024.1;0.683701,MA0025.1;0.000698174,MA0027.1;0.67344,MA0028.1;0.0363959,MA0029.1;0.0197738,MA0030.1;0.000405464,MA0031.1;0.00186004,MA0038.1;0.426721,MA0040.1;0.0354066,MA0041.1;9.69434e-09,MA0042.1;3.989e-06,MA0043.1;0.00964383,MA0046.1;0.00338115,MA0048.1;2.3936,MA0050.1;0.00110529,MA0051.1;0.0703978,MA0052.1;0.0742851,MA0055.1;3.92309,MA0056.1;0,MA0057.1;21.6001,MA0058.1;0.0907762,MA0059.1;0.243033,MA0060.1;1.91485,MA0061.1;2.15388,MA0063.1;0,MA0066.1;0.36529,MA0067.1;0.139214,MA0068.1;3.76092,MA0069.1;0.884191,MA0070.1;0.0347301,MA0071.1;0.00202146,MA0072.1;0.0585718,MA0073.1;108.27,MA0074.1;1.05127,MA0076.1;0.00559782,MA0077.1;0.659504,MA0078.1;0.71276,MA0081.1;0.060595,MA0083.1;0.712182,MA0084.1;0.177258,MA0087.1;0.030742,MA0088.1;3.81806,MA0089.1;0,MA0090.1;0.000192221,MA0091.1;0.000641629,MA0092.1;0.166073,MA0093.1;0.129237,MA0095.1;0,MA0098.1;0,MA0100.1;0.0453724,MA0101.1;0.557157,MA0103.1;0.194206,MA0105.1;8.85744,MA0106.1;0.434084,MA0107.1;0.874392,MA0108.2;0.466484,MA0109.1;0,MA0111.1;0.0355286,MA0113.1;0.0154128,MA0114.1;0.167987,MA0115.1;0.0262986,MA0116.1;3.55029,MA0117.1;0.583395,MA0119.1;0.643568,MA0122.1;0.503502,MA0124.1;0.0917395,MA0125.1;0.0986924,MA0130.1;0,MA0131.1;0.66777,MA0132.1;0,MA0133.1;0,MA0135.1;0.0405383,MA0136.1;0.000831117,MA0139.1;11.2883,MA0140.1;0.405279,MA0141.1;0.0283472,MA0142.1;0.139325,MA0143.1;1.10092,MA0144.1;0.000110506,MA0145.1;4.51392,MA0146.1;14.9194,MA0147.1;7.38911,MA0148.1;0.000372235,MA0149.1;2.94824,MA0062.2;0.0101252,MA0035.2;0.288713,MA0039.2;57.931,MA0138.2;0.499076,MA0002.2;0.00320929,MA0137.2;0.00155204,MA0104.2;11.9546,MA0047.2;0.00818741,MA0112.2;1.03801,MA0065.2;2.84291,MA0150.1;0.00879974,MA0151.1;0,MA0152.1;0.0239405,MA0153.1;0.0205836,MA0154.1;1.34132,MA0155.1;8.76863,MA0156.1;4.98764e-06,MA0157.1;0.00390113,MA0158.1;0,MA0159.1;0.261269,MA0160.1;0.00508224,MA0161.1;0,MA0162.1;29.6801,MA0163.1;44.6973,MA0164.1;0.0115567,MA0080.2;1.5112e-05,MA0018.2;0.0153688,MA0099.2;0.00180659,MA0079.2;197.21,MA0102.2;0.222525,MA0258.1;0.0937817,MA0259.1;4.33093,MA0442.1;0 | |||
}} | }} |
Revision as of 11:01, 23 January 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0007399 | nervous system development | 5.28129456494637e-15 |
GO:0042995 | cell projection | 5.81097869130196e-05 |
GO:0007275 | multicellular organismal development | 0.000171887832067215 |
GO:0005515 | protein binding | 0.000294712301354937 |
GO:0000902 | cell morphogenesis | 0.00045634801167613 |
GO:0032989 | cellular structure morphogenesis | 0.00045634801167613 |
GO:0048856 | anatomical structure development | 0.00045634801167613 |
GO:0022008 | neurogenesis | 0.00045634801167613 |
GO:0048699 | generation of neurons | 0.00070303365610037 |
GO:0032502 | developmental process | 0.000779555876001031 |
GO:0048731 | system development | 0.000842990882556572 |
GO:0007242 | intracellular signaling cascade | 0.00100632657289237 |
GO:0008092 | cytoskeletal protein binding | 0.00100632657289237 |
GO:0051258 | protein polymerization | 0.00100632657289237 |
GO:0005525 | GTP binding | 0.00186717201248836 |
GO:0043005 | neuron projection | 0.00186717201248836 |
GO:0019001 | guanyl nucleotide binding | 0.00213241147307552 |
GO:0032561 | guanyl ribonucleotide binding | 0.00213241147307552 |
GO:0048666 | neuron development | 0.002338229219504 |
GO:0050789 | regulation of biological process | 0.00253292798683891 |
GO:0007264 | small GTPase mediated signal transduction | 0.00264104714546372 |
GO:0031175 | neurite development | 0.00311964039078094 |
GO:0005856 | cytoskeleton | 0.00311964039078094 |
GO:0031252 | leading edge | 0.00311964039078094 |
GO:0048869 | cellular developmental process | 0.00473379732075601 |
GO:0030154 | cell differentiation | 0.00473379732075601 |
GO:0030695 | GTPase regulator activity | 0.00579103205429693 |
GO:0000904 | cellular morphogenesis during differentiation | 0.00673817885714017 |
GO:0050794 | regulation of cellular process | 0.00697851894839415 |
GO:0006464 | protein modification process | 0.00729968355614832 |
GO:0065007 | biological regulation | 0.00747165257765644 |
GO:0006512 | ubiquitin cycle | 0.00747165257765644 |
GO:0031253 | cell projection membrane | 0.0077772919741795 |
GO:0016477 | cell migration | 0.00904002664467781 |
GO:0048667 | neuron morphogenesis during differentiation | 0.00928158087705295 |
GO:0048812 | neurite morphogenesis | 0.00928158087705295 |
GO:0030182 | neuron differentiation | 0.0093947366362998 |
GO:0006928 | cell motility | 0.0107410535932735 |
GO:0051674 | localization of cell | 0.0107410535932735 |
GO:0015630 | microtubule cytoskeleton | 0.0117316292400924 |
GO:0032589 | neuron projection membrane | 0.0122677287239358 |
GO:0031256 | leading edge membrane | 0.0122677287239358 |
GO:0030673 | axolemma | 0.0122677287239358 |
GO:0043412 | biopolymer modification | 0.0124400892569766 |
GO:0007411 | axon guidance | 0.0145412201803707 |
GO:0001764 | neuron migration | 0.0175906744963134 |
GO:0015631 | tubulin binding | 0.0175906744963134 |
GO:0043283 | biopolymer metabolic process | 0.0176592631491856 |
GO:0048858 | cell projection morphogenesis | 0.0187686280601313 |
GO:0032990 | cell part morphogenesis | 0.0187686280601313 |
GO:0030030 | cell projection organization and biogenesis | 0.0187686280601313 |
GO:0043687 | post-translational protein modification | 0.0187686280601313 |
GO:0005874 | microtubule | 0.0208117763900921 |
GO:0007409 | axonogenesis | 0.0208117763900921 |
GO:0030424 | axon | 0.0260794651791825 |
GO:0005622 | intracellular | 0.0260799910496244 |
GO:0003779 | actin binding | 0.0268069140802124 |
GO:0007010 | cytoskeleton organization and biogenesis | 0.0273968111177718 |
GO:0016881 | acid-amino acid ligase activity | 0.0280687074773023 |
GO:0021884 | forebrain neuron development | 0.0280687074773023 |
GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | 0.0280687074773023 |
GO:0010468 | regulation of gene expression | 0.0334448710205511 |
GO:0003924 | GTPase activity | 0.0334448710205511 |
GO:0008373 | sialyltransferase activity | 0.0344731425238113 |
GO:0019898 | extrinsic to membrane | 0.0344731425238113 |
GO:0000166 | nucleotide binding | 0.0357075802831204 |
GO:0021954 | central nervous system neuron development | 0.0386791223342835 |
GO:0019222 | regulation of metabolic process | 0.0470786230030266 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.0472396551064072 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
neuron | 9.78e-20 | 33 |
neuronal stem cell | 9.78e-20 | 33 |
neuroblast | 9.78e-20 | 33 |
electrically signaling cell | 9.78e-20 | 33 |
CNS neuron (sensu Vertebrata) | 7.40e-19 | 23 |
neuroblast (sensu Vertebrata) | 7.40e-19 | 23 |
electrically responsive cell | 1.37e-14 | 39 |
electrically active cell | 1.37e-14 | 39 |
ectodermal cell | 3.25e-14 | 44 |
neurectodermal cell | 3.25e-14 | 44 |
neural cell | 4.43e-14 | 43 |
non-terminally differentiated cell | 9.81e-11 | 49 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 43.1586 |
MA0004.1 | 0.149476 |
MA0006.1 | 7.02993 |
MA0007.1 | 0.208938 |
MA0009.1 | 0.235341 |
MA0014.1 | 42.9039 |
MA0017.1 | 0.000230231 |
MA0019.1 | 0.571172 |
MA0024.1 | 0.683701 |
MA0025.1 | 0.000698174 |
MA0027.1 | 0.67344 |
MA0028.1 | 0.0363959 |
MA0029.1 | 0.0197738 |
MA0030.1 | 0.000405464 |
MA0031.1 | 0.00186004 |
MA0038.1 | 0.426721 |
MA0040.1 | 0.0354066 |
MA0041.1 | 9.69434e-09 |
MA0042.1 | 3.989e-06 |
MA0043.1 | 0.00964383 |
MA0046.1 | 0.00338115 |
MA0048.1 | 2.3936 |
MA0050.1 | 0.00110529 |
MA0051.1 | 0.0703978 |
MA0052.1 | 0.0742851 |
MA0055.1 | 3.92309 |
MA0056.1 | 0 |
MA0057.1 | 21.6001 |
MA0058.1 | 0.0907762 |
MA0059.1 | 0.243033 |
MA0060.1 | 1.91485 |
MA0061.1 | 2.15388 |
MA0063.1 | 0 |
MA0066.1 | 0.36529 |
MA0067.1 | 0.139214 |
MA0068.1 | 3.76092 |
MA0069.1 | 0.884191 |
MA0070.1 | 0.0347301 |
MA0071.1 | 0.00202146 |
MA0072.1 | 0.0585718 |
MA0073.1 | 108.27 |
MA0074.1 | 1.05127 |
MA0076.1 | 0.00559782 |
MA0077.1 | 0.659504 |
MA0078.1 | 0.71276 |
MA0081.1 | 0.060595 |
MA0083.1 | 0.712182 |
MA0084.1 | 0.177258 |
MA0087.1 | 0.030742 |
MA0088.1 | 3.81806 |
MA0089.1 | 0 |
MA0090.1 | 0.000192221 |
MA0091.1 | 0.000641629 |
MA0092.1 | 0.166073 |
MA0093.1 | 0.129237 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0453724 |
MA0101.1 | 0.557157 |
MA0103.1 | 0.194206 |
MA0105.1 | 8.85744 |
MA0106.1 | 0.434084 |
MA0107.1 | 0.874392 |
MA0108.2 | 0.466484 |
MA0109.1 | 0 |
MA0111.1 | 0.0355286 |
MA0113.1 | 0.0154128 |
MA0114.1 | 0.167987 |
MA0115.1 | 0.0262986 |
MA0116.1 | 3.55029 |
MA0117.1 | 0.583395 |
MA0119.1 | 0.643568 |
MA0122.1 | 0.503502 |
MA0124.1 | 0.0917395 |
MA0125.1 | 0.0986924 |
MA0130.1 | 0 |
MA0131.1 | 0.66777 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.0405383 |
MA0136.1 | 0.000831117 |
MA0139.1 | 11.2883 |
MA0140.1 | 0.405279 |
MA0141.1 | 0.0283472 |
MA0142.1 | 0.139325 |
MA0143.1 | 1.10092 |
MA0144.1 | 0.000110506 |
MA0145.1 | 4.51392 |
MA0146.1 | 14.9194 |
MA0147.1 | 7.38911 |
MA0148.1 | 0.000372235 |
MA0149.1 | 2.94824 |
MA0062.2 | 0.0101252 |
MA0035.2 | 0.288713 |
MA0039.2 | 57.931 |
MA0138.2 | 0.499076 |
MA0002.2 | 0.00320929 |
MA0137.2 | 0.00155204 |
MA0104.2 | 11.9546 |
MA0047.2 | 0.00818741 |
MA0112.2 | 1.03801 |
MA0065.2 | 2.84291 |
MA0150.1 | 0.00879974 |
MA0151.1 | 0 |
MA0152.1 | 0.0239405 |
MA0153.1 | 0.0205836 |
MA0154.1 | 1.34132 |
MA0155.1 | 8.76863 |
MA0156.1 | 4.98764e-06 |
MA0157.1 | 0.00390113 |
MA0158.1 | 0 |
MA0159.1 | 0.261269 |
MA0160.1 | 0.00508224 |
MA0161.1 | 0 |
MA0162.1 | 29.6801 |
MA0163.1 | 44.6973 |
MA0164.1 | 0.0115567 |
MA0080.2 | 1.5112e-05 |
MA0018.2 | 0.0153688 |
MA0099.2 | 0.00180659 |
MA0079.2 | 197.21 |
MA0102.2 | 0.222525 |
MA0258.1 | 0.0937817 |
MA0259.1 | 4.33093 |
MA0442.1 | 0 |