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MCL coexpression mm9:3390

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Phase1 CAGE Peaks

 Short description
Mm9::chr3:125106990..125107049,+p1@Ndst4
Mm9::chr5:118291848..118291866,+p4@Nos1
Mm9::chr5:118292122..118292176,+p3@Nos1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0042737drug catabolic process0.00488035647693281
GO:0042738exogenous drug catabolic process0.00488035647693281
GO:0051926negative regulation of calcium ion transport0.00488035647693281
GO:0004517nitric-oxide synthase activity0.00488035647693281
GO:0043267negative regulation of potassium ion transport0.00488035647693281
GO:0002028regulation of sodium ion transport0.00488035647693281
GO:0043271negative regulation of ion transport0.00488035647693281
GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity0.00488035647693281
GO:0043266regulation of potassium ion transport0.00488035647693281
GO:0051346negative regulation of hydrolase activity0.00488035647693281
GO:0017144drug metabolic process0.00488035647693281
GO:0051924regulation of calcium ion transport0.00626278096051241
GO:0010181FMN binding0.00825793342837634
GO:0050661NADP binding0.00843465802018453
GO:0043269regulation of ion transport0.00858778011195526
GO:0046209nitric oxide metabolic process0.0107329601891086
GO:0006809nitric oxide biosynthetic process0.0107329601891086
GO:0051051negative regulation of transport0.0107329601891086
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0124262756955159
GO:0042383sarcolemma0.0146310413010513
GO:0006941striated muscle contraction0.0146310413010513
GO:0042493response to drug0.0146310413010513
GO:0008146sulfotransferase activity0.0205179883055715
GO:0043086negative regulation of catalytic activity0.0210020079537489
GO:0016782transferase activity, transferring sulfur-containing groups0.0218754360374072
GO:0050660FAD binding0.0243281954543166
GO:0044271nitrogen compound biosynthetic process0.0299979280437709
GO:0003012muscle system process0.0299979280437709
GO:0006936muscle contraction0.0299979280437709
GO:0051049regulation of transport0.0299979280437709
GO:0006816calcium ion transport0.033305406688356
GO:0005516calmodulin binding0.033305406688356
GO:0051336regulation of hydrolase activity0.033305406688356
GO:0020037heme binding0.033305406688356
GO:0046906tetrapyrrole binding0.033305406688356
GO:0006814sodium ion transport0.033305406688356
GO:0050662coenzyme binding0.0335589023897373
GO:0004497monooxygenase activity0.0342996321555843
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0342996321555843
GO:0015674di-, tri-valent inorganic cation transport0.0354868763548967
GO:0009055electron carrier activity0.0354868763548967
GO:0006813potassium ion transport0.0389539777543435
GO:0048037cofactor binding0.0417610353083993



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
central nervous system1.48e-3473
nervous system5.60e-3475
regional part of nervous system6.37e-2654
neural tube5.45e-2452
neural rod5.45e-2452
future spinal cord5.45e-2452
neural keel5.45e-2452
ectoderm-derived structure1.52e-2395
ectoderm1.52e-2395
presumptive ectoderm1.52e-2395
neurectoderm2.06e-2264
neural plate2.06e-2264
presumptive neural plate2.06e-2264
brain5.73e-2147
future brain5.73e-2147
regional part of brain5.38e-2046
gray matter4.10e-1934
anterior neural tube2.26e-1840
regional part of forebrain1.86e-1739
forebrain1.86e-1739
future forebrain1.86e-1739
ecto-epithelium2.21e-1773
brain grey matter4.52e-1629
regional part of telencephalon4.52e-1629
telencephalon4.52e-1629
pre-chordal neural plate2.52e-1449
structure with developmental contribution from neural crest2.69e-1092
cerebral cortex3.09e-1021
cerebral hemisphere3.09e-1021
pallium3.09e-1021
autonomic nervous system2.48e-099
peripheral nervous system4.55e-0811
basal ganglion2.49e-078
nuclear complex of neuraxis2.49e-078
aggregate regional part of brain2.49e-078
collection of basal ganglia2.49e-078
cerebral subcortex2.49e-078
regional part of cerebral cortex2.50e-0717


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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